Grant Stewart

2024

DONSON: Slding in 2 the limelight

Stewart, G. S., 1 Feb 2024, In: Mutation Research. 134, 103616.

Research output: Contribution to journal › Article › peer-review

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E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease

Chauhan, A. S., Jhujh, S. S. & Stewart, G. S., 17 Jul 2024, In: The Biochemical journal. 481, 14, p. 923-944 22 p.

Research output: Contribution to journal › Review article › peer-review

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49 Downloads (Pure)

Genome-scale CRISPR screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in DLBCL

Davies, N., Francis, T., Oldreive, C., Azam, M., Wilson, J., Byrd, P. J., Burley, M., Sharma-Oates, A., Keane, P., Alatawi, S., Higgs, M. R., Rudzki, Z., Ibrahim, M., Perry, T., Agathaggelou, A., Hewitt, A.-M., Smith, E., Bonifer, C., O’Connor, M. & Forment, J. V. & 8 others, Murray, P. G., Fennell, E., Kelly, G., Chang, C., Stewart, G. S., Stankovic, T., Kwok, M. & Taylor, A. M., 6 Jun 2024, (E-pub ahead of print) In: Haematologica.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability

Hagkarim, N. C., Hajkarim, M. C., Suzuki, T., Fujiwara, T., Winkler, G. S., Stewart, G. S. & Grand, R. J., 17 Jul 2023, In: Cells. 12, 14, 34 p., 1868.

Research output: Contribution to journal › Article › peer-review

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80 Downloads (Pure)

Impaired protein hydroxylase activity causes replication stress and developmental abnormalities in humans

Fletcher, S. C., Hall, C., Kennedy, T. J., Pajusalu, S., Wojcik, M. H., Boora, U., Li, C., Oja, K. T., Hendrix, E., Westrip, C. A., Andrijes, R., Piasecka, S. K., Singh, M., El-Asrag, M. E., Ptasinska, A., Tillmann, V., Higgs, M. R., Carere, D. A., Beggs, A. D. & Pappas, J. & 5 others, Rabin, R., Smerdon, S. J., Stewart, G. S., Õunap, K. & Coleman, M. L., 3 Apr 2023, In: Journal of Clinical Investigation. 133, 7, e152784.

Research output: Contribution to journal › Article › peer-review

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The structural mechanism of dimeric DONSON in replicative helicase activation

Cvetković, M., Passaretti, P., Butryn, A., Reynolds-Winczura, A., Kingsley, G., Skagia, A., Fernandez Cuesta, C., Poovathumkadavil, D., George, R., Chauhan, A., Jhujh, S., Stewart, G., Gambus, A. & Costa, A., 16 Nov 2023, In: Molecular Cell. 83, 22, p. 4017-4031.e9 24 p.

Research output: Contribution to journal › Article › peer-review

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2022

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

Bayley, R., Borel, V., Moss, R., Sweatman, E., Ruis, P., Ormrod, A., Goula, A., Mottram, R., Stanage, T., Hewitt, G., Saponaro, M., Stewart, G., Boulton, S. & Higgs, M., 19 May 2022, In: Molecular Cell. 82, 10, p. 1924-1939.e10 26 p.

Research output: Contribution to journal › Article › peer-review

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5 Citations (Scopus)

95 Downloads (Pure)

Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy

Grange, L. J., Reynolds, J. J., Ullah, F., Isidor, B., Shearer, R. F., Latypova, X., Baxley, R. M., Oliver, A. W., Ganesh, A., Cooke, S. L., Jhujh, S. S., McNee, G. S., Hollingworth, R., Higgs, M. R., Natsume, T., Khan, T., Martos-Moreno, G. Á., Chupp, S., Mathew, C. G. & Parry, D. & 28 others, Simpson, M. A., Nahavandi, N., Yüksel, Z., Drasdo, M., Kron, A., Vogt, P., Jonasson, A., Seth, S. A., Gonzaga-Jauregui, C., Brigatti, K. W., Stegmann, A. P. A., Kanemaki, M., Josifova, D., Uchiyama, Y., Oh, Y., Morimoto, A., Osaka, H., Ammous, Z., Argente, J., Matsumoto, N., Stumpel, C. T. R. M., Taylor, A. M. R., Jackson, A. P., Bielinsky, A.-K., Mailand, N., Le Caignec, C., Davis, E. E. & Stewart, G. S., 4 Nov 2022, In: Nature Communications. 13, 1, 6664.

