Sam Lucas

Accepting PhD Students

PhD projects

Sam Lucas is an integrative physiologist whose primary research interests are focused on the mechanisms that regulate human cerebral blood flow in health and disease. He has a specific interest in how cerebral blood flow is regulated with ageing and during stress (especially hypoxia, exercise, orthostatic, thermal and cognitive) and the resultant impact on function (e.g., breathing control, neurophysiological and psychological responses). His research direction is to continue to expand knowledge in this area, as well as investigate how and what forms of exercise best improve brain and systemic vascular function. This work will improve our understanding of the role that exercise can play in improving brain and vascular health, as well as how exercise can best be utilised in disease populations with known impairment (e.g., dementia, diabetes, hypertension, chronic heart failure); including those that are unable undertake ‘traditional’ exercise programmes.

Dr Lucas is currently supervising four doctoral researchers and welcomes applications in his areas of interest.

Research activity per year

145 Article
12 Review article
8 Abstract
4 Conference contribution
More

1 - 50 out of 179 results

2024
Brief cycling intervals incrementally increase the number of hematopoietic stem and progenitor cells in human peripheral blood
Pradana, F., Nijjar, T., Cox, P. A., Morgan, P. T., Podlogar, T., Lucas, S. J. E., Drayson, M. T., Kinsella, F. A. M. & Wadley, A. J., 30 Jul 2024, In: Frontiers in Physiology. 15, 1327269.
Research output: Contribution to journal › Article › peer-review

Open Access
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34 Downloads (Pure)
Cerebrovascular Reactivity Following Spinal Cord Injury
Weber, A. M., Nightingale, T. E., Jarrett, M., Lee, A. H. X., Campbell, O. L., Walter, M., Lucas, S. J. E., Phillips, A., Rauscher, A. & Krassioukov, A. V., 23 May 2024, In: Topics in spinal cord injury rehabilitation. 30, 2, p. 78-95 18 p.
Research output: Contribution to journal › Review article › peer-review
Determinants of cerebral blood flow and arterial transit time in healthy older adults
Feron, J., Segaert, K., Rahman, F., Fosstveit, S. H., Joyce, K. E., Gilani, A., Lohne-Seiler, H., Berntsen, S., Mullinger, K. J. & Lucas, S. J. E., 18 Sept 2024, In: Aging. 16, 18, p. 12473—12497 25 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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8 Downloads (Pure)
Effects of exercise training on language comprehension in monolingual and bilingual older adults: A randomized controlled trial
Fernandes, E. G., H. Fosstveit, S., Feron, J., Rahman, F., Lucas, S., Lohne‐Seiler, H., Berntsen, S., Wetterlin, A., Segaert, K. & Wheeldon, L., 22 Nov 2024, (Accepted/In press) In: Aging, Neuropsychology, and Cognition.
Research output: Contribution to journal › Article › peer-review

Open Access
File

10 Downloads (Pure)
Evaluating the Phenotypic Patterns of Post-Traumatic Headache: A Systematic Review of Military Personnel
UK mTBI Predict Consortium, Lyons, H. S., Sassani, M., Thaller, M., Yiangou, A., Grech, O., Mollan, S. P., Wilson, D. R., Lucas, S. J. E., Mitchell, J. L., Hill, L. J. & Sinclair, A. J., 19 Jul 2024, (E-pub ahead of print) In: Military medicine. 9 p., usae353.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
111 Downloads (Pure)
Exposure to passive heat and cold stress differentially modulates cerebrovascular-CO₂ responsiveness
Skinner, B. D., Lucas, R. A. I. & Lucas, S. J. E., 1 Jan 2024, In: Journal of Applied Physiology. 136, 1, p. 23–32 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
38 Downloads (Pure)
HIIT at Home: Enhancing Cardiorespiratory Fitness in Older Adults—A Randomized Controlled Trial
Fosstveit, S. H., Berntsen, S., Feron, J., Joyce, K. E., Ivarsson, A., Segaert, K., Lucas, S. J. E. & Lohne-Seiler, H., 9 Jul 2024, In: Scandinavian Journal of Medicine and Science in Sports. 34, 7, p. e14694 e14694.
Research output: Contribution to journal › Article › peer-review

