Rowan Hardy

Research output

Research output per year 2000 2021 2023 2023

• 42 Article
• 11 Review article
• 2 Abstract

Research output per year

Research output per year

Search results

• 11 beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

  Hardy, R., Fenton, C., Croft, A., Naylor, A., Begum, R., Desanti, G., Buckley, C., Lavery, G., Cooper, M. S. & Raza, K., Aug 2018, In: Journal of Autoimmunity. 92, p. 104-113 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 100%
  • Synovitis 78%
  • Arthritis 58%
  • Joints 47%
  • Bone and Bones 39%
  11 Citations (Scopus)

  313 Downloads (Pure)

• 11β-HSD1 determines the extent of muscle atrophy in a model of acute exacerbation of COPD

  Webster, J. M., Waaijenberg, K., van de Worp, W. R. P. H., Kelders, M. C. J. M., Lambrichts, S., Martin, C., Verhaegen, F., Van der Heyden, B., Smith, C., Lavery, G. G., Schols, A. M. W. J., Hardy, R. S. & Langen, R. C. J., 1 Apr 2023, In: American journal of physiology. Lung cellular and molecular physiology. 324, 4, p. L400-L412

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Muscular Atrophy 79%
  • Glucocorticoids 62%
  • Chronic Obstructive Pulmonary Disease 61%
  • Muscles 41%
  40 Downloads (Pure)

• 11β-HSD1 Plays a critical role in trabecular bone loss associated with systemic glucocorticoid therapy

  Fenton, C., Doig, C., Fareed, S., Naylor, A., Morrell, A. P., Addison, O., Wehmeyer, C., Buckley, C., Cooper, M. S., Lavery, G., Raza, K. & Hardy, R., 16 Aug 2019, In: Arthritis Research & Therapy. 21, 1, 188.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Cancellous Bone 72%
  • Glucocorticoids 62%
  • Osteoblasts 49%
  • Corticosterone 36%
  8 Citations (Scopus)

  177 Downloads (Pure)

• 11β-hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

  Hardy, R. S., Doig, C. L., Hussain, Z., O'Leary, M., Morgan, S. A., Pearson, M. J., Naylor, A., Jones, S., Filer, A., Stewart, P. M., Buckley, C. D., Lavery, G. G., Cooper, M. S. & Raza, K., Dec 2016, In: Journal of Pathology. 240, 4, p. 472-483 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Muscles 41%
  • Inflammation 40%
  • Glucocorticoids 28%
  • Skeletal Muscle Fibers 17%
  14 Citations (Scopus)

  140 Downloads (Pure)

• 11β-hydroxysteroid dehydrogenase type 1 within osteoclasts mediates the bone protective properties of therapeutic corticosteroids in chronic inflammation

  Fenton, C. G., Crastin, A., Martin, C. S., Suresh, S., Montagna, I., Hussain, B., Naylor, A. J., Jones, S. W., Hansen, M. S., Gorvin, C. M., Price, M., Filer, A., Cooper, M. S., Lavery, G. G., Raza, K. & Hardy, R. S., 30 Jun 2022, In: International Journal of Molecular Sciences. 23, 13, p. 7334 18 p., 7334.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adrenal Cortex Hormones 100%
  • Osteoclasts 97%
  • corticosteroids 96%
  • Oxidoreductases 80%
  • 11-beta-Hydroxysteroid Dehydrogenases 77%
  41 Downloads (Pure)

• Acute respiratory distress syndrome is associated with impaired alveolar macrophage efferocytosis

  Mahida, R. Y., Scott, A., Parekh, D., Lugg, S. T., Hardy, R. S., Lavery, G. G., Matthay, M. A., Naidu, B., Perkins, G. D. & Thickett, D. R., 9 Sept 2021, In: The European respiratory journal. 58, 3, 2100829.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  32 Downloads (Pure)

• Assessment of Alveolar Macrophage Dysfunction Using an in vitro Model of Acute Respiratory Distress Syndrome

  Mahida, R. Y., Scott, A., Parekh, D., Lugg, S. T., Belchamber, K. B. R., Hardy, R. S., Matthay, M. A., Naidu, B. & Thickett, D. R., 29 Sept 2021, In: Frontiers in Medicine. 8, 737859.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alveolar Macrophages 100%
  • Adult Respiratory Distress Syndrome 98%
  • In Vitro Techniques 39%
  • Bronchoalveolar Lavage 24%
  • Phagocytosis 22%
  97 Downloads (Pure)

• Bone loss in inflammatory disorders.

