Evaggelia Liaskou

Research output

Research output per year 2008 2008 2011 2012 2013 2014 2015 2016 2017 2019

• 25 Article
• 1 Book

Research output per year

Research output per year

Search results

• 2019

  Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis

  Chen, Y-Y., Arndtz, K., Webb, G., Corrigan, M., Akiror, S., Liaskou, E., Woodward, P., Adams, D. H., Weston, C. J. & Hirschfield, G. M., Nov 2019, In: JHEP Reports. 1, 5, p. 369-376 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • Macrophages 55%
  • Liver Diseases 33%
  • Population 30%
  • Monocytes 21%
• 2018

  Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells

  Liaskou, E., Patel, S., Webb, G., Bagkou Dimakou, D., Akiror, S., Krishna, M., Mells, G. F., Jones, D., Bowman, S., Barone, F., Fisher, B. & Hirschfield, G., Nov 2018, In: Journal of Autoimmunity. 94, p. 143-155 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biliary Liver Cirrhosis 100%
  • Interleukin-12 85%
  • Regulatory T-Lymphocytes 82%
  • Interferons 76%
  • Sclerosing Cholangitis 70%
  14 Citations (Scopus)

  429 Downloads (Pure)
• 2017

  Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals

  Liaskou, E., Jeffery, L., Chanouzas, D., Soskic, B., Seldin, M. F., Harper, L., Sansom, D. & Hirschfield, G. M., 9 Aug 2017, In: Scientific Reports. 7, 1, p. 7652

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sclerosing Cholangitis 100%
  • Genetic Variation 76%
  • Vitamin D 55%
  • T-Lymphocytes 48%
  • Homozygote 21%
  1 Citation (Scopus)

  138 Downloads (Pure)

• MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

  Triantafyllou, E., Pop, O. T., Possamai, L. A., Wilhelm, A., Liaskou, E., Singanayagam, A., Bernsmeier, C., Khamri, W., Petts, G., Dargue, R., Davies, S. P., Tickle, J., Yuksel, M., Patel, V. C., Abeles, R. D., Stamataki, Z., Curbishley, S. M., Ma, Y., Coen, M., Woollard, K. J., & 7 othersQuaglia, A., Wendon, J., Thursz, M. R., Adams, D. H., Weston, C. J., Antoniades, C. G. & Wilson, I. D., 27 Apr 2017, (E-pub ahead of print) In: Gut.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Acute Liver Failure 100%
  • Protein-Tyrosine Kinases 77%
  • Macrophages 59%
  • Secretory Leukocyte Peptidase Inhibitor 57%
  • Acetaminophen 51%
  61 Citations (Scopus)

• Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome, and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner

  Trivedi, P., Tickle, J., Vesterhus, M., Eddowes, P., Bruns, T., Vainio, J., Parker, R., Smith, D., Liaskou, E., Thorbjornsen, L. W., Hirschfield, G., Auvinen, K., Hubscher, S., Salmi, M., Adams, D. & Weston, C., 20 Apr 2017, (E-pub ahead of print) In: Gut.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sclerosing Cholangitis 100%
  • Lymphocytes 54%
  • Blood Vessels 46%
  • Liver 40%
  • Cell Adhesion Molecule-1 36%
  25 Citations (Scopus)

  151 Downloads (Pure)
• 2016

  Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis

  Jendrek, S. T., Gotthardt, D., Nitzsche, T., Widmann, L., Korf, T., Michaels, M. A., Weiss, K-H., Liaskou, E., Vesterhus, M., Karlsen, T. H., Mindorf, S., Schemmer, P., Bär, F., Teegen, B., Schröder, T., Ehlers, M., Hammers, C. M., Komorowski, L., Lehnert, H., Fellermann, K., & 3 othersDerer, S., Hov, J. R. & Sina, C., 12 Jul 2016, (E-pub ahead of print) In: Gut.

