Mark Kilby

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Mark Kilby is a clinical scientist working in the field of fetal medicine and therapy.

Professor Kilby has special clinical expertise and a clinical research interest in:
1.Prenatal diagnosis (the detection of fetal anomalies).
2.Intrauterine fetal growth restriction.
3.Fetal therapy (the treatment of the baby in-utero).
4.The management of Monochorionic twins and high order pregnancies.
5.He participates (with his colleague, Dr Denise Williams), a bi-monthly joint Fetal Medicine/Clinical Genetics Clinic. He has provided evidence based research to inform the introduction of prenatal genomics into clinical practice.

His work though focuses upon diverse themes crossing the interface between laboratory-based research and translational clinical trials in valuating diagnostic tests and therapeutic interventions.

The laboratory-based work focuses upon aspects of fetal and fetoplacental endocrine/paracrine signalling including the roles of thyroid hormone, glucocorticoids and vitamin D. His group also investigates the cellular immunity (especially T-cell) between the fetoplacental unit and the mother and the control of immunomodulation in human pregnancy. His translational work has focused upon diagnostic accuracy of testing in pregnancy and the evaluation of fetal therapy in singleton and complex multiple pregnancy.

Professor Kilby supervises both clinical and non-clinical doctoral researcher projects.

Research activity per year

49 Finished

49 results

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Finished

Perinatal and 2 year neurodevelopmental outcome in late preterm fetal compromise: the TRUFFLE 2 randomised trial
Kilby, M. (Principal Investigator)
NIHR
1/12/20 → 1/12/24
Project: Other Government Departments
How should we implement advance care planning in perinatal settings? A mixed methods study using normalisation process theory
Shaw, K. (Principal Investigator), Cummins, C. (Co-Investigator), Spry, J. (Researcher), Ewer, A. (Co-Investigator) & Kilby, M. (Co-Investigator)
BIRMINGHAM CHILDRENS HOSPITAL RESEARCH FOUNDATION
13/02/20 → 12/02/21
Project: Research
ITM Fellowship - Nidhi Gulati - Study of the phenotype function and fetal specificity of decidual T cells in human malplacentation disorders
Kilby, M. (Principal Investigator), Moss, P. (Co-Investigator) & Harper, L. (Co-Investigator)
UHB CHARITABLE FUNDS
5/11/18 → 4/11/19
Project: Research
Tommys Early Miscarriage Research Centre - WP8 - Immune Phenotypes
Coomarasamy, A. (Principal Investigator), Kilby, M. (Co-Investigator), Moss, P. (Co-Investigator), Drayson, M. (Co-Investigator), Lissauer, D. (Co-Investigator) & Gallos, I. (Co-Investigator)
TOMMY'S
1/04/17 → 31/03/19
Project: Research
UKOSS single intrauterine fetal death in monochrionic twins study: incidence, maternal,fetal and neonatal consequences
Kilby, M. (Principal Investigator), Morris, K. (Co-Investigator) & Mackie, F. (Co-Investigator)
BRITISH MATERNAL & FETAL MEDICINE SOCIETY
1/05/16 → 28/02/19
Project: Research
Development of a model to predict complications in monochorionic twin pregnancies using first trimester ultrasound and biomarkers
Kilby, M. (Principal Investigator), Morris, K. (Co-Investigator) & Mackie, F. (Co-Investigator)
BRITISH MATERNAL & FETAL MEDICINE SOCIETY
1/07/15 → 31/10/16
Project: Research
Improving outcomes in monochorionic twin pregnancies complicated by twin to twin transfusion syndrome
Kilby, M. (Principal Investigator) & Morris, K. (Co-Investigator)
THE RICHARD AND JACK WISEMAN TRUST
7/04/15 → 29/02/20
