Rachel Upthegrove

Research output

Research output per year 1999 2018 2020 2021 2022 2023 2024

• 128 Article
• 15 Review article
• 5 Comment/debate
• 2 Chapter
• 4 More
  • 2 Letter
  • 1 Book/Film/Article review
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

  Wannan, C. M. J., Nelson, B., Addington, J., Allott, K., Anticevic, A., Arango, C., Baker, J. T., Bearden, C. E., Billah, T., Bouix, S., Broome, M. R., Buccilli, K., Cadenhead, K. S., Calkins, M. E., Cannon, T. D., Cecci, G., Chen, E. Y. H., Cho, K. I. K., Choi, J., Clark, S. R., & 227 othersColeman, M. J., Conus, P., Corcoran, C. M., Cornblatt, B. A., Diaz-Caneja, C. M., Dwyer, D., Ebdrup, B. H., Ellman, L. M., Fusar-Poli, P., Galindo, L., Gaspar, P. A., Gerber, C., Glenthøj, L. B., Glynn, R., Harms, M. P., Horton, L. E., Kahn, R. S., Kambeitz, J., Kambeitz-Ilankovic, L., Kane, J. M., Kapur, T., Keshavan, M. S., Kim, S. W., Koutsouleris, N., Kubicki, M., Kwon, J. S., Langbein, K., Lewandowski, K. E., Light, G. A., Mamah, D., Marcy, P. J., Mathalon, D. H., McGorry, P. D., Mittal, V. A., Nordentoft, M., Nunez, A., Pasternak, O., Pearlson, G. D., Perez, J., Perkins, D. O., Powers, A. R., Roalf, D. R., Sabb, F. W., Schiffman, J., Shah, J. L., Smesny, S., Spark, J., Stone, W. S., Strauss, G. P., Tamayo, Z., Torous, J., Upthegrove, R., Vangel, M., Verma, S., Wang, J., Rossum, I. W. V., Wolf, D. H., Wolff, P., Wood, S. J., Yung, A. R., Agurto, C., Alvarez-Jimenez, M., Amminger, P., Armando, M., Asgari-Targhi, A., Cahill, J., Carrión, R. E., Castro, E., Cetin-Karayumak, S., Mallar Chakravarty, M., Cho, Y. T., Cotter, D., D'Alfonso, S., Ennis, M., Fadnavis, S., Fonteneau, C., Gao, C., Gupta, T., Gur, R. E., Gur, R. C., Hamilton, H. K., Hoftman, G. D., Jacobs, G. R., Jarcho, J., Ji, J. L., Kohler, C. G., Lalousis, P. A., Lavoie, S., Lepage, M., Liebenthal, E., Mervis, J., Murty, V., Nicholas, S. C., Ning, L., Penzel, N., Poldrack, R., Polosecki, P., Pratt, D. N., Rabin, R., Rahimi Eichi, H., Rathi, Y., Reichenberg, A., Reinen, J., Rogers, J., Ruiz-Yu, B., Scott, I., Seitz-Holland, J., Srihari, V. H., Srivastava, A., Thompson, A., Turetsky, B. I., Walsh, B. C., Whitford, T., Wigman, J. T. W., Yao, B., Yuen, H. P., Ahmed, U., Byun, A. J. S., Chung, Y., Do, K., Hendricks, L., Huynh, K., Jeffries, C., Lane, E., Langholm, C., Lin, E., Mantua, V., Santorelli, G., Ruparel, K., Zoupou, E., Adasme, T., Addamo, L., Adery, L., Ali, M., Auther, A., Aversa, S., Baek, S. H., Bates, K., Bathery, A., Bayer, J. M. M., Beedham, R., Bilgrami, Z., Birch, S., Bonoldi, I., Borders, O., Borgatti, R., Brown, L., Bruna, A., Carrington, H., Castillo-Passi, R. I., Chen, J., Cheng, N., Ching, A. E., Clifford, C., Colton, B. L., Contreras, P., Corral, S., Damiani, S., Done, M., Estradé, A., Etuka, B. A., Formica, M., Furlan, R., Geljic, M., Germano, C., Getachew, R., Goncalves, M., Haidar, A., Hartmann, J., Jo, A., John, O., Kerins, S., Kerr, M., Kesselring, I., Kim, H., Kim, N., Kinney, K., Krcmar, M., Kotler, E., Lafanechere, M., Lee, C., Llerena, J., Markiewicz, C., Matnejl, P., Maturana, A., Mavambu, A., Mayol-Troncoso, R., McDonnell, A., McGowan, A., McLaughlin, D., McIlhenny, R., McQueen, B., Mebrahtu, Y., Mensi, M., Hui, C. L. M., Suen, Y. N., Wong, S. M. Y., Morrell, N., Omar, M., Partridge, A., Phassouliotis, C., Pichiecchio, A., Politi, P., Porter, C., Provenzani, U., Prunier, N., Raj, J., Ray, S., Rayner, V., Reyes, M., Reynolds, K., Rush, S., Salinas, C., Shetty, J., Snowball, C., Tod, S., Turra-Fariña, G., Valle, D., Veale, S., Whitson, S., Wickham, A., Youn, S., Zamorano, F., Zavaglia, E., Zinberg, J., Woods, S. W. & Shenton, M. E., May 2024, In: Schizophrenia bulletin. 50, 3, p. 496-512 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Schizophrenia 87%
  • Cohort Studies 72%
  • Prospective Studies 68%
  • Data Analysis 31%
  38 Downloads (Pure)

• Alterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders

  Hoheisel, L., Kambeitz-Ilankovic, L., Wenzel, J., Haas, S. S., Antonucci, L. A., Ruef, A., Penzel, N., Schultze-Lutter, F., Lichtenstein, T., Rosen, M., Dwyer, D. B., Salokangas, R. K. R., Lencer, R., Brambilla, P., Borgwardt, S., Wood, S. J., Upthegrove, R., Bertolino, A., Ruhrmann, S., Meisenzahl, E., & 4 othersKoutsouleris, N., Fink, G. R., Daun, S. & Kambeitz, J., 8 Mar 2024, (E-pub ahead of print) In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

  Research output: Contribution to journal › Article › peer-review

  • Psychotic Affective Disorders 100%
  • Psychotic Disorders 37%
  • Depression 26%
  • Cluster Analysis 8%
  • Control Groups 5%

• Anhedonia as a potential transdiagnostic phenotype with immune-related changes in recent onset mental health disorders

  Lalousis, P. A., Malaviya, A., Khatibi, A., Saberi, M., Kambeitz-Ilankovic, L., Haas, S. S., Wood, S. J., Barnes, N. M., Rogers, J., Chisholm, K., Bertolino, A., Borgwardt, S., Brambilla, P., Kambeitz, J., Lencer, R., Pantelis, C., Ruhrmann, S., Salokangas, R. K. R., Schultze-Lutter, F., Schmidt, A., & 6 othersMeisenzahl, E., Dwyer, D., Koutsouleris, N., Upthegrove, R., Griffiths, S. L. & PRONIA Consortium, 30 May 2024, (E-pub ahead of print) In: Biological Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Anhedonia 100%
  • Mental Disorders 61%
  • Mental Health 58%
  • Psychotic Disorders 52%
  • Phenotype 45%
  4 Downloads (Pure)

• A Realist Evaluation of Social Care Practitioners’ Experiences With and Understanding of Applied Healthcare Research

  Birdi, G. K., Wong, G., Upthegrove, R., Higgs, S., Walsh, A., Ahern, A., Allen, K., Howe, J., Habib, H., Nixon, K., Oduola, S. & Maidment, I., 24 May 2024, (E-pub ahead of print) In: Inquiry : The Journal of Health Care Organization, Provision, and Financing. 61

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Health Services Research 100%
  • Weight Gain 53%
  • Antipsychotic Agents 53%
  • Evidence-Based Practice 32%
  • Interviews 29%
  23 Downloads (Pure)

• Assessing the generalisability of the psychosis metabolic risk calculator (PsyMetRiC) for young people with first-episode psychosis with validation in a Hong Kong Chinese Han population: a 4-year follow-up study

  Tse, W., Khandaker, G. M., Zhou, H., Luo, H., Yan, W. C., Siu, M. W., Poon, L. T., Lee, E. H. M., Zhang, Q., Upthegrove, R., Osimo, E. F., Perry, B. I. & Chan, S. K. W., Jun 2024, In: The Lancet Regional Health - Western Pacific. 47, 11 p., 101089.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Changes in immunoglobulin levels during clozapine treatment in schizophrenia

  Griffiths, K., Mellado, M. R., Chung, R., Lally, J., McQueen, G., Sendt, K-V., Gillespie, A., Ibrahim, M., Richter, A., Shields, A., Ponsford, M., Jolles, S., Hodsoll, J., Pollak, T. A., Upthegrove, R., Egerton, A. & Maccabe, J. H., Jan 2024, In: Brain, Behavior, and Immunity. 115, p. 223-228 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Clozapine 100%
  • Immunoglobulins 75%
  • Schizophrenia 69%
  • Immunoglobulin A 39%
  • Immunoglobulin G 32%

• CLEAR – clozapine in early psychosis: study protocol for a multi-centre, randomised controlled trial of clozapine vs other antipsychotics for young people with treatment resistant schizophrenia in real world settings

  Casetta, C., Santosh, P., Bayley, R., Bisson, J., Byford, S., Dixon, C., Drake, R. J., Elvins, R., Emsley, R., Fung, N., Hayes, D., Howes, O., James, A., James, K., Jones, R., Killaspy, H., Lennox, B., Marchant, L., McGuire, P., Oloyede, E., & 5 othersRogdaki, M., Upthegrove, R., Walters, J., Egerton, A. & MacCabe, J. H., 14 Feb 2024, In: BMC Psychiatry. 24, 1, 13 p., 122.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clozapine 100%
  • Psychotic Disorders 79%
  • Antipsychotic Agents 77%
  • Schizophrenia 69%
  • Randomized Controlled Trials 57%
  23 Downloads (Pure)

