Jackson Kirkman-Brown

Accepting PhD Students

PhD projects

Jackson Kirkman-Brown and the ChRS team carry out internationally leading sperm and fertility-related research and welcome doctoral research applications in the following areas: Improving sperm selection as a method of improving reproductive outcomes - including the role of sperm in miscarriage events. Clinical trials related to sperm diagnostics and selection. How the human sperm interacts with the female reproductive tract, alongside research into how tract may respond to sperm presence. Fluid dynamics in the female reproductive tract and its diagnostic and therapeutic use, alongside Meurig Gallagher and David Smith. This involves various advanced imaging modalities available through our ongoing collaboration with Cairn Research and our FAST software.

Research activity per year

63 Article
6 Review article
5 Abstract
2 Paper
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1 - 50 out of 84 results

2024
Gym lifestyle factors and male reproductive health: a study into young adult usage and perceptions
Newman-Sanders, A., Kirkman-Brown, J. & Gallagher, M. T., Jan 2024, In: Reproductive BioMedicine Online. 48, 1, 103623.
Research output: Contribution to journal › Article › peer-review

Open Access
File
58 Downloads (Pure)
2023
Axonemal regulation by curvature explains sperm flagellar waveform modulation
Gallagher, M. T., Kirkman-Brown, J. & Smith, D., 9 Mar 2023, In: PNAS nexus. 2, 3, pgad072.
Research output: Contribution to journal › Article › peer-review

Open Access
File
54 Downloads (Pure)
Only the Best of the Bunch: Sperm Preparation Is Not Just about Numbers
Gallagher, M. T., Krasauskaite, I. & Kirkman-Brown, J., 19 Dec 2023, In: Seminars in Reproductive Medicine. 41, 6, p. 273-278 7 p.
Research output: Contribution to journal › Review article › peer-review
2022
Extended semen examinations in the sixth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen: contributing to the understanding of the function of the male reproductive system
Baldi, E., Gallagher, M. T., Krasnyak, S., Kirkman-Brown, J. & Editorial Board members of the World Health Organization laboratory manual for the examination and processing of human semen, 1 Mar 2022, In: Fertility and Sterility. 117, 2, p. 252-257 6 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
140 Downloads (Pure)
Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology
Björndahl, L., Barratt, C. L. R., Mortimer, D., Agarwal, A., Aitken, R. J., Alvarez, J. G., Aneck-Hahn, N., Arver, S., Baldi, E., Bassas, L., Boitrelle, F., Bornman, R., Carrell, D. T., Castilla, J. A., Cerezo parra, G., Check, J. H., Cuasnicu, P. S., Darney, S. P., De jager, C. & De jonge, C. J. & 67 others, Drevet, J. R., Drobnis, E. Z., Du plessis, S. S., Eisenberg, M. L., Esteves, S. C., Evgeni, E. A., Ferlin, A., Garrido, N., Giwercman, A., Goovaerts, I. G. F., Haugen, T. B., Henkel, R., Henningsohn, L., Hofmann, M.-C., Hotaling, J. M., Jedrzejczak, P., Jouannet, P., Jørgensen, N., Kirkman brown, J. C., Krausz, C., Kurpisz, M., Kvist, U., Lamb, D. J., Levine, H., Loveland, K. L., Mclachlan, R. I., Mahran, A., Maree, L., Martins da silva, S., Mbizvo, M. T., Meinhardt, A., Menkveld, R., Mortimer, S. T., Moskovtsev, S., Muller, C. H., Munuce, M. J., Muratori, M., Niederberger, C., O’flaherty, C., Oliva, R., Ombelet, W., Pacey, A. A., Palladino, M. A., Ramasamy, R., Ramos, L., Rives, N., Roldan, E. R., Rothmann, S., Sakkas, D., Salonia, A., Sánchez-Pozo, M. C., Sapiro, R., Schlatt, S., Schlegel, P. N., Schuppe, H.-C., Shah, R., Skakkebæk, N. E., Teerds, K., Toskin, I., Tournaye, H., Turek, P. J., Van der horst, G., Vazquez-Levin, M., Wang, C., Wetzels, A., Zeginiadou, T. & Zini, A., 16 Sept 2022, In: Human Reproduction. 2022, 6 p., deac189.
Research output: Contribution to journal › Article › peer-review

