John O'Neil

Research output

Research output per year 2004 2008 2010 2017 2021 2023

• 15 Article

Research output per year

Research output per year

Search results

• 2023

  Fibroblasts Derived From Vestibular Schwannoma Express Protumorogenic Markers

  Baruah, P., Marshall, J., Jones, P. N., Major, T., Pucino, V., O'Neil, J. D., Nefla, M., McGettrick, H., Monksfield, P., Irving, R. & Buckley, C. D., 15 Sept 2023, (E-pub ahead of print) In: Otology & Neurotology.

  Research output: Contribution to journal › Article › peer-review

  • Acoustic Neuroma 100%
  • Fibroblasts 61%
  • Reverse Transcription 24%
  • Polymerase Chain Reaction 16%
  • Galectins 15%
• 2021

  Evaluation of full-length nanopore 16S sequencing for detection of pathogens in microbial keratitis

  West Midlands Collaborative Ophthalmology Network for Clinical Effectiveness & Research by Trainees (WM CONCERT) & Rauz, S., 15 Feb 2021, In: PeerJ. 9, 24 p., e10778.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nanopore Sequencing 100%
  • nanopores 89%
  • keratitis 84%
  • microbial detection 75%
  • Keratitis 69%
  182 Downloads (Pure)

• Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48

  Clayton, S. A., Daley, K. K., Macdonald, L., Fernandez-vizarra, E., Bottegoni, G., O’Neil, J. D., Major, T., Griffin, D., Zhuang, Q., Adewoye, A. B., Woolcock, K., Jones, S. W., Goodyear, C., Elmesmari, A., Filer, A., Tennant, D. A., Alivernini, S., Buckley, C. D., Pitceathly, R. D. S., Kurowska-stolarska, M., & 1 othersClark, A. R., 8 Dec 2021, In: Science Advances. 7, 50, eabl5182.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Electron Transport Complex IV 100%
  • Macrophages 59%
  • Inflammation 50%
  • Genes 34%
  • Coronavirus 26%
  124 Downloads (Pure)
• 2018

  MAPK p38 regulates inflammatory gene expression via tristetraprolin: Doing good by stealth

  O'Neil, J. D., Ammit, A. J. & Clark, A. R., Jan 2018, In: The International Journal of Biochemistry & Cell Biology. 94, p. 6-9 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • p38 Mitogen-Activated Protein Kinases 62%
  • Gene Expression 36%
  • MAP Kinase Kinase 2 19%
  • MAP Kinase Kinase Kinases 16%
  23 Citations (Scopus)

  168 Downloads (Pure)
• 2017

  Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro, yet has overwhelmingly anti-inflammatory consequences in vivo.

  O'Neil, J., Ross, E., Ridley, M., Rosner, D., Crowley, T., Smallie, T., Buckley, C. & Clark, A., Jun 2017, In: Molecular and Cellular Biology. 37, 11, e00536-16.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Gain of Function Mutation 80%
  • Anti-Inflammatory Agents 44%
  • Macrophages 42%
  • Interleukin-10 31%
  6 Citations (Scopus)

  183 Downloads (Pure)

• The RNA-binding protein Tristetraprolin (TTP) is a critical negative regulator of the NLRP3 inflammasome

  Haneklaus, M., O'Neil, J. D., Clark, A. R., Masters, S. L. & O'Neill, L. A. J., 28 Apr 2017, In: Journal of Biological Chemistry. 292, 17, p. 6869-6881 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Inflammasomes 73%
  • RNA-Binding Proteins 70%
  • Interleukin-1 48%
  • Cleavage 41%
  28 Citations (Scopus)

  171 Downloads (Pure)

• Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression

  Ross, E., Naylor, A., O'Neil, J., Crowley, T., Ridley, M., Crowe, J., Smallie, T., Tang, J. T., Turner, J., Norling, L. V., Dominguez, S., Perlman, H., Verrills, N. M., Kollias, G., Vitek, M. P., Filer, A., Buckley, C., Dean, J. L. & Clark, A., Mar 2017, In: Annals of the Rheumatic Diseases. 76, 3, p. 612-619

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Arthritis 53%
  • Gene Expression 36%
  • Antiinflammatory 29%
  • Dephosphorylation 25%
  43 Citations (Scopus)

  170 Downloads (Pure)
• 2015

  Dominant suppression of inflammation via targeted mutation of the mRNA destabilizing protein tristetraprolin

  Ross, E. A., Smallie, T., Ding, Q., O'neil, J. D., Cunliffe, H. E., Tang, T., Rosner, D. R., Klevernic, I., Morrice, N. A., Monaco, C., Cunningham, A. F., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 265-276

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tristetraprolin 100%
  • Inflammation 35%
  • Messenger RNA 34%
  • Mutation 34%
  • Salmonella typhimurium 14%
  49 Citations (Scopus)

  181 Downloads (Pure)
• 2010

  Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors.

