Martin Read

Research output

Research output per year 1993 2001 2003 2004 2005 2006 2008 2009 2010 2011 2012 2013 2015 2016 2017 2019 2021 2023 2024

• 167 Abstract
• 61 Article
• 23 Other contribution
• 5 Paper
• 16 More
  • 5 Review article
  • 5 Preprint
  • 4 Chapter
  • 2 Poster

Research output per year

Research output per year

Search results

• 2023

  A copper-based metabolite of disulfiram upregulates sodium iodide symporter (NIS) gene expression to enhance thyroidal uptake of radionuclides in vivo

  Brookes, K., Zha, L., Small, B., Kim, J., Manivannan, S., Thornton, C., Kannappan, V., Wang, W., Nieto, H., Sunassee, K., Blower, P., Smith, V., Read, M. & McCabe, C., 30 Oct 2023, In: Endocrine Abstracts. 94, 1 p., OC7.1.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Ditiocarb 96%
  • Disulfiram 92%
  • Radioisotopes 67%
  • Copper 65%

• A critical role for copper in enhanced radioiodide uptake in thyroid cancer cells

  Brookes, K., Zha, L., Kim, J., Kannappan, V., Wang, W., Sunassee, K., Blower, P., Smith, V., Read, M. & McCabe, C., 4 Apr 2023, In: Cancer Research. 83, 7_Supplement, 5053.

  Research output: Contribution to journal › Abstract › peer-review

  • Ditiocarb 100%
  • Thyroid Neoplasms 69%
  • Copper 68%
  • sodium-iodide symporter 44%
  • Disulfiram 41%

• A critical role for the proto-oncogene PBF in regulating cellular adhesion and motility in thyroid cancer

  Manivannan, S., Banga, D., Kocbiyik, M., Read, M., Zha, L., Brookes, K., Nieto, H., McCabe, C. & Smith, V., 31 Oct 2023, In: Endocrine Abstracts. 94, 1 p., OC2.6.

  Research output: Contribution to journal › Abstract › peer-review

  • Proto-Oncogenes 100%
  • Thyroid Neoplasms 86%
  • Focal Adhesions 45%
  • Cell Adhesion 43%
  • Paxillin 32%

• Copper-based therapeutics increase sodium/iodide symporter (NIS) transcription and enhance radioiodide uptake in thyroid cancer cells

  Brookes, K., Zha, L., Kim, J., Small, B., Kocbiyik, M., Manivannan, S., Kannappan, V., Wang, W., Sunassee, K., Blower, P., Nieto, H., Smith, V., Read, M. & McCabe, C., 16 May 2023, In: Endocrine Abstracts. 90, 1 p., OC11.1.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Ditiocarb 96%
  • Thyroid Neoplasms 66%
  • Copper 65%
  • Disulfiram 57%

• Elucidating the mechanisms via which the proto-oncogene Pbf stimulates cell motility in thyroid tumor progression

  Manivannan, S., Kocbiyik, M., Alshahrani, M., EI-Asrag, M., Zha, L., Brookes, K., Nieto, H., Read, M., Beggs, A., McCabe, C. & Smith, V., 15 Sept 2023, In: Thyroid. 33, S1, p. A62-A62 1 p., Poster 338.

  Research output: Contribution to journal › Abstract › peer-review

  • Proto-Oncogenes 100%
  • Thyroid Gland 70%
  • Cell Movement 69%
  • Fibroblasts 63%
  • Neoplasms 27%

• Elucidating the mechanisms via which the proto-oncogene PBF stimulates cell motility in thyroid tumour progression

  Manivannan, S., Kocbiyik, M., Alshahrani, M., El-Asrag, M. E., Zha, L., Brookes, K., Nieto, H., Read, M., Beggs, A., McCabe, C. & Smith, V., 11 Jul 2023, In: Thyroid Research. 16, S1, p. 6-6 1 p., PO2.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • Proto-Oncogenes 100%
  • Thyroid Gland 70%
  • Cell Movement 69%
  • Fibroblasts 63%
  • Neoplasms 27%

