Marwan Cheng Kuang Kwok

Kwok, M. C. K., Oldreive, C., Rawstron, A. C., Goel, A., Papatzikas, G., Jones, R., Drennan, S., Agathanggelou, A., Sharma-Oates, A., Evans, P., Smith, E., Dalal, S., Mao, J., Hollows, R., Gordon, N., Hamada, M., Davies, N., Parry, H., Beggs, A., Munir, T., & 10 othersMoreton, P., Paneesha, S., Pratt, G., Taylor, M., Forconi, F., Baird, D., Cazier, J-B., Moss, P., Hillmen, P. & Stankovic, T., 6 Feb 2020, In: Blood. 135, 6, p. 411-428 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

163 Downloads (Pure)

Natural history and mechanism of spontaneous CLL regression: an integrative analysis of 20 cases

Kwok, M. C. K., Rawstron, A., Goel, A., Papatzikas, G., Oldreive, C., Jones, R., Drennan, S., Agathanggelou, A., Sharma-Oates, A., Evans, P., Smith, E., Dalal, S., Mao, J., Hollows, R., Gordon, N., Hamada, M., Davies, N., Parry, H., Beggs, A., Munir, T., & 10 othersMoreton, P., Paneesha, S., Pratt, G., Taylor, M., Forconi, F., Baird, D., Cazier, J-B., Moss, P., Hillmen, P. & Stankovic, T., 2020, Leukemia & Lymphoma. Taylor & Francis, Vol. 61. p. 225-226

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Open Access

2019

Long-Term Ibrutinib Therapy Reverses CD8+ T Cell Exhaustion in B Cell Chronic Lymphocytic Leukaemia

Parry, H. M., Mirajkar, N., Cutmore, N., Zuo, J., Long, H., Kwok, M., Oldrieve, C., Hudson, C., Stankovic, T., Paneesha, S., Kelly, M., Begum, J., McSkeane, T., Pratt, G. & Moss, P., 12 Dec 2019, In: Frontiers in immunology. 10, 2832.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

158 Downloads (Pure)

Outcomes following treatment discontinuation in CML: real-world experience from 3 regional UK centres

Kwok, M. C. K., Shenouda, A., Duncan, N., Hasan, Y., Ewing, J., Raghavan, M. & Wandroo, F., Jun 2019, HemaSphere. Vol. 3. p. 884 (HemaSphere).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

PALB2 variant status in hematological malignancies - a potential therapeutic target?

Oldreive, C. E., Byrd, P. J., Stewart, G. S., Taylor, A. J., Farhat, S., Skowronska, A., Smith, E., Raghavan, M., Janic, D., Dokmanovic, L., Clokie, S., Davies, N., Kwok, M., Pratt, G., Paneesha, S., Moss, P., Stankovic, T. & Taylor, A. J., 7 Jan 2019, In: Leukemia and Lymphoma. 60, 7, p. 1823-1826 4 p.

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

Targeting the Ataxia Telangiectasia and Rad3 Signaling Pathway to Overcome Chemoresistance in Cancer

Kwok, M. C. K. & Stankovic, T., 2019, Targeting Cell Survival Pathways to Enhance Response to Chemotherapy. Johnson, D. E. (ed.). Elsevier, Vol. 3. p. 203-230

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

2018

Novel insights into the clinical heterogeneity and treatment of chronic lymphocytic leukaemia

Kwok, M. C. K., 2018

Research output: Thesis › Doctoral Thesis

Targeting Replication Stress in Sporadic Tumours

Kwok, M. C. K. & Stankovic, T., 4 Sept 2018, DNA Repair and Replication: Mechanisms and Cinical Significance. Grand, R. J. A. & Reynolds, J. J. (eds.). 1st ed. CRC Press, p. 329-340 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

2017

Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts

Davies, N., Kwok, M., Gould, C., Oldreive, C., Mao, J., Parry, H., Smith, E., Agathanggelou, A., Pratt, G., Taylor, M., Moss, P., Griffiths, M. & Stankovic, T., 26 Apr 2017, In: OncoTarget. 8, 27, p. 44749-44760

Research output: Contribution to journal › Article › peer-review

Open Access

File

7 Citations (Scopus)

187 Downloads (Pure)

USP7 inhibition alters homologous recombination repair and targets CLL cells independent of ATM/p53 functional status

Agathanggelou, A., Smith, E., Davies, N., Kwok, M., Zlatanou, A., Oldreive, C., Mao, J., Da Costa, D., Yadollahi, S., Perry, T., Kearns, P., Skowronska, A., Yates, E., Parry, H., Hillmen, P., Reverdy, C., Delansorne, R., Paneesha, S., Pratt, G., Moss, P., & 3 othersTaylor, M., Stewart, G. & Stankovic, T., 13 Jul 2017, In: Blood. 130, 2, p. 156–166