Open Access
File
76 Downloads (Pure)
Teaching design for additive manufacturing: efficacy of and engagement with lecture and laboratory approaches
Thomas-Seale, L., Kanagalingam, S., Kirkman-Brown, J., Attallah, M., Espino, D. & Shepherd, D., 8 Aug 2022, (E-pub ahead of print) In: International Journal of Technology and Design Education.
Research output: Contribution to journal › Article › peer-review

Open Access
File
250 Downloads (Pure)
The ribosome inhibitor chloramphenicol induces motility deficits in human spermatozoa: a proteomic approach identifies potentially involved proteins
Bisconti, M., Leroy, B., Gallagher, M. T., Senet, C., Martinet, B., Arcadia, V., Wattiez, R., Kirkman-Brown, J., Simon, J.-F. & Hennebert, E., 2 Sept 2022, In: Frontiers in cell and developmental biology. 10, 18 p., 965076.
Research output: Contribution to journal › Article › peer-review

Open Access
File

176 Downloads (Pure)
The sixth edition of the WHO manual on semen examination: ensuring quality and standardization in basic examination of human ejaculates
Björndahl, L., Kirkman-Brown, J. & other WHO Laboratory Manual for the Examination and Processing of Human Semen Editorial Board Members, Feb 2022, In: Fertility and Sterility. 117, 2, p. 246-251
Research output: Contribution to journal › Article › peer-review

Open Access
File
124 Downloads (Pure)
2021
Complex combined steroid mix of the female tract modulates human sperm
Taiwo, B. G., Frettsome-Hook, R. L., Taylor, A. E., Correia, J. N., Lefievre, L., Publicover, S. J., Conner, S. J. & Kirkman-Brown, J. C., Dec 2021, In: Reproductive biology. 21, 4, 100561.
Research output: Contribution to journal › Article › peer-review
Heads and tails: requirements for informative and robust computational measures of sperm motility
Cupples, G., Gallagher, M. T., Smith, D. & Kirkman-Brown, J., 23 Jul 2021, XIIIth International Symposium on Spermatology. Björndahl, L., Flanagan, J., Holmberg, R. & Kvist, U. (eds.). Springer, Cham, p. 135-150
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
2020
Doing more with less: the flagellar end piece enhances the propulsive effectiveness of spermatozoa
Neal, C., Hall-McNair, A., Kirkman-Brown, J., Smith, D. & Gallagher, M. T., 6 Jul 2020, In: Physical Review Fluids. 5, 7, 073101 .
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

298 Downloads (Pure)
'Genes versus children': if the goal is parenthood, are we using the optimal approach?
Kirkman-Brown, J., 9 Jan 2020, In: Human reproduction (Oxford, England).
Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus)
SARS-CoV-2 pandemic and repercussions for male infertility patients: a proposal for the individualized provision of andrological services
Esteves, S. C. & Kirkman-Brown, J., 1 May 2020, (E-pub ahead of print) In: Andrology.
Research output: Contribution to journal › Article › peer-review

Open Access
File
19 Citations (Scopus)

111 Downloads (Pure)
Temporal design for additive manufacturing
Saliba, S., Kirkman-Brown, J. & Thomas-Seale, L., 9 Jan 2020, (E-pub ahead of print) In: The International Journal of Advanced Manufacturing Technology. 106, 9-10, p. 3849-3857
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

331 Downloads (Pure)
2019
Male Oxidative Stress Infertility (MOSI): proposed terminology and clinical practice guidelines for management of idiopathic male infertility
Agarwal, A. & Kirkman-Brown, J., 8 May 2019, In: World Journal of Men's Health. 37, 3, p. 296-312
Research output: Contribution to journal › Review article › peer-review

Open Access
File
76 Citations (Scopus)

188 Downloads (Pure)
Physiological, hyaluronan-selected intracytoplasmic sperm injection for infertility treatment (HABSelect): a parallel, two-group, randomised trial
Pavitt, S., Sharma, V., Forbes, G., Hooper, R., Bhattacharya, S., Kirkman-Brown, J., Coomarasamy, A., Lewis, S., Cutting, R., Brison, D., Pacey, A., West, R. M., Brian, K., Griffin, D., Khalaf, Y. & Miller, D. H., 2 Feb 2019, In: The Lancet. 393, 10170, p. 416-422 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
24 Citations (Scopus)

