Martin Hewison

2024

Associations between total, free and bioavailable 25-hydroxyvitamin D forms with adiponectin and irisin in maternal-neonatal pairs at birth from Greece

Arabi, T. Z., Fakhoury, H. M. A., Tamim, H., Chun, R. F., Hewison, M., AlAnouti, F., Pilz, S., Annweiler, C., Tzimagiorgis, G., Haitoglou, C. & Karras, S. N., 5 Jul 2024, In: Frontiers in Endocrinology. 15, 7 p., 1397869.

Research output: Contribution to journal › Article › peer-review

Open Access

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43 Downloads (Pure)

Inflammation Dynamically Regulates Steroid Hormone Metabolism and Action within Macrophages in Rheumatoid Arthritis  

Martin, C. S., Crastin, A., Sagmeister, M. S., Kalirai, M. S., Turner, J. D., MacDonald, L., Kurowska-Stolarska, M., Scheel-Toellner, D., Taylor, A. E., Gilligan, L. C., Storbeck, K., Price, M., Gorvin, C. M., Filer, A., Mahida, R., Clark, A. R., Jones, S. W., Raza, K., Hewison, M. & Hardy, R. S., Jul 2024, In: Journal of Autoimmunity. 147, 13 p., 103263.

Research output: Contribution to journal › Article › peer-review

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61 Downloads (Pure)

Role of vitamin D supplementation in modifying outcomes after surgery: a systematic review of randomised controlled trials

Patel, A., Caruana, E. J., Hodson, J., Morrison, R., Khor, B., Gysling, S., Trevis, J., Mangel, T., Benson, R., Zakeri, R., Manders, J., Vaja, R., Rogers, L., Baker, P., Pournaras, D. J., Thickett, D., Hewison, M., Naidu, B. & Lim, E., 17 Jan 2024, In: BMJ open. 14, 1, 8 p., e073431.

Research output: Contribution to journal › Article › peer-review

Open Access

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49 Downloads (Pure)

The Effect of an Acute Bout of Exercise on Circulating Vitamin D Metabolite Concentrations: A Randomised Crossover Study in Healthy Adults

Davies, S., Perkin, O., Betts, J., Gonzalez, J., Hewison, M., Jenkinson, C., Jones, K., Meadows, S., Parkington, D., Koulman, A. & Thompson, D., 4 Aug 2024, (E-pub ahead of print) In: The Journal of Physiology. 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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109 Downloads (Pure)

TNF-α signals through ITK-Akt-mTOR to drive CD4⁺ T cell metabolic reprogramming, which is dysregulated in rheumatoid arthritis

Bishop, E. L., Gudgeon, N., Fulton-Ward, T., Stavrou, V., Roberts, J., Boufersaoui, A., Tennant, D. A., Hewison, M., Raza, K. & Dimeloe, S., 23 Apr 2024, In: Science signaling. 17, 833, eadg5678.

Research output: Contribution to journal › Article › peer-review

Open Access

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99 Downloads (Pure)

Vitamin D deficiency and duration of COVID-19 symptoms in UK healthcare workers

Chadda, K. R., Roberts, S. A., Lugg, S. T., Faniyi, A. A., Faustini, S. E., Webster, C., Duffy, J. E., Hewison, M., Shields, A., Richter, A. G., Parekh, D., Scott, A. & Thickett, D. R., 25 Nov 2024, In: Frontiers in Medicine. 11, 8 p., 1494129.

Research output: Contribution to journal › Article › peer-review

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13 Downloads (Pure)

2023

GC-Globulin/Vitamin D-Binding Protein Is Required for Pancreatic α-Cell Adaptation to Metabolic Stress

Viloria, K., Nasteska, D., Ast, J., Hasib, A., Cuozzo, F., Heising, S., Briant, L. J. B., Hewison, M. & Hodson, D. J., Feb 2023, In: Diabetes. 72, 2, p. 275-289 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

P165 Association between vitamin D deficiency and extended duration of COVID-19 symptoms

Roberts, S., Lugg, S., Faniyi, A., Faustini, S., Faniyi, C., Duffy, J., Hewison, M., Shields, A., Richter, A., Parekh, D., Scott, A. & Thickett, D., 7 Jul 2023, In: Thorax. 77, Suppl 1, p. A170-A171

