Laura O'Neill

2013

C/EBPα and MYB regulate FLT3 expression in AML

Volpe, G., Walton, D. S., Del Pozzo, W., Garcia, P., Dassé, E., O'Neill, L. P., Griffiths, M., Frampton, J. & Dumon, S., 23 Jan 2013, In: Leukemia. 27, 7, p. 1487-1496 10 p.

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing

Boudadi, E., Stower, H., Halsall, J. A., Rutledge, C. E., Leeb, M., Wutz, A., O'Neill, L. P., Nightingale, K. P. & Turner, B. M., 1 May 2013, In: Epigenetics & Chromatin. 6, 1, 11.

Research output: Contribution to journal › Article › peer-review

Open Access

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24 Citations (Scopus)

263 Downloads (Pure)

2012

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells

Dassé, E., Volpe, G., Walton, D. S., Wilson, N., Del Pozzo, W., O'Neill, L. P., Slany, R. K., Frampton, J. & Dumon, S., Jun 2012, In: Blood Cancer Journal. 2, 6, p. e76

Research output: Contribution to journal › Article › peer-review

Open Access

14 Citations (Scopus)

Genes Are Often Sheltered from the Global Histone Hyperacetylation Induced by HDAC Inhibitors.

Halsall, J., Gupta, V., O'Neill, L., Turner, B. & Nightingale, K., 1 Jan 2012, In: PLoS ONE. 7, 3, p. e33453

Research output: Contribution to journal › Article

Open Access

39 Citations (Scopus)

Itga2b regulation at the onset of definitive hematopoiesis and commitment to differentiation

Dumon, S., Walton, D. S., Wilson, N., Dassé, E., Del Pozzo, W., Landry, J-R., Turner, B., O'Neill, L. P., Göttgens, B. & Frampton, J., 2012, In: PLoS ONE. 7, 8, p. e43300

Research output: Contribution to journal › Article › peer-review

Open Access

15 Citations (Scopus)

Recruitment of NCOR1 to VDR target genes is enhanced in prostate cancer cells and associates with altered DNA methylation patterns

Doig, C. L., Singh, P. K., Dhiman, V. K., Thorne, J. L., Battaglia, S., Sobolewski, M., Maguire, O., O'Neill, L. P., Turner, B. M., McCabe, C. J., Smiraglia, D. J. & Campbell, M. J., 2012, In: Carcinogenesis.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

2011

A systems biology approach identifies molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease

Turan, N., Kalko, S., Stincone, A., Clarke, K., Sabah, A., Howlett, K., Curnow, S., Rodriguez, DA., Cascante, M., O'Neill, L., Egginton, S., Roca, J. & Falciani, F., 1 Sept 2011, In: PLoS Computational Biology. 7, 9, p. e1002129

Research output: Contribution to journal › Article

Open Access

54 Citations (Scopus)

Epigenetic control of a VDR-governed feed-forward loop that regulates p21(waf1/cip1) expression and function in non-malignant prostate cells.

Thorne, JL., Maguire, O., Doig, C., Battaglia, S., Fehr, L., Sucheston, LE., Heinaniemi, M., O'Neill, L., McCabe, C., Turner, B., Carlberg, C. & Campbell, M., 1 Mar 2011, In: Nucleic Acids Research. 39, 6, p. 2045-56 12 p.

Research output: Contribution to journal › Article

Open Access

52 Citations (Scopus)

Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets

Sandovici, I., Smith, NH., Nitert, MD., Ackers-Johnson, M., Uribe-Lewis, S., Ito, Y., Jones, RH., Marquez, VE., Cairns, W., Tadayyon, M., O'Neill, L., Murrell, A., Ling, C., Constancia, M. & Ozanne, SE., 1 Mar 2011, In: National Academy of Sciences. Proceedings. 108, 13, p. 5449-5454 6 p.

Research output: Contribution to journal › Article

244 Citations (Scopus)

Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis.

Halsall, J., Antczak, P., O'Neill, L., Falciani, F. & Turner, B., 1 Jan 2011, In: Nature Genetics. 43, 12, p. 1169-70 2 p.

Research output: Contribution to journal › Article

53 Citations (Scopus)

2010

Elevated NCOR1 disrupts PPAR{alpha}/{gamma} signaling in prostate cancer and forms a targetable epigenetic lesion.