  Research output: Contribution to journal › Article › peer-review

  • anti-IgA 100%
  • Sclerosing Cholangitis 91%
  • Cholangiocarcinoma 83%
  • Autoantibodies 66%
  • Survival 40%
  29 Citations (Scopus)

• Gut and liver T cells of common clonal origin are detected in primary sclerosing cholangitis-inflammatory bowel disease

  Henriksen, E. K. K., Jørgensen, K. K., Kaveh, F., Holm, K., Hamm, D., Olweus, J., Melum, E., Chung, B., Eide, T. J., Lundin, K. EA., Boberg, K. M., Karlsen, T. H., Hirschfield, G. & Liaskou, E., 17 Sept 2016, (E-pub ahead of print) In: Journal of Hepatology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sclerosing Cholangitis 100%
  • Inflammatory Bowel Diseases 74%
  • T-Lymphocytes 48%
  • Liver 40%
  • Colonic Neoplasms 7%
  21 Citations (Scopus)

  253 Downloads (Pure)

• High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires

  Liaskou, E., Henriksen, E. K. K., Holm, K., Kaveh, F., Hamm, D., Fear, J., Viken, M. K., Hov, J. R., Melum, E., Robins, H., Olweus, J., Karlsen, T. H. & Hirschfield, G. M., May 2016, In: Hepatology. 63, 5, p. 1608–1619 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • T-Cell Antigen Receptor 96%
  • Biliary Liver Cirrhosis 94%
  • Liver Diseases 79%
  • Alcoholic Liver Diseases 79%
  43 Citations (Scopus)

  16 Downloads (Pure)

• Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis

  Chung, B., Guevel, B. T., Reynolds, G., Gupta Udatha, D. B. R. K., Henriksen, E. K. K., Stamataki, Z., Hirschfield, G., Karlsen, T. H. & Liaskou, E., 24 Oct 2016, (E-pub ahead of print) In: Journal of Autoimmunity. 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Sclerosing Cholangitis 100%
  • Biliary Liver Cirrhosis 94%
  • Antibody-Producing Cells 79%
  • Antibody Formation 70%
  • B-Lymphocytes 60%
  25 Citations (Scopus)

  1166 Downloads (Pure)
• 2015

  Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver

  Zimmermann, H. W., Bruns, T., Weston, C. J., Curbishley, S. M., Liaskou, E., Li, K-K., Resheq, Y. J., Badenhorst, P. W. & Adams, D. H., 2015, In: Hepatology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transendothelial and Transepithelial Migration 100%
  • Endothelium 65%
  • Monocytes 61%
  • Immunity 60%
  • Liver 38%
  23 Citations (Scopus)

  274 Downloads (Pure)

• Genetic Distinctions in Patients With Primary Sclerosing Cholangitis: Immunoglobulin G4 Elevations and HLA Risk

  Liaskou, E. & Hirschfield, G. M., May 2015, In: Gastroenterology. 148, 5, p. 886-9 4 p.

  Research output: Contribution to journal › Article › peer-review
  4 Citations (Scopus)
• 2014

  Dysregulated hepatic expression of glucose transporters in chronic disease: contribution of semicarbazide-sensitive amine oxidase to hepatic glucose uptake

  Karim, S., Liaskou, E., Fear, J., Garg, A., Reynolds, G., Claridge, L., Adams, D. H., Newsome, P. N. & Lalor, P. F., 15 Dec 2014, In: American journal of physiology. Gastrointestinal and liver physiology. 307, 12, p. G1180-90

  Research output: Contribution to journal › Article › peer-review

  • Amine Oxidase (Copper-Containing) 100%
  • Facilitative Glucose Transport Proteins 80%
  • Chronic Disease 51%
  • Glucose 43%
  • Blood Vessels 40%
  13 Citations (Scopus)

  2 Downloads (Pure)

• Genetics in PSC: what do the "risk genes" teach us?