  Hardy, R. & Cooper, M., 1 Jun 2009, In: Journal of Endocrinology. 201, 3, p. 309-20 12 p.

  Research output: Contribution to journal › Article

  • Osteitis 100%
  • Bone Resorption 77%
  • Osteogenesis 67%
  • Bone and Bones 45%
  • Bone Remodeling 39%
  226 Citations (Scopus)

• Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE-/- Mice

  Rokad, F., Moseley, R., Hardy, R., Chukkapalli, S., Crean, S., Kesavalu, L. & Singhrao, S., 18 Sept 2017, In: Journal of Alzheimer's Disease. 60, 2, p. 359-369 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Porphyromonas gingivalis 100%
  • Apolipoproteins 95%
  • Microvessels 81%
  • Knockout Mice 74%
  • brain 68%
  9 Citations (Scopus)

• Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation

  Hardy, R. S., Hülso, C., Liu, Y., Gasparini, S. J., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P. M., Raza, K., Cooper, M., Seibel, M. J. & Zhou, H., 29 Jan 2013, In: Arthritis Research & Therapy. 15, R24.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synoviocytes 100%
  • Fibroblasts 54%
  • Joints 52%
  • Inflammation 43%
  • Interleukin-6 23%
  33 Citations (Scopus)

  188 Downloads (Pure)

• Desmocollin switching in colorectal cancer

  Khan, K., Hardy, R., Haq, A., Ogunbiyi, O., Morton, D. & Chidgey, M., 31 Oct 2006, In: British Journal of Cancer. 95, p. 1367-1370 4 p.

  Research output: Contribution to journal › Article

  • Desmocollins 100%
  • Colorectal Neoplasms 47%
  • Desmosomal Cadherins 20%
  • Adenocarcinoma 18%
  • Epithelium 18%
  57 Citations (Scopus)

• Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β

  O’Neil, J. D., Bolimowska, O. O., Clayton, S. A., Tang, T., Daley, K. K., Lara-Reyna, S., Warner, J., Martin, C. S., Mahida, R. Y., Hardy, R. S., Arthur, J. S. C. & Clark, A. R., 24 Oct 2023, In: Frontiers in immunology. 14, 17 p., 1190261.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dexamethasone 100%
  • Interferons 99%
  • Lipopolysaccharides 93%
  • Macrophages 76%
  • Interferon Type I 36%
  29 Downloads (Pure)

• Differential expression, function and response to inflammatory stimuli of 11 beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation

  Hardy, R., Filer, A., Cooper, M., Parsonage, G., Raza, K., Hardie, D., Rabbitt, E., Stewart, P., Buckley, C. & Hewison, M., 17 Jun 2006, In: Arthritis Research & Therapy. 8, 4, R108.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 100%
  • Fibroblasts 49%
  • Inflammation 39%
  • Bone Marrow 15%
  • Glucocorticoids 14%
  73 Citations (Scopus)

  144 Downloads (Pure)

• Differential glucocorticoid metabolism in patients with persistent versus resolving inflammatory arthritis

  Nanus, D. E., Filer, A. D., Yeo, L., Scheel-toellner, D., Hardy, R., Lavery, G. G., Stewart, P. M., Buckley, C. D., Tomlinson, J. W., Cooper, M. S. & Raza, K., 14 May 2015, In: Arthritis Research & Therapy. 17, 1, 121.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids 100%
  • Arthritis 96%
  • 11-beta-Hydroxysteroid Dehydrogenases 95%
  • Rheumatoid Arthritis 45%
  • Synovitis 38%
  9 Citations (Scopus)