Research output: Contribution to journal › Abstract › peer-review

Prevalence of vitamin D deficiency and modifiable risk factors in patients with Crohn's disease: A prospective observational study

Fletcher, J., Brown, M., Hewison, M., Swift, A. & Cooper, S. C., Jan 2023, In: Journal of Advanced Nursing. 79, 1, p. 205-214

Research output: Contribution to journal › Article › peer-review

2022

1,25-Dihydroxyvitamin D3 suppresses CD4⁺ T-cell effector functionality by inhibition of glycolysis

Bishop, E. L., Gudgeon, N. H., Mackie, G. M., Chauss, D., Roberts, J., Tennant, D. A., Maslowski, K. M., Afzali, B., Hewison, M. & Dimeloe, S., Jul 2022, In: Immunology. 166, 3, p. 299-309 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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110 Downloads (Pure)

Autoimmune disease and interconnections with vitamin D

Fletcher, J., Bishop, E., Harrison, S., Williamson-Swift, A., Cooper, S. C., Dimeloe, S., Raza, K. & Hewison, M., 31 Mar 2022, In: Endocrine Connections. 11, 3, 16 p., e210554.

Research output: Contribution to journal › Review article › peer-review

Open Access

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83 Downloads (Pure)

Circulating conjugated and unconjugated vitamin D metabolite measurements by liquid chromatography mass spectrometry

Jenkinson, C., Desai, R., Mcleod, M. D., Mueller, J. W., Hewison, M. & Handelsman, D. J., Feb 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 2, p. 435-449 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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109 Downloads (Pure)

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

Ashley, B., Simner, C., Manousopoulou, A., Jenkinson, C., Hey, F., Frost, J. M., Rezwan, F. I., White, C. H., Lofthouse, E. M., Hyde, E., Cooke, L. D., Barton, S., Mahon, P., Curtis, E. M., Moon, R. J., Crozier, S. R., Inskip, H. M., Godfrey, K. M., Holloway, J. W. & Cooper, C. & 7 others, Jones, K. S., Lewis, R. M., Hewison, M., Garbis, S. D., Branco, M. R., Harvey, N. C. & Cleal, J. K., 8 Mar 2022, In: eLife. 11, 27 p., e71094.

Research output: Contribution to journal › Article › peer-review

Open Access

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114 Downloads (Pure)

There is more to life than serum vitamin D: a lesson from the past

Hewison, M., 27 Apr 2022, In: Clinical Science. 136, 8, p. 639-642 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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56 Downloads (Pure)

Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients

Subramanian, S., Rhodes, J. M., Taylor, J. M., Milan, A. M., Lane, S., Hewison, M., Chun, R. F., Jorgensen, A., Richardson, P., Nitchingham, D., Aslan, J., Shah, M., Chandrasekar, C. R., Wood, A., Beadsworth, M. & Pirmohamed, M., May 2022, In: The American journal of clinical nutrition. 115, 5, p. 1367-1377 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Vitamin D and miscarriage: a systematic review and meta-analysis

Tamblyn, J., Pilarski, N., Markland, A. D., Marson, E. J., Devall, A., Hewison, M., Morris, R. K. & Coomarasamy, A., 27 May 2022, (E-pub ahead of print) In: Fertility and Sterility. 118, 1, p. 111-122 12 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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400 Downloads (Pure)

Vitamin D Modulation of Mitochondrial Oxidative Metabolism and mTOR Enforces Stress Adaptations and Anticancer Responses

Quigley, M., Rieger, S., Capobianco, E., Zhao, H., Hewison, M., Lisse, T. S. & Zheng, W., Jan 2022, In: JBMR Plus. 6, 1, 20 p., e10572.

Research output: Contribution to journal › Article › peer-review

Open Access

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57 Downloads (Pure)

Vitamin D status: a U-shaped relationship for SARS-CoV-2 seropositivity in UK healthcare workers

Lugg, S. T., Mackay, W. R., Faniyi, A. A., Faustini, S. E., Webster, C., Duffy, J. E., Hewison, M., Shields, A. M., Parekh, D., Richter, A. G., Scott, A. & Thickett, D. R., 27 Sept 2022, In: BMJ Open Respiratory Research. 9, 1, 10 p., e001258.

