Martin Higgs

2024

Genome-scale CRISPR screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in DLBCL

Davies, N., Francis, T., Oldreive, C., Azam, M., Wilson, J., Byrd, P. J., Burley, M., Sharma-Oates, A., Keane, P., Alatawi, S., Higgs, M. R., Rudzki, Z., Ibrahim, M., Perry, T., Agathaggelou, A., Hewitt, A.-M., Smith, E., Bonifer, C., O’Connor, M. & Forment, J. V. & 8 others, Murray, P. G., Fennell, E., Kelly, G., Chang, C., Stewart, G. S., Stankovic, T., Kwok, M. & Taylor, A. M., 6 Jun 2024, (E-pub ahead of print) In: Haematologica.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder

Snijders Blok, L., Verseput, J., Rots, D., Venselaar, H., Innes, A. M., Stumpel, C., Õunap, K., Reinson, K., Seaby, E. G., McKee, S., Burton, B., Kim, K., van Hagen, J. M., Waisfisz, Q., Joset, P., Steindl, K., Rauch, A., Li, D., Zackai, E. H. & Sheppard, S. E. & 29 others, Keena, B., Hakonarson, H., Roos, A., Kohlschmidt, N., Cereda, A., Iascone, M., Rebessi, E., Kernohan, K. D., Campeau, P. M., Millan, F., Taylor, J. A., Lochmüller, H., Higgs, M. R., Goula, A., Bernhard, B., Velasco, D. J., Schmanski, A. A., Stark, Z., Gallacher, L., Pais, L., Marcogliese, P. C., Yamamoto, S., Raun, N., Jakub, T. E., Kramer, J. M., den Hoed, J., Fisher, S. E., Brunner, H. G. & Kleefstra, T., 12 Jan 2023, In: HGG advances. 4, 1, 9 p., 100157.

Research output: Contribution to journal › Article › peer-review

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55 Downloads (Pure)

Author Correction: C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption

Sharma, A. B., Ramlee, M. K., Kosmin, J., Higgs, M. R., Wolstenholme, A., Ronson, G. E., Jones, D., Ebner, D., Shamkhi, N., Sims, D., Wijnhoven, P. W. G., Forment, J. V., Gibbs-Seymour, I. & Lakin, N. D., 27 Nov 2023, In: Nature Communications. 14, 1, 1 p., 7784.

Research output: Contribution to journal › Comment/debate › peer-review

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C16orf72/HAPSTR1/TAPR1 functions with BRCA1/Senataxin to modulate replication-associated R-loops and confer resistance to PARP disruption

Sharma, A. B., Ramlee, M. K., Kosmin, J., Higgs, M. R., Wolstenholme, A., Ronson, G. E., Jones, D., Ebner, D., Shamkhi, N., Sims, D., Wijnhoven, P. W. G., Forment, J., Gibbs-Seymour, I. & Lakin, N. D., 17 Aug 2023, (E-pub ahead of print) In: Nature Communications. 14, 1, 5003.

Research output: Contribution to journal › Article › peer-review

Open Access

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96 Downloads (Pure)

Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans

Fletcher, S. C., Hall, C., Kennedy, T. J., Pajusalu, S., Wojcik, M. H., Boora, U., Li, C., Oja, K. T., Hendrix, E., Westrip, C. A., Andrijes, R., Piasecka, S. K., Singh, M., El-Asrag, M. E., Ptasinska, A., Tillmann, V., Higgs, M. R., Carere, D. A., Beggs, A. D. & Pappas, J. & 5 others, Rabin, R., Smerdon, S. J., Stewart, G. S., Õunap, K. & Coleman, M. L., 3 Apr 2023, In: Journal of Clinical Investigation. 133, 7, e152784.

Research output: Contribution to journal › Article › peer-review

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Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency

Mahony, C. B., Copper, L., Vrljicak, P., Noyvert, B., Constantinidou, C., Browne, S., Pan, Y., Palles, C., Ott, S., Higgs, M. R. & Monteiro, R., 27 Jun 2023, In: Cell Reports. 42, 6, 20 p., 112571.

