Eva Petermann

2024

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

Mackay, H. L., Stone, H. R., Ronson, G. E., Ellis, K., Lanz, A., Aghabi, Y., Walker, A. K., Starowicz, K., Garvin, A. J., Van Eijk, P., Koestler, S. A., Anthony, E. J., Piberger, A. L., Chauhan, A. S., Conway-Thomas, P., Vaitsiankova, A., Vijayendran, S., Beesley, J. F., Petermann, E. & Brown, E. J. & 5 others, Densham, R. M., Reed, S. H., Dobbs, F., Saponaro, M. & Morris, J. R., 16 Sept 2024, In: Nature Communications. 15, 17 p., 8102.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Downloads (Pure)

2022

Conflicts with transcription make early replication late

Petermann, E., 15 Sept 2022, In: Molecular Cell. 82, 18, p. 3315-3317 3 p.

Research output: Contribution to journal › Review article

Open Access

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130 Downloads (Pure)

Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

Petermann, E., Lan, L. & Zou, L., Aug 2022, In: Nature Reviews. Molecular Cell Biology. 23, 8, p. 521-540 20 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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547 Downloads (Pure)

2021

Hypertranscription and replication stress in cancer

Bowry, A., Kelly, R. & Petermann, E., 26 May 2021, (E-pub ahead of print) In: Trends in Cancer. 7, 9, p. 863-877

Research output: Contribution to journal › Review article › peer-review

Open Access

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246 Downloads (Pure)

MYBL2 and ATM suppress replication stress in pluripotent stem cells

Blakemore, D., Vilaplana-Lopera, N., Almaghrabi, R., Gonzalez, E., Moya, M., Ward, C., Murphy, G., Gambus, A., Petermann, E., Stewart, G. S. & García, P., 28 Mar 2021, (E-pub ahead of print) In: EMBO Reports. 22, 5, e51120.

Research output: Contribution to journal › Article › peer-review

Open Access

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223 Downloads (Pure)

2020

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

Piberger, L., Bowry, A., Kelly, R., Walker, A., Gonzalez-Acosta, D., Bailey, L., Doherty, A., Mendez, J., Morris, J., Bryant, H. E. & Petermann, E., 17 Nov 2020, In: Nature Communications. 11, 1, 5863.

Research output: Contribution to journal › Article › peer-review

Open Access

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5 Citations (Scopus)

280 Downloads (Pure)

WDR82/PNUTS-PP1 prevents transcription-replication conflicts by promoting RNA POLYMERASE II degradation on chromatin

Landsverk, H. B., Sandquist, L. E., Bay, L. T. E., Steurer, B., Campsteijn, C., Landsverk, O. J. B., Marteijn, J. A., Petermann, E., Trinkle-Mulcahy, L. & Syljuasen, R. G., 1 Dec 2020, In: Cell Reports. 33, 9, 108469.

Research output: Contribution to journal › Article › peer-review

Open Access

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3 Citations (Scopus)

206 Downloads (Pure)

2019

Adenovirus E1B 55-kilodalton protein targets SMARCAL1 for degradation during infection and modulates cellular DNA replication

Nazeer, R., Qashqari, F., Albalawi, A., Piberger, A. L., Tilotta, M., Read, M., Hu, S., Davis, S., McCabe, C., Petermann, E. & Turnell, A., 14 Jun 2019, In: Journal of virology. 93, 13, 16 p., e00402-19.

Research output: Contribution to journal › Article › peer-review

Open Access

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7 Citations (Scopus)

211 Downloads (Pure)

2018

BET inhibition induces HEXIM1- and RAD51-dependent conflicts between transcription and replication

Bowry, A., Piberger, A. L., Rojas, P., Saponaro, M. & Petermann, E., 20 Nov 2018, In: Cell Reports. 25, 8, p. 2061–2069.e4 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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16 Citations (Scopus)

321 Downloads (Pure)

BET inhibition induces transcription-replication conflicts that depend on HEXIM1 and RAD51

Bowry, A., Piberger, A. L. & Petermann, E., Oct 2018.

Research output: Contribution to conference (unpublished) › Poster

Homologous Recombination at Replication Forks

Petermann, E., 6 Sept 2018, DNA Repair and Replication: Mechanisms and Clinical Significance. Grand, R. & Reynolds, J. (eds.). Routledge

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells

Benedict, B., van Harn, T., Dekker, M., Hermsen, S., Kucukosmanoglu, A., Pieters, W., Delzenne-Goette, E., C Dorsman, J., Petermann, E., Foijer, F. & te Riele, H., 16 Oct 2018, In: eLife. 7, e37868.

Research output: Contribution to journal › Article › peer-review

Open Access

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13 Citations (Scopus)

198 Downloads (Pure)

Mechanisms of Benzo[a]pyrene-induced recombination

Piberger, A. L. & Petermann, E., Sept 2018.

Research output: Contribution to conference (unpublished) › Poster

Mechanisms of oncogene-induced replication stress: jigsaw falling into place

Kotsantis, P., Petermann, E. & Boulton, S. J., May 2018, In: Cancer Discovery. 8, 5, p. 537-555 19 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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101 Citations (Scopus)

299 Downloads (Pure)

MYBL2 supports DNA double strand break repair in haematopoietic stem cells

Bayley, R., Blakemore, D., Cancian, L., Dumon, S., Volpe, G., Ward, C., Al Maghrabi, R., Gujar, J., Reeve, N., Raghavan, M., Higgs, M., Stewart, G., Petermann, E. & Garcia, P., 15 Oct 2018, In: Cancer Research. 78, 20, p. 5767-5779 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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9 Citations (Scopus)

226 Downloads (Pure)

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

Ronson, G., Piberger, A. L., Higgs, M., Olsen, A., Stewart, G., McHugh, P., Petermann, E. & Lakin, N., Dec 2018, In: Nature Communications. 9, 1, 12 p., 746.

