Mike Hannon

Accepting PhD Students

PhD projects

Mike Hannon's research interests cover anti-cancer metallo-drugs, bioinorganic chemistry and chemical biology. His group are exploring synthetic nanosized cylinders that bind strongly in the major groove of DNA or at DNA junctions and which induce remarkable intramolecular DNA coiling that is unprecedented with synthetic agents. This offers the possibility of coiling and immobilising specific genes. The work is underpinned by a programme on design of sophisticated metallo-supramolecular nanoscale architectures in one-pot reactions from commercial agents. Professor Hannon's group offers opportunities for doctoral research in the following areas: Imaging chemistry for biology and medicine Molecular probe design Bioinorganic chemistry Metal-based drugs DNA recognition Biological chemistry and chemical biology Supramolecular chemistry

Research activity per year

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87 Article
1 Book
1 Chapter (peer-reviewed)
1 Paper
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1 - 50 out of 93 results

Accessible synthetic probes for staining actin inside platelets and megakaryocytes by employing Lifeact peptide
Cardo, L., Thomas, S., Mazharian, A., Pikramenou, Z., Rappoport, J., Hannon, M. & Watson, S., 27 Jul 2015, In: ChemBioChem. 16, 11, p. 1680-1688 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

124 Downloads (Pure)
A dendritic structure containing a designed cleft which controls ligand coordination behavior in an analogous way to proteins
Hannon, M., Mayers, PC. & Taylor, PC., 1 Jan 2001, In: Angewandte Chemie (International Edition) . 40, p. 1081-1084 4 p.
Research output: Contribution to journal › Article

15 Citations (Scopus)
A DNA-binding copper(I) metallo-supramolecular cylinder that can act as an artificial nuclease
Childs, LJ., Malina, J., Rolfsnes, BE., Pascu, M., Prieto, MJ., Broome, MJ., Rodger, PM., Sletten, E., Moreno, V., Rodger, A. & Hannon, M., 14 Jun 2006, In: Chemistry: A European Journal. 12, p. 4919-4927 9 p.
Research output: Contribution to journal › Article
50 Citations (Scopus)
Aggregation of imine-based metallo-supramolecular architectures through ??? interactions
Pascu, M., Clarkson, GJ., Kariuki, B. & Hannon, M., 1 Jan 2006, In: Dalton Transactions. 22, p. 2635-2642 8 p.
Research output: Contribution to journal › Article
22 Citations (Scopus)
Aggregation of metallo-supramolecular architectures by metallo-assembled hydrogen bonding sites
Lavalette, A., Tuna, F., Hamblin, J., Jackson, A., Clarkson, G., Alcock, NW. & Hannon, M., 1 Jan 2003, In: Chemical Communications. p. 2666-2667 2 p.
Research output: Contribution to journal › Article
49 Citations (Scopus)
A luminescent europium hairpin for DNA photosensing in the visible, based on trimetallic bis-intercalators
Scarpantonio, L., Cotton, S. A., Del Giorgio, E., McCallum, M., Hannon, M. J. & Pikramenou, Z., Aug 2020, In: Journal of Inorganic Biochemistry. 209, p. 111119
Research output: Contribution to journal › Article › peer-review
A luminescent europium hairpin for DNA photosensing in the visible, based on trimetallic bis-intercalators
Scarpantonio, L., Cotton, S. A., Del Giorgio, E., Mccallum, M., Hannon, M. & Pikramenou, Z., Aug 2020, In: Journal of Inorganic Biochemistry. 209, 111119.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

105 Downloads (Pure)
An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug
Huxley, M., Sanchez-Cano, C., Browning, MJ., Navarro-Ranninger, C., Quiroga, AG., Rodger, A., Hannon, MJ. & Hannon, M., 1 Jan 2010, In: Dalton Transactions. 39, 47, p. 11353-11364 12 p.
Research output: Contribution to journal › Article
53 Citations (Scopus)
An estrogen-platinum terpyridine conjugate: DNA and protein binding and cellular delivery
Hannon, M., Green, PS., Fisher, DM., Derrick, PJ., Beck, JL., Watt, SJ., Sheil, MM., Barker, PR., Alcock, NW., Price, RJ., Sanders, KJ., Pither, R., Davis, J. & Rodger, A., 1 Jan 2006, In: Chemistry: A European Journal. xx, p. xxx-xxx
Research output: Contribution to journal › Article