  185 Downloads (Pure)

• DKK1 expression by synovial fibroblasts in very early rheumatoid arthritis associates with lymphocyte adhesion in an in vitro flow co-culture system

  Juarez, M., McGettrick, H. M., Scheel-Toellner, D., Yeo, L., Spengler, J., de Paz, B., Hardy, R., Cooper, M., Raza, K., Buckley, C. D. & Filer, A., 19 Jan 2016, In: Arthritis Research & Therapy. 18, 1, 14.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Coculture Techniques 100%
  • Rheumatoid Arthritis 83%
  • Fibroblasts 74%
  • Lymphocytes 69%
  • Arthritis 55%
  11 Citations (Scopus)

  220 Downloads (Pure)

• Exploring the interface between inflammatory and therapeutic glucocorticoid induced bone and muscle loss

  Webster, J., Fenton, C., Langen, R. & Hardy, R., 16 Nov 2019, In: International Journal of Molecular Sciences. 20, 22, 22 p., 5768.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids 100%
  • glucocorticoids 92%
  • Glucocorticoid 65%
  • muscles 53%
  • bones 49%
  7 Citations (Scopus)

  158 Downloads (Pure)

• Expression of 11β-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments

  Patel, P., Hardy, R., Sumathi, V., Bartle, G., Kindblom, L-G., Grimer, R., Bujalska, I., Stewart, P. M., Rabbitt, E., Gittoes, N. J. L. & Cooper, M. S., 2012, In: Endocrine-related cancer. 19, 4, p. 589-98 10 p.

  Research output: Contribution to journal › Article › peer-review

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Osteosarcoma 71%
  • Enzymes 37%
  • Glucocorticoids 37%
  • Cortisone 16%
  9 Citations (Scopus)

• GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells

  Hansen, M. S., Søe, K., Christensen, L. L., Fernandez-Guerra, P., Hansen, N. W., Wyatt, R. A., Martin, C., Hardy, R. S., Andersen, T. L., Olesen, J. B., Hartmann, B., Rosenkilde, M. M., Kassem, M., Rauch, A., Gorvin, C. & Frost, M., 16 Jan 2023, In: European Journal of Endocrinology . 188, 1, lvac004.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • gastric inhibitory polypeptide receptor 100%
  • Osteoclasts 69%
  • Osteoblasts 64%
  • Peptides 42%
  • Glucose 42%
  63 Downloads (Pure)

• Global deletion of 11β-HSD1 prevents muscle wasting associated with glucocorticoid therapy in polyarthritis

  Webster, J. M., Sagmeister, M. S., Fenton, C. G., Seabright, A. P., Lai, Y. C., Jones, S. W., Filer, A., Cooper, M. S., Lavery, G. G., Raza, K., Langen, R. & Hardy, R. S., 22 Jul 2021, In: International Journal of Molecular Sciences. 22, 15, 14 p., 7828.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids 100%
  • glucocorticoids 92%
  • Oxidoreductases 77%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 76%
  • dehydrogenases 73%
  157 Downloads (Pure)

• Glucocorticoid activation by 11β-hydroxysteroid dehydrogenase enzymes in relation to inflammation and glycaemic control in chronic kidney disease: A cross-sectional study

  Sagmeister, M., Taylor, A., Fenton, A., Wall, N., Chanouzas, D., Nightingale, P., Ferro, C. J., Arlt, W., Cockwell, P., Hardy, R. & Harper, L., Jan 2019, In: Clinical Endocrinology. 90, 1, p. 241-249 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tetrahydrocortisone 100%
  • 11-beta-Hydroxysteroid Dehydrogenases 82%
  • Chronic Renal Insufficiency 52%
  • Glucocorticoids 51%
  • Glomerular Filtration Rate 43%
  4 Citations (Scopus)

  161 Downloads (Pure)

• Glucocorticoid-induced osteoporosis - a disorder of mesenchymal stromal cells?