Research output: Contribution to journal › Article › peer-review

Open Access

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55 Downloads (Pure)

New perspectives on epigenetic modifications and PARP inhibitor resistance in HR-deficient cancers

Bayley, R., Sweatman, E. & Higgs, M., 4 Jan 2023, In: Cancer drug resistance (Alhambra, Calif.). 6, p. 35-44 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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60 Downloads (Pure)

2022

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

Bayley, R., Borel, V., Moss, R., Sweatman, E., Ruis, P., Ormrod, A., Goula, A., Mottram, R., Stanage, T., Hewitt, G., Saponaro, M., Stewart, G., Boulton, S. & Higgs, M., 19 May 2022, In: Molecular Cell. 82, 10, p. 1924-1939.e10 26 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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5 Citations (Scopus)

95 Downloads (Pure)

Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy

Grange, L. J., Reynolds, J. J., Ullah, F., Isidor, B., Shearer, R. F., Latypova, X., Baxley, R. M., Oliver, A. W., Ganesh, A., Cooke, S. L., Jhujh, S. S., McNee, G. S., Hollingworth, R., Higgs, M. R., Natsume, T., Khan, T., Martos-Moreno, G. Á., Chupp, S., Mathew, C. G. & Parry, D. & 28 others, Simpson, M. A., Nahavandi, N., Yüksel, Z., Drasdo, M., Kron, A., Vogt, P., Jonasson, A., Seth, S. A., Gonzaga-Jauregui, C., Brigatti, K. W., Stegmann, A. P. A., Kanemaki, M., Josifova, D., Uchiyama, Y., Oh, Y., Morimoto, A., Osaka, H., Ammous, Z., Argente, J., Matsumoto, N., Stumpel, C. T. R. M., Taylor, A. M. R., Jackson, A. P., Bielinsky, A.-K., Mailand, N., Le Caignec, C., Davis, E. E. & Stewart, G. S., 4 Nov 2022, In: Nature Communications. 13, 1, 6664.

Research output: Contribution to journal › Article › peer-review

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54 Downloads (Pure)

2021

Gata2a maintains cebpa and npm1a in haematopoietic stem cells to sustain lineage differentiation and genome stability

Mahony, C. B., Noyvert, B., Vrljicak, P., Ott, S., Higgs, M. & Monteiro, R., 19 Jul 2021, bioRxiv.

Research output: Working paper/Preprint › Preprint

Open Access

Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M

Wang, J., Rojas, P., Mao, J., Muste Sadurni, M., Garnier, O., Xiao, S., Higgs, M., Garcia, P. & Saponaro, M., 16 Feb 2021, In: Cell Reports. 34, 7, 108759.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

301 Downloads (Pure)

2020

Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome

Kummerling, J., Stremmelaar, D. E., Raun, N., Reijnders, M. R. F., Willemsen, M. H., Ruiterkamp-Versteeg, M., Schepens, M., Man, C. C. O., Gilissen, C., Cho, M. T., McWalter, K., Sinnema, M., Wheless, J. W., Simon, M. E. H., Genetti, C. A., Casey, A. M., Terhal, P. A., van der Smagt, J. J., van Gassen, K. L. I. & Joset, P. & 23 others, Bahr, A., Steindl, K., Rauch, A., Keller, E., Raas-Rothschild, A., Koolen, D. A., Agrawal, P. B., Hoffman, T. L., Powell-Hamilton, N. N., Thiffault, I., Engleman, K., Zhou, D., Bodamer, O., Hoefele, J., Riedhammer, K. M., Schwaibold, E. M. C., Tasic, V., Schubert, D., Top, D., Pfundt, R., Higgs, M., Kramer, J. M. & Kleefstra, T., 28 Apr 2020, In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

279 Downloads (Pure)

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

The COMPLEXO Network, 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4069-4080 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

260 Downloads (Pure)

2019

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis

Wing, P., Davenne, T., Wettengel, J., Lai, A. G., Zhuang, X., Chakraborty, A., d'Arienzo, V., Kramer, C., Ko, C., Harris, J., Schreiner, S., Higgs, M., Roessler, S., Parish, J., Protzer, U., Balfe, P., Rehwinkel, J. & McKeating, J. A., 27 Mar 2019, In: Life Science Alliance. 2, 2

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

240 Downloads (Pure)

Biallelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes

Burrage, L., Reynolds, J., Baratang, N., Phillips, J., Wegner, J., McFarquhar, A., Higgs, M., Christiansen, A., Lanza, D., Seavitt, J., Jain, M., Li, X., Parry, D., Raman, V., Chitayat, D., Chinn, I., Bertuch, A., Karaviti, L., Schlesinger, A. & Earl, D. & 38 others, Bamshad, M., Savarirayan, R., Doddapaneni, H., Muzny, D., Jhangiani, S., Eng, C., Gibbs, R., Bi, W., Emrick, L., Rosenfeld, J., Postlethwait, J., Westerfield, M., Dickinson, M., Beaudet, A., Ranza, E., Huber, C., Cormier-Daire, V., Shen, W., Mao, R., Heaney, J., Orange, J., Bertola, D., Yamamoto, G., Baratela, W., Butler, M., Ali, A., Adeli, M., Cohn, D., Krakow, D., Jackson, A., Lees, M., Offiah, A., Carlston, C., Carey, J., Stewart, G., Bacino, C., Campeau, P. & Lee, B., 7 Mar 2019, In: American Journal of Human Genetics. 104, 3, p. 422-438 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