• Exploiting endocytic factors as druggable targets to enhance sodium iodide symporter activity with clinical implications for radioiodide therapy

  Brookes, K., Zha, L., Kim, J., Kocbiyik, M., Manivannan, S., Sunassee, K., Blower, P., Nieto, H., Smith, V., Read, M. & McCabe, C., 11 Jul 2023, In: Thyroid Research. 16, Supplement 1, p. 4-4 1 p., OR4.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • sodium-iodide symporter 100%
  • Chloroquine 74%
  • Cell Membrane 47%
  • N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide 45%
  • Biotinylation 36%

• Exploiting endocytic factors as druggable targets to enhance sodium iodide symporter activity with clinical implications for radioiodide therapy

  Brookes, K., Zha, L., Kim, J., Kocbiyik, M., Manivannan, S., Sunassee, K., Blower, P., Nieto, H., Smith, V., Read, M. & McCabe, C., 15 Sept 2023, In: Thyroid. 33, S1, p. A33-A34 2 p., Poster 273.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Endocytosis 66%
  • Chloroquine 61%
  • Cell Membrane 39%
  • N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide 37%

• Manipulating NIS endocytosis as a druggable target to enhance radioiodide uptake and prognostic indictor of thyroid cancer recurrence

  Read, M., Brookes, K., Zha, L., Manivannan, S., Kim, J., Firth, G., Sunassee, K., Blower, P., Boelaert, K., Nieto, H., Smith, V. & McCabe, C., 31 Oct 2023, In: Endocrine Abstracts. 94, 1 p., OC2.1.

  Research output: Contribution to journal › Abstract › peer-review

  • Chloroquine 100%
  • Thyroid Neoplasms 89%
  • Endocytosis 89%
  • Recurrence 50%
  • Biotinylation 35%

• Rational drug design of VCP inhibitors to enhance nis function in radioiodide therapy

  Read, M., Zha, L., Brookes, K., Kim, J., Small, B., Kocbiyik, M., Manivannan, S., Bottegoni, G., Cox, L., Kannappan, V., Wang, W., Sunassee, K., Blower, P., Nieto, H., Smith, V. & McCabe, C., 15 Sept 2023, In: Thyroid. 33, S1, p. A4-A4 1 p., Oral 8.

  Research output: Contribution to journal › Abstract › peer-review

  • Valosin Containing Protein 100%
  • Drug Design 69%
  • Clotrimazole 51%
  • Disulfiram 51%
  • Biological Availability 22%

• Rational drug design of VCP inhibitors to enhance NIS function in radioiodide therapy

  Zha, L., Brookes, K., Kim, J., Small, B., Kocbiyik, M., Manivannan, S., Nieto, H., Bottegoni, G., Cox, L., Kannappan, V., Wang, W., Sunassee, K., Blower, P., Smith, V., Read, M. & McCabe, C., 11 Jul 2023, In: Thyroid Research. 16, S1, p. 4-4 1 p., OR3.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • Valosin Containing Protein 100%
  • Ditiocarb 71%
  • Drug Design 69%
  • Clotrimazole 51%
  • Disulfiram 51%
• 2022

  Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy

  Read, M., Brookes, K., Zha, L., Thornton, C., Kim, J., Fletcher, A., Firth, G., Sunassee, K., Blower, P., Nieto, H., Smith, V. & McCabe, C., 11 Oct 2022, In: Thyroid. 32, S1, p. A92-A92 1 p., OC29.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Adaptor Protein Complex Subunits 92%
  • Thyroid Neoplasms 50%
  • Endocytosis 49%
  • Dipeptides 42%

• Enhancing radioiodide uptake by addressing the mechanism of sodium/iodide symporter (NIS) endocytosis