Open Access
File
99 Downloads (Pure)
Isometric Exercise Training and Arterial Hypertension: An Updated Review
Edwards, J. J., Coleman, D. A., Ritti-Dias, R. M., Farah, B. Q., Stensel, D. J., Lucas, S. J. E., Millar, P. J., Gordon, B. D. H., Cornelissen, V., Smart, N. A., Carlson, D. J., McGowan, C., Swaine, I., Pescatello, L. S., Howden, R., Bruce-Low, S., Farmer, C. K. T., Leeson, P., Sharma, R. & O'Driscoll, J. M., 19 May 2024, (E-pub ahead of print) In: Sports Medicine.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
358 Downloads (Pure)
Neurovascular coupling methods in healthy individuals using transcranial doppler ultrasonography: A systematic review and consensus agreement
Ball, J. D., Hills, E., Altaf, A., Ramesh, P., Green, M., Surti, F. B., Minhas, J. S., Robinson, T. G., Bond, B., Lester, A., Hoiland, R., Klein, T., Liu, J., Nasr, N., Junejo, R. T., Müller, M., Lecchini-Visintini, A., Mitsis, G., Burma, J. S. & Smirl, J. D. & 11 others, Pizzi, M. A., Manquat, E., Lucas, S. J., Mullinger, K. J., Mayhew, S., Bailey, D. M., Rodrigues, G., Soares, P. P., Phillips, A. A., Prokopiou, P. C. & C Beishon, L., 7 Aug 2024, (E-pub ahead of print) In: Journal of Cerebral Blood Flow and Metabolism.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
87 Downloads (Pure)
Nocturnal pulse oximetry for the detection and prediction of acute mountain sickness: An observational study
Joyce, K., Ashdown, K., Bradley, C., Delamere, J., Lewis, C. T., Letchford, A., Lucas, B., Malein, W., Thomas, O., Bradwell, J. & Lucas, S., 1 Nov 2024, In: Experimental Physiology. 109, 11, p. 1856-1868 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
80 Downloads (Pure)
Pulse oximetry for the prediction of acute mountain sickness: A systematic review
Goves, J., Joyce, K., Broughton, S., Greig, J., Ashdown, K., Bradwell, J. & Lucas, S., 25 Sept 2024, (E-pub ahead of print) In: Experimental Physiology. 16 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
72 Downloads (Pure)
The Environmental Impact of a High-Altitude Medical Research Expedition
Joyce, K. E., Campbell, C. A., Bradwell, A. R., Lucas, S. J. E., Lewis, C. T., Lucas, R. A. I. & Edsell, M., 25 Oct 2024, (E-pub ahead of print) In: High Altitude Medicine and Biology.
Research output: Contribution to journal › Article › peer-review

Open Access
File
26 Downloads (Pure)
The impact of uninterrupted sitting on central and peripheral cardiovascular function in pre-menopausal and post-menopausal women
Moinuddin, A., Stone, K., Turner, L., Paterson, C., Hall, N., Daykin, A., Lucas, S., Faulkner, J. & Fryer, S., Oct 2024, In: European Journal of Applied Physiology. 124, 10, p. 3021–3029 9 p.
Research output: Contribution to journal › Article › peer-review
The Impact of Valsalva Manoeuvres and Exercise on Intracranial Pressure and Cerebrovascular Dynamics in Idiopathic Intracranial Hypertension
Yiangou, A., Weaver, S. R. C., Thaller, M., Mitchell, J. L., Lyons, H. S., Tsermoulas, G., Mollan, S. P., Lucas, S. J. E. & Sinclair, A. J., 22 Nov 2024, In: Neuro-Ophthalmology. 48, 2, p. 122-133 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
48 Downloads (Pure)
The intensity paradox: A systematic review and meta‐analysis of its impact on the cardiorespiratory fitness of older adults
H. Fosstveit, S., Lohne‐Seiler, H., Feron, J., Lucas, S. J. E., Ivarsson, A. & Berntsen, S., 5 Feb 2024, In: Scandinavian Journal of Medicine and Science in Sports. 34, 2, 20 p., e14573.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
41 Downloads (Pure)
Variability of flow-mediated dilation across lower and upper limb conduit arteries
Daniele, A., Lucas, S. J. E. & Rendeiro, C., 15 Jun 2024, (E-pub ahead of print) In: European Journal of Applied Physiology. 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
43 Downloads (Pure)
2023
Effects of Stroop task duration on subsequent cognitive and physical performance
Dallaway, N., Lucas, S. J. E. & Ring, C., 1 Sept 2023, In: Psychology of Sport and Exercise. 68, 8 p., 102459.
Research output: Contribution to journal › Article › peer-review