Project: Research
An open randomised trial of the Arabin pessary to prevent preterm birth in twin pregnancy - STOPPIT2
Kilby, M. (Principal Investigator)
NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE
1/11/14 → 31/10/18
Project: Other Government Departments
Prenatal Asessment of Genomes and Exomes (PAGE)
Greenfield, S. (Co-Investigator), Barton, P. (Co-Investigator) & Kilby, M. (Principal Investigator)
The Wellcome Trust
1/10/14 → 30/09/18
Project: Research
Vitamin D and pregnancy:effects on immune function of the decidua
Kilby, M. (Principal Investigator), Hewison, M. (Co-Investigator), Inman, C. (Co-Investigator), Lissauer, D. (Co-Investigator) & Moss, P. (Co-Investigator)
MASON MEDICAL RESEARCH FOUNDATION, WELLBEING OF WOMEN
1/10/14 → 30/09/17
Project: Research
Regulation of the cellular immune response to fetal antigens in human pregnancy
Lissauer, D. (Principal Investigator), Kilby, M. (Co-Investigator), Moss, P. (Co-Investigator), Inman, C. (Co-Investigator) & Long, H. (Co-Investigator)
THE ACADEMY OF MEDICAL SCIENCES
31/08/14 → 30/08/16
Project: Research
Serum Vitamin D and IVF Outcome
Coomarasamy, A. (Principal Investigator), Kilby, M. (Co-Investigator) & Afifi, Y. (Co-Investigator)
BIRMINGHAM WOMENS NHS TRUST
1/08/13 → 30/04/15
Project: Research
Villitis of Unknown Aetiology: Implications for Maternal Allograft Rejection
Kilby, M. (Principal Investigator), Lissauer, D. (Co-Investigator) & Moss, P. (Co-Investigator)
BIRMINGHAM CHILDRENS HOSPITAL RESEARCH FOUNDATION
1/03/13 → 29/02/16
Project: Research
VItamin D Insufficiency and Pre-Eclampsia; Establishing a Causal Link Through Effects on Placental
Kilby, M. (Principal Investigator)
ACTION MEDICAL RESEARCH
23/04/12 → 18/12/15
Project: Research
Obstetric Outcomes and Antenatal Thyroid Screening and Mechanisms of Adverse Pregnancy Effects in Maternal
Kilby, M. (Principal Investigator) & Chan, S. (Co-Investigator)
BIRMINGHAM WOMENS NHS TRUST
1/09/11 → 31/08/12
Project: Research
The Immunological Consequences of First Trimester Progesterone Treatment in Recurrent Miscarriage (PROMISE PLUS)
Lissauer, D. (Principal Investigator), Coomarasamy, A. (Co-Investigator), Kilby, M. (Co-Investigator) & Moss, P. (Co-Investigator)
BIRMINGHAM WOMENS NHS TRUST
4/07/11 → 30/09/15
Project: Research
Efficacy and Mechanism of Thyroxine Treatment on Pregnancy and Neonatal Outcomes in Women with Thyroid Antibodies: A Randomised, Placebo-Controlled, Double-Blind, Multi-Centre Trial
Kilby, M. (Co-Investigator), Middleton, L. (Co-Investigator), Coomarasamy, A. (Principal Investigator) & Boelaert, K. (Co-Investigator)
NIHR
1/06/11 → 31/03/18
Project: Other Government Departments
The STAMP Trial: A Proof of Principle, Double Blind, Randomised Placebo-Controlled, Multi Centre Trial of Statins to Ameliorate Early Onset Preeclampsia
Daniels, J. (Principal Investigator) & Kilby, M. (Co-Investigator)
Medical Research Council
1/10/10 → 30/04/14
Project: Research Councils
Thyroid Hormone Action in the Decidua During Human Pregnancy
Chan, S. (Principal Investigator), Franklyn, J. (Co-Investigator), Kilby, M. (Co-Investigator) & Loubiere, L. (Co-Investigator)
WELLBEING OF WOMEN
1/10/09 → 28/02/13
Project: Research
Prenatal Detection of Chromosomal Anomalies Using Microarrays in Prenatally Diagnosed Congenital Cardiac Disease and Associated Anomalies
Kilby, M. (Principal Investigator)
SPORT AIDING MEDICAL RESEARCH FOR KIDS
1/09/09 → 14/03/13
Project: Research
Monocarboxylate Transporter 10 (MCT10) in Human Placental Development and in the Pathophysiology of Intrauterine Growth-Restriction (IUGR)
