Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders
Shen, Y., Benlabiod, C., Watson, E., Gurashi, K., Fower, A., Rodriguez-Romera, A., Reyat, J. S., Adnan-Awad, S., Hargreaves, R., Kemble, S., Smith, C. G., Croft, A. P., Oppermann, U., Welsh, A., Murphy, L., Murphy, E., Moetazedian, A., Jooss, N., Wong, Z. C. & Rayes, J. & 5 others, , 23 Feb 2026, (E-pub ahead of print) In: Cell stem cell.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Downloads (Pure) -
Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice
Hain, S., Fu, M. S., Wigg, L., George, L., Lecky, D., Whitehead, A. J., Clipston, E., Sato, K., Ono, M., Wuthrich, M., Klein, B., Kawakami, K., Rayes, J., Bending, D. & Drummond, R. A., 9 Oct 2025, In: Nature Communications. 16, 1, 19 p., 8995.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection
Perez-Toledo, M., Beristain-Covarrubias, N., Pillaye, J., Persaud, R., Marcial Juarez, E., Jossi, S., Hitchcock, J., Alshayea, A., Channell, W., Wiersma, N., Lamerton, R., Kavanagh, D., Carestia, A., Horsnell, W., Henderson, I. R., Mackman, N., Clark, A. R., Jenne, C. N., Rayes, J. & Watson, S. & 1 others, , 10 Mar 2025, In: Nature Communications. 16, 16 p., 2356.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Platelet-specific SLFN14 deletion causes macrothrombocytopenia and platelet dysfunction through dysregulated megakaryocyte and platelet gene expression
Stapley, R. J., Sawkulycz, X., Da Mota Araujo, G. H. M., Englert, M., Garcia-Quintanilla, L., Smith, S. R. M., Ahmed, A., Haining, E. J., Kaur, N., Bacon, A., Pisarev, A. V., Poulter, N. S., Kavanagh, D. P. J., Thomas, S. G., Montague, S. J., Rayes, J., Nagy, Z. & Morgan, N. V., 12 Aug 2025, (E-pub ahead of print) In: Journal of Clinical Investigation.Research output: Contribution to journal › Article › peer-review
Open Access -
Spleen tyrosine kinase inhibition mitigates hemin-induced thromboinflammation in an organ-specific manner in sickle cell mice
El-awaisi, J., Perrella, G., Mayer, N., Tinkova, V., Simon, C. J., Grygielska, B., Watson, S. P., Dimitrov, J. D., Brill, A., Hassan, E., Nicolson, P. L. R., Kavanagh, D., Kalia, N. & Rayes, J., 15 Aug 2025, (E-pub ahead of print) In: Arteriosclerosis Thrombosis and Vascular Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Downloads (Pure)
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Investigating microvascular occlusion and silent stroke in sickle cell disease
Rayes, J. (Principal Investigator)
10/02/26 → 9/02/28
Project: Research
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Neutrophil S100 proteins synergistically fuel a hyperinflammatory platelet subset driving immunothrombosis
Slater, A. (Co-Investigator) & Rayes, J. (Principal Investigator)
5/01/26 → 4/01/29
Project: Research
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Organ specific mechanisms of Vaso-Occlusive Crisis and organ damage in Sickle Cell Disease using intravital microscopy and microfluidic flow assays
Rayes, J. (Principal Investigator)
1/12/25 → 31/05/29
Project: EU
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Development of a novel strategy to reduce inflammation-driven clotting in sepsis
Slater, A. (Co-Investigator) & Rayes, J. (Principal Investigator)
Sepsis Research (FEAT), The Stoneygate Trust, ROSETREES TRUST
1/06/25 → 31/05/26
Project: Research
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Mapping platelet heterogenous response to the alarmin S100A8/A9 using correlative super resolution microscopy
Herten, D. (Co-Investigator), Thomas, S. (Co-Investigator), Rayes, J. (Principal Investigator) & Herten, D. (Co-Investigator)
5/03/25 → 4/03/28
Project: Research