Open Access
File
118 Downloads (Pure)
Exercise and aerobic capacity in individuals with spinal cord injury: A systematic review with meta-analysis and meta-regression
Hodgkiss, D., Bhangu, G. S., Lunny, C., Jutzeler, C. R., Chiou, S.-Y., Walter, M., Lucas, S., Krassioukov, A. & Nightingale, T. E., 27 Nov 2023, (E-pub ahead of print) In: PLoS Medicine. 20, 11, 40 p., e1004082.
Research output: Contribution to journal › Article › peer-review

Open Access
File
123 Downloads (Pure)
Fat Consumption Attenuates Cortical Oxygenation during Mental Stress in Young Healthy Adults
Baynham, R., Lucas, S. J. E., Weaver, S. R. C., Veldhuijzen van Zanten, J. J. C. S. & Rendeiro, C., 14 Sept 2023, In: Nutrients. 15, 18, 15 p., 3969.
Research output: Contribution to journal › Article › peer-review

Open Access
File
57 Downloads (Pure)
Loop gain response to increased cerebral blood flow at high altitude
Burgess, A., Andrews, G., Colby, K. M. E., Lucas, S. J. E., Sprecher, K., Donnelly, J., Ainslie, P. N., Basnet, A. S. & Burgess, K. R., 12 Dec 2023, (E-pub ahead of print) In: Sleep and Breathing.
Research output: Contribution to journal › Article › peer-review
Menstrual phase influences cerebrovascular responsiveness in females but may not affect sex differences
Skinner, B. D., Weaver, S. R. C., Lucas, S. J. E. & Lucas, R. A. I., 4 Jan 2023, In: Frontiers in Physiology. 13, 12 p., 1035452.
Research output: Contribution to journal › Article › peer-review

Open Access
File
81 Downloads (Pure)
Prior brain endurance training improves endurance exercise performance
Dallaway, N., Lucas, S., Marks, J. & Ring, C., 5 Feb 2023, (E-pub ahead of print) In: European Journal of Sport Science.
Research output: Contribution to journal › Article › peer-review

Open Access
File
157 Downloads (Pure)
Single vesicle analysis reveals the release of tetraspanin positive extracellular vesicles into circulation with high intensity intermittent exercise
McIlvenna, L. C., Parker, H., Seabright, A. P., Sale, B., Anghileri, G., Weaver, S. R. C., Lucas, S. J. E. & Whitham, M., 28 Feb 2023, (E-pub ahead of print) In: The Journal of Physiology. 0, 0, p. 1-14 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
83 Downloads (Pure)
Transfer function analysis of dynamic cerebral autoregulation: a CARNet white paper 2022 update
Panerai, R., Brassard, P., Burma, J., Castro, P., Claassen, J., van Lieshout, J. J., Liu, J., Lucas, S., Minhas, J. S., Mitsis, G. D., Nogueira, R. C., Ogoh, S., Payne, S. J., Rickards, C. A., Robertson, A. D., Rodrigues, G. D., Smirl, J. D. & Simpson, D. M., Jan 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 1, 23 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
157 Downloads (Pure)
2022
Baseline psychological traits contribute to Lake Louise acute mountain sickness score at high altitude
Talks, B. J., Campbell, C., Larcombe, S. J., Marlow, L., Finnegan, S. L., Lewis, C. T., Lucas, S. J. E., Harrison, O. K. & Pattinson, K. T. S., 28 Mar 2022, In: High Altitude Medicine and Biology. 23, 1, p. 69-77 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
77 Downloads (Pure)
Cognitive tasks elicit mental fatigue and impair subsequent physical task endurance: effects of task duration and type
Dallaway, N., Lucas, S. & Ring, C., 21 Jun 2022, (E-pub ahead of print) In: Psychophysiology. 13 p., e14126.
Research output: Contribution to journal › Article › peer-review