Battaglia, S., Maguire, O., Thorne, JL., Hornung, LB., Doig, C., Liu, S., Sucheston, LE., Bianchi, A., Khanim, F., Gommersall, LM., Coulter, HS., Rakha, S., Giddings, I., O'Neill, L., Cooper, CS., McCabe, C., Bunce, C. & Campbell, M., 13 May 2010, In: Carcinogenesis. 31, 9, p. 1650-1660 11 p.

Research output: Contribution to journal › Article

42 Citations (Scopus)

Immunostaining of modified histones defines high-level features of the human metaphase epigenome.

Terrenoire, E., McRonald, F., Halsall, J., Page, P., Illingworth, RS., Taylor, A., Davison, V., O'Neill, L. & Turner, B., 1 Jan 2010, In: Genome Biology. 11, 11, p. R110

Research output: Contribution to journal › Article

34 Citations (Scopus)

Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment

Alder, O., Lavial, F., Helness, A., Brookes, E., Pinho, S., Chandrashekran, A., Arnaud, P., Pombo, A., O'Neill, L. & Azuara, V., 1 Aug 2010, In: Development (Cambridge). 137, 15, p. 2483-2492 10 p.

Research output: Contribution to journal › Article

82 Citations (Scopus)

Undifferentiated Embryonic Cell Transcription Factor 1 Regulates ESC Chromatin Organization and Gene Expression

Kooistra, SM., van den Boom, V., Thummer, RP., Johannes, F., Wardenaar, R., Tesson, BM., Veenhoff, LM., Fusetti, F., O'Neill, L., Turner, B., de Haan, G. & Eggen, BJL., 1 Oct 2010, In: Stem Cells. 28, 10, p. 1703-1714 12 p.

Research output: Contribution to journal › Article

24 Citations (Scopus)

2009

Transcription-independent heritability of induced histone modifications in the mouse preimplantation embryo

VerMilyea, MD., O'Neill, L. & Turner, B., 1 Jan 2009, In: PLoS ONE. 4, 6, p. e6086

Research output: Contribution to journal › Article

Open Access

51 Citations (Scopus)

2008

Differential loss of histone H3 isoforms mono-, di- and tri-methylated at lysine 4 during X-inactivation in female embryonic stem cells

O'Neill, L., Spotswood, HT., Fernando, M. & Turner, B., 1 Apr 2008, In: Biological Chemistry. 389, 4, p. 365-70 6 p.

Research output: Contribution to journal › Article

13 Citations (Scopus)

2007

Dosage Compensation in the Mouse Balances Up-Regulation and Silencing of X-Linked Genes

Lin, H., Gupta, V., Vermilyea, M., Falciani, F., Lee, JT., O'Neill, L. & Turner, B., 1 Jan 2007, In: PLoS Biology. 5, 12, p. e326

Research output: Contribution to journal › Article

Open Access

115 Citations (Scopus)

2006

Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells

Banwell, CM., MacCartney, DPC., Guy, M., Miles, A., Uskokovic, MR., Mansi, J., Stewart, P., O'Neill, L., Turner, B., Colston, KW. & Campbell, M., 1 Apr 2006, In: Clinical Cancer Research. 12, p. 2004-2013 10 p.

Research output: Contribution to journal › Article

66 Citations (Scopus)

Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations

O'Neill, L., Vermilyea, M. & Turner, B., 11 Jun 2006, In: Nature Genetics. 38, 7, p. 835-41 7 p.

Research output: Contribution to journal › Article

222 Citations (Scopus)

Histone modifications: signalling receptors and potential elements of a heritable epigenetic code

Nightingale, K., O'Neill, L. & Turner, B., 1 Apr 2006, In: Current Opinion in Genetics & Development. 16, p. 125-136 12 p.

Research output: Contribution to journal › Article

214 Citations (Scopus)

2004

Altered SMRT levels disrupt vitamin D3 receptor signalling in prostate cancer cells

Khanim, F., Gommersall, L., Wood, V., Smith, KL., Montalvo, L., O'Neill, L., Xu, Y., Peehl, DM., Stewart, P., Turner, B. & Campbell, M., 2 Sept 2004, In: Oncogene. 23, 40, p. 6712-25 14 p.

