Mike Hannon

Accepting PhD Students

PhD projects

Mike Hannon's research interests cover anti-cancer metallo-drugs, bioinorganic chemistry and chemical biology. His group are exploring synthetic nanosized cylinders that bind strongly in the major groove of DNA or at DNA junctions and which induce remarkable intramolecular DNA coiling that is unprecedented with synthetic agents. This offers the possibility of coiling and immobilising specific genes. The work is underpinned by a programme on design of sophisticated metallo-supramolecular nanoscale architectures in one-pot reactions from commercial agents. Professor Hannon's group offers opportunities for doctoral research in the following areas:

Imaging chemistry for biology and medicine
Molecular probe design
Bioinorganic chemistry
Metal-based drugs
DNA recognition
Biological chemistry and chemical biology
Supramolecular chemistry

Research activity per year

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

SDG 3 Good Health and Well-being

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1 Similar Profiles

91 Article
1 Book
1 Chapter (peer-reviewed)
1 Paper
More

A Flexible Quadruple-Stranded Helicate Demonstrates a Strong Binding Preference for DNA Three-Way Junctions by Induced Fit
Williams, H. D., Dettmer, S. J., Bajpai, S. & Hannon, M. J., 22 Oct 2025, (E-pub ahead of print) In: Journal of the American Chemical Society.
Research output: Contribution to journal › Article › peer-review

Open Access
File
14 Downloads (Pure)
Folate receptor-targeted gold nanoparticles bearing a DNA-binding anthraquinone
Caballero, A. B., Hodges, N. J. & Hannon, M. J., 17 Mar 2025, In: Inorganics. 13, 3, 12 p., 87.
Research output: Contribution to journal › Article › peer-review

Open Access
File
75 Downloads (Pure)
Interactions of elongated dinuclear metallo-cylinders with DNA three-way and four-way junctions
Dettmer, S. J., Stock, H. M. P. & Hannon, M. J., 15 Sept 2025, (E-pub ahead of print) In: Journal of Biological Inorganic Chemistry.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Supramolecular Recognition of a DNA Four-Way Junction by an M₂L₄ Metallo-Cage, Inspired by a Simulation-Guided Design Approach
Dettmer, S. J., Williams, H. D., Napier, R., Beames, J. M., Walker‑Griffiths, S., Craggs, T. D. & Hannon, M. J., 24 Jun 2025, In: Angewandte Chemie - International Edition. 64, 26, 11 p., e202504866.
Research output: Contribution to journal › Article › peer-review

Open Access
File
72 Downloads (Pure)
Switching on Supramolecular DNA Junction Binding Using a Human Enzyme
Karmakar, S., Dettmer, S. J., Hooper, C. A. J., Hodges, N. J. & Hannon, M. J., 15 Mar 2025, (E-pub ahead of print) In: Angewandte Chemie (International Edition) . e202503683.
Research output: Contribution to journal › Letter › peer-review

Open Access
File
76 Downloads (Pure)

3 Active
13 Finished

MRC IAA: A new class of broad-spectrum anti-virals based on a new supramolecular approach
Hannon, M. (Principal Investigator) & Stamataki, Z. (Co-Investigator)
Medical Research Council
1/04/26 → 30/09/26
Project: Research Councils
Replacing Animal Testing with Innovative Spheroid Models: Targeted Nanoparticle Therapy for Head and Neck Cancer
Hannon, M. (Co-Investigator), Hodges, N. (Principal Investigator) & Pikramenou, Z. (Co-Investigator)
THE HUMANE RESEARCH TRUST
5/01/26 → 4/01/28
Project: Research
Luminescent gold nanoparticles decorated with functional metal complexes
Hannon, M. (Co-Investigator) & Pikramenou, Z. (Principal Investigator)
British Academy
20/12/24 → 31/07/26
Project: Research Councils
TumourActivRotaxanes - Tumour Selective Activation of Rotaxanated DNA-fork-binding Metallo-supramolecular Nano-cylinder Helicates
Hannon, M. (Principal Investigator)
UKRI Horizon Europe Underwriting EPSRC
1/03/23 → 28/02/25
Project: Research
Tumour specific enzyme activation of DNA-coiling nanoparticles combined with targeted normoxic photo-damage and hypoxic drug release
Hannon, M. (Principal Investigator)
The Royal Society
1/03/21 → 28/02/23
Project: Research Councils