  T, F., Liaskou, E., Anderson, C. A. & Karlsen, T. H., 16 Apr 2014, In: Clinical Reviews in Allergy & Immunology. 48, 2, p. 154-164

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • Genes 31%
  • Immunogenetics 17%
  • Gene-Environment Interaction 16%
  • Genetic Loci 16%
  23 Citations (Scopus)

• Loss of CD28 Expression by Liver-Infiltrating T Cells Contributes to Pathogenesis of Primary Sclerosing Cholangitis

  Liaskou, E., Jeffery, L. E., Trivedi, P. J., Reynolds, G. M., Suresh, S., Bruns, T., Adams, D. H., Sansom, D. M. & Hirschfield, G. M., 1 Jul 2014, In: Gastroenterology. 147, 1, p. 221–232

  Research output: Contribution to journal › Article › peer-review

  • Sclerosing Cholangitis 100%
  • T-Lymphocytes 48%
  • Liver 40%
  • Tumor Necrosis Factor-alpha 31%
  • Vitamin D 24%
  46 Citations (Scopus)

  9 Downloads (Pure)

• Mechanisms of tissue injury in autoimmune liver diseases

  Liaskou, E., Hirschfield, G. M. & Gershwin, M. E., Sept 2014, In: Seminars in immunopathology. 36, 5, p. 553-568

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Autoimmune Diseases 100%
  • Sclerosing Cholangitis 97%
  • Autoimmune Hepatitis 97%
  • Liver Diseases 97%
  • Biliary Liver Cirrhosis 92%
  42 Citations (Scopus)

  316 Downloads (Pure)
• 2013

  An in vitro model of human acute ethanol exposure that incorporates CXCR3- and CXCR4-dependent recruitment of immune cells

  Karim, S., Liaskou, E., Hadley, S., Youster, J., Faint, J., Adams, D. H. & Lalor, P. F., Mar 2013, In: Toxicological Sciences. 132, 1, p. 131-41 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ethanol 100%
  • Lymphocytes 61%
  • Liver 61%
  • Alcoholic Liver Diseases 55%
  • In Vitro Techniques 51%
  17 Citations (Scopus)

  1 Downloads (Pure)

• Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics

  Liaskou, E., Zimmermann, H. W., Li, K-K., Oo, Y. H., Suresh, S., Stamataki, Z., Qureshi, O., Lalor, P. F., Shaw, J., Syn, W., Curbishley, S. M. & Adams, D. H., 7 Jan 2013, In: Hepatology. 57, 1, p. 385-98 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Liver Diseases 100%
  • Monocytes 98%
  • Liver 40%
  • Chemokine CCL1 24%
  • Wound Healing 23%
  139 Citations (Scopus)
• 2012

  CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver

  Oo, Y. H., Banz, V., Kavanagh, D., Liaskou, E., Withers, D. R., Humphreys, E., Reynolds, G. M., Lee-Turner, L., Kalia, N., Hubscher, S. G., Klenerman, P., Eksteen, B. & Adams, D. H., Nov 2012, In: Journal of Hepatology. 57, 5, p. 1044-1051 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Th17 Cells 100%
  • Liver 62%
  • Interleukin-17 38%
  • Bile Ducts 36%
  • Helper-Inducer T-Lymphocytes 24%
  115 Citations (Scopus)

  267 Downloads (Pure)

• Innate immune cells in liver inflammation

  Liaskou, E., Wilson, D. & Oo, Y. H., 9 Aug 2012, In: Mediators of Inflammation. 2012, 21 p., 949157.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Inflammation 100%
  • Liver 87%
  • Gastrointestinal Tract 59%
  • Immune System 53%
  • Portal Vein 34%
  123 Citations (Scopus)