Research output: Contribution to journal › Article

107 Citations (Scopus)

Epigenome changes in active and inactive Polycomb group controlled regions

Breiling, A., O'Neill, L., D'Eliseo, D., Turner, B. & Orlando, V., 1 Jan 2004, In: EMBO Reports. 5, 10, p. 976-82 7 p.

Research output: Contribution to journal › Article

42 Citations (Scopus)

Targeting 1alpha,25-dihydroxyvitamin D3 antiproliferative insensitivity in breast cancer cells by co-treatment with histone deacetylation inhibitors.

Banwell, C., O'Neill, L., Uskokovic, MR. & Campbell, M., 1 May 2004, In: The Journal of Steroid Biochemistry and Molecular Biology. 89-90, 1-5, p. 245-9 5 p.

Research output: Contribution to journal › Article

36 Citations (Scopus)

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

Schubeler, D., MacAlpine, DM., Scalzo, D., Wirbelauer, C., Kooperberg, C., van Leeuwen, F., Gottschling, D., O'Neill, L., Turner, B., Delrow, J., Bell, SP. & Groudine, M., 1 Jun 2004, In: Genes & Development. 18, p. 1263-71 9 p.

Research output: Contribution to journal › Article

613 Citations (Scopus)

2003

Immunoprecipitation of native chromatin; NChIP

O'Neill, L. & Turner, B., 1 Jan 2003, In: Methods. 31, p. 76-82 7 p.

Research output: Contribution to journal › Article

160 Citations (Scopus)

X-linked genes in female embryonic stem cells carry on epigenetic mark prior to the onset of X inactivation

O'Neill, L., Randall, T., Lavender, J., Spotswood, H., Lee, JT. & Turner, B., 1 Aug 2003, In: Human Molecular Genetics. 12, 15, p. 1783-90 8 p.

Research output: Contribution to journal › Article

26 Citations (Scopus)

2002

Human Class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dpendent chaperone protein Hsp70

Johnson, C., White, D., Lavender, J., O'Neill, L. & Turner, B., 8 Mar 2002, In: Journal of Biological Chemistry. 277, 11, p. 9590-7 8 p.

Research output: Contribution to journal › Article

97 Citations (Scopus)

Inhibition of histone deacetylases alters allelic chromatin confirmation at the imprinted U2afl-rs1 locus in mouse embroyonic stem cells

Gregory, RI., O'Neill, L., Randall, T., Fournier, C., Khosla, S., Turner, B. & Feil, R., 29 Mar 2002, In: Journal of Biological Chemistry. 277, 14, p. 11728-34 7 p.

Research output: Contribution to journal › Article

30 Citations (Scopus)

2001

Chromatin remodeling at the Ig loci prior to V(D)J recombination

Maes, J., O'Neill, L., Cavelier, P., Turner, B., Rougeon, F. & Goodhardt, M., 1 Jul 2001, In: Journal of Immunology. 167, 2, p. 866-874 9 p.

Research output: Contribution to journal › Article

90 Citations (Scopus)

DNA methylation is linked to deactetylation of histone H3, but not H4, on the imprinted genes Snrpn and U2afl-rsl

Gregory, RI., Randall, T., Johnson, C., Khosla, S., Hatada, I., O'Neill, L., Turner, B. & Feil, R., 15 Aug 2001, In: Molecular and Cellular Biology. 21, 16, p. 5426-36 11 p.

Research output: Contribution to journal › Article

115 Citations (Scopus)

Relationship between DNA methylaytion, histone H4 acetylation and gene expression in the mouse imprinted Igf2-H10 domain

Grandjean, V., O'Neill, L., Sado, T., Turner, B. & Ferguson-Smith, A., 19 Jan 2001, In: FEBS Letters. 488, 3, p. 165-169 5 p.

Research output: Contribution to journal › Article

76 Citations (Scopus)

1998

Distinctive patterns of H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome

Johnson, C., O'Neill, L., Mitchell, A. & Turner, B., 1 Feb 1998, In: Nucleic Acids Research. 26, 4, p. 994-1001 8 p.

Research output: Contribution to journal › Article

Open Access

67 Citations (Scopus)

Laura O'Neill

Research output

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