Research output per year
Research output per year
Dr.
Accepting PhD Students
PhD projects
Richard is interested in supervising doctoral research examining how exercise and physical activity influence brain health, ageing and neurodegenerative disease. Potential projects may use human exercise interventions, blood-based biomarkers, and induced pluripotent stem cell models of brain and skeletal muscle to investigate mechanisms linking exercise, metabolism and brain health.<br/><br/>Areas of particular interest include exercise-responsive biomarkers of brain health, lactate and metabolic signalling, muscle–brain communication, cellular models of exercise and neurodegeneration, and exercise strategies to reduce dementia risk or support healthy ageing.
Research activity per year
Richard completed his undergraduate degree at the University of Gloucestershire before undertaking a Master’s degree in Sport, Exercise and Rehabilitation Sciences at the University of Birmingham. He subsequently spent five years as a postdoctoral researcher investigating how induced pluripotent stem cells can be used to model the brain and Alzheimer’s disease pathology.
He is now an Assistant Professor in Exercise and Brain Health at the University of Birmingham. His current work brings together exercise physiology, blood-based biomarkers and stem-cell models to investigate how exercise influences brain health, ageing and neurodegenerative disease.
Alongside his research, Richard contributes to undergraduate and postgraduate teaching and supervises research projects across exercise science and physiotherapy.
In his spare time, Richard is a keen runner and enjoys competing in ultramarathons, where he applies his knowledge of exercise physiology, metabolism and performance to his own training and racing.
Richard’s research investigates how exercise and physical activity influence brain health, with a particular focus on the biological mechanisms linking exercise, metabolism, ageing and neurodegenerative disease. His work spans human exercise studies, blood-based biomarkers, and induced pluripotent stem cell models of brain and skeletal muscle.
A major focus of Richard’s research is understanding how acute and chronic exercise influence circulating biomarkers associated with brain health and neurodegeneration. This includes markers of neuronal injury, astrocytic activity and tau pathology, alongside neuroprotective and metabolic signals. His work also examines how these responses vary with exercise dose, ageing and cardiometabolic risk.
Richard is interested in how metabolic responses to exercise contribute to brain health across the lifespan. Current work includes investigating lactate as a potential signalling molecule linking exercise and brain function, including how brain and blood lactate responses differ with age and exercise dose, and how these responses relate to circulating markers of brain health.
Richard uses induced pluripotent stem cell-derived models of neurons, astrocytes and skeletal muscle to investigate cellular mechanisms linking exercise, metabolism and neurodegenerative disease. This work includes studying metabolic signalling, amyloid biology and communication between skeletal muscle and the brain, including the potential role of extracellular vesicles and other exercise-responsive factors.
Richard also develops and evaluates exercise and physical-activity approaches aimed at supporting brain health and reducing dementia risk. This work ranges from mechanistic studies in people at elevated cardiometabolic risk through to community-based activity programmes for people affected by dementia.
His research is interdisciplinary and collaborative, combining exercise physiology, biochemistry, neuroscience, cell biology and neuroimaging to better understand how exercise can be used to promote brain health and resilience across the lifespan.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Lucas, S. (Principal Investigator), Wilson, M. (Researcher), Segaert, K. (Co-Investigator), Elsworthy, R. (Researcher) & Mullinger, K. (Co-Investigator)
Biotechnology & Biological Sciences Research Council
1/04/26 → 31/03/30
Project: Research Councils
Di Maio, A. (Co-Investigator), Whitham, M. (Co-Investigator), Elsworthy, R. (Principal Investigator) & Aldred, S. (Co-Investigator)
1/04/25 → 31/03/27
Project: Research
Elsworthy, R. (Principal Investigator) & Aldred, S. (Co-Investigator)
1/09/25 → 31/08/26
Project: Research
Elsworthy, R. (Co-Investigator) & Aldred, S. (Principal Investigator)
20/01/25 → 30/06/26
Project: Research
Aldred, S. (Co-Investigator) & Elsworthy, R. (Principal Investigator)
20/01/25 → 30/12/25
Project: Research
Spencer, F. (Creator), Elsworthy, R. (Creator), Aldred, S. (Creator), Breen, L. (Creator), Bishop, J. R. B. (Creator) & Lucas, S. J. E. (Creator), University of Birmingham, 27 Jan 2025
DOI: 10.25500/edata.bham.00001239
Dataset
22/10/24
1 Media contribution
Press/Media: Press / Media