Research output per year
Research output per year
- 1 - 50 out of 76 results
Search results
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2024
Analysis of the electrical activity in detrusor smooth muscle: inferences on syncytial function
Padmakumar, M., Brain, K. & Manchanda, R., 1 Jan 2024, Urinary Bladder Physiology: Computational Insights. Appukuttan, S. & Manchanda, R. (eds.). 1 ed. New Delhi: Publ Narosa Publishing HouseResearch output: Chapter in Book/Report/Conference proceeding › Chapter
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A novel, enhanced model for the detrusor syncytium: incorporating innervated bundles
Sengupta, N., Brain, K. & Manchanda, R., 1 Jan 2024, Urinary Bladder Physiology: Computational Insights. Manchanda, R. & Appukuttan, S. (eds.). New Delhi: Publ Narosa Publishing HouseResearch output: Chapter in Book/Report/Conference proceeding › Chapter
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Biophysically Realistic Modles of Detrusor Ion Channels: role in shaping spike and excitavility
Mahapatra, C., Brain, K. & Manchanda, R., 1 Jan 2024, Urinary Bladder Physiology: Computational Insights. 1 ed. New Delhi: Publ Narosa Publishing HouseResearch output: Chapter in Book/Report/Conference proceeding › Chapter
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High-resolution ex-vivo structural and functional analysis of sympathetic innervation using a novel confocal fluorescence technique
Briggs, D., Hunt, J., Raut, S., Saleeb-Mousa, J., Coney, A., Kalla, M., Holmes, A. & Brain, K., 25 Jul 2024, p. 177-177. 1 p.Research output: Contribution to conference (unpublished) › Abstract
Open AccessFile80 Downloads (Pure) -
2023
A modified Angoff B screening method for collusion detection in examinations delivered on the MSCAA and Speedwell platforms
Brain, K. & Nagy, Z., 19 Oct 2023, In: The Clinical Teacher. 20, S1, p. 85-86 2 p.Research output: Contribution to journal › Abstract › peer-review
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Mechanisms of Atrial Fibrillation in Obstructive Sleep Apnoea
Saleeb-Mousa, J., Nathanael, D., Coney, A. M., Kalla, M., Brain, K. L. & Holmes, A. P., 19 Jun 2023, In: Cells. 12, 12, 12 p., 1661.Research output: Contribution to journal › Review article › peer-review
Open AccessFile57 Downloads (Pure) -
2021
Effect of variations in gap junctional coupling on the frequency of oscillatory action potentials in a smooth muscle syncytium
Appukuttan, S., Brain, K. & Manchanda, R., 1 Oct 2021, In: Frontiers in Physiology. 12, 12 p., 655225.Research output: Contribution to journal › Article › peer-review
Open AccessFile103 Downloads (Pure) -
Resting cardiac sympathetic firing frequencies suppress terminal norepinephrine transporter uptake
Cao, L., Marshall, J., Fabritz, L. & Brain, K., May 2021, In: Autonomic Neuroscience. 232, 10 p., 102794.Research output: Contribution to journal › Article › peer-review
Open AccessFile104 Downloads (Pure) -
β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia
Alzahrani, A. A., Cao, L. L., Aldossary, H. S., Nathanael, D., Fu, J., Ray, C. J., Brain, K. L., Kumar, P., Coney, A. M. & Holmes, A. P., Jan 2021, In: Pfluegers Archiv: European journal of physiology . 473, 1, p. 37-51 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)205 Downloads (Pure) -
2020
Cannabinoid type I receptor-mediated inhibition of neuronal noradrenaline reuptake in the mouse heart
Cao, L., Marshall, J. & Brain, K., 8 Dec 2020, British Journal of Pharmacology. Vol. 178. p. 423-423 P047Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open Access -
Dynamic monitoring of single-terminal norepinephrine transporter rate in the rodent cardiovascular system: a novel fluorescence imaging method
Cao, L., Holmes, A., Marshall, J., Fabritz, L. & Brain, K., Jan 2020, In: Autonomic Neuroscience. 223, 12 p., 102611.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)215 Downloads (Pure) -