Research output: Contribution to journal › Article › peer-review

Open Access

File

35 Citations (Scopus)

238 Downloads (Pure)

2016

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 or ATM defective chronic lymphocytic leukemia cells

Kwok, M., Davies, N., Agathanggelou, A., Smith, E., Oldreive, C., Petermann, E., Stewart, G., Brown, J., Lau, A., Pratt, G., Parry, H., Taylor, M., Moss, P., Hillmen, P. & Stankovic, T., 4 Feb 2016, In: Blood. 127, 5, p. 582-595

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

32 Downloads (Pure)

Minimal residual disease is an independent predictor for 10-year survival in CLL

Kwok, M., Rawstron, A., Varghese, A., Evans, P., O’Connor, S., Doughty, C., Newton, D., Moreton, P. & Hillmen, P., 15 Dec 2016, In: Blood. 128, 24, p. 2770-2773

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

2015

Kinetics of CLL Subclonal Architecture: Spontaneous Disease Progression or Treatment-Induced Selection?

Oldreive, C., Davies, N., Skowronska, A., Kwok, M. C. K., Pratt, G., Moss, P., Griffiths, M., Clokie, S. J., Taylor, M. & Stankovic, T., 3 Dec 2015, Blood. American Society of Hematology, Vol. 126. p. 167 (Blood).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway

Kwok, M., Davies, N., Agathanggelou, A., Smith, E., Petermann, E., Yates, E., Brown, J., Lau, A. & Stankovic, T., 26 Feb 2015, In: The Lancet. 385 Suppl 1, p. S58

Research output: Contribution to journal › Abstract › peer-review

2014

ATR Inhibition Exacerbates Replication Stress in TP53 or ATM Deficient CLL Cells and Enhances Sensitivity to Chemotherapy and Targeted Therapy

Kwok, M. C. K., Davies, N., Agathanggelou, A., Smith, E., Petermann, E., Yates, E., Brown, J., Lau, A. & Stankovic, T., 6 Dec 2014, Blood. Vol. 124. p. 3340 (Blood).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

CLL Progression Is Associated with Increased Clonal Diversity and Replication Stress

Agathanggelou, A., Skowronska, A., Davies, N., Kwok, M. C. K., Clokie, S. J., Griffiths, M., Taylor, M. & Stankovic, T., 6 Dec 2014, Blood. Vol. 124. p. 1977 (Blood).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Independent prognostic significance of minimal residual disease status in chronic lymphocytic leukaemia

Kwok, M. C. K., Rawstron, A. C., Varghese, A., Evans, P., O'Connor, S., Doughty, C., Newton, D., Moreton, P. & Hillmen, P., Feb 2014, Lancet. Vol. 383. p. S66 (The Lancet).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2013

Synthetic Lethality In CLL With DNA Damage Response Defect By Targeting ATR Pathway

Stankovic, T., Davies, N., Kwok, M. C. K., Smith, E., Yates, E., Agathanggelou, A., Brown, J. & Lau, A., 15 Nov 2013, Blood. Vol. 122. p. 120 (Blood).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2010

Achieving minimal residual disease (MRD) negativity in CLL is independently associated with improved progression-free and overall survival and is an appropriate end-point of therapy

Kwok, M. C. K., Rawstron, A. C., Varghese, A. & Hillmen, P., 2010, British Journal of Haematology. Vol. 149. p. 20 21 p. (British Journal of Haematology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2009

Minimal Residual Disease Is a Predictor for Progression-Free and Overall Survival in Chronic Lymphocytic Leukemia (CLL) That Is Independent of the Type or Line of Therapy.

Kwok, M. C. K., Rawstron, A. C., Varghese, A. & Hillmen, P., 20 Nov 2009, Blood. Vol. 114. p. 540 (Blood).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2008

Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia

Rawstron, A. C., Bennett, F., O'Connor, S., Kwok, M. C. K., Fenton, J., Plummer, M., de Tute, R., Owen, R., Richards, S., Jack, A. & Hillmen, P., 7 Aug 2008, In: New England Journal of Medicine. p. 575-583

Research output: Contribution to journal › Article › peer-review

Open Access

2007

Monoclonal B-Cell Lymphocytosis (MBL) Is a Precursor State for Chronic Lymphocytic Leukemia (CLL) with 1% Progression Per Year.

Rawstron, A., Bennet, F., O'Connor, S., Kwok, M. C. K., Fenton, J., Plummer, M., de Tute, R., Owen, R., Richard, S., Jack, A. & Hillmen, P., 16 Nov 2007, Blood. American Society of Hematology, Vol. 110. p. 749 (Blood).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2005

Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells

Chuah, C., Barnes, D. J., Kwok, M., Corbin, A., Deininger, M. W. N., Druker, B. J. & Melo, J. V., 1 Nov 2005, In: Leukemia. 19, 11, p. 1896-1904 9 p.

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Marwan Cheng Kuang Kwok

Research output

Search results