249 Downloads (Pure)
Rapid sperm capture: High-throughput flagellar waveform analysis
Gallagher, M. T., Cupples, G., Ooi, E. H., Kirkman-Brown, J. & Smith, D., Jul 2019, In: Human Reproduction. 34, 7, p. 1173–1185
Research output: Contribution to journal › Article › peer-review

Open Access
File
17 Citations (Scopus)

254 Downloads (Pure)
Sperm selection for assisted reproduction by prior hyaluronan binding: the HABSelect RCT
Kirkman-Brown, J. & Coomarasamy, A., 1 Feb 2019, In: Efficacy and Mechanism Evaluation. 6, 1
Research output: Contribution to journal › Abstract › peer-review

Open Access
File
224 Downloads (Pure)
The analogies between human development and additive manufacture: expanding the definition of design
Thomas-Seale, L., Kirkman-Brown, J., Kanagalingam, S., Attallah, M., Espino, D. & Shepherd, D., 16 Sept 2019, In: Cogent Engineering. 6, 1, 1662631.
Research output: Contribution to journal › Article › peer-review

Open Access
File
4 Citations (Scopus)

371 Downloads (Pure)
Vitamin D and assisted reproductive treatment outcome: a prospective cohort study
Chu, J., Gallos, I., Tobias, A., Robinson, L., Kirkman-Brown, J., Dhillon-Smith, R., Harb, H., Eapen, A., Rajkhowa, M. & Coomarasamy, A., 15 Jul 2019, In: Reproductive Health. 16, 1, p. 106
Research output: Contribution to journal › Article › peer-review
2018
CASA: tracking the past and plotting the future
Gallagher, M. T., Smith, D. & Kirkman-Brown, J., 29 May 2018, In: Reproduction Fertility and Development. 30, 6, p. 867-874 8 p.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
22 Citations (Scopus)

332 Downloads (Pure)
Human sperm swimming in a high viscosity mucus analogue
Ishimoto, K., Gadelha, H., Gaffney, E., Smith, D. & Kirkman-Brown, J., 7 Jun 2018, In: Journal of Theoretical Biology. 446, p. 1-10
Research output: Contribution to journal › Article › peer-review

Open Access
File
18 Citations (Scopus)

244 Downloads (Pure)
On-Demand Electrical Switching of Antibody-Antigen Binding on Surfaces
Gomes, B., Cantini, E., Tommasone, S., Gibson, J., Wang, X., Zhu, Q., McGettrick, J., Watson, T., Preece, J., Kirkman-Brown, J., Publicover, S. & Mendes, P., 17 Sept 2018, In: ACS Applied Bio Materials. 1, 3, p. 738–747
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

207 Downloads (Pure)
The barriers to the progression of additive manufacture: perspectives from UK industry
Thomas-Seale, L., Kirkman-Brown, J., Espino, D., Attallah, M. & Shepherd, D., 1 Apr 2018, In: International Journal of Production Economics. 198, p. 104-118
Research output: Contribution to journal › Article › peer-review

Open Access
File
82 Citations (Scopus)

486 Downloads (Pure)
The future of additive manufacture: drawing innovation from spatio-temporal analysis of human development
Thomas-Seale, L., Kirkman-Brown, J., Kanagalingam, S., Attallah, M., Espino, D. & Shepherd, D., 10 Jul 2018.
Research output: Contribution to conference (unpublished) › Poster › peer-review
2017
Coarse-graining the fluid flow around a human sperm
Ishimoto, K., Gadelha, H., Gaffney, E. A., Smith, D. & Kirkman-Brown, J., 24 Mar 2017, In: Physical Review Letters. 118, 12, 5 p., 124501 .
Research output: Contribution to journal › Article › peer-review

Open Access
File
37 Citations (Scopus)

297 Downloads (Pure)
Multiscale Design for the Additive Manufacture of Medical Devices
Thomas-Seale, L., Kanagalingam, S., Shaw, D., Triantaphyllou, A., Essa, K., Kirkman-Brown, J., Attallah, M., Espino, D. & Shepherd, D., Jul 2017.
Research output: Contribution to conference (unpublished) › Poster

File
102 Downloads (Pure)
Sperm DNA fragmentation in miscarriage – a promising diagnostic, or a test too far?
Kirkman-Brown, J. & De Jonge, C., Jan 2017, In: Reproductive Bio Medicine Online. 34, 1, p. 3-4
Research output: Contribution to journal › Editorial › peer-review