Program and Abstracts of the 31st International Symposium on the Autonomic Nervous System: Norepinephrine transporter saturation at physiological sympathetic firing rates in the murine heart
Cao, L., Marshall, J., Fabritz, L. & Brain, K., 6 Nov 2020, Clinical Autonomic Research. Springer, Vol. 30. p. 470-471 21Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open Access -
2019
Analysis of spontaneous depolarization-linked hyperpolarizations in mouse detrusor smooth muscle cells
Padmakumar, M., Brain, K. & Manchanda, R., 22 Nov 2019, In: Biomedical Research Journal. 6, 2, p. 49-55Research output: Contribution to journal › Article › peer-review
Open AccessFile189 Downloads (Pure) -
Ca2+ changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries - relation to noradrenaline release and contraction
Hansen, T., Tarasova, O. S., Khammy, M. M., Ferreira, A., Kennard, J. A., Andresen, J., Staehr, C., Brain, K., Nilsson, H. & Aalkjær, C., 31 Aug 2019, In: Acta Physiologica. 226, 4, e13279.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)350 Downloads (Pure) -
Investigation of the syncytial nature of detrusor smooth muscle as a determinant of action potential shape
Appukuttan, S., Padmakumar, M., Young, J., Brain, K. & Manchanda, R., 20 Sept 2019, Simulating normal and arrhythmic dynamics: from sub-cellular to tissue and organ level. Dierckx, H., Fenton, F. H., Filippi, S. & Pumir, A. (eds.). Frontiers, p. 64-76Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open AccessFile222 Downloads (Pure) -
2018
A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle
Mahapatra, C., Brain, K. & Manchanda, R., 26 Jul 2018, In: PLoS ONE. 13, 7, p. 1-32 e0200712.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)228 Downloads (Pure) -
A four-component model of the action potential in mouse detrusor smooth muscle cell
Padmakumar, M., Brain, K., Young, J. & Manchanda, R., 19 Jan 2018, In: PLoS ONE. 13, 1, e0190016.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)173 Downloads (Pure) -
Investigation of the syncytial nature of detrusor smooth muscle as a determinant of action potential shape
Appukuttan, S., Padmakumar, M., Young, J., Brain, K. & Manchanda, R., 20 Sept 2018, In: Frontiers in Physiology. 9, 13 p., 1300.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)162 Downloads (Pure) -
2017
A method for the analysis of AP foot convexity: insights into smooth muscle biophysics
Appukuttan, S., Padmakumar, M., Brain, K. & Manchanda, R., 26 Oct 2017, In: Frontiers in Bioengineering and Biotechnology. 64Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)320 Downloads (Pure) -
Computational study of ATP gated Potassium ion channel in urinary bladder over activity
Mahapatra, C., Brain, K. & Manchanda, R., 19 Jan 2017, 2016 International Conference on Inventive Computation Technologies (ICICT). Institute of Electrical and Electronics Engineers (IEEE), Vol. 2016. p. 1-4 4 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
1 Citation (Scopus) -
Investigation of action potential propagation in a syncytium
Appukuttan, S., Brain, K. & Manchanda, R., 1 Apr 2017, In: Biomedical Research Journal. 4, 1, p. 102-115Research output: Contribution to journal › Article › peer-review
Open AccessFile232 Downloads (Pure) -
Modeling extracellular fields for a three-dimensional network of cells using NEURON
Appukuttan, S., Brain, K. L. & Manchanda, R., 1 Oct 2017, In: Journal of Neuroscience Methods. 290, p. 27-38 12 p., NSM_7781.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)445 Downloads (Pure) -
2016
A regional reduction in Ito and IKaCh in the murine posterior left atrial myocardium is associated with action potential prolongation and increased ectopic activity
