Personal profile
Research interests
John Colbourne’s investigations encompass the fields of evolutionary ecology, high-throughput biology, environmental and functional genomics. From this blend of disciplines emerges a research program that centers on connecting gene expression and genome structure with individual fitness and population-level responses to environmental challenges.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 11 Sustainable Cities and Communities -
SDG 12 Responsible Consumption and Production -
SDG 13 Climate Action -
SDG 15 Life on Land
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Collaborations and top research areas from the last five years
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An Alternative Safety Profiling Algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process
Leist, M., Tangianu, S., Affourtit, F., Braakhuis, H., Colbourne, J., Cöllen, E., Dreser, N., Escher, S. E., Gardner, I., Hahn, S., Hardy, B., Herzler, M., Islam, B., Kamp, H., Magel, V., Marx-Stoelting, P., Moné, M. J., Lundquist, P., Ottenbros, I. & Ouedraogo, G. & 6 others, , 13 Jan 2026, In: Altex. 43, 1, p. 158-175 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Downloads (Pure) -
Conserved Molecular Responses to Arsenite Exposure in Drosophila melanogaster
Smoot, S. R., Tourigny, J., Holsopple-Bowen, J. M., Fitt, A. J., Pena-Garcia, Y., Lowe, M. R., Rose, D. A., Zolman, N. C., Thrasher, G. H., Arya, S. S., Vires, H. B., Adams, E. C., Colbourne, J. K., Shaw, J. R., Oliver, B., Nemkov, T., D'Alessandro, A., Kaufman, T. C. & Tennessen, J. M., 10 Feb 2026, bioRxiv.Research output: Working paper/Preprint › Preprint
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Network-Based Assessment of Environmental Neurotoxicants Using High-Throughput Transcriptomics in Zebrafish Embryos
Xia, P., Wang, P., Liu, S., Peng, Y., Gou, X., Tan, H., Guo, J., Shi, W., Colbourne, J. K., Giesy, J. P. & Zhang, X., 24 Mar 2026, In: Environmental Science and Technology. 60, 11, p. 8326–8338 13 p.Research output: Contribution to journal › Article › peer-review
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Alternative Vertebrate and Invertebrate Model Organisms Show Similar Sensitivity as Rodents to a Diverse Set of Chemicals
Hayot, G., Lloyd, G. R., Diwan, G. D., Keith, N., Smoot, S. R., Cramer von Clausbruch, C. A., Kaufman, T. C., Barnard, M., Tindall, A. J., Glaholt, S. P., Massei, R., Martínez, R., Strähle, U., Orsini, L., Russell, R. B., Tennessen, J. M., Scholz, S., Shaw, J. R., Freedman, J. H. & Colbourne, J. K. & 2 others, , 24 Nov 2025, (E-pub ahead of print) In: Environmental Science and Technology. 15 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Downloads (Pure) -
Animal-free Safety Assessment of Chemicals: Project Cluster for Implementation of Novel Strategies (ASPIS) definition of new approach methodologies
Colbourne, J. K., Escher, S. E., Lee, R. R., Vinken, M., Van de Water, B. & Freedman, J. H., Sept 2025, In: Environmental Toxicology and Chemistry. 44, 9, p. 2395-2397 3 p., vgae093.Research output: Contribution to journal › Article
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PrecisionTox: New Approach Methodologies for Chemical Safety
Viant, M. (Researcher), Lee, R. (Co-Investigator), Roberts, R. (Researcher), Orsini, L. (Co-Investigator), Müller, F. (Co-Investigator), Zhou, J. (Co-Investigator), Colbourne, J. (Principal Investigator), Weber, R. (Co-Investigator), Cavoski, A. (Co-Investigator) & Beggs, A. (Researcher)
1/02/21 → 31/07/26
Project: EU
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Enhancing multi-omic single cell sequencing to resolve fundamental biological mechanisms in humans and non-human organisms
Müller, F. (Co-Investigator), Colbourne, J. (Co-Investigator), Bonifer, C. (Co-Investigator) & Beggs, A. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/08/22 → 31/07/23
Project: Research Councils
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Fellowship in Computational Toxicology with the Food Standards Agency
Viant, M. (Principal Investigator), Cazier, J.-B. (Co-Investigator), Zhou, J. (Researcher), Colbourne, J. (Researcher) & Weber, R. (Researcher)
2/08/21 → 31/01/26
Project: Other Government Departments
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MultiOmicsTox - Multi-view learning and quantitative genetics to identify the molecular basis of adaptation to chemical pollutants
Colbourne, J. (Principal Investigator)
1/05/21 → 30/04/23
Project: EU
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Genetic Factors that Influence Arsenic Toxicity
Viant, M. (Principal Investigator), Colbourne, J. (Co-Investigator) & Valsami-Jones, E. (Co-Investigator)
NATIONAL INSTITUTE OF HEALTH, USA
1/02/19 → 31/01/24
Project: Research
Prizes
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Probing the metabolic response of induced diapause in the crustacean Daphnia
Orsini, L. (Recipient) & Colbourne, J. (Recipient), 2016
Prize: Fellowship awarded competitively