45 Citations (Scopus)
Angewandte Chemie International Edition
Pascu, G., Hotze, A., Sanchez-Cano, C., Kariuki, B. & Hannon, M., 1 Jan 2007, Not Known.
Research output: Book/Report › Book

162 Citations (Scopus)
Antimicrobial activity of an iron triple helicate
Richards, AD., Rodger, A., Hannon, M. & Bolhuis, A., 1 May 2009, In: International Journal of Antimicrobial Agents. 33, 5, p. 469-472 4 p.
Research output: Contribution to journal › Article
56 Citations (Scopus)
Anti-tumour platinum acylthiourea complexes and their interactions with DNA
Rodger, A., Patel, KK., Sanders, KJ., Datt, M., Sacht, C. & Hannon, M., 2 Oct 2002, In: Journal of the Chemical Society. Dalton Transactions. 19, p. 3656-63 8 p.
Research output: Contribution to journal › Article

32 Citations (Scopus)
A Potent Ruthenium(II) Antitumor Complex Bearing a Lipophilic Levonorgestrel Group
Ruiz, J., Rodriguez, V., Cutillas, N., Espinosa, A. & Hannon, M., 1 Sep 2011, In: Inorganic Chemistry. 50, 18, p. 9164-9171 8 p.
Research output: Contribution to journal › Article
59 Citations (Scopus)
Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity.
Cardo, L., Sadovnikova, V., Phongtongpasuk, S., Hodges, N. & Hannon, M., 9 May 2011, In: Chemical Communications. 47, 23, p. 6575-6577 3 p.
Research output: Contribution to journal › Article
40 Citations (Scopus)
Aryl substituted ruthenium bisterpyridine complexes: intercalation and groove binding with DNA
Patel, KK., Plummer, EA., Darwish, M., Rodger, A. & Hannon, M., 1 Jan 2002, In: Journal of Inorganic Biochemistry. 91, p. 220-229 10 p.
Research output: Contribution to journal › Article

76 Citations (Scopus)
Assembly of a nanoscale chiral ball through supramolecular aggregation of bowl-shaped triangular helicates
Childs, LJ., Alcock, NW. & Hannon, M., 1 Jan 2002, In: Angewandte Chemie (International Edition) . 41, p. 4244-4247 4 p.
Research output: Contribution to journal › Article

91 Citations (Scopus)
Assembly of nano-scale circular supramolecular arrays through pi-pi aggregation of arc-shaped helicate units
Childs, LJ., Alcock, NW. & Hannon, M., 1 Jan 2001, In: Angewandte Chemie (International Edition) . 40, p. 1079-1081 3 p.
Research output: Contribution to journal › Article

85 Citations (Scopus)
Assisted delivery of anti-tumour platinum drugs using DNA-coiling gold nanoparticles bearing lumophores and intercalators: towards a new generation of multimodal nanocarriers with enhanced action
Caballero, A. B., Cardo, L., Claire, S., Craig, J. S., Hodges, N. J., Vladyka, A., Albrecht, T., Rochford, L. A., Pikramenou, Z. & Hannon, M. J., 28 Oct 2019, In: Chemical Science. 10, 40, p. 9244-9256 13 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
5 Citations (Scopus)

183 Downloads (Pure)
Binding of a Designed Anti-Cancer Drug to the Central Cavity of an RNA Three-Way Junction
Phongtongpasuk, S., Paulus, S., Schnabl, J., Sigel, R. K. O., Spingler, B., Hannon, M. J. & Freisinger, E., 25 Oct 2013, In: Angewandte Chemie (International Edition) . 52, 44, p. 11513-11516 4 p.
Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)
Binding sites on the outside of metallo-supramolecular architectures; engineering coordination polymers from discrete architecturesElectronic supplementary information (ESI) available: Fig. S1: View showing the herringbone style packing of the ?-stacked columns in the structure of ligand La
Pascu, M., Tuna, F., Kolodziejczyk, E., Pascu, G., Clarkson, G. & Hannon, M., 1 Jan 2004, In: Dalton Transactions. 10, p. 1546-55 10 p.
Research output: Contribution to journal › Article

