Nikolas Hodges

Accepting PhD Students

PhD projects

Nik Hodges is interested in the mechanisms of genetic toxicology, cellular oxidative stress and repair of oxidative DNA damage, and his lab was the first to identify that the variant form of the repair protein OGG1 is repair-deficient under conditions of oxidative stress, which could have important consequences for individual susceptibility to cancer.

In particular, Dr Hodges’s team is interested in the cellular consequences of pertubation of redox homeostasis both by chemical and biological mechanisms, including:

OGG1 (DNA repair protein)
Cellular oxidative stress
Cytoglobin
Iron cylinders

Research activity per year

44 Article
9 Abstract
4 Paper
1 Conference contribution
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1 - 50 out of 62 results

2023
Chelating silica nanoparticles for efficient antibiotic delivery and particle imaging in Gram-negative bacteria
Muguruza, A. R., di Maio, A., Hodges, N. J., Blair, J. & Pikramenou, Z., 7 May 2023, In: Nanoscale Advances. 5, 9, p. 2453-2461 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
55 Downloads (Pure)
2022
A ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells
Rana, M., Perotti, A., Bisset, L. M., Smith, J. D., Lamden, E., Khan, Z., Ismail, M. K., Ellis, K., Armstrong, K. A., Hodder, S. L., Bertoli, C., Meneguello, L., de Bruin, R. A. M., Morris, J. R., Romero-Canelon, I., Tucker, J. H. R. & Hodges, N. J., 11 Jun 2022, (E-pub ahead of print) In: Metallomics. 14, 7, 15 p., mfac041.
Research output: Contribution to journal › Article › peer-review

Open Access
File
66 Downloads (Pure)
Exploring mitochondrial energy metabolism of single 3D microtissue spheroids using extracellular flux analysis
Coltman, N. J., Rochford, G., Hodges, N. J., Ali-Boucetta, H. & Barlow, J. P., 3 Feb 2022, In: Journal of Visualized Experiments. 2022, 180, e63346.
Research output: Contribution to journal › Article › peer-review
Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe
De, S., Edwards, D. M., Dwivedi, V., Wang, J., Varsally, W., Dixon, H. L., Singh, A. K., Owuamalam, P. O., Wright, M. T., Summers, R. P., Hossain, M. N., Price, E. M., Wojewodzic, M. W., Falciani, F., Hodges, N. J., Saponaro, M., Tanaka, K., Azzalin, C. M., Baumann, P., Hebenstreit, D., & 1 othersBrogna, S., 11 Jan 2022, In: Nucleic Acids Research. 50, 1, p. 350-367 18 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
56 Downloads (Pure)
2021
Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin
Thorne, L. S., Rochford, G., Williams, T. D., Southam, A. D., Rodriguez-Blanco, G., Dunn, W. B. & Hodges, N. J., 13 Jan 2021, In: Scientific Reports. 11, 1, 985.
Research output: Contribution to journal › Article › peer-review

Open Access
File
186 Downloads (Pure)
Genome-wide chromosomal association of Upf1 is linked to Pol II transcription in Schizosaccharomyces pombe
De, S., Dwivedi, V., Wang, J., Edwards, D. M., Varsally, W., Singh, A. K., Dixon, H. L., Wojewodzic, M. W., Falciani, F., Hodges, N. J., Saponaro, M., Tanaka, K., Azzalin, C. M., Baumann, P., Hebenstreit, D. & Brogna, S., 12 Apr 2021, bioRxiv.
Research output: Working paper/Preprint › Preprint
Quantification by luminescence tracking of red emissive gold nanoparticles in cells
Dosumu, A. N., Claire, S., Watson, L. S., Girio, P. M., Osborne, S. A. M., Pikramenou, Z. & Hodges, N. J., 22 Feb 2021, In: JACS Au. 1, 2, p. 174-186 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
225 Downloads (Pure)
Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication**
Melidis, L., Hill, H. J., Coltman, N. J., Davies, S. P., Winczura, K., Chauhan, T., Craig, J. S., Garai, A., Hooper, C. A. J., Egan, R. T., McKeating, J. A., Hodges, N. J., Stamataki, Z., Grzechnik, P. & Hannon, M. J., 9 Aug 2021, In: Angewandte Chemie (International Edition) . 60, 33, p. 18144-18151 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
194 Downloads (Pure)
2020
Organometallic nucleoside analogues: effect of the metallocene metal atom on cancer cell line toxicity
Ismail, M. K., Armstrong, K. A., Hodder, S. L., Horswell, S. L., Male, L., Nguyen, H. V., Wilkinson, E. A., Hodges, N. J. & Tucker, J. H. R., 28 Jan 2020, In: Dalton Transactions. 49, 4, p. 1181-1190 10 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
5 Citations (Scopus)