  Zha, L., Brookes, K., Thornton, C., Fletcher, A., Kim, J., Sunassee, K., Blower, P., Nieto, H., Smith, V., Read, M. & McCabe, C., 16 Nov 2022, In: Endocrine Abstracts. 86, 1 p., OC6.2.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Endocytosis 66%
  • Dipeptides 56%
  • Chloroquine 49%
  • Cell Membrane 47%

• Promotion of thyroid cancer cell migration and invasion by the proto-oncogene PBF is mediated by FGD1 and N-WASP

  Manivannan, S., Alshahrani, M., Thornton, C., Raja, S., Kocbiyik, M., Zha, L., Brookes, K., Nieto, H., Read, M., McCabe, C. & Smith, V., 11 Oct 2022, In: Thyroid. 32, S1, p. A91-A91 1 p., OC27.

  Research output: Contribution to journal › Abstract › peer-review

  • Wiskott-Aldrich Syndrome Protein 100%
  • Proto-Oncogenes 75%
  • Thyroid Neoplasms 65%
  • Cell Movement 52%
  • Monomeric GTP-Binding Proteins 25%

• Repurposing disulfiram as a therapeutic agent to enhance sodium iodide symporter activity in radioiodide therapy

  Read, M., Brookes, K., Zha, L., Moolla, M., Kocbiyik, M., Manivannan, S., Hoare, R., Kannappan, V., Wang, W., Sunassee, K., Blower, P., Nieto, H., Smith, V. & McCabe, C., 16 Nov 2022, In: Endocrine Abstracts. 86, 1 p., OC2.6.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Ditiocarb 96%
  • Disulfiram 92%
  • Coordination Complexes 22%
  • Therapeutics 10%

• Repurposing of disulfiram and diethyldithiocarbamate (DDC)-metal complexes to enhance sodium iodide symporter function in radioiodide therapy

  Brookes, K., Zha, L., Moolla, M., Kim, J., Kocbiyik, M., Manivannan, S., Nieto, H., Kannappan, V., Wang, W., Sunassee, K., Blower, P., Smith, V., Read, M. & McCabe, C., 11 Oct 2022, In: Thyroid. 32, S1, p. A96-A97 2 p., OC40.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Coordination Complexes 97%
  • Ditiocarb 96%
  • Disulfiram 92%
  • Thyroid Gland 19%
• 2021

  Abstract PO-006: Exploiting non-canonical pathways of NIS regulation to enhance radioiodide uptake and identify predictive markers of recurrence in thyroid cancer

  Read, M., Brookes, K., Thornton, C., Nieto, H., Fletcher, A., Borges de Souza, P., Alshahrani, M., Zha, L., Webster, J., Alderwick, L., Boelaert, K., Smith, V. & McCabe, C., 15 Apr 2021, In: Clinical Cancer Research. 27, 8 Supplement, 1 p., PO-006.

  Research output: Contribution to journal › Abstract › peer-review

  • Proteostasis 100%
  • Thyroid Neoplasms 77%
  • Iodides 64%
  • Recurrence 43%
  • Papillary Thyroid Cancer 43%

• An emerging role for proteostasis modulators targeting NIS activity to enhance radioiodide therapy in thyroid cancer

  Read, M., Brookes, K., Thornton, C., Nieto, H., Zha, L., Fletcher, A., Boelaert, K., Smith, V. & McCabe, C., 8 Nov 2021, In: Endocrine Abstracts. 77, 1 p., OC2.2.