Research output: Contribution to journal › Article › peer-review

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RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1

Abu-Libdeh, B., Jhujh, S., Dhar, S., Sommers, J. A., Datta, A., Longo, G. M. C., Grange, L. J., Reynolds, J., Cooke, S., McNee, G., Hollingworth, R., Woodward, B., Ganesh, A. N., Smerdon, S., Nicolae, C. M., Durlacher-Bezer, K., Molho-Pessach, V., Abu-Libdeh, A., Meiner, V. & Moldovan, G.-L. & 4 others, Roukos, V., Harel, T., Brosh Jr., R. M. & Stewart, G., 1 Mar 2022, In: Journal of Clinical Investigation. 132, 5, e147301.

Research output: Contribution to journal › Article › peer-review

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2021

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair

Sanchez-Bailon, P., Choi, S., Dufficy, E., Sharma, K., McNee, G., Gunnell, E., Chiang, K., Sahay, D., Maslen, S., Stewart, G., Skehel, M., Dreveny, I. & Davies, C., Dec 2021, In: Nature Communications. 12, 1, 18 p., 6313 .

Research output: Contribution to journal › Article › peer-review

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108 Downloads (Pure)

MYBL2 and ATM suppress replication stress in pluripotent stem cells

Blakemore, D., Vilaplana-Lopera, N., Almaghrabi, R., Gonzalez, E., Moya, M., Ward, C., Murphy, G., Gambus, A., Petermann, E., Stewart, G. S. & García, P., 28 Mar 2021, (E-pub ahead of print) In: EMBO Reports. 22, 5, e51120.

Research output: Contribution to journal › Article › peer-review

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223 Downloads (Pure)

The Promotion of Genomic Instability in Human Fibroblasts by Adenovirus 12 Early Region 1B 55K Protein in the Absence of Viral Infection

Abualfaraj, T., Hagkarim, N. C., Hollingworth, R., Grange, L., Jhujh, S., Stewart, G. S. & Grand, R. J., 6 Dec 2021, In: Viruses. 13, 12, 2444.

Research output: Contribution to journal › Article › peer-review

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63 Downloads (Pure)

2020

Germline RBBP8 variants associated with early-onset breast cancer compromise replication fork stability

The COMPLEXO Network, 3 Aug 2020, In: Journal of Clinical Investigation. 130, 8, p. 4069-4080 12 p.

Research output: Contribution to journal › Article › peer-review

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4 Citations (Scopus)

260 Downloads (Pure)

Productive herpesvirus lytic replication in primary effusion lymphoma cells requires S-phase entry

Hollingworth, R., Stewart, G. S. & Grand, R. J., Aug 2020, In: Journal of General Virology. 101, 8, p. 873-883

Research output: Contribution to journal › Article › peer-review

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1 Citation (Scopus)

251 Downloads (Pure)

Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion

van Schie, J., Faramarz, A., Balk, J., Stewart, G., Cantelli, E., Oostra, A., Rooimans, M., Parish, J., de Almeida Esteves, C., Dumic, K., Barisic, I., Diderich, K., van Slegtenhorst, M., Mahtab, M., Pisani, F., te Riele, H., Ameziane, N., Wolthuis, R. & de Lange, J., 27 Aug 2020, In: Nature Communications. 11, 1, 4287.