• Exercise4Psychosis: A randomised control trial assessing the effect of moderate-to-vigorous exercise on inflammatory biomarkers and negative symptom profiles in men with first-episode psychosis

  Dunleavy, C., Elsworthy, R. J., Wood, S. J., Allott, K., Spencer, F., Upthegrove, R. & Aldred, S., 1 Aug 2024, In: Brain, Behavior, and Immunity. 120, p. 379-390 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  14 Downloads (Pure)

• Role of Inflammation in Short Sleep Duration Across Childhood and Psychosis in Young Adulthood

  Morales-Munoz, I., Marwaha, S., Upthegrove, R. & Cropley, V., 8 May 2024, (E-pub ahead of print) In: JAMA psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Sleep 83%
  • Inflammation 62%
  • C-Reactive Protein 41%
  • Latent Class Analysis 39%
  15 Downloads (Pure)

• Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness

  Wenzel, J., Badde, L., Haas, S. S., Bonivento, C., Van Rheenen, T. E., Antonucci, L. A., Ruef, A., Penzel, N., Rosen, M., Lichtenstein, T., Lalousis, P. A., Paolini, M., Stainton, A., Dannlowski, U., Romer, G., Brambilla, P., Wood, S. J., Upthegrove, R., Borgwardt, S., Meisenzahl, E., & 9 othersSalokangas, R. K. R., Pantelis, C., Lencer, R., Bertolino, A., Kambeitz, J., Koutsouleris, N., Dwyer, D. B., Kambeitz-Ilankovic, L. & PRONIA Consortium, Feb 2024, In: Neuropsychopharmacology. 49, 3, p. 573-583 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Cognitive Dysfunction 87%
  • Clinical Trials 46%
  • Registries 42%
  • Psychotic Affective Disorders 25%
  39 Downloads (Pure)

• Understanding how traumatic brain injury-related changes in fluid biomarkers affect quality of life outcomes in veterans: a prospective observational trial protocol (UNTANGLE)

  Metry, Y., Mcmullan, C., Upthegrove, R., Belli, A., Gomes, R. S. M., Blanch, R. J. & Ahmed, Z., 19 Aug 2024, In: BMJ open. 14, 8, e084818.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  7 Downloads (Pure)
• 2023

  A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression

  Jauhar, S., Arnone, D., Baldwin, D. S., Bloomfield, M., Browning, M., Cleare, A. J., Corlett, P., Deakin, J. F. W., Erritzoe, D., Fu, C., Fusar-Poli, P., Goodwin, G. M., Hayes, J., Howard, R., Howes, O. D., Juruena, M. F., Lam, R. W., Lawrie, S. M., McAllister-Williams, H., Marwaha, S., & 15 othersMatuskey, D., McCutcheon, R. A., Nutt, D. J., Pariante, C., Pillinger, T., Radhakrishnan, R., Rucker, J., Selvaraj, S., Stokes, P., Upthegrove, R., Yalin, N., Yatham, L., Young, A. H., Zahn, R. & Cowen, P. J., Aug 2023, In: Molecular Psychiatry. 28, 8, p. 3149-3152 4 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  File

  • Serotonin 100%
  • Molecular Imaging 45%
  • Tryptophan 41%
  • Research Design 30%
  • Biomarkers 25%
  108 Downloads (Pure)

• Antidepressants for the prevention of depression following first-episode psychosis (ADEPP): study protocol for a multi-centre, double-blind, randomised controlled trial

  Palmer, E. R., Griffiths, S. L., Watkins, B., Weetman, T., Ottridge, R., Patel, S., Woolley, R., Tearne, S., Au, P., Taylor, E., Sadiq, Z., Al-Janabi, H., Major, B., Marriott, C., Husain, N., Katshu, M. Z. U. H., Giacco, D., Barnes, N. M., Walters, J. T. R., Barnes, T. R. E., & 3 othersBirchwood, M., Drake, R. & Upthegrove, R., 6 Oct 2023, In: Trials. 24, 1, 646.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sertraline 100%
  • Psychotic Disorders 88%
  • Antidepressive Agents 85%
  • Randomized Controlled Trials 64%
  • Depression 62%
  74 Downloads (Pure)

• Disentangling heterogeneity of psychosis expression in the general population: Sex-specific moderation effects of environmental risk factors on symptom networks

  Betz, L. T., Penzel, N., Rosen, M., Bhui, K., Upthegrove, R. & Kambeitz, J., Apr 2023, In: Psychological Medicine. 53, 5, p. 1860-1869 10 p.