  Research output: Contribution to journal › Abstract › peer-review

  • Proteostasis 100%
  • Thyroid Neoplasms 77%
  • CB-5083 72%
  • Disulfiram 61%
  • Papillary Thyroid Cancer 25%

• AP-2 and moesin regulate the internalisation of the sodium-iodide symporter and affect I¹²⁵ Uptake in thyroid cancer cells

  Thornton, C., Brookes, K., Fletcher, A., Nieto, H., Zha, L., Kocbiyik, M., Read, M., Smith, V. & McCabe, C., 8 Nov 2021, In: Endocrine Abstracts. 77, 1 p., OC6.4.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • moesin 97%
  • Thyroid Neoplasms 66%
  • Clathrin 40%
  • Endocytosis 33%

• Exploiting non-canonical pathways of NIS regulation to enhance radioiodide uptake and identify predictive markers of thyroid cancer recurrence

  Read, M., Brookes, K., Thornton, C., Nieto, H., Fletcher, A., Zha, L., Alderwick, L., Boelaert, K., Smith, V. & McCabe, C., May 2021, In: Nuclear Medicine Communications. 42, 5

  Research output: Contribution to journal › Abstract › peer-review

  • Thyroid Neoplasms 100%
  • Proteostasis 64%
  • Iodides 62%
  • Recurrence 56%
  • Pharmaceutical Preparations 40%

• PBF phosphorylation regulates cell motility of thyroid and breast cancer cells

  Kocbiyik, M., Alshahrani, M., Poole, V., Jeyanathan, S., Thornton, C., Zha, L., Brookes, K., Nieto, H., Read, M., McCabe, C. & Smith, V., 8 Nov 2021, In: Endocrine Abstracts. 77, 1 p., OC2.4.

  Research output: Contribution to journal › Abstract › peer-review

  • Thyroid Neoplasms 100%
  • Cell Movement 80%
  • Phosphorylation 68%
  • Breast Neoplasms 63%
  • Endocytosis 49%

• Targeting non-canonical pathways as a strategy to modulate radioiodide uptake in thyroid cancer

  Read, M., Brookes, K., Thornton, C., Nieto, H., Fletcher, A., Zha, L., Alderwick, L., Boelaert, K., Smith, V. & McCabe, C., Jun 2021.

  Research output: Contribution to conference (unpublished) › Abstract › peer-review

  • Proteostasis 100%
  • Thyroid Neoplasms 77%
  • Thyroid Epithelial Cells 50%
  • Iodides 48%
  • Papillary Thyroid Cancer 43%
• 2020

  Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer

  Read, M., Brookes, K., Fletcher, A., Thornton, C., Alshahrani, M., Khan, R., Nieto, H., Adcock, H., Webster, J., Cox, L., Alderwick, L., Boelaert, K., Smith, V. & McCabe, C., 8 May 2020, In: Journal of the Endocrine Society. 4, Issue Supplement 1, 1 p., OR28-03.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  File

  • Drug Repositioning 100%
  • Proteostasis 95%
  • Thyroid Neoplasms 73%
  • Iodides 61%
  • Vorinostat 51%
  210 Downloads (Pure)

• Drug repurposing identifies inhibitors of the proteostasis network to augment radioiodine uptake in combinatorial approaches targeting thyroid cancer

  Read, M., Brookes, K., Fletcher, A., Thornton, C., Alshahrani, M., Khan, R., Nieto, H., Adcock, H., Webster, J., Cox, L., Alderwick, L., Boelaert, K., Smith, V. & McCabe, C., Sept 2020, In: Endocrine Abstracts. 70, 1 p., OC5.4.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • Drug Repositioning 100%
  • Proteostasis 95%
  • Thyroid Neoplasms 73%
  • Iodides 61%
  • Vorinostat 51%
• 2019

  A high-throughput yellow fluorescent protein (YFP) cell-based screen identifies autophagy modulators to increase the effectiveness of radioiodine therapy

  Read, M., Brookes, K., Fletcher, A., Thornton, C., Alshahrani, M., Nieto, H., Khan, R., Webster, J., Haggie, P., Verkman, A., Alderwick, L., Boelaert, K., Smith, V. & McCabe, C., 13 Nov 2019, In: Endocrine Abstracts. 65, 1 p., OC4.1.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • Iodides 100%
  • Autophagy 86%
  • Pharmaceutical Preparations 37%
  • Thyroid Neoplasms 34%
  • Proteins 33%

• Driver events in thyroid cancer recurrence

  Nieto, H., Thornton, C., Fletcher, A., Antao Nobre De Menezes, A. M., Brookes, K., Alshahrani, M., Read, M., Boelaert, K., Smith, V., Cazier, J-B., Mehanna, H. & McCabe, C., 13 Nov 2019, In: Endocrine Abstracts. 65, OC4.6.