Holmes, A. P., Yu, T. Y., Tull, S., Syeda, F., Kuhlmann, S. M., O'Brien, S.-M., Patel, P., Brain, K. L., Pavlovic, D., Brown, N. A., Fabritz, L. & Kirchhof, P., 5 May 2016, In: PLoS ONE. 11, 5, e0154077.Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)295 Downloads (Pure) -
High probability neurotransmitter release sites represent an energy efficient design
Zhongmin, L., Chouhan, A. K., Rossano, A. J., Brain, K. L., Zhou, Y., Borycz, J. A., Lu, Z., Meinertzhagen, I. A. & Macleod, G. T., 10 Oct 2016, In: Current Biology. 26, 19, p. 2562-2571 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)231 Downloads (Pure) -
2015
A computational model of urinary bladder smooth muscle syncytium: Validation and investigation of electrical properties
Appukuttan, S., Brain, K. L. & Manchanda, R., Feb 2015, In: Journal of Computational Neuroscience. 38, p. 167-87 21 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Optical mapping design for murine atrial electrophysiology
Yu, T. Y., Dehghani, H., Brain, K., Syeda, F., Holmes, A. P., Kirchhof, P. & Fabritz, L., 15 Nov 2015, (E-pub ahead of print) In: Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. 5, 5, p. 368-376 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)292 Downloads (Pure) -
Spatiotemporal dynamics of synaptic drive in urinary bladder syncytium: A computational investigation
Sengupta, N., Brain, K. L. & Manchanda, R., Aug 2015, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2015 . Institute of Electrical and Electronics Engineers (IEEE), p. 8074-7 4 p. (IEEE Engineering in Medicine and Biology Society. Conference Proceedings).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Open AccessFile1 Citation (Scopus)225 Downloads (Pure) -
Syncytial basis for diversity in spike shapes and their propagation in detrusor smooth muscle
Appukuttan, S., Brain, K. & Manchanda, R., 1 Jun 2015, In: Procedia Computer Science. 51, p. 785-794Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)152 Downloads (Pure) -
2014
191 Advancement of Optical Mapping through Automated Algorithms and Second Generation CMOS Detectors to Reveal Murine Atrial Activation Patterns and Regional Variation of Action Potential Duration
Yu, T. Y., Syeda, F., Dehghani, H., Brain, K., Kirchhof, P. & Fabritz, L., 1 Jun 2014, In: Heart. 100, Suppl 3, p. A106-A106Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials
Yu, T. Y., Syeda, F., Holmes, A. P., Osborne, B., Dehghani, H., Brain, K. L., Kirchhof, P. & Fabritz, L., 15 Aug 2014, In: Progress in Biophysics and Molecular Biology. 115, p. 340-348 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)291 Downloads (Pure) -
2013
5-Chloroindole: a potent allosteric modulator of the 5-HT3 receptor: Allosteric modulation of the 5-HT3receptor
Newman, A. S., Batis, N., Grafton, G., Caputo, F., Brady, C. A., Lambert, J. J., Peters, J. A., Gordon, J., Brain, K. L., Powell, A. D. & Barnes, N. M., Jul 2013, In: British Journal of Pharmacology. 169, 6, p. 1228-1238 11 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus) -
2012
Prostaglandin E(2) induces spontaneous rhythmic activity in mouse urinary bladder independently of efferent nerves
Kobayter, S., Young, J. & Brain, K., 1 Jan 2012, In: British Journal of Pharmacology. 165, 2, p. 401-413 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Citations (Scopus)219 Downloads (Pure) -
Real-time stochastic detection of multiple neurotransmitters with a protein nanopore
Boersma, A. J., Brain, K. L. & Bayley, H., 2012, In: ACS Nano. 6, 6, p. 5304-8 5 p.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus) -
2011
Ion Channel Modulators
Andersson, K., Michel, M., Brading, A. & Brain, K., 1 Jan 2011, Handbook of Experimental Pharmacology: Urinary Tract.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Mechanisms Involved in Nicotinic Acetylcholine Receptor-Induced Neurotransmitter Release from Sympathetic Nerve Terminals in the Mouse Vas Deferens