  Research output: Contribution to journal › Article › peer-review

  • psychosis 100%
  • Psychotic Disorders 81%
  • Domestic Violence 56%
  • Minority Groups 37%
  • Population 33%

• Five-year illness trajectories across racial groups in the UK following a first episode psychosis

  Griffiths, S. L., Bogatsu, T., Longhi, M., Butler, E., Alexander, B., Bandawar, M., Everard, L., Jones, P. B., Fowler, D., Hodgekins, J., Amos, T., Freemantle, N., McCrone, P., Singh, S. P., Birchwood, M. & Upthegrove, R., Apr 2023, In: Social Psychiatry and Psychiatric Epidemiology. 58, 4, p. 569-579 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • psychosis 100%
  • racial group 92%
  • Psychotic Disorders 81%
  • social deprivation 71%
  • illness 69%
  46 Downloads (Pure)

• Impact of anxiety and depression across childhood and adolescence on adverse outcomes in young adulthood: a UK birth cohort study

  Morales-Muñoz, I., Mallikarjun, P. K., Chandan, J. S., Thayakaran, R., Upthegrove, R. & Marwaha, S., 15 Mar 2023, (E-pub ahead of print) In: British Journal of Psychiatry . p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Anxiety 100%
  • Parturition 96%
  • Cohort Studies 95%
  • Depression 91%
  • Mental Health 15%
  61 Downloads (Pure)

• Inflammatory subgroups of schizophrenia and their association with brain structure: A semi-supervised machine learning examination of heterogeneity

  Lalousis, P. A., Schmaal, L., Wood, S., Reniers, R., Cropley, V. L., Watson, A., Pantelis, C., Suckling, J., Barnes, N., Pariante, C. M., Jones, P., Joyce, E., Barnes, T. RE., Lawrie, SM., Husain, N., Dazzan, P., Deakin, B., Weickert, C. S. & Upthegrove, R., 1 Oct 2023, In: Brain, Behavior, and Immunity. 113, p. 166-175

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Supervised Machine Learning 100%
  • Schizophrenia 51%
  • Gray Matter 36%
  • Brain 30%
  • Inflammation 26%
  64 Downloads (Pure)

• Network analysis of inflammation and symptoms in recent onset schizophrenia and the influence of minocycline during a clinical trial

  Herniman, S. E., Wood, S. J., Khandaker, G., Dazzan, P., Pariante, C. M., Barnes, N. M., Krynicki, C. R., Nikkheslat, N., Vincent, R. C., Roberts, A., Giordano, A., Watson, A., Suckling, J., Barnes, T. R. E., Husain, N., Jones, P. B., Joyce, E., Lawrie, S. M., Lewis, S., Deakin, B., & 1 othersUpthegrove, R., 18 Sept 2023, In: Translational Psychiatry. 13, 1, 10 p., 297.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Minocycline 100%
  • Schizophrenia 65%
  • Clinical Trials 52%
  • Cytokines 49%
  • Inflammation 47%
  46 Downloads (Pure)

• Novel and emerging treatments for major depression

  Marwaha, S., Palmer, E., Suppes, T., Cons, E., Young, A. H. & Upthegrove, R., 14 Jan 2023, In: The Lancet. 401, 10371, p. 141-153 13 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Depression 100%
  • Major Depressive Disorder 79%
  • Global Health 74%
  • Suicide 70%
  • Public Health 54%
  851 Downloads (Pure)

• Personality traits as risk factors for relapse or recurrence in major depression: a systematic review

  Altaweel, N., Upthegrove, R., Surtees, A., Durdurak, B. & Marwaha, S., 5 May 2023, In: Frontiers in Psychiatry. 14, 1176355.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Personality 100%
  • Systematic Reviews 81%
  • Depression 72%
  • Recurrence 63%
  • Compulsive Personality Disorder 52%
  33 Downloads (Pure)

• Predicting treatment resistance from first-episode psychosis using routinely collected clinical information

  Osimo, E. F., Perry, B., Mallikarjun, P., Prichard, M., Lewis, J., Katunda, A., Murray, G. K., Perez, J., Jones, P., Cardinal, R. N., Howes, O. D., Upthegrove, R. & Khandaker, G., 19 Jan 2023, In: Nature Mental Health. 1, p. 25-35 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clozapine 100%
  • Psychotic Disorders 95%
  • Calibration 35%
  • Schizophrenia 27%
  • Data Visualization 24%
  36 Downloads (Pure)

• Protocol for the Psychosis Immune Mechanism Stratified Medicine (PIMS) trial: a randomised double-blind placebo-controlled trial of single-dose tocilizumab in patients with psychosis

  Foley, E. M., Griffiths, L., Murray, A., Rogers, J., Corsi-Zuelli, F., Hickinbotham, H., Warwick, E., Wilson, M., Kaser, M., Murray, G. K., Deakin, B., Jadon, D., Suckling, J., Barnes, N., Upthegrove, R. & Khandaker, G. M., 24 Mar 2023, In: BMJ open. 13, 3, 10 p., e067944.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • tocilizumab 100%
  • Psychotic Disorders 66%
  • Medicine 51%
  • Placebos 48%
  • Interleukin-6 40%
  24 Downloads (Pure)

• Psychosis brain subtypes validated in first-episode cohorts and related to illness remission: results from the PHENOM consortium