  Research output: Contribution to journal › Abstract › peer-review

  • Thyroid Neoplasms 100%
  • Cell Movement 64%
  • IMP Dehydrogenase 63%
  • Recurrence 56%
  • Mutation 55%

• Investigating the mechanism behind sodium-iodide symporter trafficking by the small GTPase ARF4

  Thornton, C., Fletcher, A., Nieto, H., Brookes, K., Alshahrani, M., Read, M., Boelaert, K., Stewart, G., Smith, V. & McCabe, C., 13 Nov 2019, In: Endocrine Abstracts. 65, P393.

  Research output: Contribution to journal › Abstract › peer-review

  • ADP-Ribosylation Factors 100%
  • sodium-iodide symporter 99%
  • Monomeric GTP-Binding Proteins 76%
  • Cell Membrane 11%
  • Thyroid Gland 9%

• Novel driver events in thyroid cancer recurrence

  Nieto, H., Thornton, C., Fletcher, A., Antao Nobre De Menezes, A. M., Brookes, K., Alshahrani, M., Read, M., Boelaert, K., Smith, V., Cazier, J-B., Mehanna, H. & McCabe, C., 19 Nov 2019, In: Thyroid Research. 12(Suppl 1), 11, p. 3 1 p., O5.

  Research output: Contribution to journal › Abstract › peer-review

  • Thyroid Neoplasms 100%
  • Inosine Monophosphate 65%
  • Recurrence 56%
  • Proto-Oncogene Proteins 43%
  • Platypus 43%

• Novel driver mutations in thyroid cancer recurrence

  Nieto, H., Thornton, C., Fletcher, A., Antao Nobre De Menezes, A. M., Brookes, K., Alshahrani, M., Read, M., Boelaert, K., Smith, V., Cazier, J-B., Mehanna, H. & McCabe, C., 21 May 2019, In: Endocrine Abstracts. 63, OC9.3.

  Research output: Contribution to journal › Abstract › peer-review

  • Thyroid Neoplasms 100%
  • IMP Dehydrogenase 79%
  • Recurrence 56%
  • Mutation 55%
  • Atlases 35%

• p97/VCP: A novel interactor of the sodium iodide symporter, which can be pharmacologically targeted to increase radioiodine uptake in thyroid and breast cancer cells

  Fletcher, A., Read, M., Poole, V., Smith, V. & McCabe, C., 1 Jul 2019, In: Cancer Research. 79, 13_Suppl, 1 p., 920.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Thyroid Neoplasms 66%
  • Papillary Thyroid Cancer 64%
  • Breast Neoplasms 42%
  • Disease-Free Survival 26%

• The proto-oncogene PBF mediates Src modulation of radioiodine uptake

  Alshahrani, M., Fletcher, A., Thornton, C., Brookes, K., Nieto, H., Thompson, R., Raja, S., Read, M., Boelaert, K., McCabe, C. & Smith, V., 13 Nov 2019, In: Endocrine Abstracts. 65, OP2.4.