  210 Downloads (Pure)

• NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

  Syn, W-K., Agboola, K. M., Swiderska, M., Michelotti, G. A., Liaskou, E., Pang, H., Xie, G., Philips, G., Chan, I. S., Karaca, G. F., Pereira, T. D. A., Chen, Y., Mi, Z., Kuo, P. C., Choi, S. S., Guy, C. D., Abdelmalek, M. F. & Diehl, A. M., Sept 2012, In: Gut. 61, 9, p. 1323-9 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Hedgehogs 100%
  • Osteopontin 90%
  • Non-alcoholic Fatty Liver Disease 81%
  • Natural Killer T-Cells 72%
  • Fatty Liver 64%
  152 Citations (Scopus)
• 2011

  Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis

  Syn, W-K., Choi, S. S., Liaskou, E., Karaca, G. F., Agboola, K. M., Oo, Y. H., Mi, Z., Pereira, T. A., Zdanowicz, M., Malladi, P., Chen, Y., Moylan, C., Jung, Y., Bhattacharya, S. D., Teaberry, V., Omenetti, A., Abdelmalek, M. F., Guy, C. D., Adams, D. H., Kuo, P. C., & 3 othersMichelotti, G. A., Whitington, P. F. & Diehl, A. M., Jan 2011, In: Hepatology. 53, 1, p. 106-15 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Hedgehogs 100%
  • Osteopontin 90%
  • Non-alcoholic Fatty Liver Disease 81%
  • Fibrosis 56%
  • Liver Cirrhosis 26%
  167 Citations (Scopus)

  3 Downloads (Pure)

• Regulation of mucosal addressin cell adhesion molecule 1 expression in human and mice by vascular adhesion protein 1 amine oxidase activity.

  Liaskou, E., Karikoski, M., Reynolds, GM., Lalor, P., Weston, C., Pullen, N., Salmi, M., Jalkanen, S. & Adams, D., 1 Feb 2011, In: Hepatology. 53, 2, p. 661-672 12 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • mouse semicarbazide-sensitive amine oxidase-vascular adhesion protein-1 100%
  • human AOC3 protein 85%
  • Cell Adhesion Molecule-1 63%
  • Amines 47%
  • Oxidoreductases 41%
  72 Citations (Scopus)

  150 Downloads (Pure)
• 2010

  CX(3)CR1 and Vascular Adhesion Protein-1-Dependent Recruitment of CD16(+) Monocytes Across Human Liver Sinusoidal Endothelium

  Aspinall, AI., Curbishley, S., Lalor, P., Weston, C., Blahova, M., Liaskou, E., Adams, RM., Holt, A. & Adams, D., 1 Jun 2010, In: Hepatology. 51, 6, p. 2030-2039 10 p.

  Research output: Contribution to journal › Article › peer-review

  • CX3C Chemokine Receptor 1 100%
  • Endothelium 53%
  • Monocytes 49%
  • Blood Vessels 35%
  • Liver 30%
  66 Citations (Scopus)

  9 Downloads (Pure)
• 2008

  CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.

  Miles, A., Liaskou, E., Eksteen, J., Lalor, P. & Adams, D., 1 May 2008, In: American journal of physiology. Gastrointestinal and liver physiology. 294, 5, p. G1257-67

  Research output: Contribution to journal › Article › peer-review

  • integrin beta7 100%
  • Integrin alpha4 95%
  • Cell Adhesion Molecule-1 68%
  • Chemokines 45%
  • Lymphocytes 33%
  48 Citations (Scopus)

• Lymphocyte homing and its role in the pathogenesis of IBD

  Eksteen, J., Liaskou, E. & Adams, D., 1 Jan 2008, In: Inflammatory Bowel Diseases. 14, 9, p. 1298-1312 15 p.

  Research output: Contribution to journal › Article

  • Inflammatory Bowel Diseases 100%
  • Lymphocytes 73%
  • Crohn Disease 57%
  • Ulcerative Colitis 44%
  • Inflammation 35%
  42 Citations (Scopus)