42 Citations (Scopus)
Channel structures in a simple inorganic salt; an open framework formed through structural integration of distinct sodium acetate and sodium perchlorate domains
Lavalette, A., Lawrance, G., Alcock, NW. & Hannon, M., 1 Jan 2004, In: European Journal of Inorganic Chemistry. p. 3981-3983 3 p.
Research output: Contribution to journal › Article

3 Citations (Scopus)
Competing supramolecular interactions give a new twist to terpyridyl chemistry; anion and solvent induced formation of spiral arrays in silver(I) complexes of a simple terpyridine
Hannon, M., Painting, CL., Plummer, EA., Childs, LJ. & Alcock, NW., 1 Jan 2002, In: Chemistry: A European Journal. 8, p. 2225-2238 14 p.
Research output: Contribution to journal › Article
144 Citations (Scopus)
Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(II) complexes with DNA, causing significant alterations to the DNA helix
Sanchez-Cano, C., Huxley, M., Ducani, C., Hamad, A., Browning, MJ., Navarro-Ranninger, C., Quiroga, AG., Rodger, A. & Hannon, M., 1 Jan 2010, In: Dalton Transactions. 39, 47, p. 11365-11374 10 p.
Research output: Contribution to journal › Article
34 Citations (Scopus)
Cytotoxicity, cellular localisation and biomolecular interaction of non-covalent metallo-intercalators with appended sex hormone steroid vectors
Sanchez-Cano, C. & Hannon, M., 1 Jan 2009, In: Dalton Transactions. 48, p. 10765-10773 9 p.
Research output: Contribution to journal › Article
36 Citations (Scopus)
Design and DNA binding of an extended triple-stranded metallo-supramolecular cylinder
Uerpmann, C., Malina, J., Pascu, M., Clarkson, GJ., Moreno, V., Rodger, A., Grandas, A. & Hannon, M., 1 Jan 2005, In: Chemistry: A European Journal. 11, p. 1750-1756 7 p.
Research output: Contribution to journal › Article
53 Citations (Scopus)
Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides
Cardo, L. & Hannon, M., 1 Feb 2009, In: Inorganica Chimica Acta. 362, 3, p. 784-792 9 p.
Research output: Contribution to journal › Article
21 Citations (Scopus)
Design and Non-Covalent DNA Binding of Platinum(II) Metallacalix[4]arenes
Galindo, MA., Olea, D., Romero, MA., Gómez, J., Castillo, P., Hannon, M., Rodger, A., Zamora, F. & Navarro, JAR., 15 Jun 2007, In: Chemistry: A European Journal. 13, 18, p. 5075 1 p.
Research output: Contribution to journal › Article
51 Citations (Scopus)
Determining the cellular uptake and localisation of novel anti-cancer drugs using fluorescence microscopy
Rowley, L., Hodges, N., Bunch, J., Claridge, E. & Hannon, M., 1 Sep 2011.
Research output: Contribution to conference (unpublished) › Poster
Dinuclear Double Stranded Metallo-supramolecular Ruthenium Complexes; Potential Anticancer Drugs
Hotze, A., Kariuki, B. & Hannon, M., 17 Jul 2006, In: Angewandte Chemie (International Edition) . 45, p. 4839-4842 4 p.
Research output: Contribution to journal › Article

83 Citations (Scopus)
Directed one-pot syntheses of enantiopure dinuclear silver(i) and copper(i) metallo-supramolecular double helicates
Hamblin, J., Childs, LJ., Alcock, NW. & Hannon, M., 9 Jan 2002, In: Journal of the Chemical Society. Dalton Transactions. 2, p. 164-169 6 p.
Research output: Contribution to journal › Article