  Research output: Contribution to journal › Abstract › peer-review

  • Proto-Oncogenes 100%
  • Thyroid Neoplasms 86%
  • Breast Neoplasms 54%
  • glycylpeptide N-tetradecanoyltransferase 37%
  • sodium-iodide symporter 32%

• VCP: A novel interactor of the sodium iodide symporter, which can be pharmacologically targeted to increase radioiodine uptake in human and mouse thyrocytes

  Fletcher, A., Read, M., Thornton, C., Poole, V., Boelaert, K., Smith, V. & McCabe, C., 19 Nov 2019, In: Thyroid Research. 12(Suppl 1), 11, p. 3 1 p., O4.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Thyroid Epithelial Cells 87%
  • Papillary Thyroid Cancer 60%
  • Clotrimazole 18%
  • Breast Neoplasms 16%
• 2018

  Abstract LB-327: Identification of novel sodium iodide symporter (NIS) interactors which modulate iodide uptake

  Fletcher, A., Thompson, R., Read, M., Turnell, A., Smith, V. & McCabe, C., 1 Jul 2018, In: Cancer Research. 78, 13 Supplement, p. LB327-LB327 1 p.

  Research output: Contribution to journal › Abstract › peer-review

• Identification of novel sodium iodide symporter (NIS) interactors which modulate radioiodine uptake

  Fletcher, A., Poole, V., Thornton, C., Brookes, K., Thompson, R., Nieto, H., Alshahrani, M., Read, M., Turnell, A., Boelaert, K., Smith, V. & McCabe, C., 21 Nov 2018, In: Endocrine Abstracts. 59, P224.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • ADP-Ribosylation Factors 53%
  • Valosin Containing Protein 50%
  • Thyroid Neoplasms 15%
  • NMS-873 8%

• Oncogenic action of pituitary-tumor transforming gene (PBF) in head and neck cancer is associated with poorer overall survival

  Read, M., Modasia, B., Fletcher, A., Thompson, R., Brookes, K., Nieto, H., Campbell, M., Boelaert, K., Turnell, A., Smith, V., Mehanna, H. & McCabe, C., 1 Nov 2018, In: Endocrine Abstracts. 59, 1 p., P119.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • Endocrine Gland Neoplasms 100%
  • p53 Genes 70%
  • Pituitary Neoplasms 68%
  • Thyroid Neoplasms 64%
  • Head and Neck Neoplasms 63%

• PO-124 PTTG and PBF functionally interact with P53 and predict overall survival in head and neck cancer

  Read, M., Modasia, B., Fletcher, A., Thompson, R., Baker, K., Boelaert, K., Turnell, A., Smith, V., Mehanna, H. & McCabe, C., 1 Jul 2018, In: ESMO Open. 3, Suppl. 2, p. A69-A69 1 p.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  • Pituitary Neoplasms 100%
  • Head and Neck Neoplasms 92%
  • Oncogenes 87%
  • Squamous Cell Carcinoma of Head and Neck 75%
  • Survival 50%

• Using lightsheet microscopy to explore the relationship between NIS and its functional interactors ARF4, VCP and PBF

  Thornton, C., Fletcher, A., Brookes, K., Alshahrani, M., Read, M., Boelaert, K., Smith, V. & McCabe, C., 21 Nov 2018, In: Endocrine Abstracts. 59, P225.

  Research output: Contribution to journal › Abstract › peer-review

  • Iodides 100%
  • sodium-iodide symporter 79%
  • Microscopy 65%
  • Cell Membrane 57%
  • Thyroid Neoplasms 53%

• Yellow fluorescent protein (YFP) as a biosensor for intracellular iodide in thyroid cancer cells

  Read, M., Baker, K., Thornton, C., Alshahrani, M., Fletcher, A., Thompson, R., Haggie, P., Verkman, A., Boelaert, K., Smith, V. & McCabe, C., 15 May 2018.