Research output: Contribution to journal › Article › peer-review

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7 Citations (Scopus)

275 Downloads (Pure)

2019

Biallelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes

Burrage, L., Reynolds, J., Baratang, N., Phillips, J., Wegner, J., McFarquhar, A., Higgs, M., Christiansen, A., Lanza, D., Seavitt, J., Jain, M., Li, X., Parry, D., Raman, V., Chitayat, D., Chinn, I., Bertuch, A., Karaviti, L., Schlesinger, A. & Earl, D. & 38 others, Bamshad, M., Savarirayan, R., Doddapaneni, H., Muzny, D., Jhangiani, S., Eng, C., Gibbs, R., Bi, W., Emrick, L., Rosenfeld, J., Postlethwait, J., Westerfield, M., Dickinson, M., Beaudet, A., Ranza, E., Huber, C., Cormier-Daire, V., Shen, W., Mao, R., Heaney, J., Orange, J., Bertola, D., Yamamoto, G., Baratela, W., Butler, M., Ali, A., Adeli, M., Cohn, D., Krakow, D., Jackson, A., Lees, M., Offiah, A., Carlston, C., Carey, J., Stewart, G., Bacino, C., Campeau, P. & Lee, B., 7 Mar 2019, In: American Journal of Human Genetics. 104, 3, p. 422-438 17 p.

Research output: Contribution to journal › Article › peer-review

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6 Citations (Scopus)

249 Downloads (Pure)

Hypomorphic Mutations in TONSL Cause SPONASTRIME Dysplasia

Chang, H. R., Cho, S. Y., Lee, J. H., Lee, E., Soo, J., Lee, H. R., Cavalcanti, D. P., Mäkitie, O., Valta, H., Girisha, K. M., Lee, C., Neethukrishna, K., Bhavani, G. S., Shukla, A., Nampoothiri, S., Phadke, S. R., Park, M. J., Ikegawa, S., Wang, Z. & Higgs, M. & 15 others, Stewart, G., Jung, E., Lee, M.-S., Park, J. H., Lee, E. A., Kim, H., Myung, K., Jeon, W., Lee, K., Kim, D., Kim, O.-H., Choi, M., Lee, H.-W., Kim, Y. & Cho, T.-J., 7 Mar 2019, In: American Journal of Human Genetics. 104, 3, p. 439-453

Research output: Contribution to journal › Article › peer-review

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7 Citations (Scopus)

211 Downloads (Pure)

Investigating the mechanism behind sodium-iodide symporter trafficking by the small GTPase ARF4

Thornton, C., Fletcher, A., Nieto, H., Brookes, K., Alshahrani, M., Read, M., Boelaert, K., Stewart, G., Smith, V. & McCabe, C., 13 Nov 2019, In: Endocrine Abstracts. 65, P393.

Research output: Contribution to journal › Abstract › peer-review

Isomerization of BRCA1-BARD1 promotes replication fork protection

Daza-Martin, M., Starowicz, K., Jamshad, M., Tye, S., Ronson, G. E., MacKay, H. L., Chauhan, A. S., Walker, A. K., Stone, H. R., Beesley, J. F. J., Coles, J. L., Garvin, A. J., Stewart, G. S., McCorvie, T. J., Zhang, X., Densham, R. M. & Morris, J. R., 25 Jul 2019, In: Nature. 571, 7766, p. 521-527

Research output: Contribution to journal › Article › peer-review

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31 Citations (Scopus)

788 Downloads (Pure)

PALB2 variant status in hematological malignancies - a potential therapeutic target?

Oldreive, C. E., Byrd, P. J., Stewart, G. S., Taylor, A. J., Farhat, S., Skowronska, A., Smith, E., Raghavan, M., Janic, D., Dokmanovic, L., Clokie, S., Davies, N., Kwok, M., Pratt, G., Paneesha, S., Moss, P., Stankovic, T. & Taylor, A. J., 7 Jan 2019, In: Leukemia and Lymphoma. 60, 7, p. 1823-1826 4 p.