249 Downloads (Pure)

Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia

Chang, H. R., Cho, S. Y., Lee, J. H., Lee, E., Soo, J., Lee, H. R., Cavalcanti, D. P., Mäkitie, O., Valta, H., Girisha, K. M., Lee, C., Neethukrishna, K., Bhavani, G. S., Shukla, A., Nampoothiri, S., Phadke, S. R., Park, M. J., Ikegawa, S., Wang, Z. & Higgs, M. & 15 others, Stewart, G., Jung, E., Lee, M.-S., Park, J. H., Lee, E. A., Kim, H., Myung, K., Jeon, W., Lee, K., Kim, D., Kim, O.-H., Choi, M., Lee, H.-W., Kim, Y. & Cho, T.-J., 7 Mar 2019, In: American Journal of Human Genetics. 104, 3, p. 439-453

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

211 Downloads (Pure)

2018

Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2

Higgs, M., Sato, K., Reynolds, J., Begum, S., Bayley, R., Goula, A., Vernet, A., Paquin, K., Skalnik, D., Kobayashi, W., Takata, M., Howlett, N., Kurumizaka, H., Kimura, H. & Stewart, G., 5 Jul 2018, In: Molecular Cell. 71, 1, p. 25-41.e6 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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37 Citations (Scopus)

280 Downloads (Pure)

MYBL2 supports DNA double strand break repair in haematopoietic stem cells

Bayley, R., Blakemore, D., Cancian, L., Dumon, S., Volpe, G., Ward, C., Al Maghrabi, R., Gujar, J., Reeve, N., Raghavan, M., Higgs, M., Stewart, G., Petermann, E. & Garcia, P., 15 Oct 2018, In: Cancer Research. 78, 20, p. 5767-5779 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

226 Downloads (Pure)

On your marks, get SET(D1A): the race to protect stalled replication forks

Begum, S., Goula, A., Bayley, R. & Higgs, M., 2018, In: Molecular and Cellular Oncology. 5, 6, e1511209.

Research output: Contribution to journal › Comment/debate › peer-review

Open Access

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2 Citations (Scopus)

216 Downloads (Pure)

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

Ronson, G., Piberger, A. L., Higgs, M., Olsen, A., Stewart, G., McHugh, P., Petermann, E. & Lakin, N., Dec 2018, In: Nature Communications. 9, 1, 12 p., 746.

Research output: Contribution to journal › Article › peer-review

Open Access

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65 Citations (Scopus)

317 Downloads (Pure)

2017

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein

Marsh, E., Delury, C., Davies, N., Weston, C., Miah, M. A. L., Banks, L., Parish, J., Higgs, M. & Roberts, S., 3 Jan 2017, In: OncoTarget. 8, p. 19491-19506 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

378 Downloads (Pure)

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

Reynolds, J., Higgs, M., Zlatanou, A., Vernet, A., Mottram, R., Brean, A., Taylor, M., Alkuraya, F. S., Mathew, C. G., Jackson, A. P. & Stewart, G., Apr 2017, In: Nature Genetics. 49, p. 537–549

Research output: Contribution to journal › Article › peer-review

Open Access

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44 Citations (Scopus)

565 Downloads (Pure)

2016

Protection or resection: BOD1L as a novel replication fork protection factor

Higgs, M. & Stewart, G., 18 Feb 2016, (E-pub ahead of print) In: Nucleus (Austin).