Research output: Contribution to journal › Article › peer-review

Open Access

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28 Downloads (Pure)

2021

Development of a LC-MS/MS method to measure serum 3-sulfate and 3-glucuronide 25-hydroxyvitamin D3 metabolites; comparisons to unconjugated 25OHD in pregnancy and polycystic ovary syndrome

Huynh, K., Kempegowda, P., Tamblyn, J., O'Reilly, M., Mueller, J. W., Hewison, M. & Jenkinson, C., May 2021, In: Steroids. 169, 108812.

Research output: Contribution to journal › Article › peer-review

Open Access

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1 Citation (Scopus)

134 Downloads (Pure)

Effect of vitamin D supplementation on patient reported outcomes in patients with inflammatory bowel disease: a systematic review

Fletcher, J., Cooper, S. C., Cooney, R., Hewison, M., Iqbal, T. & Swift, A., 2021, Centre for Reviews and Dissemination, University of York.

Research output: Other contribution

Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19

Faniyi, A. A., Lugg, S. T., Faustini, S. E., Webster, C., Duffy, J. E., Hewison, M., Shields, A., Nightingale, P., Richter, A. G. & Thickett, D. R., 6 May 2021, In: The European respiratory journal. 57, 5, 2100653.

Research output: Contribution to journal › Article › peer-review

Open Access

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172 Downloads (Pure)

Patient and public involvement in research design and oversight

Fletcher, J., Swift, A., Hewison, M. & Cooper, S., 19 Aug 2021, (E-pub ahead of print) In: Nurse Researcher. e1786.

Research output: Contribution to journal › Review article › peer-review

Protocol for an open-label feasibility study for a randomised controlled trial of vitamin D supplementation in Crohn’s Disease patients with vitamin D deficiency: D-CODE Feasiblity study

Fletcher, J., Bedson, E., Brown, M., Hewison, M., Swift, A. & Cooper, S. C., Dec 2021, In: Pilot and Feasibility Studies. 7, 1, 13 p., 79.

Research output: Contribution to journal › Article › peer-review

Open Access

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Simultaneous measurement of 13 circulating vitamin D3 and D2 mono and dihydroxy metabolites using liquid chromatography mass spectrometry

Jenkinson, C., Desai, R., Slominski, A. T., Tuckey, R. C., Hewison, M. & Handelsman, D. J., 27 Sept 2021, In: Clinical Chemistry and Laboratory Medicine. 59, 10, p. 1642-1652 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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53 Downloads (Pure)

Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis

Garcia, A. M., Bishop, E., Li, D., Jeffery, L., Garten, A., Thakker, A., Certo, M., Mauro, C., Tennant, D. A., Dimeloe, S., Evelo, C. T., Coort, S. L. & Hewison, M., Jul 2021, In: The Journal of Steroid Biochemistry and Molecular Biology. 211, 10 p., 105891.

Research output: Contribution to journal › Article › peer-review

Open Access

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224 Downloads (Pure)

Trophoblast uptake of DBP regulates intracellular actin and promotes matrix invasion

Ganguly, A., Tamblyn, J. A., Shattock, A., Joseph, A., Larner, D. P., Jenkinson, C., Gupta, J., Gross, S. R. & Hewison, M., Apr 2021, In: Journal of Endocrinology. 249, 1, p. 43-55 13 p.

Research output: Contribution to journal › Article › peer-review

Vitamin D-binding protein/GC-globulin: a novel regulator of alpha cell function and glucagon secretion

Viloria, K., Hewison, M. & Hodson, D., 15 Mar 2021, (E-pub ahead of print) In: Journal of Physiology.

Research output: Contribution to journal › Article › peer-review

Open Access

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221 Downloads (Pure)

Vitamin D status and seroconversion for COVID-19 in UK healthcare workers

Faniyi, A., Lugg, S., Faustini, S., Webster, C., Duffy, J., Hewison, M., Shields, A., Nightingale, P. G., Richter, A. & Thickett, D., Apr 2021, In: European Respiratory Journal. 57, 4, 2004234.