  Hardy, R. & Cooper, M. S., 2011, In: Frontiers in Endocrinology. 2, p. 24

  Research output: Contribution to journal › Article › peer-review

  • Glucocorticoids 100%
  • Mesenchymal Stem Cells 98%
  • Osteoporosis 97%
  • Tissue Engineering 15%
  • Cartilage 13%
  18 Citations (Scopus)

• Glucocorticoid metabolism in rheumatoid arthritis

  Raza, K. & Hardy, R., May 2014, In: Annals of the New York Academy of Sciences. 1318, p. 18-26

  Research output: Contribution to journal › Article › peer-review

  • Enzymes 100%
  • Glucocorticoid 91%
  • Inflammation 86%
  • Metabolism 72%
  • Glucocorticoids 64%
  7 Citations (Scopus)

  26 Downloads (Pure)

• Glucocorticoids and bone: consequences of endogenous and exogenous excess and replacement therapy

  Hardy, R., Zhou, H., Seibel, M. J. & Cooper, M. S., 13 Jun 2018, In: Endocrine Reviews. er.2018-00097.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids 100%
  • Bone and Bones 65%
  • Cushing Syndrome 21%
  • Therapeutics 17%
  • Addison Disease 12%
  55 Citations (Scopus)

  260 Downloads (Pure)

• Impaired alveolar macrophage 11β-hydroxysteroid dehydrogenase type 1 reductase activity contributes to increased pulmonary inflammation and mortality in sepsis-related ARDS

  Mahida, R. Y., Lax, S., Bassford, C. R., Scott, A., Parekh, D., Hardy, R. S., Naidu, B., Matthay, M. A., Stewart, P. M., Cooper, M. C., Perkins, G. D. & Thickett, D. R., 27 Apr 2023, In: Frontiers in immunology. 14, 14 p., 1159831.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Alveolar Macrophages 76%
  • Adult Respiratory Distress Syndrome 75%
  • Oxidoreductases 62%
  • Pneumonia 55%
  31 Downloads (Pure)

• Inflammation-based Scores In Benign Adrenocortical Tumours Are Linked To The Degree Of Cortisol Excess: a retrospective single centre study

  Favero, V., Prete, A., Mangone, A., Elhassan, Y., Pucino, V., Asia, M., Hardy, R., Chiodini, I. & Ronchi, C., 23 Nov 2023, In: European Journal of Endocrinology. 183, p. 517-526 10 p., lvad151.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hydrocortisone 100%
  • Cushing Syndrome 77%
  • Inflammation 66%
  • Lymphocytes 39%
  • Neoplasms 36%
  9 Downloads (Pure)

• Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

  Ahasan, MM., Hardy, R., Jones, C., Kaur, K., Nanus, D., Juarez, M., Morgan, S., Hassan-Smith, Z., Bénézech, C., Caamaño, JH., Hewison, M., Lavery, G., Rabbitt, E., Clark, AR., Filer, A., Buckley, C., Raza, K., Stewart, P. & Cooper, M., Jul 2012, In: Arthritis & Rheumatism. 67, 7, p. 2404-2413

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Glucocorticoids 62%
  • Mesenchymal Stem Cells 61%
  • Dual Specificity Phosphatase 1 29%
  • Stromal Cells 19%
  33 Citations (Scopus)

  113 Downloads (Pure)

• LOCAL ACTIVATION OF ENDOGENOUS GLUCOCORTICOIDS ATTENUATE BONE LOSS IN CHRONIC INFLAMMATORY ARTHRITIS

  Hardy, R. S., Begum, R., Naylor, A., Saghir, A., Lavery, G., Filer, A., Jones, S. W., Buckley, C., Cooper, M. & Raza, K., 2017, In: Rheumatology.