Research output: Contribution to journal › Letter › peer-review

1 Citation (Scopus)

2018

Degradation of a novel DNA damage response protein, tankyrase 1 binding protein 1, following adenovirus infection

Chalabi Hagkarim, N., Ryan, E., Byrd, P., Hollingworth, R., Shimwell, N., Agathanggelou, A., Vavasseur, M., Kolbe, V., Speisder, T., Dobner, T., Stewart, G. & Grand, R., 28 Mar 2018, (E-pub ahead of print) In: Journal of virology. 24 p., JVI.02034-17.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

226 Downloads (Pure)

Histone methylation by SETD1A protects nascent DNA through the nucleosome chaperone activity of FANCD2

Higgs, M., Sato, K., Reynolds, J., Begum, S., Bayley, R., Goula, A., Vernet, A., Paquin, K., Skalnik, D., Kobayashi, W., Takata, M., Howlett, N., Kurumizaka, H., Kimura, H. & Stewart, G., 5 Jul 2018, In: Molecular Cell. 71, 1, p. 25-41.e6 23 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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37 Citations (Scopus)

280 Downloads (Pure)

MYBL2 supports DNA double strand break repair in haematopoietic stem cells

Bayley, R., Blakemore, D., Cancian, L., Dumon, S., Volpe, G., Ward, C., Al Maghrabi, R., Gujar, J., Reeve, N., Raghavan, M., Higgs, M., Stewart, G., Petermann, E. & Garcia, P., 15 Oct 2018, In: Cancer Research. 78, 20, p. 5767-5779 13 p.

Research output: Contribution to journal › Article › peer-review

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9 Citations (Scopus)

226 Downloads (Pure)

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

Ronson, G., Piberger, A. L., Higgs, M., Olsen, A., Stewart, G., McHugh, P., Petermann, E. & Lakin, N., Dec 2018, In: Nature Communications. 9, 1, 12 p., 746.

Research output: Contribution to journal › Article › peer-review

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65 Citations (Scopus)

317 Downloads (Pure)

2017

Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus

Hollingworth, R., Horniblow, R., Forrest, C., Stewart, G. & Grand, R., 27 Oct 2017, (E-pub ahead of print) In: Journal of virology. 91, e00930-17.

Research output: Contribution to journal › Article › peer-review

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13 Citations (Scopus)

188 Downloads (Pure)

Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism

Reynolds, J., Higgs, M., Zlatanou, A., Vernet, A., Mottram, R., Brean, A., Taylor, M., Alkuraya, F. S., Mathew, C. G., Jackson, A. P. & Stewart, G., Apr 2017, In: Nature Genetics. 49, p. 537–549

Research output: Contribution to journal › Article › peer-review

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44 Citations (Scopus)

565 Downloads (Pure)

Novel 3q27.2-qter deletion in a patient with Diamond-Blackfan anemia and immunodeficiency: Case report and review of literature

Alkhunaizi, E., Schrewe, B., Alizadehfar, R., Vézina, C., Stewart, G. S. & Braverman, N., Jun 2017, In: American Journal of Medical Genetics. Part A. 173, 6, p. 1514-1520 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

330 Downloads (Pure)

PRMT5-dependent methylation of the TIP60 coactivator RUVBL1 is a key regulator of homologous recombination

Clarke, T., Sanchez-Bailon, M., Chiang, K., Reynolds, J., Herrero Ruiz, J. A., Banderias, T., Matias, P., Maslen, S., Shekel, M., Stewart, G. & Davies, C., 2 Mar 2017, In: Molecular Cell. 65, 2, p. 900–916.e7

Research output: Contribution to journal › Article › peer-review

Open Access

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55 Citations (Scopus)

463 Downloads (Pure)

USP7 inhibition alters homologous recombination repair and targets CLL cells independent of ATM/p53 functional status

Agathanggelou, A., Smith, E., Davies, N., Kwok, M., Zlatanou, A., Oldreive, C., Mao, J., Da Costa, D., Yadollahi, S., Perry, T., Kearns, P., Skowronska, A., Yates, E., Parry, H., Hillmen, P., Reverdy, C., Delansorne, R., Paneesha, S., Pratt, G. & Moss, P. & 3 others, Taylor, M., Stewart, G. & Stankovic, T., 13 Jul 2017, In: Blood. 130, 2, p. 156–166

Research output: Contribution to journal › Article › peer-review

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35 Citations (Scopus)

250 Downloads (Pure)

2016

A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development

Byrd, P. J., Stewart, G. S., Smith, A., Eaton, C., Taylor, A. J., Guy, C., Eringyte, I., Fooks, P., Last, J. I., Horsley, R., Oliver, A. W., Janic, D., Dokmanovic, L., Stankovic, T. & Taylor, A. M. R., 18 Mar 2016, In: PLoS Genetics. 12, 3, e1005945.