Research output: Contribution to journal › Article › peer-review

Open Access

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6 Citations (Scopus)

55 Downloads (Pure)

2020

Screening and treatment of vitamin D deficiency in UK patients with crohn’s disease: Self-reported practice among gastroenterologists

Fletcher, J., Swift, A., Hewison, M. & Cooper, S. C., Apr 2020, In: Nutrients. 12, 4, 1064.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

Vitamin D and early rheumatoid arthritis

Harrison, S. R., Jutley, G., Li, D., Sahbudin, I., Filer, A., Hewison, M. & Raza, K., 27 Jul 2020, In: BMC Rheumatology. 4, 1, 38.

Research output: Contribution to journal › Article › peer-review

Open Access

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213 Downloads (Pure)

Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory

Bishop, E., Ismailova, A., Dimeloe, S. K., Hewison, M. & White, J. H., 22 Aug 2020, (E-pub ahead of print) In: JBMR Plus.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Vitamin D and SARS-CoV-2 virus/COVID-19 disease

Lanham-New, S., Webb, A., Cashman, K., Buttriss, J., Fallowfield, J., Masud, T., Hewison, M., Mathers, J. C., Kiely, M., Welch, A., Ward, K., Magee, P., Darling, A., Hill, T. R., Greig, C., Smith, C. P., Murphy, R. J., Leyland, S., Bouillon, R. & Ray, S. & 1 others, Kohlmeier, M., 13 May 2020, (E-pub ahead of print) In: BMJ Nutrition, Prevention & Health.

Research output: Contribution to journal › Article › peer-review

Open Access

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184 Downloads (Pure)

Vitamin-D-binding protein contributes to the maintenance of α cell function and glucagon secretion

Viloria, K. M., Nasteska, D., Briant, L. J. B., Heising, S., Larner, D., Fine, N., Ashford, F., Da Silva Xavier, G., Jimenez-Gonzalez, M., Hasib, A., Cuozzo, F., Manning Fox, J., MacDonald, P., Akerman, I., Lavery, G., Flaxman, C., Morgan, N., Richardson, S., Hewison, M. & Hodson, D., 16 Jun 2020, In: Cell Reports. 31, 11, 19 p., 107761.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

233 Downloads (Pure)

VITAMIN D IN EARLY RHEUMATOID ARTHRITIS

Harrison, S. R., Jutley, G., Li, D., Sahbudin, I., Filer, A., Hewison, M. & Raza, K., 2020, In: Rheumatology.

Research output: Contribution to journal › Article › peer-review

Vitamin D promotes trophoblast cell induced separation of vascular smooth muscle cells in vascular remodeling via induction of G-CSF

Zhang, J., Wu, P., Chen, D., Ning, F., Lu, Q., Qiu, X., Hewison, M., Tamblyn, J., Kilby, M. & Lash, G., 22 Dec 2020, In: Frontiers in cell and developmental biology. 8, 601043.

Research output: Contribution to journal › Article › peer-review

Open Access

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222 Downloads (Pure)

2019

Defining vitamin D status using multi-metabolite mathematical modelling: a pregnancy perspective

Beentjes, C. H. L., Taylor-King, J. P., Bayani, A., Davis, C. N., Dunster, J. L., Jabbari, S., Mirams, G. R., Jenkinson, C., Kilby, M. D., Hewison, M. & Tamblyn, J. A., Jun 2019, In: The Journal of Steroid Biochemistry and Molecular Biology. 190, p. 152-160 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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4 Citations (Scopus)

139 Downloads (Pure)

Free versus total serum 25-hydroxyvitamin D in a murine model of colitis

Larner, D. P., Jenkinson, C., Chun, R. F., Westgate, C. S. J., Adams, J. S. & Hewison, M., May 2019, In: The Journal of Steroid Biochemistry and Molecular Biology. 189, p. 204-209 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

128 Downloads (Pure)

Non-linear associations of 25-hydroxyvitamin D concentrations with risk of cardiovascular disease and all-cause mortality: results from The Health Improvement Network (THIN) database

Crowe, F., Thayakaran, T., Gittoes, N., Hewison, M., Thomas, G. N., Scragg, R. & Nirantharakumar, K., 1 Dec 2019, In: The Journal of Steroid Biochemistry and Molecular Biology. 195, 6 p., 105480.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

169 Downloads (Pure)

Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis

Li, D., Jeffery, L. E., Jenkinson, C., Harrison, S. R., Chun, R. F., Adams, J. S., Raza, K. & Hewison, M., Mar 2019, In: The Journal of Steroid Biochemistry and Molecular Biology. 187, p. 1-8 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

9 Citations (Scopus)

160 Downloads (Pure)

The Role of Vitamin D in Inflammatory Bowel Disease: Mechanism to Management

Fletcher, J., Cooper, S. C., Ghosh, S. & Hewison, M., 7 May 2019, In: Nutrients. 11, 5, 1019.