  Research output: Contribution to conference (unpublished) › Abstract › peer-review

  • Iodides 100%
  • Biosensing Techniques 95%
  • Thyroid Neoplasms 79%
  • Proteins 28%
  • Thyroid Gland 18%
• 2017

  An investigation into sodium-iodide symporter (NIS) dimerisation and its impact on radioiodide uptake in thyroid cancer

  Thompson, R., Fletcher, A., Nieto, H., Alshahrani, M., Brookes, K., Mueller, J. W., Fine, N., Hodson, D., Read, M., Boelaert, K., Smith, V. & McCabe, C., 19 Sept 2017, In: Thyroid Research. 10(Suppl 2), 5, p. 5 1 p., P2.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Dimerization 74%
  • Thyroid Neoplasms 66%
  • Ligation 21%
  • Leucine Zippers 10%

• An investigation into sodium-iodide symporter (NIS) dimerization and its impact on radioiodide uptake in thyroid cancer

  Thompson, R., Fletcher, A., Nieto, H., Alshahrani, M., Brookes, K., Mueller, J. W., Fine, N., Hodson, D., Read, M., Boelaert, K., Smith, V. & McCabe, C., 2017, In: Endocrine Abstracts. 50, OC1.4.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Dimerization 74%
  • Thyroid Neoplasms 66%
  • Glycine 13%
  • HeLa Cells 13%

• A novel ESR2 frameshift mutation predisposes to medullary thyroid carcinoma and causes inappropriate RET expression

  Read, M., Smith, J., Hoffman, J., Smith, V., Morgan, N., Campbell, C., Wake, N., Watkinson, J., Wallis, Y., Maher, E., McCabe, C. & Woodward, E., 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2, p. 5 1 p., P4.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  File

  • Medullary Thyroid cancer 100%
  • Frameshift Mutation 97%
  • Multiple Endocrine Neoplasia Type 2a 37%
  • Germ-Line Mutation 29%
  • P-30 composite resin 20%
  237 Downloads (Pure)

• Comparative analysis of human and mouse expression data identifies proto-oncogene PTTG- and PBF-associated genes in thyroid cancer

  Read, M., Fong, J., Imruetaicharoenchoke, W., Modasia, B., Nieto, H., Fletcher, A., Thompson, R., Sharma, N., Watkinson, J., Turnell, A., Boelaert, K., Smith, V. & McCabe, C., 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2, p. 2 1 p., O3.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  File

  • Proto-Oncogenes 100%
  • Thyroid Neoplasms 86%
  • Thyroid Epithelial Cells 75%
  • DNA Repair 52%
  • DNA Damage 49%
  97 Downloads (Pure)

• Identification of novel sodium iodide symporter (NIS) interactors which modulate iodide uptake

  Fletcher, A., Poole, V., Modasia, B., Imruetaicharoenchoke, W., Thompson, R., Sharma, N., Nieto, H., Read, M., Turnell, A., Boelaert, K., Smith, V. & McCabe, C., 19 Sept 2017, In: Thyroid Research. 10(Suppl 2), 5, p. 4 1 p., O6.

  Research output: Contribution to journal › Abstract › peer-review

  • sodium-iodide symporter 100%
  • Iodides 83%
  • ADP-Ribosylation Factors 41%
  • Valosin Containing Protein 36%
  • Thyroid Gland 13%

• Identification of novel sodium iodide symporter interactors which modulate iodide uptake

  Fletcher, A., Poole, V., Modasia, B., Imruetaicharoenchoke, W., Thompson, R., Sharma, N., Nieto, H., Brookes, K., Alshahrani, M., Read, M., Turnell, A., Boelaert, K., Smith, V. & McCabe, C., 8 Nov 2017, In: Endocrine Abstracts. 50, OC3.6.

  Research output: Contribution to journal › Abstract › peer-review

  • Valosin Containing Protein 100%
  • sodium-iodide symporter 92%
  • Iodides 77%
  • ADP-Ribosylation Factors 62%
  • Thyroid Neoplasms 30%

• Novel driver mutations in thyroid cancer recurrence

  Nieto, H., Fletcher, A., Thompson, R., Brookes, K., Alshahrani, M., Antao Nobre De Menezes, A. M., Read, M., Boelaert, K., Smith, V., Cazier, J-B., Mehanna, H. & McCabe, C., 2017, In: Endocrine Abstracts. 50, P383.

