Jason Parsons

2024

Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia

Hill, R. M., Li, C., Hughes, J. R., Rocha, S., Grundy, G. J. & Parsons, J. L., 20 Jun 2024, In: Journal of Cellular and Molecular Medicine. 28, 12, 11 p., e18482.

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Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation

Fabbrizi, M. R., Doggett, T. J., Hughes, J. R., Melia, E., Dufficy, E. R., Hill, R. M., Goula, A., Phoenix, B. & Parsons, J. L., 12 Jun 2024, In: Cell Death Discovery. 10, 1, 10 p., 282.

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KH-like Domains in PARP9/DTX3L and PARP14 Coordinate Protein–Protein Interactions to Promote Cancer Cell Survival

Saleh, H., Liloglou, T., Rigden, D. J., Parsons, J. L. & Grundy, G. J., 15 Feb 2024, In: Journal of Molecular Biology. 436, 4, 168434.

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Myoferlin: a potential marker of response to radiotherapy and survival in locally advanced rectal cancer

Fowler, H., Clifford, R. E., Bowden, D., Sutton, P. A., Govindarajah, N., Fok, M., Glenn, M., Wall, M., Rubbi, C., Buczacki, S. J., Mandal, A., Francies, H., Parsons, J. L. & Vimalachandran, D., 10 Jun 2024, (E-pub ahead of print) In: International Journal of Radiation: Oncology - Biology - Physics .

Research output: Contribution to journal › Article › peer-review

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Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

Fabbrizi, M. R., Nickson, C. M., Hughes, J. R., Robinson, E. A., Vaidya, K., Rubbi, C. P., Kacperek, A., Bryant, H. E., Helleday, T. & Parsons, J. L., 17 Feb 2024, In: Cell Death and Disease. 15, 2, 11 p., 150.

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The Potential for Targeting G₂/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy

Melia, E. & Parsons, J. L., 29 Aug 2024, In: Cancers. 16, 17, 3016.

Research output: Contribution to journal › Review article › peer-review

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2023

DNA damage and repair dependencies of ionising radiation modalities

Melia, E. & Parsons, J. L., Oct 2023, In: Bioscience Reports. 43, 10, 15 p., BSR20222586.

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Most DNA repair defects do not modify the relationship between relative biological effectiveness and linear energy transfer in CRISPR‐edited cells

Guerra Liberal, F. D. C., Parsons, J. L. & McMahon, S. J., 27 Sept 2023, (E-pub ahead of print) In: Medical Physics.

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The Cellular Response to Complex DNA Damage Induced by Ionising Radiation

Wilkinson, B., Hill, M. A. & Parsons, J. L., 3 Mar 2023, In: International Journal of Molecular Sciences. 24, 5, 15 p., 4920.

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The role of autophagy in hypoxia-induced radioresistance

Hill, R. M., Fok, M., Grundy, G., Parsons, J. L. & Rocha, S., Dec 2023, In: Radiotherapy & Oncology. 189, 8 p., 109951.

Research output: Contribution to journal › Review article › peer-review

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2022

ATM regulates differentiation of myofibroblastic cancer-associated fibroblasts and can be targeted to overcome immunotherapy resistance

Mellone, M., Piotrowska, K., Venturi, G., James, L., Bzura, A., Lopez, M. A., James, S., Wang, C., Ellis, M. J., Hanley, C. J., Buckingham, J. F., Cox, K. L., Hughes, G., Valge-Archer, V., King, E. V., Beers, S. A., Jaquet, V., Jones, G. D. D., Savelyeva, N. & Sayan, E. & 3 others, Parsons, J. L., Durant, S. & Thomas, G. J., 16 Dec 2022, In: Cancer Research. 82, 24, p. 4571-4585 15 p.

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Cell death mechanisms in head and neck cancer cells in response to low and high-LET radiation

Fabbrizi, M. R. & Parsons, J. L., 12 Jan 2022, In: Expert Reviews in Molecular Medicine. 24, 11 p., e2.

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Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma

Zhou, C., Fabbrizi, M. R., Hughes, J. R., Grundy, G. J. & Parsons, J. L., 16 Aug 2022, In: Frontiers in Oncology. 12, 15 p., 940377.

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Factors affecting the radiation response in glioblastoma

Aiyappa-Maudsley, R., Chalmers, A. J. & Parsons, J. L., 25 Sept 2022, In: Neuro-oncology advances. 4, 1, 10 p., vdac156.

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Histone deacetylases and their potential as targets to enhance tumour radiosensitisation

Antrobus, J. & Parsons, J., 18 Mar 2022, In: Radiation. 2, 1, p. 149-167 19 p.

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Overcoming the impact of hypoxia in driving radiotherapy resistance in head and neck squamous cell carcinoma

Hill, R. M., Rocha, S. & Parsons, J. L., 26 Aug 2022, In: Cancers. 14, 17, 20 p., 4130.