Open Access
File
430 Downloads (Pure)
Detrimental effects of physical inactivity on peripheral and brain vasculature in humans: insights into mechanisms, long-term health consequences and protective strategies
Daniele, A., Lucas, S. & Rendeiro, C., 27 Sept 2022, In: Frontiers in Physiology. 13, 34 p., 998380.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
286 Downloads (Pure)
Non-pharmacological interventions for vascular health and the role of the endothelium
Weaver, S., Rendeiro, C., Lucas, B., Cable, N., Nightingale, T. E., McGettrick, H. & Lucas, S., Dec 2022, In: European Journal of Applied Physiology. 122, 12, p. 2493–2514 22 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
66 Downloads (Pure)
Overnight and morning peripheral oxygenation are not equal during ascent to altitude
Joyce, K., Ashdown, K., Lewis, C. T., Bradley, C., Letchford, A., Lucas, B., Malein, W., Owen, T., Bradwell, J. & Lucas, S., 2 Sept 2022.
Research output: Contribution to conference (unpublished) › Paper › peer-review
Post-exercise urinary alpha-1 acid glycoprotein is not dependent on hypoxia
Joyce, K. E., Balanos, G. M., Bradley, C., Fountain, A., Bradwell, A. R. & Lucas, S. J. E., 1 Jan 2022, In: Journal of Applied Physiology. 132, 1, p. 261-269 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
73 Downloads (Pure)
2021
A systematic review and meta-analysis examining whether changing ovarian sex steroid hormone levels influence cerebrovascular function
Skinner, B., Davies, R., Weaver, S., Cable, N., Lucas, S. & Lucas, B., 17 Jun 2021, In: Frontiers in Physiology. 12, 687591.
Research output: Contribution to journal › Article › peer-review

Open Access
File
176 Downloads (Pure)
Baseline psychological traits contribute to Lake Louise Acute Mountain Sickness score at high altitude
Talks, B. J., Campbell, C., Larcombe, S. J., Marlow, L., Finnegan, S. L., Lewis, C. T., Lucas, S. J. E., Harrison, O. K. & Pattinson, K. T., 23 Jul 2021, bioRxiv.
Research output: Working paper/Preprint › Preprint
Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise
Weaver, S., Skinner, B., Furlong, R., Lucas, B., Cable, N., Rendeiro, C., McGettrick, H. & Lucas, S., 21 Jan 2021, In: Frontiers in Physiology. 11, 609935.
Research output: Contribution to journal › Article › peer-review

Open Access
File
180 Downloads (Pure)
Contrasting measures of cerebrovascular reactivity between MRI and Doppler: a cross-sectional study of younger and older healthy individuals
Burley, C., Francis, S., Thomas, K. N., Whittaker, A., Lucas, S. & Mullinger, K., 12 Apr 2021, In: Frontiers in Physiology. 12, 17 p., 656746.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

174 Downloads (Pure)
Corrigendum: Cerebral Hemodynamic and Neurotrophic Factor Responses Are Dependent on the Type of Exercise
Weaver, S. R., Skinner, B. D., Furlong, R., Lucas, R. A. I., Cable, N. T., Rendeiro, C., McGettrick, H. M. & Lucas, S. J. E., 24 Feb 2021, In: Frontiers in Physiology. 12, 659873.
Research output: Contribution to journal › Article › peer-review

Open Access
File
143 Downloads (Pure)
Effect of losartan on performance and physiological responses to exercise at high altitude (5035 m)
Lucas, S. J. E., Malein, W. L., Thomas, O. D., Ashdown, K. M., Rue, C. A., Joyce, K. E., Newman, C., Cadigan, P., Johnson, B., Myers, S. D., Myers, F. A., Wright, A. D., Delamere, J., Imray, C. H. E., Bradwell, A. R. & Edsell, M., 7 Jan 2021, In: BMJ Open Sport & Exercise Medicine. 7, 1, e000982.
Research output: Contribution to journal › Article › peer-review

Open Access
File
167 Downloads (Pure)
Imaging cerebral blood flow for brain health measurement
Burley, C., Mullinger, K., Thomas, K. N., Rendeiro, C., Dehghani, H. & Lucas, S., 17 Sept 2021, Encyclopedia of Behavioral Neuroscience: Second Edition. Sala, S. D. (ed.). Elsevier, Vol. 1. p. 126-135 10 p.
Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary
Indomethacin markedly blunts cerebral perfusion and reactivity, with little cognitive consequence in healthy young and older adults
Shoemaker, L., Wilson, L., Lucas, S., Machado, L., Walker, R. & Cotter, J. D., 15 Feb 2021, In: The Journal of Physiology. 599, 4, p. 1097-1113
Research output: Contribution to journal › Article › peer-review

Open Access
File
6 Citations (Scopus)