  Owen, TJ., O'Neil, J., Dawson, C., Hu, C., Chen, X., Yao, Y., Wood, VH., Mitchell, LE., White, RJ., Young, L. & Arrand, J., 1 Jan 2010, In: Molecular Cancer. 9, p. 241 1 p.

  Research output: Contribution to journal › Article

  Open Access

  • EBV-encoded nuclear antigen 1 100%
  • RNA Polymerase III 90%
  • Human Herpesvirus 4 65%
  • Transcription Factors 49%
  • RNA 45%
  16 Citations (Scopus)

• Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappa B pathway in carcinoma cells by inhibiting IKK phosphorylation

  Valentine, R., Dawson, C., Hu, C., Shah, K., Owen, T., Date, K., Maia, S., Arrand, J., Young, L., O'Neil, J. & Shao, J., 1 Jan 2010, In: Molecular Cancer. 9, p. 1 1 p.

  Research output: Contribution to journal › Article

  Open Access

  • Nasopharyngeal Carcinoma 100%
  • NF-kappa B 93%
  • Human Herpesvirus 4 87%
  • Transcription Factor RelA 73%
  • Phosphorylation 60%
  52 Citations (Scopus)
• 2009

  The EBV-encoded latent membrane proteins, LMP2A and LMP2B, limit the actions of interferon by targeting interferon receptors for degradation

  Shah, K., Stewart, SE., Wei, W., Woodman, C., O'Neil, J., Dawson, C. & Young, L., 5 Nov 2009, In: Oncogene. 28, 44, p. 3903-14 12 p.

  Research output: Contribution to journal › Article

  • Interferon Receptors 100%
  • type II interferon receptor 63%
  • Human Herpesvirus 4 62%
  • Interferons 58%
  • Membrane Proteins 52%
  60 Citations (Scopus)
• 2008

  Epstein-Barr virus-encoded EBNA1 modulates the AP-1 transcription factor pathway in nasopharyngeal carcinoma cells and enhances angiogenesis in vitro.

  O'Neil, J., Owen, TJ., Wood, VH., Date, KL., Valentine, R., Chukwuma, MB., Arrand, J., Dawson, C. & Young, LS., 1 Nov 2008, In: Journal of General Virology. 89, Pt 11, p. 2833-42 10 p.

  Research output: Contribution to journal › Article

  • Nasopharyngeal Carcinoma 100%
  • Transcription Factor AP-1 97%
  • Human Herpesvirus 4 87%
  • In Vitro Techniques 38%
  • Vascular Endothelial Growth Factor A 30%
  83 Citations (Scopus)

• Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes.

  Morris, M., Dawson, C., Wei, W., O'Neil, J., Stewart, SE., Jia, J., Bell, A., Young, L. & Arrand, J., 1 Nov 2008, In: Journal of General Virology. 89, Pt 11, p. 2806-20 15 p.

  Research output: Contribution to journal › Article

  • Epstein-Barr virus EBV-associated membrane antigen 100%
  • Keratinocytes 63%
  • Membrane Proteins 54%
  • Gene Expression 39%
  • Cell Movement 23%
  30 Citations (Scopus)
• 2007

  Epstein-Barr virus-encoded EBNA1 regulates cellular gene transcription and modulates the STAT1 and TGFβ signaling pathways

  Wood, V., O'Neil, J., Wei, W., Stewart, S., Dawson, C. & Young, L., 7 May 2007, In: Oncogene. 26, p. 4135-4147 13 p.

  Research output: Contribution to journal › Article

  • Human Herpesvirus 4 100%
  • Genes 40%
  • Proteins 37%
  • Carcinoma 33%
  • Oncogenic Viruses 32%
  85 Citations (Scopus)
• 2004

  Expression of the cellular FLICE inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death

  Dutton, A., O'Neil, J., Milner, A., Reynolds, G., Starczynski, J., Crocker, J., Young, L. & Murray, P., 19 Apr 2004, In: National Academy of Sciences. Proceedings. 101, p. 6611-6616 6 p.

  Research output: Contribution to journal › Article

  • CASP8 and FADD-Like Apoptosis Regulating Protein 100%
  • Hodgkin Disease 87%
  • Fas Ligand Protein 64%
  • Enzymes 46%
  • Reed-Sternberg Cells 45%
  102 Citations (Scopus)