Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Rewiring protein binding specificity in paralogous DRG/DFRP complexes
Westrip, C. A. E., Smerdon, S. J. & Coleman, M. L., 7 Nov 2024, In: Structure. 32, 11, p. 2049-2062.e4 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Downloads (Pure) -
5‑Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji‑C Domain-Containing Protein 5
Brewitz, L., Nakashima, Y., Piasecka, S. K., Salah, E., Fletcher, S. C., Tumber, A., Corner, T. P., Kennedy, T. J., Fiorini, G., Thalhammer, A., Christensen, K. E., Coleman, M. L. & Schofield, C. J., 10 Aug 2023, In: Journal of Medicinal Chemistry. 66, 15, p. 10849-10865 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile113 Downloads (Pure) -
Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans
Fletcher, S. C., Hall, C., Kennedy, T. J., Pajusalu, S., Wojcik, M. H., Boora, U., Li, C., Oja, K. T., Hendrix, E., Westrip, C. A., Andrijes, R., Piasecka, S. K., Singh, M., El-Asrag, M. E., Ptasinska, A., Tillmann, V., Higgs, M. R., Carere, D. A., Beggs, A. D. & Pappas, J. & 5 others, , 3 Apr 2023, In: Journal of Clinical Investigation. 133, 7, e152784.Research output: Contribution to journal › Article › peer-review
Open AccessFile92 Downloads (Pure) -
Inactivation of DRG1, encoding a translation factor GTPase, causes a recessive neurodevelopmental disorder
Westrip, C. A. E., Paul, F., Al-Murshedi, F., Qaitoon, H., Cham, B., Fletcher, S. C., Hendrix, E., Boora, U., Ng, A. Y. J., Bonnard, C., Najafi, M., Alawbathani, S., Lambert, I., Fox, G., Venkatesh, B., Bertoli-Avella, A., Tan, E. S., Al-Maawali, A., Reversade, B. & Coleman, M. L., Sept 2023, In: Genetics in Medicine. 25, 9, 9 p., 100893.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Downloads (Pure) -
Developmentally regulated GTPases: structure, function and roles in disease
Westrip, C. A. E., Zhuang, Q., Hall, C., Eaton, C. D. & Coleman, M. L., 19 Oct 2021, In: Cellular and Molecular Life Sciences. 78, 23, p. 7219-7235 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile274 Downloads (Pure)
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Defining and targeting the cellular origin of meningioma
Coleman, M. (Principal Investigator)
1/12/25 → 31/07/26
Project: Research
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Investigating the role of a hydroxylated translation factor GTPase in nuclear ubiquitin biology
Coleman, M. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/04/25 → 31/03/28
Project: Research Councils
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Dissecting Hydroxylase Biology Implicated in Development Disorders and Cancer
Coleman, M. (Principal Investigator) & Smerdon, S. (Co-Investigator)
1/12/24 → 30/11/27
Project: Research Councils
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ChondrOx 2.0 : Investigation of next-generation chondrosarcoma models and therapeutic strategies
Coleman, M. (Principal Investigator) & Fletcher, S. (Co-Investigator)
1/09/24 → 28/02/25
Project: Research
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MRC IAA: Targeting translational termination to treat nonsense mutation driven disease
Beggs, A. (Co-Investigator) & Coleman, M. (Principal Investigator)
The Wellcome Trust, Medical Research Council
1/12/23 → 31/03/25
Project: Research