260 Downloads (Pure)
2018
Iridium nanoparticles for multichannel luminescence lifetime imaging, mapping localization in live cancer cells
King, S. M., Claire, S., Teixeira, R. I., Dosumu, A. N., Carrod, A. J., Dehghani, H., Hannon, M. J., Ward, A. D., Bicknell, R., Botchway, S. W., Hodges, N. J. & Pikramenou, Z., 15 Aug 2018, In: Journal of the American Chemical Society. 140, 32, p. 10242-10249 8 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
20 Citations (Scopus)

370 Downloads (Pure)
The effects of oxygenation on ex vivo kidneys undergoing Hypothermic Machine Perfusion
Patel, K., Smith, T. B., Neil, D. A., Thakker, A., Tsuchiya, Y., Higgs, E. B., Hodges, N. J., Ready, A. R., Nath, J. & Ludwig, C., 19 Nov 2018, (E-pub ahead of print) In: Transplantation.
Research output: Contribution to journal › Article › peer-review
19 Citations (Scopus)
2017
Bi-directional effects of vitamin B 12 and methotrexate on Daphnia magna fitness and genomic methylation
Kusari, F., O'Doherty, A., Hodges, N. & Wojewodzic, M., 19 Sept 2017, In: Scientific Reports. 7, 11872.
Research output: Contribution to journal › Article › peer-review

Open Access
File
9 Citations (Scopus)

176 Downloads (Pure)
Bio-Fuel Or Bio-Foul?-Characterizing The Risk Of Novel Candidate Bio-Fuel 2-Methylfuran
Hodges, N., Perotti, A. & Santos, J., 26 Aug 2017, (E-pub ahead of print) In: Environmental and Molecular Mutagenesis. 58, Supplement S1 September 2017 , p. S57 1 p.
Research output: Contribution to journal › Abstract
Development of cultures of the marine sponge Hymeniacidon perleve for genotoxicity assessment using the alkaline comet assay
Akpiri, R., Konya, R. & Hodges, N., Dec 2017, In: Environmental Toxicology and Chemistry. 36, 12, p. 3314-3323
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
Organometallic nucleoside analogues: effect of hydroxylalkyl linker length on cancer cell line toxicity
Kedge, J., Nguyen, V. H., Khan, Z., Male, L., Ismail, M., Roberts, H., Hodges, N., Horswell, S. L., Mehellou, Y. & Tucker, J., 10 Jan 2017, In: European Journal of Inorganic Chemistry. 2017, 2, p. 466-476 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
19 Citations (Scopus)

155 Downloads (Pure)
2015
Cytoglobin as a biomarker in cancer: potential perspective for diagnosis and management
Bholah, T., Neergheen-Bhunjun, V., Hodges, N., Dyall, S. & Bahorun, T., 3 Aug 2015, In: BioMed Research International. 2015, 6 p., 824514.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
10 Citations (Scopus)

120 Downloads (Pure)
Cytoglobin expression in the hepatic stellate cell line HSC-T6 is regulated by extracellular matrix proteins dependent on FAK-signalling
Stone, L., Thorne, L., Weston, C., Graham, M. & Hodges, N., 21 Aug 2015, In: Fibrogenesis & Tissue Repair. 8, 15.
Research output: Contribution to journal › Article › peer-review

Open Access
File
9 Citations (Scopus)

198 Downloads (Pure)
Molecular basis of carcinogenicity of tungsten alloy particles
Harris, R. M., Williams, T., Waring, R. H. & Hodges, N. J., 15 Mar 2015, In: Toxicology and applied pharmacology. 283, 3, p. 223-33 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
7 Citations (Scopus)

322 Downloads (Pure)
Nanoparticle growth and surface chemistry changes in cell-conditioned culture medium
Kendall, M., Hodges, N., Whitwell, H., Tyrrell, J. & Cangul, H., 5 Feb 2015, In: Philosophical Transactions of the Royal Society of London Series B. 370, 9 p., 20140100.
Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus)
Study of gaseous benzene effects upon A549 lung epithelial cells using a novel exposure system
Hodges, N., Delgado Saborit, J. M., Mascelloni, M. & Harrison, R., 19 Aug 2015, In: Toxicology Letters. 237, 1, p. 38-45 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Citations (Scopus)

251 Downloads (Pure)
2014
Cellular accumulation of Cys326-OGG1 protein complexes under conditions of oxidative stress
Kaur, M., Guggenheim, E. J., Pulisciano, C., Akbar, S., Kershaw, R. & Hodges, N., 25 Apr 2014, In: Biochemical and Biophysical Research Communications. 447, 1, p. 12-18 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Citations (Scopus)