Research output: Contribution to journal › Article › peer-review

Open Access

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37 Citations (Scopus)

242 Downloads (Pure)

Transcriptomic analysis of vitamin D responses in uterine and peripheral NK cells

Tamblyn, J., Jeffery, L., Susarla, R., Lissauer, D., Coort, S. L., Munoz Garcia, A., Knoblich, K., Fletcher, A., Bulmer, J., Kilby, M. & Hewison, M., 1 Aug 2019, In: Reproduction. 158, 2, p. 211-221 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2 Citations (Scopus)

151 Downloads (Pure)

Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005-2015

Crowe, F., Jolly, K., MacArthur, C., Manaseki-Holland, S., Gittoes, N., Hewison, M., Scragg, R. & Nirantharakumar, K., 4 Jun 2019, In: BMJ open. 9, 6, 8 p., e028355.

Research output: Contribution to journal › Article › peer-review

Open Access

File

14 Citations (Scopus)

176 Downloads (Pure)

Vitamin D, Autoimmune Disease and Rheumatoid Arthritis

Harrison, S. R., Li, D., Jeffery, L. E., Raza, K. & Hewison, M., 8 Jul 2019, (E-pub ahead of print) In: Calcified Tissue International.

Research output: Contribution to journal › Review article › peer-review

Open Access

File

24 Citations (Scopus)

347 Downloads (Pure)

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

Viloria, K., Nasteska, D., Briant, L. J. B., Heising, S., Larner, D., Fine, N. H. F., Ashford, F. B., Xavier, G. D. S., Ramos, M. J., Fox, J. E. M., MacDonald, P. E., Akerman, I., Lavery, G. G., Flaxman, C., Morgan, N. G., Richardson, S. J., Hewison, M. & Hodson, D. J., 19 Dec 2019, bioRxiv.

Research output: Working paper/Preprint › Working paper

2018

Analysis of multiple vitamin D metabolites by ultra-performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)

Taylor, A., Storbeck, K.-H., Hewison, M. & Jenkinson, C., 18 Apr 2018, (E-pub ahead of print) In: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1087-1088, p. 43-48

Research output: Contribution to journal › Article › peer-review

Open Access

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16 Citations (Scopus)

378 Downloads (Pure)

Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization

Jenkinson, C., Taylor, A., Storbeck, K.-H. & Hewison, M., 1 Oct 2018, In: Data in Brief. 20, p. 426-435

Research output: Contribution to journal › Article › peer-review

Open Access

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229 Downloads (Pure)

Decreased sensitivity to 1,25-dihydroxyvitamin D3 in T cells from the rheumatoid joint

Jeffery, L., Henley, P., Marium, N., Filer, A., Sansom, D. M., Hewison, M. & Raza, K., Mar 2018, In: Journal of Autoimmunity. 88, p. 50-60 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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12 Citations (Scopus)

186 Downloads (Pure)

Serum and urine vitamin D metabolite analysis in early preeclampsia

Tamblyn, J., Jenkinson, C., Larner, D., Hewison, M. & Kilby, M., Jan 2018, In: Endocrine Connections. 7, 1, p. 199-210 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

196 Downloads (Pure)

2017

25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression

Hassan-Smith, Z. K., Jenkinson, C., Smith, D., Hernandez, I., Morgan, S., Crabtree, N. J., Gittoes, N., Keevil, B. G., Stewart, P. M. & Hewison, M., 15 Feb 2017, In: PLoS ONE. 12, 2, e0170665.

Research output: Contribution to journal › Article › peer-review

Open Access

File

36 Citations (Scopus)

216 Downloads (Pure)

Automated development of an LC-MS/MS method for measuring multiple vitamin D metabolites using MUSCLE software

Jenkinson, C., Bradbury, J., Taylor, A., Adams, J. S., He, S., Viant, M. & Hewison, M., 20 Apr 2017, (E-pub ahead of print) In: Analytical Methods.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

209 Downloads (Pure)

Martin Hewison

Research output

Search results