84 Citations (Scopus)
DNA binding and bending by dinuclear complexes comprising ruthenium polypyridyl centres linked by a bis(pyridylimine) ligand
McDonnell, U., Hicks, MR., Hannon, M. & Rodger, A., 1 Dec 2008, In: Journal of Inorganic Biochemistry. 102, 12, p. 2052-2059 8 p.
Research output: Contribution to journal › Article
51 Citations (Scopus)
DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference
Malina, J., Hannon, M. & Brabec, V., 1 Jan 2008, In: Nucleic Acids Research. 36, 11, p. 3630-3638 9 p.
Research output: Contribution to journal › Article

Open Access
32 Citations (Scopus)
DNA binding studies and cytotoxicity of a dinuclear Pt^II diazapyrenium-based metallo-supramolecular rectangular box
Terenzi, A., Ducani, C., Blanco, V., Zerzankova, L., Westendorf, A. F., Peinador, C., Quintela, J. M., Bednarski, P. J., Barone, G. & Hannon, M. J., 27 Aug 2012, In: Chemistry - A European Journal. 18, 35, p. 10983-10990 8 p.
Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus)
DNA Three-Way Junction with a Dinuclear Iron(II) Supramolecular Helicate at the Center: A NMR Structural Study
Cerasino, L., Hannon, M. & Sletten, E., 6 Aug 2007, In: Inorganic Chemistry. 46, 16, p. 6245 1 p.
Research output: Contribution to journal › Article
57 Citations (Scopus)
Effect of adenine moiety on DNA binding property of copper(ii)–terpyridine complexes
Jiang, Q., Wu, Z., Zhang, Y., Hotze, ACG., Hannon, M. & Guo, Z., 1 Jan 2008, In: Dalton Transactions. 2006, 23, p. 3054-3060 7 p.
Research output: Contribution to journal › Article

19 Citations (Scopus)
Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron (ii) triple helicates
Parajo, Y., Malina, J., Meistermann, I., Clarkson, GJ., Pascu, M., Rodger, A. & Hannon, M., 1 Jan 2007, In: Dalton Trans. 25, p. 4868-4874 7 p.
Research output: Contribution to journal › Article
25 Citations (Scopus)
Electron capture dissociation mass spectrometry of metallo-supramolecular complexes
Kaczorowska, M., Hotze, ACG., Hannon, M. & Cooper, H., 1 Feb 2010, In: Journal of the American Society for Mass Spectrometry. 21, 2, p. 300-309 10 p.
Research output: Contribution to journal › Article › peer-review

File
12 Citations (Scopus)

74 Downloads (Pure)
Enantiomeric resolution of supramolecular helicates with different surface topographies
Kerckhoffs, JMCA., Peberdy, JC., Meistermann, I., Childs, LJ., Isaac, CJ., Pearmund, R., Reudegger, V., Khalid, S., Alcock, NW., Hannon, M. & Rodger, A., 1 Jan 2007, In: Dalton Transactions. 2007, 7, p. 734-742 9 p.
Research output: Contribution to journal › Article
42 Citations (Scopus)
Estrogen-derived steroidal metal complexes: agents for cellular delivery of metal centers to estrogen receptor-positive cells
Jackson, A., Davis, J., Pither, RJ., Rodger, A. & Hannon, M., 1 Jan 2001, In: Inorganic Chemistry. 40, p. 3964-3973 10 p.
Research output: Contribution to journal › Article
82 Citations (Scopus)
Far-red luminescent ruthenium pyridylimine complexes; building blocks for multinuclear arrays
Hotze, A., Faiz, J., Mourtzis, N., Pascu, G., Webber, PRA., Clarkson, GJ., Yannakopoulou, K., Pikramenou, Z. & Hannon, M., 12 Jun 2006, In: Dalton Transactions. 24, p. 3025-3034 10 p.
Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus)
Flow oriented linear dichroism to probe protein orientation in membrane environments
Rodger, A., Rajendra, J., Mortimer, R., Andrews, T., Hirst, JB., Gilbert, ATB., Marrington, R., Halsall, D., Dafforn, T., Ardhammer, M., Norden, B., Woolhead, CA., Robinson, C., Pinheiro, T., Kazlauskaite, J., Seymour, M., Perez, N. & Hannon, M., 1 Jan 2003.
Research output: Contribution to conference (unpublished) › Paper
Flow oriented linear dichroism to probe protein orientation in membrane environments
Rodger, A., Rajendra, J., Marrington, R., Ardhammar, M., Norden, B., Hirst, JD., Gilbert, ATB., Dafforn, TR., Halsall, DJ., Woolhead, CA., Robinson, C., Pinheiro, TJT., Kazlauskaite, J., Seymour, M., Perez, N. & Hannon, M., 1 Jan 2002, In: Physical Chemistry Chemical Physics. 4, p. 4051-4057 7 p.
Research output: Contribution to journal › Article