346 Downloads (Pure)
High coating of Ru(II) complexes on gold nanoparticles for single particle luminescence imaging in cells
Rogers, N. J., Claire, S., Harris, R. M., Farabi, S., Zikeli, G., Styles, I. B., Hodges, N. J. & Pikramenou, Z., 18 Jan 2014, In: Chemical Communications. 50, 5, p. 617-9 3 p.
Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus)
Nanoparticles coated with luminescent metal complexes for imaging in cells
Pikramenou, Z., Claire, S., Styles, I., Watson, S., Thomas, S. & Hodges, N., 2014, Journal of Biological Inorganic Chemistry. Vol. 19 S717-S718.
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Novel ferrocenyl compounds
Tselepis, C., Tucker, J., Nguyen, V. H., Hodges, N. & Mehellou, Y., 2014, Patent No. US20160318964 A1, Priority date 20 Dec 2013
Research output: Patent
Organometallic nucleoside analogues with ferrocenyl linker groups: synthesis and cancer cell line studies
Nguyen, H. V., Sallustrau, A., Balzarini, J., Bedford, M. R., Eden, J. C., Georgousi, N., Hodges, N. J., Kedge, J., Mehellou, Y., Tselepis, C. & Tucker, J. H. R., 10 Jul 2014, In: Journal of Medicinal Chemistry. 57, 13, p. 5817-22 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
40 Citations (Scopus)

393 Downloads (Pure)
2013
Cryopreservation and storage of mussel (Mytilus spp.) haemocytes for latent analysis by the Comet assay
Kwok, A., Bean, T., Hodges, N. & Lyons, B., 20 Jan 2013, In: Mutation Research. 750, 1-2, p. 86-91
Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)
2012
Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells.
McRonald, F., Risk, JM. & Hodges, N., 1 Jan 2012, In: PLoS ONE. 7, 2, p. e30587
Research output: Contribution to journal › Article

Open Access
25 Citations (Scopus)
Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair protein OGG1.
Kershaw, R. & Hodges, N., 25 Mar 2012, In: Mutagenesis.
Research output: Contribution to journal › Article
37 Citations (Scopus)
2011
Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity.
Cardo, L., Sadovnikova, V., Phongtongpasuk, S., Hodges, N. & Hannon, M., 9 May 2011, In: Chemical Communications. 47, 23, p. 6575-6577 3 p.
Research output: Contribution to journal › Article
40 Citations (Scopus)
Determining the cellular uptake and localisation of novel anti-cancer drugs using fluorescence microscopy
Rowley, L., Hodges, N., Bunch, J., Claridge, E. & Hannon, M., 1 Sept 2011.
Research output: Contribution to conference (unpublished) › Poster
Prolonged depletion of antioxidant capacity after ultraendurance exercise
Turner, J. E., Hodges, N. J., Bosch, J. A. & Aldred, S., 1 Sept 2011, In: Medicine and Science in Sports and Exercise. 43, 9, p. 1770-1776 7 p.
Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus)
Reactive oxygen species and oxidative DNA damage mediate the cytotoxicity of tungsten-nickel-cobalt alloys in vitro.
Harris, R., Williams, T., Hodges, N. & Waring, R., 1 Jan 2011, In: Toxicology and applied pharmacology. 250, 1, p. 19-28 10 p.
Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus)

50 Downloads (Pure)
2010
Direct visualization of repair of oxidative damage by OGG1 in the nuclei of live cells.
Zielinska, A., Davies, OT., Meldrum, RA. & Hodges, N., 15 Nov 2010, In: Journal of biochemical and molecular toxicology.
Research output: Contribution to journal › Article
21 Citations (Scopus)
Noncovalent DNA-binding metallo-supramolecular cylinders prevent DNA transactions in vitro.
Ducani, C., Leczkowska, A., Hodges, N. & Hannon, M., 15 Nov 2010, In: Angewandte Chemie (International Edition) . 49, 47, p. 8942-5 4 p.
Research output: Contribution to journal › Article