  Dwyer, D. B., Chand, G. B., Pigoni, A., Khuntia, A., Wen, J., Antoniades, M., Hwang, G., Erus, G., Doshi, J., Srinivasan, D., Varol, E., Kahn, R. S., Schnack, H. G., Meisenzahl, E., Wood, S. J., Zhuo, C., Sotiras, A., Shinohara, R. T., Shou, H., Fan, Y., & 22 othersSchaulfelberger, M., Rosa, P., Lalousis, P. A., Upthegrove, R., Kaczkurkin, A. N., Moore, T. M., Nelson, B., Gur, R. E., Gur, R. C., Ritchie, M. D., Satterthwaite, T. D., Murray, R. M., Di Forti, M., Ciufolini, S., Zanetti, M. V., Wolf, D. H., Pantelis, C., Crespo-Facorro, B., Busatto, G. F., Davatzikos, C., Koutsouleris, N. & Dazzan, P., 5 May 2023, (E-pub ahead of print) In: Molecular Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Brain 52%
  • Corpus Striatum 29%
  • Schizophrenia 24%
  • Supervised Machine Learning 24%
  169 Downloads (Pure)

• Satisfaction with cognitive remediation therapy: its effects on implementation and outcomes using the cognitive remediation satisfaction scale

  Evans, J., Tinch-Taylor, R., Csipke, E., Cella, M., Pickles, A., McCrone, P., Stringer, D., Oliver, A., Reeder, C., Birchwood, M., Fowler, D., Greenwood, K., Johnson, S., Perez, J., Ritunnano, R., Thompson, A., Upthegrove, R., Wilson, J., Kenny, A., Isok, I., & 2 othersJoyce, E. M. & Wykes, T., 30 Sept 2023, In: Schizophrenia. 9, 1, 8 p., 67.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • psychometrics 100%
  • therapist 49%
  • cognition 47%
  • factor analysis 45%
  • discrimination 43%
  74 Downloads (Pure)

• Structural and functional brain patterns predict formal thought disorder’s severity and its persistence in recent-onset psychosis: Results from the PRONIA Study

  PRONIA Consortium, 19 Jun 2023, (E-pub ahead of print) In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

  Research output: Contribution to journal › Article › peer-review

  • Thinking 100%
  • Psychotic Disorders 95%
  • Brain 50%
  • Gray Matter 31%
  • White Matter 18%

• The neural, stress hormone and inflammatory correlates of childhood deprivation and threat in psychosis: a systematic review

  Thomas, M., Rakesh, D., Whittle, S., Sheridan, M., Upthegrove, R. & Cropley, V., 21 Aug 2023, (E-pub ahead of print) In: Psychoneuroendocrinology. 106371.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Systematic Reviews 78%
  • Hormones 75%
  • Prefrontal Cortex 19%
  • Hydrocortisone 18%
  13 Downloads (Pure)

• The role of inflammation in the prospective associations between early childhood sleep problems and ADHD at 10 years: findings from a UK birth cohort study

  Morales-Muñoz, I., Upthegrove, R., Lawrence, K., Thayakaran, R., Kooij, S., Gregory, A. M. & Marwaha, S., 3 Jan 2023, (E-pub ahead of print) In: Journal of Child Psychology and Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • sleep 100%
  • ADHD 97%
  • Attention Deficit Disorder with Hyperactivity 93%
  • Sleep 72%
  • Parturition 64%
  186 Downloads (Pure)

• Transdiagnostic structural neuroimaging features in depression and psychosis: A systematic review

  Alexandros Lalousis, P., Wood, S., Reniers, R., Schmaal, L., Azam, H., Mazziota, A., Saeed, H., Wragg, C. & Upthegrove, R., 29 Mar 2023, In: NeuroImage: Clinical. 38, 9 p., 103388.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Neuroimaging 96%
  • Systematic Reviews 78%
  • Depression 70%
  • Prefrontal Cortex 64%
  168 Downloads (Pure)

• Treatments for major depression – Authors' reply

  Marwaha, S., Young, A. H., Suppes, T. & Upthegrove, R., 24 Jun 2023, In: The Lancet. 401, 10394, p. 2111-2112 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• We need timely access to mental health data: implications of the Goldacre review

  Astle, D. E., Moore, A., Marryat, L., Viding, E., Mansfield, K. L., Fazel, M., Pierce, M., Abel, K. M., Green, J., John, A., Broome, M. R., Upthegrove, R., Bould, H., Minnis, H., Gajwani, R., Groom, M. J., Hollis, C., Liddle, E., Sayal, K., Berry, V., & 21 othersCollishaw, S., Dawes, H., Cortese, S., Violato, M., Pollard, J., MacCabe, J. H., Blakemore, S-J., Simonoff, E., Watkins, E., Hiller, R. M., Townsend, E., Armour, C., Geddes, J. R., Thompson, L., Schwannauer, M., Nicholls, D., Hotopf, M., Downs, J., Rahman, A., Sharma, A. N. & Ford, T. J., Apr 2023, In: The Lancet Psychiatry. 10, 4, p. 242-244 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review
• 2022

  A review of economic evaluations of health care for people at risk of psychosis and for first-episode psychosis

