Research output per year
Research output per year
Personal profile
Research interests
The goal of my research is to understand how mitochondrial dysfunction impacts on eye disease and whether it can be targeted for therapy. Irreversible mitochondrial dysfunction involves a major event in many ocular disorders, including diabetic retinopathy, optic neuropathies, inflammatory and aging-related disorders. The accumulation of dysfunctional mitochondria may pose a severe risk for vision, since 1) damaged mitochondria do not produce energy efficiently and disrupts the power system of the retina and 2) they are a source of toxic waste, which may origin retinal disease. In the healthy retina, this problem is prevented by tight Mitochondrial Quality Control (MQC), where faulty mitochondria are simply removed and replaced by newly-synthetized functional units. Using appropriate disease models, my research pursues to determine how MQC becomes dysregulated in ocular disease and its contribution to neurovascular degeneration. My main goal focuses in applying this knowledge to develop novel interventional strategies for eye therapy.
We are recruiting a Postdoctoral Research Fellow and a Research Technician to join our team. If you are interested, please visit:
PDRA: https://bham.taleo.net/careersection/external/jobdetail.ftl?job=2200004Y&tz=GMT%2B00%3A00&tzname=Europe%2FLondon
Research technician: https://bham.taleo.net/careersection/external/jobdetail.ftl?job=2200004Z&tz=GMT%2B00%3A00&tzname=Europe%2FLondon
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Q Science (General)
- Mitochondria
- autophagy
- retinal degeneration
- Ageing
- Inflammation
- drug discovery
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Collaborations and top research areas from the last five years
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Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenosine confers neuroprotection regardless of glycaemic status
Anderson, A., Alfahad, N., Wimalachandra, D., Bouzinab, K., Rudzinska, P., Wood, H., Fazey, I., Xu, H., Lyons, T. J., Barnes, N. M., Narendran, P., Lord, J. M., Rauz, S., Ganley, I. G., Curtis, T. M., Wallace, G. R. & Hombrebueno, J. R., 6 Feb 2024, In: Nature Communications. 15, 1, 16 p., 1124.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Editorial: Understanding retinal remodeling: Retinal alterations and therapeutic implications
García-Ayuso, D., Esquiva, G. & Hombrebueno, J. R., 5 Apr 2023, In: Frontiers in Neuroanatomy. 17, 2 p., 1191906.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile -
Peripheral Blood Mononuclear Cells from Patients with Type 1 Diabetes and Diabetic Retinopathy Produce Higher Levels of IL-17A, IL-10 and IL-6 and Lower Levels of IFN-γ-A Pilot Study
Obasanmi, G., Lois, N., Armstrong, D., Hombrebueno, J. R., Lynch, A., Chen, M. & Xu, H., 31 Jan 2023, In: Cells. 12, 3, 17 p., 467.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats
O'Hare, M., Esquiva, G., McGahon, M. K., Hombrebueno, J. R., Augustine, J., Canning, P., Edgar, K. S., Barabas, P., Friedel, T., Cincolà, P., Mayne, K., Ferrin, H., Stitt , A. W., Lyons, T. J., Brazil, D. P., Grieve, D. J., McGeown, J. G., Curtis, T. M. & Henry, J., 22 Sept 2022, In: JCI Insight. 7, 18, 19 p., e155128.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
ECSIT is a critical limiting factor for cardiac function
Xu, L., Humphries, F., Delagic, N., Wang, B., Holland, A., Edgar, K. S., Hombrebueno, J. R., Stolz, D. B., Oleszycka, E., Rodgers, A. M., Glezeva, N., McDonald, K., Ledwidge, M. T., Ingram, R. J., Grieve, D. J., Moynagh, P. N. & Watson, C. J., 22 Jun 2021, In: JCI Insight. 6, 12, 19 p., e142801.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Developing mitochondrial-targeted therapies for the multisystem management of diabetic eye disease
Rauz, S. (Co-Investigator), Romero, J. (Principal Investigator), Barnes, N. (Co-Investigator) & Wallace, G. (Co-Investigator)
1/09/24 → 31/08/27
Project: Research
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Impact of Oral Disulfiram on Aldehyde Dehydrogenase (ALDH) Mediated Ocular Fibrosis in Mucous Membrane Pemphigoid [OcMMP]
Barton, D. (Co-Investigator), Fletcher, P. (Co-Investigator), Rauz, S. (Principal Investigator), Low, L. (Co-Investigator), Romero, J. (Co-Investigator), Barnes, N. (Co-Investigator) & Wallace, G. (Co-Investigator)
1/10/23 → 31/05/26
Project: Research Councils
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Towards the trialling of geroprotective agents to improve dynamic resilience in clinical populations: Closing fundamental knowledge gaps
Duggal, N. (Co-Investigator), Romero, J. (Co-Investigator), Jackson, T. (Principal Investigator), Acharjee, A. (Co-Investigator), Lourenco Rocha De Magalhaes, J. P. (Researcher), Mazaheri, A. (Co-Investigator), Pinkney, T. (Co-Investigator), Jones, S. (Co-Investigator), McGettrick, H. (Co-Investigator), Lord, J. (Co-Investigator), Wilson, D. (Co-Investigator) & Naylor, A. (Researcher)
7/09/23 → 6/09/26
Project: Research
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Sustained Delivery of Anti-fibrotic Agents for Ocular Mucous Membrane Pemphigoid
Romero, J. (Co-Investigator), Grover, L. (Co-Investigator), Barnes, N. (Co-Investigator) & Rauz, S. (Principal Investigator)
1/04/23 → 31/01/26
Project: Research
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NIHR BRC Theme - Sarcopenia
Greig, C. (Co-Investigator), Hardy, R. (Co-Investigator), Mauro, C. (Researcher), Gkoutos, G. (Co-Investigator), Romero, J. (Researcher), Fenton, S. (Researcher), Jackson, T. (Researcher), Nirantharakumar, K. (Co-Investigator), Lai, Y.-C. (Researcher), Duggal, N. (Researcher), Rowe, A. (Co-Investigator), Sinclair, A. (Co-Investigator), Jones, S. (Principal Investigator), Breen, L. (Co-Investigator) & Lord, J. (Co-Investigator)
1/12/22 → 30/11/27
Project: Other Government Departments