56 Citations (Scopus)
Groovy DNA recognition; new agents for gene regulation?
Hannon, M. & Rodger, A., 1 Jan 2002, In: Pharmaceutical Visions. Aut, p. 14-16 3 p.
Research output: Contribution to journal › Article
Helical (Isotactic) and Syndiotactic Silver(I) Metallo-Supramolecular Coordination Polymers assembled from a readily-prepared Bis-Pyridylimine Ligand containing a 1,5-Naphthalene Spacer
Tuna, F., Hamblin, J., Clarkson, G., Errington, W., Alcock, NW. & Hannon, M., 1 Jan 2002, In: Chemistry: A European Journal. 8, p. 4957-4964 8 p.
Research output: Contribution to journal › Article
52 Citations (Scopus)
Helices and Helicates
Childs, LJ. & Hannon, M., 1 Jan 2004, In: Supramolecular Chemistry. 16, p. 7-22 16 p.
Research output: Contribution to journal › Article

234 Citations (Scopus)
Immobilization of π-assembled metallo-supramolecular arrays in thin films: from crystal-engineered structures to processable materials
Krass, H., Plummer, EA., Haider, J., Barker, PR., Alcock, NW., Pikramenou, Z., Hannon, M. & Kurth, DG., 15 Oct 2001, In: Angewandte Chemie (International Edition) . 40, 20, p. 3862-3865 4 p.
Research output: Contribution to journal › Article › peer-review
62 Citations (Scopus)
Immobilization of π-assembled metallo-supramolecular arrays in thin films: from crystal-engineered structures to processable materials
Krass, H., Plummer, E. A., Haider, J. M., Barker, P. R., Alcock, N. W., Pikramenou, Z., Hannon, M. J. & Kurth, D. G., 15 Oct 2001, In: Angewandte Chemie (International Edition) . 113, 20, p. 3980-3983 4 p.
Research output: Contribution to journal › Article › peer-review
Influence of surface shape on DNA binding of bimetallo helicates
Peberdy, JC., Malina, J., Khalid, S., Hannon, M. & Rodger, A., 1 Nov 2007, In: Journal of Inorganic Biochemistry. 101, 11-12, p. 1937 1 p.
Research output: Contribution to journal › Article
42 Citations (Scopus)
Interaction between a DNA oligonucleotide and dinuclear iron(II) supramolecular cylinder; a NMR and molecular dynamics study
Molderheim, E., Meistermann, I., Rodger, A., Hannon, M. & Sletten, E., 1 Jan 2002, In: Journal of Biological Inorganic Chemistry. 7, p. 770-780 11 p.
Research output: Contribution to journal › Article

34 Citations (Scopus)
Interaction of Dinuclear Ruthenium(II) Supramolecular Cylinders with DNA: Sequence-Specific Binding, Unwinding, and Photocleavage
Malina, J., Hannon, M. & Brabec, V., 1 Jan 2008, In: Chemistry: A European Journal. 14, 33, p. 10408-10414 7 p.
Research output: Contribution to journal › Article
35 Citations (Scopus)

Mike Hannon

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