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

252 Downloads (Pure)

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

Harley, M. E., Murina, O., Leitch, A., Higgs, M., Bicknell, L. S., Yigit, G., Blackford, A. N., Zlatanou, A., Mackenzie, K. J., Reddy, K., Halachev, M., McGlasson, S., Reijns, M. A. M., Fluteau, A., Martin, C.-A., Sabbioneda, S., Elcioglu, N. H., Altmüller, J., Thiele, H. & Greenhalgh, L. & 10 others, Chessa, L., Maghnie, M., Salim, M., Bober, M. B., Nürnberg, P., Jackson, S. P., Hurles, M. E., Wollnik, B., Stewart, G. & Jackson, A., Jan 2016, In: Nature Genetics. 48, 1, p. 36-43 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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49 Citations (Scopus)

681 Downloads (Pure)

2015

Bod1l is required to suppress deleterious resection of stressed replication forks

Higgs, M., Reynolds, J., Winczura, A., Blackford, A., Borel, V., Miller, E., Zlatanou, A., Nieminuszczy, J., Ryan, E., Davies, N., Stankovic, T., Boulton, S., Niedzwiedz, W. & Stewart, G., 6 Aug 2015, In: Molecular Cell. 59, 3, p. 462-477

Research output: Contribution to journal › Article › peer-review

File

88 Citations (Scopus)

336 Downloads (Pure)

Cancer Therapy and Replication Stress: Forks on the Road to Perdition

Kotsantis, P., Jones, R., Higgs, M. & Petermann, E., 24 Apr 2015, Advances in Clinical Chemistry. Makowski, G. S. (ed.). Academic Press (Elsevier), Vol. 69. p. 91-138

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

19 Citations (Scopus)

2014

'Liver let die': oxidative DNA damage and hepatotropic viruses

Higgs, M., Chouteau, P. & Lerat, H., May 2014, In: Journal of General Virology. 95, 5, p. 991-1004

Research output: Contribution to journal › Article › peer-review

File

50 Citations (Scopus)

617 Downloads (Pure)

2013

Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes

Maqbool, M. A., Imache, M. R., Higgs, M. R., Carmouse, S., Pawlotsky, J.-M. & Lerat, H., May 2013, In: Journal of virology. 87, 10, p. 5523-39 17 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

2012

A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses

Polyak, S. J., Morishima, C., Scott, J. D., Gastaminza, P., Cox, A., de Araújo, E. S. A., Higgs, M. R., Loo, Y.-M., Golden-Mason, L., Lindenbach, B. D., Baumert, T. F., Randall, G. & Gale, M., Jan 2012, In: Gastroenterology. 142, 1, p. e1-5

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Hepatitis C virus (HCV) protein expression enhances hepatic fibrosis in HCV transgenic mice exposed to a fibrogenic agent

Chouteau, P., Defer, N., Florimond, A., Caldéraro, J., Higgs, M., Gaudin, A., Mérour, E., Dhumeaux, D., Lerat, H. & Pawlotsky, J.-M., Sept 2012, In: International journal of hepatology. 57, 3, p. 499-507 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events

Higgs, M. R., Lerat, H. & Pawlotsky, J.-M., 29 Oct 2012, In: Oncogene.

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

2011

Animal models in the study of hepatitis C virus-associated liver pathologies

Lerat, H., Higgs, M. & Pawlotsky, J.-M., Jun 2011, In: Expert review of gastroenterology & hepatology. 5, 3, p. 341-52 12 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Genetic background of hepatocyte cell lines: are in vitro hepatitis C virus research data reliable?

Bensadoun, P., Rodriguez, C., Soulier, A., Higgs, M., Chevaliez, S. & Pawlotsky, J.-M., Aug 2011, In: Hepatology. 54, 2, p. 748

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

2010

Downregulation of Gadd45beta expression by hepatitis C virus leads to defective cell cycle arrest

Higgs, M. R., Lerat, H. & Pawlotsky, J.-M., 15 Jun 2010, In: Cancer Research. 70, 12, p. 4901-11 11 p.

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

2009

Hepatitis C virus proteins induce lipogenesis and defective triglyceride secretion in transgenic mice

Lerat, H., Kammoun, H. L., Hainault, I., Mérour, E., Higgs, M. R., Callens, C., Lemon, S. M., Foufelle, F. & Pawlotsky, J.-M., 27 Nov 2009, In: Journal of Biological Chemistry. 284, 48, p. 33466-74 9 p.

Research output: Contribution to journal › Article › peer-review

72 Citations (Scopus)

Mutational analysis of the herpes simplex virus type 1 DNA packaging protein UL33

Beilstein, F., Higgs, M. R. & Stow, N. D., Sept 2009, In: Journal of virology. 83, 17, p. 8938-45 8 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

2008

The UL15 protein of herpes simplex virus type 1 is necessary for the localization of the UL28 and UL33 proteins to viral DNA replication centres

Higgs, M. R., Preston, V. G. & Stow, N. D., Jul 2008, In: Journal of General Virology. 89, Pt 7, p. 1709-15 7 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Martin Higgs

Research output

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