Kilby, M. (Principal Investigator), Chan, S. (Co-Investigator), Franklyn, J. (Co-Investigator) & Loubiere, L. (Co-Investigator)
ACTION MEDICAL RESEARCH
1/11/08 → 31/10/10
Project: Research
The PLUTO Trial: Percutaneous Shunting in Lower Urinary Tract Obstruction
Kilby, M. (Principal Investigator), Morris, K. (Co-Investigator), Daniels, J. (Co-Investigator), Khan, K. (Co-Investigator), Middleton, L. (Co-Investigator), Bryan, S. (Co-Investigator), Roberts, T. (Co-Investigator), Taylor, C. (Co-Investigator), Gray, R. (Co-Investigator), Lilford, R. (Co-Investigator) & Quinlan-Jones, E. (Co-Investigator)
THE NHS HEALTH TECHNOLOGY ASSESMENT PROGRAMME (HTA)
1/09/08 → 30/06/12
Project: Research
Study of the Biological and Clinical Significance of Maternal Cellular Immunity to Fetal Antigens
Kilby, M. (Principal Investigator) & Lissauer, D. (Co-Investigator)
BRITISH MATERNAL AND FETAL MEDICINE SOCIETY, WELLBEING OF WOMEN
4/08/08 → 30/11/15
Project: Research
The Role of Monocarboxylate Transporter 8 During Human Placental Development in Normal and IUGR Pregnancies
Chan, S. (Principal Investigator), Franklyn, J. (Co-Investigator), Kilby, M. (Co-Investigator) & McCabe, C. (Co-Investigator)
Medical Research Council
3/01/07 → 2/01/09
Project: Research Councils
Amniotic Fluid Cytokine Response and Maternal Placental Angiogenic Growth Factor Concentrations in Twin-to-Twin Transfusion Syndrome: The Response to Fetal Therapy
Kilby, M. (Principal Investigator) & Whittle, M. (Co-Investigator)
WELLBEING OF WOMEN
1/12/06 → 31/12/12
Project: Research
Monocarboxylate Transporter 8 in Human Central Nervous System Development and the Effects of Intrauterine Growth Restriction
Franklyn, J. (Principal Investigator), Chan, S. (Co-Investigator), Kilby, M. (Co-Investigator), Logan, A. (Co-Investigator) & McCabe, C. (Co-Investigator)
ACTION MEDICAL RESEARCH
27/11/06 → 26/05/08
Project: Research
The Role of Monocarboxylate Transporter 8 (MCT8) in Human Fetal Brain Development and the Effects of Intrauterine Growth Restriction
Chan, S. (Principal Investigator), Franklyn, J. (Co-Investigator), Kilby, M. (Co-Investigator), Logan, A. (Co-Investigator) & McCabe, C. (Co-Investigator)
THE HEALTH FOUNDATION
15/09/06 → 30/06/14
Project: Research
Securin and Separase Expression and Effects in Intrauterine Growth Restricted (IUGR) Fetal Brains
Chan, S. (Principal Investigator) & Kilby, M. (Co-Investigator)
BIRMINGHAM CHILDRENS HOSPITAL RESEARCH FOUNDATION
23/08/06 → 22/08/07
Project: Research
How Do Regulatory T Cells Influence Materno-Fetal Tolerance?
Sansom, D. (Principal Investigator), Kilby, M. (Co-Investigator) & Walker, L. (Co-Investigator)
Medical Research Council
1/01/06 → 31/12/09
Project: Research Councils
A randomised controlled trial evaluationg the efficacy of vesico amniotic shunting in fetuses with bladder outflow obstruction effects on morbidity & survival
Kilby, M. (Principal Investigator) & Somerset, D. (Co-Investigator)
BIRMINGHAM WOMENS NHS TRUST
1/09/05 → 31/12/09
Project: Research
A Multi-Centre Randomised Controlled Trial Comparing Intra-Uterine Vesico-Amniotic Shunting vs Not Shunting in the Treatment of Congenital Bladder Outflow Obstruction
Kilby, M. (Principal Investigator), Daniels, J. (Co-Investigator), Gray, R. (Co-Investigator), Khan, K. (Co-Investigator) & Somerset, D. (Co-Investigator)
WELLBEING OF WOMEN
1/09/05 → 31/10/12
Project: Research
The Role Of The Iodothyronine Transporter MCT-8 In Neutral Cell Development
Kilby, M. (Principal Investigator), Barrett, T. (Co-Investigator), Franklyn, J. (Co-Investigator) & McCabe, C. (Co-Investigator)