  Research output: Contribution to journal › Abstract › peer-review

  • Thyroid Neoplasms 100%
  • IMP Dehydrogenase 70%
  • Recurrence 56%
  • Mutation 55%
  • Neoplasms 31%

• Pharmacological enhancement of radioiodine uptake using Src kinase inhibitors

  Poole, V., Fletcher, A., Modasia, B., Sharma, N., Thompson, R., Imruetaicharoenchoke, W., Read, M., Boelaert, K., McCabe, C. & Smith, V., 13 Feb 2017, In: Thyroid Research. 10(Suppl 1), 2, p. 2 1 p., O2.

  Research output: Contribution to journal › Abstract › peer-review

  Open Access

  File

  • src-Family Kinases 100%
  • Dasatinib 87%
  • Cell Membrane 61%
  • Pharmacology 56%
  • Phosphorylation 43%
  92 Downloads (Pure)
• 2016

  A novel ESR2 frameshift mutation predisposes to medullary thyroid carcinoma and causes inappropriate RET expression

  Read, M., Smith, J., Smith, V., Morgan, N., Wake, N., Watkinson, J., Wallis, Y., Maher, E., McCabe, C. & Woodward, E., 1 Jul 2016, In: European Journal of Cancer. 61, Suppl 1, p. S20 1 p., 141.

  Research output: Contribution to journal › Abstract › peer-review

  • Medullary Thyroid cancer 100%
  • Frameshift Mutation 97%
  • Hyperplasia 31%
  • Germ-Line Mutation 29%
  • Multiple Endocrine Neoplasia Type 2a 25%
  11 Citations (Scopus)

• Comparative analysis of human and mouse expression data identifies distinct proto-oncogene PBF- and PTTG-associated genes in thyroid cancer

  Read, M., Fong, J., Imruetaicharoenchoke, W., Modasia, B., Nieto, H., Watkinson, J., Boelaert, K., Smith, V., Turnell, A. & McCabe, C., 1 Jul 2016, In: European Journal of Cancer. 61, Suppl 1, p. S36 1 p., 202.

  Research output: Contribution to journal › Abstract › peer-review

  • Proto-Oncogenes 100%
  • Thyroid Neoplasms 86%
  • Thyroid Epithelial Cells 70%
  • DNA Damage 55%
  • DNA Repair 49%
  11 Citations (Scopus)

• Comparative analysis of human and mouse expression data identifies proto-oncogene PTTG- and PBF-associated genes in thyroid cancer

  Read, M., Fong, J., Imruetaicharoenchoke, W., Modasia, B., Nieto, H., Fletcher, A., Thompson, R., Sharma, N., Watkinson, J., Turnell, A., Boelaert, K., Smith, V. & McCabe, C., 13 May 2016.

  Research output: Contribution to conference (unpublished) › Abstract › peer-review

  • Proto-Oncogenes 100%
  • Thyroid Neoplasms 86%
  • Thyroid Epithelial Cells 75%
  • DNA Repair 52%
  • DNA Damage 49%

• High tumoral expression of PBF and PTTG modulates the DNA damage response and is associated with poor survival in thyroid cancer

  Read, M., Fong, J., Imruetaicharoenchoke, W., Nieto, H., Modasia, B., Fletcher, A., Thompson, R., Sharma, N., Bacon, A., Watkinson, J., Boelaert, K., Turnell, A., Smith, V. & McCabe, C., 4 Nov 2016, In: Endocrine Abstracts. 44, P246.

  Research output: Contribution to journal › Abstract › peer-review

  • Thyroid Neoplasms 100%
  • Thyroid Epithelial Cells 87%
  • DNA Damage 86%
  • DNA Repair 60%
  • Survival 54%