Williams, D., Sidaway, P., Cunnane, T. & Brain, K., 1 Dec 2011, In: PLoS ONE. 6, 12, p. e29209Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)201 Downloads (Pure) -
Obituary: Professor Alison Brading, PhD
Brain, K., 1 Jan 2011, In: Neurourology and Urodynamics. 30, 3, p. 282-283 2 p.Research output: Contribution to journal › Article
File138 Downloads (Pure) -
Optical techniques for monitoring norephinephrine, and vesicular monoamine, transporter rates in sympathetic nerve terminals of mouse vas deferens
Brain, K., 1 Jan 2011, p. 68-69. 2 p.Research output: Contribution to conference (unpublished) › Paper
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Professor Alison Brading
Brading, K., Brain, K. & Rang, H., 1 Apr 2011, In: Pharmacology Matters. 30, p. 282-283 2 p.Research output: Contribution to journal › Article
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Real time monitoring of neurotransmitter uptake and storage in PC-12 cells: Implication for co-storage and co-transmission
Sidaway, P. & Brain, K., 1 Jan 2011, p. 69. 1 p.Research output: Contribution to conference (unpublished) › Paper
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2010
Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate
Brain, K., Kennard, J., Shanks, J. & Parker, E., 1 Feb 2010, In: British Journal of Pharmacology. 159, 4, p. 797-807 11 p.Research output: Contribution to journal › Article › peer-review
12 Citations (Scopus)3 Downloads (Pure) -
Ion channel modulators and urinary tract function
Andersson, K., Michel, M., Brading, A. & Brain, K., 1 Jan 2010, Handbook of Experimental Pharmacology: The Urinary Tract. Vol. 202.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Parasympathetic cholinergic transmission, minus the vesicles
Brain, K., 1 Feb 2010, In: Experimental Physiology. 95, 2, p. 263-264 2 p.Research output: Contribution to journal › Editorial
File77 Downloads (Pure) -
Real-time electrochemical detection of ATP release in isolated mouse vas deferens
Sidaway, P. & Brain, K., 1 Sept 2010.Research output: Contribution to conference (unpublished) › Paper
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Standard Computerised Revalidation Instrument for Prescribing and Therapeutics
Ferner, R., Coleman, J., Brain, K. & Spruce, A., 1 Jan 2010Research output: Non-textual form › Web publication/site
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Vesicular tracking and stimulus-dependent modification of NET rate in sympathetic nerve terminals
Brain, K., Kennard, J., Shanks, J. & Parker, L., 1 Jan 2010.Research output: Contribution to conference (unpublished) › Paper
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2009
). Vesicular tracking and stimulus-dependent modification of NET rate in sympathetic nerve terminals
Shanks, J., Parker, L., Kennard, J. & Brain, K., 1 Jan 2009.Research output: Contribution to conference (unpublished) › Paper
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Effects of 17β-oestradiol on rat detrusor smooth muscle contractility
Valeri, A., Brain, K., Young, J., Sgaragli, G. & Pessina, F., 1 Jul 2009, In: Experimental Physiology. 94, 7, p. 834-846 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)189 Downloads (Pure) -
Focal Ca2+ transient detection in smooth muscle
Young, J. S., Amos, R. J. & Brain, K. L., 2009, In: Journal of Visualized Experiments. 28Research output: Contribution to journal › Article › peer-review
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Neuroeffector Ca2+ transients for the direct measurement of purine release and indirect measurement of cotransmitters in rodents
Brain, K., 1 Jan 2009, In: Experimental Physiology. 94, 1, p. 25-30 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)154 Downloads (Pure) -
P3.7 Cellular mechanism of action of Prostaglandin E2 on mouse urinary bladder
Kobayter, S., Young, J. & Brain, K., 12 Aug 2009, p. 84-85. 2 p.Research output: Contribution to conference (unpublished) › Abstract