  Shields, G. E., Buck, D., Varese, F., Yung, A. R., Thompson, A., Husain, N., Broome, M. R., Upthegrove, R., Byrne, R. & Davies, L. M., 17 Feb 2022, In: BMC Psychiatry. 22, 1, 126.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Cost-Benefit Analysis 92%
  • Delivery of Health Care 65%
  • Databases 21%
  • Costs and Cost Analysis 14%
  70 Downloads (Pure)

• Clinical, brain, and multilevel clustering in early psychosis and affective stages

  the PRONIA consortium, Dwyer, D. B., Buciuman, M. O., Ruef, A., Kambeitz, J., Sen Dong, M., Stinson, C., Kambeitz-Ilankovic, L., Degenhardt, F., Sanfelici, R., Antonucci, L. A., Lalousis, P. A., Wenzel, J., Urquijo-Castro, M. F., Popovic, D., Oeztuerk, O. F., Haas, S. S., Weiske, J., Hauke, D., Neufang, S., & 31 othersSchmidt-Kraepelin, C., Ruhrmann, S., Penzel, N., Lichtenstein, T., Rosen, M., Chisholm, K., Riecher-Rössler, A., Egloff, L., Schmidt, A., Andreou, C., Hietala, J., Schirmer, T., Romer, G., Michel, C., Rössler, W., Maj, C., Borisov, O., Krawitz, P. M., Falkai, P., Pantelis, C., Lencer, R., Bertolino, A., Borgwardt, S., Noethen, M., Brambilla, P., Schultze-Lutter, F., Meisenzahl, E., Wood, S. J., Davatzikos, C., Upthegrove, R. & Salokangas, R. K. R., Jul 2022, In: JAMA psychiatry. 79, 7, p. 677-689 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Psychotic Affective Disorders 100%
  • Psychotic Disorders 65%
  • Cluster Analysis 62%
  • Depression 34%
  • Brain 34%
  1 Citation (Scopus)

• Cognitive function in early-phase schizophrenia-spectrum disorder: IQ subtypes, brain volume and immune markers

  Watson, A. J., Giordano, A., Suckling, J., Barnes, T. R. E., Husain, N., Jones, P. B., Krynicki, C. R., Lawrie, S. M., Lewis, S., Nikkheslat, N., Pariante, C. M., Upthegrove, R., Deakin, B., Dazzan, P. & Joyce, E. M., 18 Feb 2022, (E-pub ahead of print) In: Psychological Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • schizophrenia 100%
  • brain 77%
  • Schizophrenia 74%
  • Cognition 72%
  • Biomarkers 59%

• Detailed clinical phenotyping and generalisability in prognostic models of functioning in at-risk populations

  Rosen, M., Betz, L. T., Kaiser, N., Penzel, N., Dwyer, D., Lichtenstein, T. K., Schultze-Lutter, F., Kambeitz-Ilankovic, L., Bertolino, A., Borgwardt, S., Brambilla, P., Lencer, R., Meisenzahl, E., Pantelis, C., Salokangas, R. K. R., Upthegrove, R., Wood, S., Ruhrmann, S., Koutsouleris, N. & Kambeitz, J., 16 Jun 2022, In: British Journal of Psychiatry. 220, 6, p. 318-321 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Psychotic Disorders 100%
  • Neuroimaging 96%
  • Psychiatry 79%
  • Depression 70%
  • Clinical Trials 69%

• Duration of prior psychotic illness and clozapine response: a retrospective observational study using electronic health records

  Jones, R., Upthegrove, R., Price, M., Pritchard, M., Chandan, J., Legge, S. & MacCabe, J., 20 Jun 2022, In: Therapeutic advances in psychopharmacology. 12, p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clozapine 100%
  • Electronic Health Records 87%
  • Observational Studies 66%
  • Retrospective Studies 57%
  • Schizophrenia 25%
  103 Downloads (Pure)

• Evidence for shared genetic aetiology between schizophrenia, cardiometabolic and inflammation related traits: genetic correlation and colocalization analyses

  Perry, B., Bowker, N., Burgess, S., Wareham, N. J., Upthegrove, R., Jones, P., Khandaker, G. M. & Langenberg, C., 11 Jan 2022, In: Schizophrenia Bulletin Open. 3, 1, sgac001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Schizophrenia 100%
  • Brain-Derived Neurotrophic Factor 77%
  • Inflammation 72%
  • Glucose 46%
  • Fasting 39%
  141 Downloads (Pure)

• Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function

  Haas, S. S., Doucet, G. E., Antoniades, M., Modabbernia, A., Corcoran, C. M., Kahn, R. S., Kambeitz, J., Kambeitz-Ilankovic, L., Borgwardt, S., Brambilla, P., Upthegrove, R., Wood, S. J., Salokangas, R. K. R., Hietala, J., Meisenzahl, E., Koutsouleris, N. & Frangou, S., Sept 2022, In: Schizophrenia Research: Cognition. 29, 8 p., 100252.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Psychopathology 42%
  • Brain 31%
  • Normal Distribution 25%
  • Machine Learning 24%
  60 Downloads (Pure)