Research output: Contribution to journal › Article › peer-review

Open Access

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12 Citations (Scopus)

218 Downloads (Pure)

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 or ATM defective chronic lymphocytic leukemia cells

Kwok, M., Davies, N., Agathanggelou, A., Smith, E., Oldreive, C., Petermann, E., Stewart, G., Brown, J., Lau, A., Pratt, G., Parry, H., Taylor, M., Moss, P., Hillmen, P. & Stankovic, T., 4 Feb 2016, In: Blood. 127, 5, p. 582-595

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

32 Downloads (Pure)

Protection or resection: BOD1L as a novel replication fork protection factor

Higgs, M. & Stewart, G., 18 Feb 2016, (E-pub ahead of print) In: Nucleus (Austin).

Research output: Contribution to journal › Article › peer-review

Open Access

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8 Citations (Scopus)

252 Downloads (Pure)

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

Guturi, K. K. N., Bohgaki, M., Bohgaki, T., Srikumar, T., Ng, D., Kumareswaran, R., El Ghamrasni, S., Jeon, J., Patel, P., Eldin, M. S., Bristow, R., Cheung, P., Stewart, G. S., Raught, B., Hakem, A. & Hakem, R., 25 Aug 2016, (E-pub ahead of print) In: Nature Communications. 7, p. 12638

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism

Harley, M. E., Murina, O., Leitch, A., Higgs, M., Bicknell, L. S., Yigit, G., Blackford, A. N., Zlatanou, A., Mackenzie, K. J., Reddy, K., Halachev, M., McGlasson, S., Reijns, M. A. M., Fluteau, A., Martin, C.-A., Sabbioneda, S., Elcioglu, N. H., Altmüller, J., Thiele, H. & Greenhalgh, L. & 10 others, Chessa, L., Maghnie, M., Salim, M., Bober, M. B., Nürnberg, P., Jackson, S. P., Hurles, M. E., Wollnik, B., Stewart, G. & Jackson, A., Jan 2016, In: Nature Genetics. 48, 1, p. 36-43 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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49 Citations (Scopus)

681 Downloads (Pure)

2015

Activation of DNA Damage Response Pathways during Lytic Replication of KSHV

Hollingworth, R., Skalka, G. L., Stewart, G. S., Hislop, A. D., Blackbourn, D. J. & Grand, R. J., 5 Jun 2015, In: Viruses. 7, 6, p. 2908-27 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

26 Citations (Scopus)

Alchemix, p53 and topoisomerase

Grand, R. & Stewart, G., 2015, In: Aging. 7, 9, p. 601-602 2 p.

Research output: Contribution to journal › Editorial › peer-review

Bod1l is required to suppress deleterious resection of stressed replication forks

Higgs, M., Reynolds, J., Winczura, A., Blackford, A., Borel, V., Miller, E., Zlatanou, A., Nieminuszczy, J., Ryan, E., Davies, N., Stankovic, T., Boulton, S., Niedzwiedz, W. & Stewart, G., 6 Aug 2015, In: Molecular Cell. 59, 3, p. 462-477

Research output: Contribution to journal › Article › peer-review

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88 Citations (Scopus)