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TRIM26 maintains cell survival in response to oxidative stress through regulating DNA glycosylase stability

Konis, S. M. R., Hughes, J. R. & Parsons, J. L., 1 Oct 2022, In: International Journal of Molecular Sciences. 23, 19, 14 p., 11613.

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2021

The enzyme-modified neutral comet (EMNC) assay for complex DNA damage detection

Fabbrizi, M. R., Hughes, J. R. & Parsons, J. L., 16 Feb 2021, In: Methods and Protocols. 4, 1, 12 p., 14.

Research output: Contribution to journal › Article › peer-review

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USP9X Inhibition Enhances Radiosensitisation of Head and Neck Cancer Cells in Response to High-LET Radiation by Destabilising Centrosome Proteins

Fabbrizi, M. R., Nickson, C. M., Carter, R. J., Hughes, J. R., Kacperek, A., Hill, M. A. & Parsons, J. L., 29 Jan 2021, In: Medical Sciences Forum. 3, 1, p. 1 2.

Research output: Contribution to journal › Abstract › peer-review

Open Access

USP9X is required to maintain cell survival in response to high-LET radiation

Nickson, C. M., Fabbrizi, M. R., Carter, R. J., Hughes, J. R., Kacperek, A., Hill, M. A. & Parsons, J. L., 1 Jul 2021, In: Frontiers in Oncology. 11, 12 p., 671431.

Research output: Contribution to journal › Article › peer-review

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2020

Base excision repair and its implications to cancer therapy

Grundy, G. & Parsons, J., 26 Oct 2020, In: Essays in Biochemistry.

Research output: Contribution to journal › Article › peer-review

Base Excision Repair in Chromatin and the Requirement for Chromatin Remodelling

Madders, E. C. E. T. & Parsons, J. L., 2020, In: Advances in Experimental Medicine and Biology. 1241, p. 59-75 17 p.

Research output: Contribution to journal › Review article › peer-review

FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy

Hughes, J. R. & Parsons, J. L., 5 Sept 2020, In: International Journal of Molecular Sciences.

Research output: Contribution to journal › Article › peer-review

HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling

Bennett, L., Madders, E. C. E. T. & Parsons, J. L., 20 Feb 2020, In: Nucleic Acids Research. 48, 3, p. 1301-1313 13 p.

Research output: Contribution to journal › Article › peer-review

Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons

Hussain, R. N., Coupland, S. E., Khzouz, J., Kalirai, H. & Parsons, J. L., 28 May 2020, In: Cancers. 12, 6

Research output: Contribution to journal › Article › peer-review

microRNA-184 is induced by store-operated calcium entry and regulates early keratinocyte differentiation

Richardson, A., Powell, A. K., Sexton, D. W., Parsons, J. L., Reynolds, N. J. & Ross, K., Oct 2020, In: Journal of Cellular Physiology. 235, 10, p. 6854-6861 8 p.

Research output: Contribution to journal › Article › peer-review

Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment

Fabbrizi, M. R. & Parsons, J. L., 2020, In: Cancer drug resistance (Alhambra, Calif.). 3, 4, p. 775-790 16 p.

Research output: Contribution to journal › Review article › peer-review

Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer

Clifford, R. E., Govindarajah, N., Bowden, D., Sutton, P., Glenn, M., Darvish-Damavandi, M., Buczacki, S., McDermott, U., Szulc, Z., Ogretmen, B., Parsons, J. L. & Vimalachandran, D., 15 Dec 2020, In: Cells. 9, 12

Research output: Contribution to journal › Article › peer-review

Targeting DNA Double-Strand Break Repair Enhances Radiosensitivity of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma to Photons and Protons

Vitti, E. T., Kacperek, A. & Parsons, J. L., 7 Jun 2020, In: Cancers. 12, 6

Research output: Contribution to journal › Article › peer-review

The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response

Hughes, J. R. & Parsons, J. L., 2020, In: Frontiers in cell and developmental biology. 8, p. 607060

Research output: Contribution to journal › Article › peer-review

The radiobiology of HPV-positive and HPV-negative head and neck squamous cell carcinoma

Zhou, C. & Parsons, J. L., 2 Jul 2020, In: Expert Reviews in Molecular Medicine. 22, p. e3

Research output: Contribution to journal › Review article › peer-review

2019

Characterisation of Deubiquitylating Enzymes in the Cellular Response to High-LET Ionizing Radiation and Complex DNA Damage

Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A. & Parsons, J. L., 1 Jul 2019, In: International Journal of Radiation: Oncology - Biology - Physics . 104, 3, p. 656-665 10 p.

Research output: Contribution to journal › Article › peer-review

Sphingolipids and acid ceramidase as therapeutic targets in cancer therapy

Govindarajah, N., Clifford, R., Bowden, D., Sutton, P. A., Parsons, J. L. & Vimalachandran, D., Jun 2019, In: Critical Reviews in Oncology/Hematology. 138, p. 104-111 8 p.