• Exploring links between psychosis and frontotemporal dementia using multimodal machine learning: Dementia Praecox revisited

  International FTD-Genetics Consortium (IFGC), the German Frontotemporal Lobar Degeneration (FTLD) Consortium, PRONIA Consortium, Koutsouleris, N., Pantelis, C., Velakoulis, D., Mcguire, P., Dwyer, D. B., Urquijo-Castro, M. F., Paul, R., Dong, S., Popovic, D., Oeztuerk, O., Kambeitz, J., Salokangas, R. K. R., Hietala, J., Bertolino, A., Brambilla, P., Upthegrove, R., Wood, S. J., & 24 othersLencer, R., Borgwardt, S., Maj, C., Nöthen, M., Degenhardt, F., Polyakova, M., Mueller, K., Villringer, A., Danek, A., Fassbender, K., Fliessbach, K., Jahn, H., Kornhuber, J., Landwehrmeyer, B., Anderl-Straub, S., Prudlo, J., Synofzik, M., Wiltfang, J., Riedl, L., Diehl-Schmid, J., Otto, M., Meisenzahl, E., Falkai, P. & Schroeter, M. L., 1 Sept 2022, In: JAMA psychiatry. 79, 9, p. 907-919 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Frontotemporal Dementia 100%
  • Machine Learning 90%
  • Psychotic Disorders 74%
  • Schizophrenia 65%
  • Alzheimer Disease 31%
  95 Downloads (Pure)

• From co-morbidity to transdiagnostic potential and novel immunotherapies for psychosis

  Upthegrove, R., Nov 2022, In: Psychiatry Research. 317, 3 p., 114866.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Immunotherapy 94%
  • Affective Symptoms 64%
  • Morbidity 63%
  • Schizophrenia 43%
  65 Downloads (Pure)

• Heterogeneity in treatment outcomes and incomplete recovery in first episode psychosis: does one size fit all?

  Griffiths, S. L., Lalousis, P. A., Wood, S. J. & Upthegrove, R., 17 Nov 2022, In: Translational Psychiatry. 12, 1, 6 p., 485.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Machine Learning 40%
  • Gold 36%
  • Terminology 35%
  • Therapeutics 17%
  51 Downloads (Pure)

• Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: A Mendelian randomization study

  PIMS collaboration, 30 Mar 2022, (E-pub ahead of print) In: JAMA psychiatry. 2022, 5, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Encephalitis 100%
  • Random Allocation 91%
  • Schizophrenia 76%
  • Mendelian Randomization Analysis 50%
  • Brain 46%
  48 Downloads (Pure)

• Inflammation in first-episode psychosis: The contribution of inflammatory biomarkers to the emergence of negative symptoms, a systematic review and meta-analysis

  Dunleavy, C., Elsworthy, R. J., Upthegrove, R., Wood, S. J. & Aldred, S., 24 Feb 2022, (E-pub ahead of print) In: Acta Psychiatrica Scandinavica. 146, 1, p. 6-20

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Meta-Analysis 79%
  • Systematic Reviews 78%
  • Biomarkers 69%
  • Cytokines 66%
  297 Downloads (Pure)

• Medication optimisation in severe mental illness (MEDIATE): protocol for a realist review

  Maidment, I., Wong, G., Duddy, C., Upthegrove, R., Oduola, S., Allen, K., Jacklin, S., Howe, J. & Macphee, M., 24 Jan 2022, In: BMJ open. 12, 1, e058524.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Organized Financing 100%
  • Ethics 86%
  • Congresses 83%
  • Caregivers 72%
  • Publications 70%
  20 Downloads (Pure)

• Neurobiologically based stratification of recent-onset depression and psychosis: identification of two distinct transdiagnostic phenotypes

  PRONIA Consortium, Lalousis, P. A., Schmaal, L., Wood, S., Reniers, R., Barnes, N., Chisholm, K., Griffiths, L., Stainton, A., Wen, J., Hwang, G., Davatzikos, C., Wenzel, J., Kambeitz-Ilankovic, L., Andreou, C., Bonivento, C., Dannlowski, U., Ferro, A., Liechtenstein, T., Riecher-Rössler, A., & 16 othersRomer, G., Rosen, M., Bertolino, A., Borgwardt, S., Brambilla, P., Kambeitz, J., Lencer, R., Pantelis, C., Ruhrmann, S., Salokangas, R. K. R., Schultze-Lutter, F., Schmidt, A., Meisenzahl, E. M., Koutsouleris, N., Dwyer, D. & Upthegrove, R., 1 Oct 2022, In: Biological Psychiatry. 92, 7, p. 552-562 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Depression 70%
  • Phenotype 64%
  • Cluster Analysis 38%
  • Discriminant Analysis 23%
  40 Downloads (Pure)

• Novel gyrification networks reveal links with psychiatric risk factors in early illness