336 Downloads (Pure)

Mutations in the NHEJ Component XRCC4 Cause Primordial Dwarfism

Murray, J. E., van der Burg, M., IJspeert, H., Carroll, P., Wu, Q., Ochi, T., Leitch, A., Miller, E. S., Kysela, B., Jawad, A., Bottani, A., Brancati, F., Cappa, M., Cormier-Daire, V., Deshpande, C., Faqeih, E. A., Graham, G. E., Ranza, E., Blundell, T. L. & Jackson, A. P. & 2 others, Stewart, G. S. & Bicknell, L. S., 5 Mar 2015, In: American Journal of Human Genetics. 96, 3, p. 412-424

Research output: Contribution to journal › Article › peer-review

Open Access

46 Citations (Scopus)

Targeting the ataxia telangiectasia mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S. J., Hole, P. S., Darley, R. L., McMahon, M., Hayes, J. D., Moss, P., Stewart, G. S. & Taylor, A. M. R. & 1 others, Stankovic, T., 31 Aug 2015, In: Haematologica. 100, 8, p. 1076-1085 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

164 Downloads (Pure)

The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53

Thomas, A., Perry, T., Berhane, S., Oldreive, C., Zlatanou, A., Williams, L. R., Weston, V. J., Stankovic, T., Kearns, P., Pors, K., Grand, R. J. & Stewart, G. S., 18 Jun 2015, In: Oncogene. 34, 25, p. 3336-3348 13 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168

Kocyłowski, M. K., Rey, A. J., Stewart, G. S. & Halazonetis, T. D., 19 Feb 2015, In: Cell Cycle. p. 0

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

USP7 is essential for maintaining Rad18 stability and DNA damage tolerance

Zlatanou, A., Stewart, G., Agathanggelou, A., Stankovic, T. & Miller, E., 2015, In: Oncogene.

Research output: Contribution to journal › Article › peer-review

Open Access

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45 Citations (Scopus)

736 Downloads (Pure)

2014

BRCA2 and RAD51 promote double-strand break formation and cell death in response to Gemcitabine

Jones, R., Kotsantis, P., Stewart, G., Groth, P. & Petermann, E., Oct 2014, In: Molecular Cancer Therapeutics. 13, 10, p. 2412-2421

Research output: Contribution to journal › Article › peer-review

Open Access

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27 Citations (Scopus)

305 Downloads (Pure)

New roles for BRCA2 and RAD51 at stalled replication forks

Jones, R., Kotsantis, P., Stewart, G., Groth, P. & Petermann, E., 19 May 2014.

Research output: Contribution to conference (unpublished) › Poster

Reply: A single strand that links multiple neuropathologies in human disease

Reynolds, J. J. & Stewart, G. S., Apr 2014, In: Brain. 137, Pt 4, p. e267

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

2013

A nervous predisposition to unrepaired DNA double strand breaks

Reynolds, J. J. & Stewart, G. S., Aug 2013, In: Mutation Research. 12, 8, p. 588-99 12 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

A single strand that links multiple neuropathologies in human disease

Reynolds, J. J. & Stewart, G. S., Jan 2013, In: Brain. 136, Pt 1, p. 14-27 14 p.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia

Da Costa, D., Agathanggelou, A., Perry, T., Weston, V., Petermann, E., Zlatanou, A., Oldreive, C., Wei, W., Stewart, G., Longman, J., Smith, E., Kearns, P., Knapp, S. & Stankovic, T., Jul 2013, In: Blood Cancer Journal. 3, 7, e126.

Research output: Contribution to journal › Article › peer-review

Open Access

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62 Citations (Scopus)

253 Downloads (Pure)

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

Bohgaki, M., Bohgaki, T., El Ghamrasni, S., Srikumar, T., Maire, G., Panier, S., Fradet-Turcotte, A., Stewart, G. S., Raught, B., Hakem, A. & Hakem, R., 24 Dec 2013, In: National Academy of Sciences. Proceedings. 110, 52, p. 20982-7 6 p.

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination

Tikoo, S., Madhavan, V., Hussain, M., Miller, E. S., Arora, P., Zlatanou, A., Modi, P., Townsend, K., Stewart, G. S. & Sengupta, S., 12 Jun 2013, In: The EMBO journal. 32, 12, p. 1778-92 15 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Grant Stewart

Research output

Search results