Research data supporting the publication "Switching On Supramolecular DNA Junction Binding Using a Human Enzyme"
Karmakar, S. (Creator), Dettmer, S. (Creator) & Hannon, M. (Creator), University of Birmingham, 4 Mar 2025
DOI: 10.25500/edata.bham.00001250
Dataset
Raw dataset for submitted publication Recognition of a DNA Four Way Junction by an M2L4 Supramolecular Metallocage, Inspired by a Simulation-Guided Approach
Hannon, M. (Creator) & Dettmer, S. (Creator), University of Birmingham, 28 Aug 2024
DOI: 10.25500/edata.bham.00001165
Dataset
Raw Dataset for the Publication: Supramolecular Recognition of a DNA Four Way Junction by an M2L4 Metallo-cage, Inspired by a Simulation-Guided Design Approach
Dettmer, S. (Creator) & Hannon, M. (Creator), University of Birmingham, 26 Sept 2025
Dataset
Dataset supporting submitted publication "Interactions of Elongated Dinuclear Metallo-Cylinders with DNA Three-Way and Four-Way Junctions"
Hannon, M. (Creator) & Dettmer, S. (Creator), University of Birmingham, 25 Apr 2025
DOI: 10.25500/edata.bham.00001275
Dataset
Raw Dataset supporting publication "A Flexible Quadruple-Stranded Helicate Demonstrates a Strong Binding Preference for Three-Way Junctions by Induced-Fit"
Hannon, M. (Creator), Dettmer, S. (Creator) & Williams, H. (Creator), University of Birmingham, 15 Jul 2025
DOI: 10.25500/edata.bham.00001327
Dataset

DNA recognition using supramolecular peptide metal helicates
Hannon, M. (Host)
6 Jun 2024
Activity: Academic and Industrial events › Guest lecture or Invited talk
Remote-controlled nucleic acids for biology and medicine
Hannon, M. (Host)
3 Jun 2024
Activity: Academic and Industrial events › Guest lecture or Invited talk

File
How can inorganic chemists tackle the issue of toxic amyloid aggregation?
Hannon, M. (Host)
1 Mar 2024
Activity: Academic and Industrial events › Guest lecture or Invited talk

Mike Hannon

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

A Flexible Quadruple-Stranded Helicate Demonstrates a Strong Binding Preference for DNA Three-Way Junctions by Induced Fit

Folate receptor-targeted gold nanoparticles bearing a DNA-binding anthraquinone

Interactions of elongated dinuclear metallo-cylinders with DNA three-way and four-way junctions

Supramolecular Recognition of a DNA Four-Way Junction by an M₂L₄ Metallo-Cage, Inspired by a Simulation-Guided Design Approach

Switching on Supramolecular DNA Junction Binding Using a Human Enzyme

MRC IAA: A new class of broad-spectrum anti-virals based on a new supramolecular approach

Replacing Animal Testing with Innovative Spheroid Models: Targeted Nanoparticle Therapy for Head and Neck Cancer

Luminescent gold nanoparticles decorated with functional metal complexes

TumourActivRotaxanes - Tumour Selective Activation of Rotaxanated DNA-fork-binding Metallo-supramolecular Nano-cylinder Helicates

Tumour specific enzyme activation of DNA-coiling nanoparticles combined with targeted normoxic photo-damage and hypoxic drug release

Research data supporting the publication "Switching On Supramolecular DNA Junction Binding Using a Human Enzyme"

Raw dataset for submitted publication Recognition of a DNA Four Way Junction by an M2L4 Supramolecular Metallocage, Inspired by a Simulation-Guided Approach

Raw Dataset for the Publication: Supramolecular Recognition of a DNA Four Way Junction by an M2L4 Metallo-cage, Inspired by a Simulation-Guided Design Approach

Dataset supporting submitted publication "Interactions of Elongated Dinuclear Metallo-Cylinders with DNA Three-Way and Four-Way Junctions"

Raw Dataset supporting publication "A Flexible Quadruple-Stranded Helicate Demonstrates a Strong Binding Preference for Three-Way Junctions by Induced-Fit"

DNA recognition using supramolecular peptide metal helicates

Remote-controlled nucleic acids for biology and medicine

How can inorganic chemists tackle the issue of toxic amyloid aggregation?

Mike Hannon

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects

Datasets

Activities