BIRMINGHAM CHILDRENS HOSPITAL RESEARCH FOUNDATION
1/10/04 → 30/09/07
Project: Research
Metabolic Responses to Acute Bouts of Exercise During Pregnancy & Postpartum
Jeukendrup, A. (Principal Investigator) & Kilby, M. (Co-Investigator)
QINETIQ LTD
1/09/03 → 30/09/05
Project: Industry
Vitamins in Pre-Eclampsia - Research Midwife
Kilby, M. (Principal Investigator)
University of Leicester
14/07/03 → 13/06/05
Project: Research
Vitiamins in Pre-Eclampsia - Research Midwife
Kilby, M. (Principal Investigator)
Wellcome Trust
1/07/03 → 18/09/05
Project: Research
A Study of the Relationship Between Maternal Thyroid Status in the First Trimester of Pregnancy and Neonatal Outcome
Kilby, M. (Principal Investigator)
BRITISH THYROID FOUNDATION
6/01/03 → 31/12/05
Project: Research
Thyroid Hormone Deiodinases and Receptors in the Human Placenta
Kilby, M. (Principal Investigator) & Franklyn, J. (Co-Investigator)
Wellcome Trust
1/05/02 → 30/04/03
Project: Research
O & G Research
Kilby, M. (Principal Investigator)
BIRMINGHAM WOMENS NHS TRUST
1/05/02 → 31/03/03
Project: Research
1,25-Dihydroxyvitamin D3, HOXA10 and Fetal Implantation: A Novel Role for Extra-Renal Expression of 1Alpha-Hydroxylase
Hewison, M. (Principal Investigator) & Kilby, M. (Co-Investigator)
Biotechnology & Biological Sciences Research Council
5/03/01 → 30/09/04
Project: Research Councils
Does Paternal Mitochondrial DNA Regulate Trophoblast Cell Development?
Kilby, M. (Principal Investigator) & St John, J. (Co-Investigator)
UHB CHARITABLE FUNDS
2/02/01 → 30/09/02
Project: Research
The Co-Expression of Thyroid Receptor Isoforms and Neuronal Cytoskeletal Proteins in the Central Nervous System of Growth Restricted Fetal Guinea Pigs
Kilby, M. (Principal Investigator)
MASON MEDICAL RESEARCH FOUNDATION
1/01/01 → 31/12/01
Project: Research
Psychosocial factors & wellbeing in women receving a detailed ultrasound scan
Kilby, M. (Principal Investigator)
BIRMINGHAM WOMENS NHS TRUST
1/01/01 → 31/12/04
Project: Research
Thyroid Status and Intrauterine Growth Restriction
Kilby, M. (Principal Investigator) & Franklyn, J. (Co-Investigator)
Medical Research Council
1/10/00 → 30/09/03
Project: Research Councils
A Collaboration study to identfy Susceptibility in pre-eclampsia (BHF project sub -contract with Notts Uni.)
Kilby, M. (Principal Investigator)
British Heart Foundation
1/12/99 → 31/05/03
Project: Research
Functional Characterisation and Cellular Expression OfHepatocyte Growth Factor And It's Interaction With Other ...
Ahmed, A. (Principal Investigator) & Kilby, M. (Co-Investigator)
British Heart Foundation
4/01/99 → 3/05/03
Project: Research
The Expression of Placental 11beta Hydroxysteroid Dehydrogenase Enzymes in Human Intrauterine Growth Restriction
Kilby, M. (Co-Investigator) & Stewart, P. (Principal Investigator)
ACTION RES. FOR THE CRIPPLED CHILD
1/10/98 → 31/03/01
Project: Research
Thyroid Hormone Receptor Expression in Human Fetal Central Nervous System: the Effects of Intrauterine Growth Restriction
Kilby, M. (Principal Investigator) & Franklyn, J. (Co-Investigator)
UHB CHARITABLE FUNDS
1/09/98 → 31/10/01
Project: Research
Prenatal Programming Of Lipoprotein Metabolism And EffectsOn Vascular Adhesion Molecule Expression In Intrauterine ...
Kilby, M. (Principal Investigator)
TOMMY'S
1/01/97 → 31/12/04
Project: Research
Nuetrophil Activation in the Feto-placental Circulation ofthe Growth Retarded Fetus
Kilby, M. (Principal Investigator)
BIRMINGHAM WOMENS NHS TRUST
1/12/95 → 31/03/97
Project: Research

Mark Kilby

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