  Research output: Contribution to journal › Article › peer-review

• Local and systemic glucocorticoid metabolism in inflammatory arthritis

  Hardy, R., Rabbitt, E., Filer, A., Emery, P., Hewison, M., Stewart, P., Gittoes, N., Buckley, C., Raza, K. & Cooper, M., 1 Jan 2008, In: Annals of the Rheumatic Diseases. 67, 9, p. 1204-1210 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Glucocorticoid 100%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 72%
  • Glucocorticoids 70%
  • Arthritis 68%
  • Pharmacological Metabolism 60%
  88 Citations (Scopus)

  1 Downloads (Pure)

• Local glucocorticoid synthesis regulates house dust mite-induced airway hypersensitivity in mice

  Merk, V. M., Phan, T. S., Wiedmann, A., Hardy, R. S., Lavery, G. G. & Brunner, T., 23 Oct 2023, In: Frontiers in immunology. 14, 13 p., 1252874.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pyroglyphidae 100%
  • Glucocorticoids 71%
  • Hypersensitivity 64%
  • Wild Animals 32%
  • Inflammation 23%
  9 Downloads (Pure)

• Localization, Age- and Site-Dependent Expression, and Regulation of 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Skin

  Tiganescu, A., Walker, E., Hardy, R., Mayes, AE. & Stewart, P., 1 Jan 2011, In: Journal of Investigative Dermatology. 131, 1, p. 30-36 7 p.

  Research output: Contribution to journal › Article

  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 100%
  • Glucocorticoid 85%
  • Cortisol 51%
  • Skin 36%
  • Glucocorticoids 25%
  90 Citations (Scopus)

• Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids

  Fenton, C., Martin, C., Jones, R., Croft, A., Campos, J., Naylor, A., Taylor, A., Chimen, M., Cooper, M., Lavery, G., Raza, K. & Hardy, R., Feb 2021, In: Annals of the Rheumatic Diseases. 80, 2, p. 250-260 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Glucocorticoid 88%
  • Antiinflammatory 65%
  • Steroid 63%
  • Glucocorticoids 62%
  4 Citations (Scopus)

  184 Downloads (Pure)

• Microtibial embolectomy.

  Mahmood, A., Hardy, R., Garnham, A., Samman, Y., Sintler, M., Smith, S., Vohra, R. & Simms, M., 1 Jan 2003, In: European Journal of Vascular and Endovascular Surgery. 25, 1, p. 35-9 5 p.

  Research output: Contribution to journal › Article

  • Embolectomy 100%
  • Foot 60%
  • Limb Salvage 38%
  • Leg 33%
  • Embolism 20%
  7 Citations (Scopus)

• Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma

  Jethwa, P., Naqvi, M., Hardy, R., Hotchin, N., Roberts, S., Spychal, R. & Tselepis, C., 1 Jan 2008, In: World Journal of Gastroenterology. 14, 7, p. 1044-1052 9 p.

  Research output: Contribution to journal › Article

  Open Access

  • Gastropoda 100%
  • Adenocarcinoma 58%
  • Cadherins 42%
  • Barrett Esophagus 20%
  • Messenger RNA 14%
  66 Citations (Scopus)

• Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss

  Kaur, K., Hardy, R., Ahasan, M., Eijken, M., van Leeuwen, JP., Filer, A., Thomas, A., Raza, K., Buckley, C., Stewart, P., Rabbitt, E., Hewison, M. & Cooper, M., 1 Jun 2010, In: Annals of the Rheumatic Diseases. 69, 6, p. 1185-90 6 p.

  Research output: Contribution to journal › Article

  File

  • Osteitis 100%
  • Glucocorticoid 98%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 89%
  • Glucocorticoids 69%
  • Cytokines 47%
  48 Citations (Scopus)

  130 Downloads (Pure)

• Synovial DKK1 expression is regulated by local glucocorticoid metabolism in inflammatory arthritis

  Hardy, R., Juarez, M., Naylor, A., Tu, J., Rabbitt, E. H., Filer, A., Stewart, P. M., Buckley, C. D., Raza, K. & Cooper, M. S., 18 Oct 2012, In: Arthritis Research & Therapy. 14, 5, R226.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids 100%
  • Arthritis 96%
  • Fibroblasts 48%
  • 11-beta-Hydroxysteroid Dehydrogenase Type 1 32%
  • Bone Remodeling 22%
  28 Citations (Scopus)

