Grant Stewart

Accepting PhD Students

PhD projects

Professor Stewart is interested in supervising doctoral research on:

Regulation of the cellular response to DNA damage by the ubiquitin/SUMO system
Identification of novel human disease genes involved in the repair of DNA damage by total genome sequencing
Functional regulation of the DNA damage response by phosphorylation/dephosphorylation

Research activity per year

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

SDG 3 Good Health and Well-being

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Dive into the research topics where Grant Stewart is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

1 Similar Profiles

104 Article
3 Review article
2 Editorial
2 Letter
More

Identification of a Non-Coding Causative Variant Underlying Warsaw Breakage Syndrome Using Long-Read Based Genomic Sequencing and Transcriptome Analysis
DuBois, M., Dixon, K., Sherlaw-Sturrock, C., Shen, Y., Probst, F., Clarke, L., Lyalin, D., Shuman, C., Jones, S., Boerkoel, C., Stewart, G. S., Richmond, P. & Myers, A., Feb 2026, In: American Journal of Medical Genetics, Part A. 200, 2, p. 432-437 6 p.
Research output: Contribution to journal › Article › peer-review
Dominant negative variants in ITPR3 impair T cell Ca²⁺ dynamics causing combined immunodeficiency
Blanco, E., Camps, C., Bahal, S., Kerai, M. D., Ferla, M. P., Rochussen, A. M., Handel, A. E., Golwala, Z. M., Spiridou Goncalves, H., Kricke, S., Klein, F., Zhang, F., Zinghirino, F., Evans, G., Keane, T. M., Lizot, S., Kusters, M. A. A., Iro, M. A., Patel, S. V. & Morris, E. C. & 21 others, Burns, S. O., Radcliffe, R., Vasudevan, P., Price, A., Gillham, O., Valdebenito, G. E., Stewart, G. S., Worth, A., Adams, S. P., Duchen, M., André, I., Adams, D. J., Santili, G., Gilmour, K. C., Holländer, G. A., Graham Davies, E., Taylor, J. C., Griffiths, G. M., Thrasher, A. J., Dhalla, F. & Kreins, A. Y., 6 Jan 2025, In: Journal of Experimental Medicine. 222, 1, 34 p., e20220979.
Research output: Contribution to journal › Article › peer-review

Open Access
File
127 Downloads (Pure)
Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin
Woodward, B. L., Lahiri, S., Chauhan, A. S., Garcia, M. R., Goodley, L. E., Clarke, T. L., Pal, M., Agathanggelou, A., Jhujh, S. S., Ganesh, A. N., Hollins, F. M., Deforie, V. G., Maroofian, R., Efthymiou, S., Meinhardt, A., Mathew, C. G., Simpson, M. A., Mefford, H. C., Faqeih, E. A. & Rosenzweig, S. D. & 16 others, Volpi, S., Di Matteo, G., Cancrini, C., Scardamaglia, A., Shackley, F., Davies, E. G., Ibrahim, S., Arkwright, P. D., Zaki, M. S., Stankovic, T., Taylor, A. M. R., Mazur, A. J., Di Donato, N., Houlden, H., Rothenberg, E. & Stewart, G. S., Dec 2025, In: Nature Communications. 16, 1, 20 p., 4491.
Research output: Contribution to journal › Article › peer-review

Open Access
File
58 Downloads (Pure)
Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay
Hough, S. H., Jhujh, S. S., Awwad, S. W., Lewis, O. E., Lam, S., Thomas, J. C., Mosler, T., Bader, A., Bartik, L., McKee, S., Amudhavalli, S., Colin, E., Damseh, N., Clement, E., Cacheiro, P., Majumdar, A., Smedley, D., Fluss, J., Giannini, R. & Thiffault, I. & 8 others, Zagnoli Vieira, G., Belotserkovskaya, R., Smerdon, S. J., Beli, P., Galanty, Y., Carnie, C. J., Stewart, G. S. & Jackson, S. P., 19 Dec 2025, (E-pub ahead of print) In: EMBO Molecular Medicine. 22 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance
Chauhan, A. S., Mackintosh, M. J. W., Cassar, J., Lanz, A. J., Jamshad, M., Mackay, H. L., Garvin, A. J., Walker, A. K., Jhujh, S. S., Carlomagno, T., Leney, A. C., Stewart, G. S. & Morris, J. R., 14 Apr 2025, In: Nature Communications. 16, 1, 18 p., 3399.
Research output: Contribution to journal › Article › peer-review

Open Access
File
30 Downloads (Pure)

7 Active
29 Finished

Defining a new paradigm for regulating homologous recombination-dependent processes at DNA breaks and damaged replication forks
Stewart, G. (Principal Investigator)
Medical Research Council
1/01/26 → 31/12/28
Project: Research Councils
Defining how defects in actin-dependent DNA repair and replication cause disease
Stewart, G. (Principal Investigator)
Medical Research Council
1/06/25 → 31/05/28
Project: Research Councils
Defining a role for DNA phosphorylation in maintaining replication fork stability
Smerdon, S. (Co-Investigator) & Stewart, G. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/02/25 → 31/01/28
Project: Research Councils
Investigating therapeutic vulnerabilities of pre-leukaemic syndromes and optimising conditioning chemotherapy for stem cell transplantation
Stankovic, T. (Co-Investigator), Potluri, S. (Principal Investigator), Agathanggelou, A. (Co-Investigator) & Stewart, G. (Co-Investigator)
BIRMINGHAM WOMEN'S CHARITABLE FUNDS
1/01/25 → 30/06/26
Project: Research
Repurposing of small molecule enhancers of autophagy for treating ataxia-telangiectasia
Stewart, G. (Co-Investigator), Barrett, T. (Co-Investigator), Sarkar, S. (Co-Investigator) & Tuxworth, R. (Principal Investigator)
Action For A-T
1/07/24 → 30/06/27
Project: Research

Grant Stewart

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Identification of a Non-Coding Causative Variant Underlying Warsaw Breakage Syndrome Using Long-Read Based Genomic Sequencing and Transcriptome Analysis

Dominant negative variants in ITPR3 impair T cell Ca²⁺ dynamics causing combined immunodeficiency

Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin

Loss of CTLH component MAEA impairs DNA repair and replication and leads to developmental delay

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance

Defining a new paradigm for regulating homologous recombination-dependent processes at DNA breaks and damaged replication forks

Defining how defects in actin-dependent DNA repair and replication cause disease

Defining a role for DNA phosphorylation in maintaining replication fork stability

Investigating therapeutic vulnerabilities of pre-leukaemic syndromes and optimising conditioning chemotherapy for stem cell transplantation

Repurposing of small molecule enhancers of autophagy for treating ataxia-telangiectasia

Grant Stewart

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects