Jose Romero

Dr.

Accepting PhD Students

20102022

Research activity per year

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Research interests

The goal of my research is to understand how mitochondrial dysfunction impacts on eye disease and whether it can be targeted for therapy. Irreversible mitochondrial dysfunction involves a major event in many ocular disorders, including diabetic retinopathy, optic neuropathies, inflammatory and aging-related disorders. The accumulation of dysfunctional mitochondria may pose a severe risk for vision, since 1) damaged mitochondria do not produce energy efficiently and disrupts the power system of the retina and 2) they are a source of toxic waste, which may origin retinal disease. In the healthy retina, this problem is prevented by tight Mitochondrial Quality Control (MQC), where faulty mitochondria are simply removed and replaced by newly-synthetized functional units. Using appropriate disease models, my research pursues to determine how MQC becomes dysregulated in ocular disease and its contribution to neurovascular degeneration. My main goal focuses in applying this knowledge to develop novel interventional strategies for eye therapy.

 

We are recruiting a Postdoctoral Research Fellow and a Research Technician to join our team. If you are interested, please visit:

PDRA: https://bham.taleo.net/careersection/external/jobdetail.ftl?job=2200004Y&tz=GMT%2B00%3A00&tzname=Europe%2FLondon

Research technician: https://bham.taleo.net/careersection/external/jobdetail.ftl?job=2200004Z&tz=GMT%2B00%3A00&tzname=Europe%2FLondon

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 14 - Life Below Water

Keywords

  • Q Science (General)
  • Mitochondria
  • autophagy
  • retinal degeneration
  • Ageing
  • Inflammation
  • drug discovery

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