Open Access
File

5 Citations (Scopus)

314 Downloads (Pure)
The steroid metabolome in the isolated ovarian follicle and its response to androgen exposure and antagonism
Lebbe, M., Taylor, A., Visser, J. A., Kirkman-Brown, J., Woodruff, T. K. & Arlt, W., May 2017, In: Endocrinology. 158, 5, p. 1474-1485
Research output: Contribution to journal › Article › peer-review

Open Access
File
18 Citations (Scopus)

212 Downloads (Pure)
2016
2016 Laboratory guidelines for postvasectomy semen analysis: Association of Biomedical Andrologists, the British Andrology Society and the British Association of Urological Surgeons
Hancock, P., Woodward, B., Muneer, A. & Kirkman-Brown, J., 15 Apr 2016, (E-pub ahead of print) In: Journal of Clinical Pathology.
Research output: Contribution to journal › Article › peer-review

Open Access
File
8 Citations (Scopus)

4470 Downloads (Pure)
Hyaluronic Acid Binding Sperm Selection for assisted reproduction treatment (HABSelect): study protocol for a multicentre randomised controlled trial
Witt, K., Beresford, L., Bhattacharya, S., Brian, K., Coomarasamy, A., Hooper, R., Kirkman-Brown, J., Khalaf, Y., Lewis, S., Pacey, A., Pavitt, S., West, R. & Miller, D., 1 Oct 2016, In: BMJ open. 6, 10, e012609.
Research output: Contribution to journal › Article › peer-review

Open Access
File
9 Citations (Scopus)

203 Downloads (Pure)
Replacing IUI with IVF for initial treatment of unexplained infertility: why this NICE recommendation is cause for concern
Kirkman-Brown, J., Woodward, B. & Tomlinson, M., 13 May 2016, (E-pub ahead of print) In: Human Fertility.
Research output: Contribution to journal › Article › peer-review

Open Access
File
6 Citations (Scopus)

323 Downloads (Pure)
2015
Evolving minimum standards in responsible international sperm donor offspring quota
Janssens, P. M. W., Thorn, P., Castilla, J. A., Frith, L., Crawshaw, M., Mochtar, M., Bjorndahl, L., Kvist, U. & Kirkman-brown, J. C., 10 Feb 2015, (E-pub ahead of print) In: Reproductive BioMedicine Online.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Citations (Scopus)

262 Downloads (Pure)
Traumatic andropause after combat injury
Jones, G. H., Kirkman-Brown, J., Sharma, D. M. & Bowley, D., 28 Aug 2015, In: BMJ case reports.
Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus)
2014

The mechanics of hyperactivation in adhered human sperm
Ooi, E. H., Smith, D., Gadelha, H., Gaffney, E. & Kirkman-Brown, J., 1 Oct 2014, In: Royal Society Open Science. 1, 140230
Research output: Contribution to journal › Article › peer-review

Open Access

12 Citations (Scopus)
2013
Blast injury to the perineum
Genitourinary Working Group (Trauma), Mar 2013, In: Journal of the Royal Army Medical Corps. 159 , Suppl 1, p. i1-3 3 p.
Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)
Ca²⁺ signalling through CatSper and Ca²⁺ stores regulate different behaviours in human sperm
Alasmari, W., Costello, S., Correia, J., Oxenham, S. K., Morris, J., Fernandes, L., Ramalho-Santos, J., Kirkman-Brown, J., Michelangeli, F., Publicover, S. & Barratt, C. L. R., 1 Mar 2013, In: Journal of Biological Chemistry. 288, 9, p. 6248-6258
Research output: Contribution to journal › Article › peer-review

Open Access
File
100 Citations (Scopus)

385 Downloads (Pure)
Glyph-based video visualization for semen analysis
Duffy, B., Thiyagalingam, J., Walton, S., Smith, D., Trefethen, A., Kirkman-Brown, J. C., Gaffney, E. A. & Chen, M., 13 Dec 2013, In: IEEE transactions on visualization and computer graphics.
Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus)
2012
2-APB-potentiated channels amplify CatSper-induced Ca2+ signals in human sperm
Lefièvre, L., Nash, K., Mansell, S., Costello, S., Punt, E., Correia, J., Morris, J., Kirkman-Brown, J., Wilson, S., Barratt, C. L. R. & Publicover, S., 1 Dec 2012, In: Biochemical Journal. 448, 2, p. 189-200 448(2).
Research output: Contribution to journal › Article › peer-review