51 Citations (Scopus)
2009
Anomalous genotoxic responses induced in mouse lymphoma L5178Y cells by potassium bromate
Priestley, CC., Green, R., Fellows, MD., Doherty, AT., Hodges, N. & O’Donovan, MR., 22 Oct 2009, In: Toxicology.
Research output: Contribution to journal › Article
10 Citations (Scopus)
Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells.
Mirbahai, L., Kershaw, R., Green, R., Hayden, R., Meldrum, RA. & Hodges, N., 28 Dec 2009, In: DNA Repair.
Research output: Contribution to journal › Article
25 Citations (Scopus)
2008
Cellular protection from oxidative DNA damage by over-expression of the novel globin cytoglobin in vitro.
Hodges, N., Innocent, N., Dhanda, S. & Graham, M., 1 Jul 2008, In: Mutagenesis. 23, 4, p. 293-8 6 p.
Research output: Contribution to journal › Article
56 Citations (Scopus)
Development of a novel technique to quantify activity and localisation of the base excision repair protein OGG1 in individual cells and its induction by the pro-oxidant potassium bromate
Mirbahai, L., Kershaw, RM., Meldrum, R. & Hodges, N., 15 Dec 2008.
Research output: Contribution to conference (unpublished) › Abstract
Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls.
Green, R., Hodges, N., Chipman, J., O'Donovan, MR. & Graham, M., 1 Nov 2008, In: Mutagenesis. 23, 6, p. 457-63 7 p.
Research output: Contribution to journal › Article
29 Citations (Scopus)
Supramolecular iron cylinder with unprecedented DNA binding is a potent cytostatic and apoptotic agent without exhibiting genotoxicity.
Hotze, AC., Hodges, N., Hayden, R., Sanchez-Cano, C., Paines, C., Male, N., Tse, MK., Bunce, C., Chipman, J. & Hannon, M., 22 Dec 2008, In: Chemistry & Biology. 15, 12, p. 1258-67 10 p.
Research output: Contribution to journal › Article
61 Citations (Scopus)
2007
Induction of DNA strand breaks and oxidative stress in HeLa cells by ethanol is dependent on CYP2E1 expression
Hodges, N., Green, R., Chipman, J. & Graham, M., 31 Jan 2007, In: Mutagenesis. 22, 3, p. 189-194 6 p.
Research output: Contribution to journal › Article
17 Citations (Scopus)
Uncoupling of the hCYP1B1 catalytic cycle by non-ortho-substituted polychlorinated biphenyl congeners is an indirect mechanism for genotoxicity
Green, R., Graham, M., O'Donovan, MR., Chipman, J. & Hodges, N., 1 Jan 2007, In: Toxicology. 240, 3, p. 155-156 2 p.
Research output: Contribution to journal › Article
2006
Activity of OGG1 variants in the repair of pro-oxidant-induced 8-oxo-2'-deoxyguanosine
Smart, D. J., Chipman, J. K. & Hodges, N. J., 8 Nov 2006, In: DNA Repair. 5, 11, p. 1337-45 9 p.
Research output: Contribution to journal › Article › peer-review
68 Citations (Scopus)
Oxidative damage produced by Cr(VI) and repair in mussel (Mytilus edulis L.) gill
Emmanouil, C., Smart, D. J., Hodges, N. J. & Chipman, J. K., Jul 2006, In: Marine Environmental Research. 62 Suppl, p. S292-296
Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus)
Subcellular compartmentalization of glutathione: Correllations with parameters of oxidative stress related to genotoxicity
Green, RM., Graham, M., O'Donovan, MR., Chipman, J. & Hodges, N., 29 Sept 2006, In: Mutagenesis. 21, 6, p. 383-390 8 p.
Research output: Contribution to journal › Article
92 Citations (Scopus)
2005

Direct DNA strand breaks detected by the comet assay are generated by the OGG1/base excision repair pathway and not by pro-oxidants per se
Smart, D., Hodges, N. & Chipman, J., 1 Jan 2005.
Research output: Contribution to conference (unpublished) › Paper
Direct DNA strand breaks detected by the 'comet' assay are generated by the OGG1/base excision repair pathway and not by pro-oxidants per se
Smart, D., Hodges, N. & Chipman, J., 1 Jan 2005, In: EMBO Journal.
Research output: Contribution to journal › Abstract
Inter-individual variability in response to sodium dichromate induced oxidative DNA damage. Role of the Ser(326)Cys polymorphism in the DNA-repair protein of 8-oxo-7,8-dihydro-2 -deoxyguanosine DNA glycosylase 1
Lee, AJ., Hodges, N. & Chipman, J., 1 Jan 2005, In: Cancer Epidemiology Biomarkers &amp Prevention. 14, 2, p. 497-505 9 p.
Research output: Contribution to journal › Article
78 Citations (Scopus)
Negative linear correlation between the nuclear pool of glutathione and oxidative genotoxicity
Green, R., Hodges, N., Graham, M., O'Donovan, M. & Chipman, J., 1 Jan 2005, In: EMBO Journal.
Research output: Contribution to journal › Abstract
Nuclear localisation and DNA repair capacity of hOGG1 variants polymorphic at residue 326 following transfection of ogg1-/- null mouse fibroblasts
Smart, D., Hodges, N. & Chipman, J., 1 Jan 2005, In: The Toxicologist. 84, p. 458 1 p.
Research output: Contribution to journal › Abstract

Nikolas Hodges

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