Research output: Contribution to journal › Review article › peer-review

The Biochemical Role of the Human NEIL1 and NEIL3 DNA Glycosylases on Model DNA Replication Forks

Albelazi, M. S., Martin, P. R., Mohammed, S., Mutti, L., Parsons, J. L. & Elder, R. H., 23 Apr 2019, In: Genes. 10, 4

Research output: Contribution to journal › Article › peer-review

The Radiobiological Effects of Proton Beam Therapy: Impact on DNA Damage and Repair

Vitti, E. T. & Parsons, J. L., 5 Jul 2019, In: Cancers. 11, 7

Research output: Contribution to journal › Review article › peer-review

2018

Complex DNA Damage Induced by High Linear Energy Transfer Alpha-Particles and Protons Triggers a Specific Cellular DNA Damage Response

Carter, R. J., Nickson, C. M., Thompson, J. M., Kacperek, A., Hill, M. A. & Parsons, J. L., 1 Mar 2018, In: International Journal of Radiation: Oncology - Biology - Physics . 100, 3, p. 776-784 9 p.

Research output: Contribution to journal › Article › peer-review

NTH1 Is a New Target for Ubiquitylation-Dependent Regulation by TRIM26 Required for the Cellular Response to Oxidative Stress

Williams, S. C. & Parsons, J. L., 15 Jun 2018, In: Molecular and Cellular Biology. 38, 12

Research output: Contribution to journal › Article › peer-review

Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response

Bowden, D. L., Sutton, P. A., Wall, M. A., Jithesh, P. V., Jenkins, R. E., Palmer, D. H., Goldring, C. E., Parsons, J. L., Park, B. K., Kitteringham, N. R. & Vimalachandran, D., 15 May 2018, In: Journal of Proteomics. 179, p. 53-60 8 p.

Research output: Contribution to journal › Article › peer-review

Systematic review of treatment intensification using novel agents for chemoradiotherapy in rectal cancer

Clifford, R., Govindarajah, N., Parsons, J. L., Gollins, S., West, N. P. & Vimalachandran, D., Nov 2018, In: British Journal of Surgery. 105, 12, p. 1553-1572 20 p.

Research output: Contribution to journal › Article › peer-review

2017

Misregulation of DNA damage repair pathways in HPV-positive head and neck squamous cell carcinoma contributes to cellular radiosensitivity

Nickson, C. M., Moori, P., Carter, R. J., Rubbi, C. P. & Parsons, J. L., 2 May 2017, In: OncoTarget. 8, 18, p. 29963-29975 13 p.

Research output: Contribution to journal › Article › peer-review

The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Martin, P. R., Couvé, S., Zutterling, C., Albelazi, M. S., Groisman, R., Matkarimov, B. T., Parsons, J. L., Elder, R. H. & Saparbaev, M. K., 12 Dec 2017, In: Scientific Reports. 7, 1, p. 17438

Research output: Contribution to journal › Article › peer-review

Ubiquitylation-dependent regulation of NEIL1 by Mule and TRIM26 is required for the cellular DNA damage response

Edmonds, M. J., Carter, R. J., Nickson, C. M., Williams, S. C. & Parsons, J. L., 25 Jan 2017, In: Nucleic Acids Research. 45, 2, p. 726-738 13 p.

Research output: Contribution to journal › Article › peer-review

2016

Base Excision Repair, a Pathway Regulated by Posttranslational Modifications

Carter, R. J. & Parsons, J. L., 15 May 2016, In: Molecular and Cellular Biology. 36, 10, p. 1426-37 12 p.

Research output: Contribution to journal › Review article › peer-review

2014

2013

Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer

Parsons, J. L., Nicolay, N. H. & Sharma, R. A., 10 Mar 2013, In: Antioxidants & Redox Signaling. 18, 8, p. 851-73 23 p.

Research output: Contribution to journal › Review article › peer-review

Co-ordination of base excision repair and genome stability

Parsons, J. L. & Dianov, G. L., 1 May 2013, In: Mutation Research. 12, 5, p. 326-33 8 p.

Research output: Contribution to journal › Review article › peer-review

2012

ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage

Khoronenkova, S. V., Dianova, I. I., Ternette, N., Kessler, B. M., Parsons, J. L. & Dianov, G. L., 30 Mar 2012, In: Molecular Cell. 45, 6, p. 801-13 13 p.

Research output: Contribution to journal › Article › peer-review

In vitro base excision repair using mammalian cell extracts

Parsons, J. L. & Dianov, G. L., 2012, In: Methods in molecular biology (Clifton, N.J.). 920, p. 245-62 18 p.

Research output: Contribution to journal › Article › peer-review

Jason Parsons

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