  143 Downloads (Pure)

• Synthesis, molecular docking, bio-evaluation and quantitative structure activity relationship of new chalcone derivatives as antioxidants

  Siddiqa, A., Tajammal, A., Irfan, A., Azam, M., Munawar, M. A., Hardy, R. S. & Asim Raza Basra, M., 15 Dec 2022, (E-pub ahead of print) In: Journal of Molecular Structure. 134814.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chalcone 100%
  • QSAR Study 88%
  • Antiinflammatory 81%
  • Antioxidant Agent 65%
  • Chalcones 49%
  28 Downloads (Pure)

• The 11{beta}-hydroxysteroid dehydrogenase enzymes--arbiters of the effects of glucocorticoids in synovium and bone

  Raza, K., Hardy, R. & Cooper, M., 15 Jul 2010, In: Rheumatology.

  Research output: Contribution to journal › Article › peer-review

  • 11-beta-Hydroxysteroid Dehydrogenases 100%
  • Synovial Membrane 80%
  • Glucocorticoids 62%
  • Bone and Bones 40%
  • Enzymes 37%
  25 Citations (Scopus)

  3 Downloads (Pure)

• The local and sytemic effects of glucocorticoid generation in synovium

  Hardy, R., Rabbitt, E., Raza, K., Buckley, C., Stewart, P. & Cooper, MC., 1 Jan 2007, In: Journal of Bone and Mineral Research. 22, 7, p. 1115-1116 2 p.

  Research output: Contribution to journal › Article

• Therapeutic glucocorticoids prevent bone loss but drive muscle wasting when administered in chronic polyarthritis

  Fenton, C., Webster, J., Martin, C., Fareed, S., Wehmeyer, C., Mackie, H., Jones, R., Seabright, A., Lewis, J., Lai, Y-C., Goodyear, C. S., Jones, S., Cooper, M. S., Lavery, G., Langen, R., Raza, K. & Hardy, R., 1 Aug 2019, In: Arthritis Research & Therapy. 21, 1, 182.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids 100%
  • Arthritis 96%
  • Muscles 66%
  • Bone and Bones 65%
  • Osteoclasts 42%
  7 Citations (Scopus)

  197 Downloads (Pure)

• TNFα depleting therapy improves fertility and animal welfare in TNFα-driven transgenic models of polyarthritis when administered in their routine breeding

  Naylor, A., Desanti, G., Saghir, A. & Hardy, R., 8 May 2017, (E-pub ahead of print) In: Laboratory Animals.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Animal Welfare 100%
  • arthritis 84%
  • Infliximab 80%
  • Breeding 80%
  • animal welfare 70%
  4 Citations (Scopus)

  164 Downloads (Pure)

• Unravelling how glucocorticoids work in rheumatoid arthritis

  Hardy, R. & Cooper, M. S., 4 Sept 2018, In: Nature Reviews Rheumatology. p. 1759-4804 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucocorticoids 100%
  • Arthritis 96%
  • Rheumatoid Arthritis 90%
  • Glucocorticoid Receptors 60%
  • Stromal Cells 55%
  24 Citations (Scopus)

  290 Downloads (Pure)

• Upregulation of the oncogene c-myc in Barrett's adenocarcinoma: induction of c-myc by acidified bile acid in vitro.

  Tselepis, C., Morris, CD., Wakelin, D., Hardy, R., Perry, I., Luong, Q., Harper, E., Harrison, R., Attwood, SE. & Jankowski, JA., 1 Feb 2003, In: Gut. 52, 2, p. 174-80 7 p.

  Research output: Contribution to journal › Article

  • myc Genes 100%
  • Barrett Esophagus 97%
  • Bile Acids and Salts 83%
  • Adenocarcinoma 63%
  • Up-Regulation 58%
  125 Citations (Scopus)