Open Access
File
30 Citations (Scopus)

241 Downloads (Pure)
Human spermatozoa migration in microchannels reveals boundary-following navigation
Denissenko, P., Kantsler, V., Smith, D. J. & Kirkman-Brown, J., 22 May 2012, In: National Academy of Sciences. Proceedings. 109, 21, p. 8007-8010 4 p.
Research output: Contribution to journal › Article › peer-review
151 Citations (Scopus)
Modelling a tethered mammalian sperm cell undergoing hyperactivation
Curtis, M. P., Kirkman-Brown, J. C., Connolly, T. J. & Gaffney, E. A., 21 Sept 2012, In: Journal of Theoretical Biology. 309, p. 1-10 10 p.
Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus)
The effect of sperm DNA fragmentation on miscarriage rates: a systematic review and meta-analysis
Robinson, L., Gallos, I. D., Conner, S. J., Rajkhowa, M., Lewis, S., Kirkman-Brown, J., Coomarasamy, A. & Miller, D. H., Oct 2012, In: Human Reproduction. 27, 10, p. 2908-17 10 p.
Research output: Contribution to journal › Article › peer-review
302 Citations (Scopus)
2011
Comment on the article by j. Elgeti, u. B. Kaupp, and g. Gompper: hydrodynamics of sperm cells near surfaces.
Smith, D., Gaffney, E., Shum, H., Gadêlha, H. & Kirkman-Brown, J., 4 May 2011, In: Biophysical Journal. 100, 9, p. 2318-20 3 p.
Research output: Contribution to journal › Review article
13 Citations (Scopus)
Mammalian Sperm Motility: Observation and Theory
Gaffney, E., Gadelha, H., Smith, D., Blake, J. & Kirkman-Brown, J., 1 Jan 2011, In: Annual Review of Fluid Mechanics. 43, p. 501-528 28 p.
Research output: Contribution to journal › Review article
188 Citations (Scopus)
Sperm motility: is viscosity fundamental to progress?
Kirkman-Brown, J. & Smith, D., 1 Aug 2011, In: Molecular Human Reproduction. 17, 8, p. 539-544 6 p.
Research output: Contribution to journal › Article
64 Citations (Scopus)
2010
Nonlinear instability in flagellar dynamics: a novel modulation mechanism in sperm migration?
Gadelha, H., Gaffney, E., Smith, D. & Kirkman-Brown, J., 12 May 2010, In: Journal of The Royal Society Interface. 7, p. 1689-1697 9 p.
Research output: Contribution to journal › Article
68 Citations (Scopus)
Techniques for Imaging Ca²⁺ Signaling in Human Sperm
Nash, K., Lefievre, L., Peralta-Arias, R., Morris, J., Morales-Garcia, A., Connolly, T., Costello, S., Kirkman-Brown, J. & Publicover, S., 16 Jun 2010, In: Journal of Visualized Experiments. 16, 40
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Citations (Scopus)

257 Downloads (Pure)
2009
Bend Propagation in the Flagella of Migrating Human Sperm, and Its Modulation by Viscosity
Smith, D., Gaffney, E., Gadelha, H., Kapur, N. & Kirkman-Brown, J., 1 Apr 2009, In: Cell Motility and the Cytoskeleton. 66, 4, p. 220-236 17 p.
Research output: Contribution to journal › Article
129 Citations (Scopus)
Ca2+-stores in sperm: their identities and functions
Costello, S., Michelangeli, F., Nash, K., Lefievre, L., Morris, J., Machado-Oliveira, G., Barratt, C., Kirkman-Brown, J. & Publicover, S., 1 Sept 2009, In: Reproduction. 138, 3, p. 425-37 13 p.
Research output: Contribution to journal › Article
125 Citations (Scopus)
Evaluation of a disposable plastic Neubauer counting chamber for semen analysis
Kirkman-Brown, J. & Bjorndahl, L., 1 Feb 2009, p. 627-631. 5 p.
Research output: Contribution to conference (unpublished) › Paper

23 Citations (Scopus)

Jackson Kirkman-Brown

Research output

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