  Sanfelici, R., Ruef, A., Antonucci, L. A., Penzel, N., Sotiras, A., Dong, M. S., Urquijo-Castro, M., Wenzel, J., Kambeitz-Ilankovic, L., Hettwer, M. D., Ruhrmann, S., Chisholm, K., Riecher-Rössler, A., Falkai, P., Pantelis, C., Salokangas, R. K. R., Lencer, R., Bertolino, A., Kambeitz, J., Meisenzahl, E., & 7 othersBorgwardt, S., Brambilla, P., Wood, S. J., Upthegrove, R., Schultze-Lutter, F., Koutsouleris, N. & Dwyer, D. B., 15 Apr 2022, In: Cerebral Cortex. 32, 8, p. 1625-1636 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Mental Disorders 100%
  • Psychiatry 91%
  • Psychotic Disorders 57%
  • Cognition 48%
  • Linear Models 48%
  1 Citation (Scopus)

• Psychosocial functioning in the balance between autism and psychosis: evidence from three populations

  Abu-Akel, A., Wood, S. J., Upthegrove, R., Chisholm, K., Lin, A., Hansen, P. C., Gillespie, S. M., Apperly, I. A. & Montag, C., Jul 2022, In: Molecular Psychiatry. 27, 7, p. 2976-2984 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Autistic Disorder 100%
  • Psychotic Disorders 93%
  • Schizophrenia 69%
  • Population 39%
  • Genetic Profile 18%
  112 Downloads (Pure)

• REalist Synthesis Of non-pharmacologicaL interVEntions for antipsychotic-induced weight gain (RESOLVE) in people living with severe mental illness (SMI)

  Maidment, I. D., Wong, G., Duddy, C., Upthegrove, R., Oduola, S., Robotham, D., Higgs, S., Ahern, A. & Birdi, G., Dec 2022, In: Systematic Reviews. 11, 1, 7 p., 42.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Weight Gain 100%
  • Antipsychotic Agents 99%
  • Gray Literature 34%
  • Caregivers 23%
  • Schizophrenia 22%
  62 Downloads (Pure)

• Relationships between global functioning and neuropsychological predictors in subjects at high risk of psychosis or with a recent onset of depression

  the PRONIA consortium, Squarcina, L., Kambeitz-Ilankovic, L., Bonivento, C., Prunas, C., Oldani, L., Wenzel, J., Ruef, A., Dwyer, D., Ferro, A., Borgwardt, S., Kambeitz, J., Lichtenstein, T. K., Meisenzahl, E., Pantelis, C., Rosen, M., Upthegrove, R., Antonucci, L. A., Bertolino, A., Lencer, R., & 8 othersRuhrmann, S., Salokangas, R. R. K., Schultze-Lutter, F., Chisholm, K., Stainton, A., Wood, S. J., Koutsouleris, N. & Brambilla, P., 14 Sept 2022, In: World Journal of Biological Psychiatry. 23, 8, p. 573-581 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Psychotic Disorders 100%
  • Depression 70%
  • Symptom Assessment 61%
  • Executive Function 55%
  • Cognition 42%

• The clinical relevance of formal thought disorder in the early stages of psychosis: results from the PRONIA study

  the PRONIA consortium, Oeztuerk, O. F., Pigoni, A., Wenzel, J., Haas, S. S., Popovic, D., Ruef, A., Dwyer, D. B., Kambeitz-Ilankovic, L., Ruhrmann, S., Chisholm, K., Lalousis, P., Griffiths, S. L., Lichtenstein, T., Rosen, M., Kambeitz, J., Schultze-Lutter, F., Liddle, P., Upthegrove, R., Salokangas, R. K. R., & 8 othersPantelis, C., Meisenzahl, E., Wood, S. J., Brambilla, P., Borgwardt, S., Falkai, P., Antonucci, L. A. & Koutsouleris, N., Apr 2022, In: European Archives of Psychiatry and Clinical Neuroscience. 272, p. 403-413 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Thinking 100%
  • Psychotic Disorders 95%
  • Cluster Analysis 36%
  • Poverty 21%
  • Symptom Assessment 11%
  32 Downloads (Pure)

• The impact of visual dysfunctions in recent-onset psychosis and clinical high-risk state for psychosis

  the PRONIA consortium, Schwarzer, J. M., Meyhoefer, I., Antonucci, L. A., Kambeitz-Ilankovic, L., Surmann, M., Bienek, O., Romer, G., Dannlowski, U., Hahn, T., Korda, A., Dwyer, D. B., Ruef, A., Haas, S. S., Rosen, M., Lichtenstein, T., Ruhrmann, S., Kambeitz, J., Salokangas, R. K. R., Pantelis, C., & 9 othersSchultze-Lutter, F., Meisenzahl, E., Brambilla, P., Bertolino, A., Borgwardt, S., Upthegrove, R., Koutsouleris, N., Lencer, R. & Urquijo, M. F., Nov 2022, In: Neuropsychopharmacology. 47, 12, p. 2051-2060 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Multivariate Analysis 37%
  • Schizophrenia 29%
  • Quality of Life 22%
  • Electronic Data Processing 18%
  28 Downloads (Pure)