135 Downloads (Pure)
Losing the dogmatic view of cerebral autoregulation
Brassard, P., Labrecque, L., Smirl, J. D., Tymko, M. M., Caldwell, H. G., Hoiland, R. L., Lucas, S., Denault, A., Couture, E. & Ainslie, P. N., Aug 2021, In: Physiological reports. 9, 15, 11 p., e14982.
Research output: Contribution to journal › Article › peer-review

Open Access
File
321 Downloads (Pure)
Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: comparison in younger and older adults
Burley, C., Francis, S., Whittaker, A., Mullinger, K. & Lucas, S., Jul 2021, In: Brain and Behavior. 11, 7, 13 p., e02126.
Research output: Contribution to journal › Article › peer-review

Open Access
File
258 Downloads (Pure)
Regulation of cerebral blood flow by arterial PCO₂ independent of metabolic acidosis at 5,050 m
Caldwell, H. G., Smith, K. J., Lewis, N. C. S., Hoiland, R. L., Willie, C. K., Lucas, S., Stembridge, M., Burgess, K. R., MacLeod, D. B. & Ainslie, P. N., 28 May 2021, (E-pub ahead of print) In: The Journal of Physiology. 599, 14, p. 3513-3530
Research output: Contribution to journal › Article › peer-review

Open Access
File
96 Downloads (Pure)
Sex differences in adaptation to intermittent post-exercise sauna bathing in trained middle-distance runners
Kirby, N., Lucas, S., Cable, T., Armstrong, O., Weaver, S. & Lucas, B., 23 Jul 2021, In: Sports Medicine - Open. 7, 1, 18 p., 51.
Research output: Contribution to journal › Article › peer-review

Open Access
File
144 Downloads (Pure)
Subject specific atlas-based frequency domain diffuse optical tomography
Perkins, G. A., Lucas, S. J. E. & Dehghani, H., 9 Dec 2021, Diffuse Optical Spectroscopy and Imaging VIII. Contini, D., Hoshi, Y. & O'Sullivan, T. D. (eds.). SPIE, 119200L. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 11920).
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
The acute cardiorespiratory and cerebrovascular response to resistance exercise
Perry, B. G. & Lucas, S., Dec 2021, In: Sports Medicine - Open. 7, 1, 19 p., 36 .
Research output: Contribution to journal › Review article › peer-review

Open Access
File
150 Downloads (Pure)
2020

Acetazolamide can impair exercise performance; it depends upon the cohort studied
Joyce, K. E., Lucas, S. J. E. & Bradwell, A. R., 15 May 2020, In: Journal of Applied Physiology. 128, 5, p. 1457 1 p.
Research output: Contribution to journal › Letter › peer-review

Open Access

1 Citation (Scopus)
Acute exercise-related cognitive effects are not attributable to changes in end-tidal CO2 or cerebral blood velocity
Shoemaker, L. N., Wilson, L. C., Lucas, S. J. E., Machado, L. & Cotter, J. D., 31 May 2020, (E-pub ahead of print) In: European Journal of Applied Physiology. 120, 7, p. 1637-1649
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
A novel mixed living high training low intervention and the hematological module of the athlete biological passport
Voss, S., Al-Hamad, K., Samsam, W., Cherif, A., Georgakopoulos, C., Al Maadheed, M., Balanos, G., Lucas, S., Sottas, P.-E., Wilson, M. & Townsend, N., Mar 2020, In: Drug Testing and Analysis. 12, 3, p. 323-330 8 p.
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Concurrent brain endurance training improves endurance exercise performance
Dallaway, N., Lucas, S. & Ring, C., 21 Oct 2020, (E-pub ahead of print) In: Journal of Science and Medicine in Sport.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

529 Downloads (Pure)
Dietary flavanols improve cerebral cortical oxygenation and cognition in healthy adults
Gratton, G., Weaver, S., Burley, C., Low, K., Maclin, E., Johns, P., Pham, Q., Lucas, S., Fabiani, M. & Rendeiro, C., 24 Nov 2020, In: Scientific Reports. 10, 19409.
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Citations (Scopus)

266 Downloads (Pure)
Does Heat Thermotherapy Improve Cardiovascular and Cardiometabolic Health? A Systematic Review and Narrative Synthesis of the Literature
Price, B. S., Lucas, S. J. E., Gifford, R. E., Cable, N. T. & Lucas, R. A. I., 26 May 2020, medRxiv.
Research output: Working paper/Preprint › Preprint

Sam Lucas

Research output

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