Research output: Contribution to journal › Article › peer-review

Open Access

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65 Citations (Scopus)

317 Downloads (Pure)

RNA/DNA hybrid metabolism and replication stress in cancer

Tang, H. M., Kotsantis, P., Gromak, N. & Petermann, E., Oct 2018.

Research output: Contribution to conference (unpublished) › Poster

2017

Increased global transcription activity as a mechanism of oncogene-induced replication stress

Kotsantis, P., Marques Silva, L., Irmscher, S., Jones, R., Folkes, L., Gromak, N. & Petermann, E., Jul 2017.

Research output: Contribution to conference (unpublished) › Poster

2016

ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 or ATM defective chronic lymphocytic leukemia cells

Kwok, M., Davies, N., Agathanggelou, A., Smith, E., Oldreive, C., Petermann, E., Stewart, G., Brown, J., Lau, A., Pratt, G., Parry, H., Taylor, M., Moss, P., Hillmen, P. & Stankovic, T., 4 Feb 2016, In: Blood. 127, 5, p. 582-595

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

32 Downloads (Pure)

Increased global transcription activity as a mechanism of replication stress in cancer

Kotsantis, P., Marques Silva, L., Irmscher, S., Jones, R., Folkes, L., Gromak, N. & Petermann, E., Dec 2016, In: Nature Communications. 7, 1, 13 p., 13087.

Research output: Contribution to journal › Article › peer-review

Open Access

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114 Citations (Scopus)

298 Downloads (Pure)

Increased global transcription activity as a mechanism of replication stress in cancer

Kotsantis, P., Marques Silva, L., Irmscher, S., Jones, R., Folkes, L., Gromak, N. & Petermann, E., Jun 2016.

Research output: Contribution to conference (unpublished) › Poster

2015

Cancer Therapy and Replication Stress: Forks on the Road to Perdition

Kotsantis, P., Jones, R., Higgs, M. & Petermann, E., 24 Apr 2015, Advances in Clinical Chemistry. Makowski, G. S. (ed.). Academic Press (Elsevier), Vol. 69. p. 91-138

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

19 Citations (Scopus)

Synthetic lethality in chronic lymphocytic leukaemia with DNA damage response defects by targeting the ATR pathway

Kwok, M., Davies, N., Agathanggelou, A., Smith, E., Petermann, E., Yates, E., Brown, J., Lau, A. & Stankovic, T., 26 Feb 2015, In: The Lancet. 385 Suppl 1, p. S58

Research output: Contribution to journal › Abstract › peer-review

2014

ATR Inhibition Exacerbates Replication Stress in TP53 or ATM Deficient CLL Cells and Enhances Sensitivity to Chemotherapy and Targeted Therapy

Kwok, M. C. K., Davies, N., Agathanggelou, A., Smith, E., Petermann, E., Yates, E., Brown, J., Lau, A. & Stankovic, T., 6 Dec 2014, Blood. Vol. 124. p. 3340 (Blood).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

BRCA2 and RAD51 promote double-strand break formation and cell death in response to Gemcitabine

Jones, R., Kotsantis, P., Stewart, G., Groth, P. & Petermann, E., Oct 2014, In: Molecular Cancer Therapeutics. 13, 10, p. 2412-2421

Research output: Contribution to journal › Article › peer-review

Open Access

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27 Citations (Scopus)

305 Downloads (Pure)

Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress

Gagou, M. E., Ganesh, A., Phear, G., Robinson, D., Petermann, E., Cox, A. & Meuth, M., 5 Nov 2014, In: OncoTarget. 5, 22, p. 11381-11398 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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18 Citations (Scopus)

126 Downloads (Pure)

Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

Bolderson, E., Petermann, E., Croft, L., Suraweera, A., Pandita, R., Pandita, T., Helleday, T., Khanna, K. & Richard, D., Jun 2014, In: Nucleic Acids Research. 42, 10, p. 6326-6336

Research output: Contribution to journal › Article › peer-review

Open Access

35 Citations (Scopus)

New roles for BRCA2 and RAD51 at stalled replication forks

Jones, R., Kotsantis, P., Stewart, G., Groth, P. & Petermann, E., 19 May 2014.

Research output: Contribution to conference (unpublished) › Poster

2013

BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia

Da Costa, D., Agathanggelou, A., Perry, T., Weston, V., Petermann, E., Zlatanou, A., Oldreive, C., Wei, W., Stewart, G., Longman, J., Smith, E., Kearns, P., Knapp, S. & Stankovic, T., Jul 2013, In: Blood Cancer Journal. 3, 7, e126.

Research output: Contribution to journal › Article › peer-review

Open Access

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62 Citations (Scopus)

253 Downloads (Pure)

Diminished origin licensing capacity specifically sensitises tumour cells to replication stress

Zimmerman, K. M., Jones, R., Petermann, E. & Jeggo, P. A., 2013, In: Molecular cancer research : MCR.

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

3 Downloads (Pure)

2012

DNA damage by X-rays and their impact on replication processes

Parplys, A., Petermann, E., Petersen, C., Dikomey, E. & Borgmann, K., 1 Mar 2012, In: Radiotherapy & Oncology. 102, 3, p. 466-471 6 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

Jones, R., Mortusewicz, O., Afzal, I., Lorvellec, M., García, P., Helleday, T. & Petermann, E., 2012, In: Oncogene.

Research output: Contribution to journal › Article › peer-review

146 Citations (Scopus)

Replication fork dynamics and the DNA damage response

Jones, R. & Petermann, E., 1 Apr 2012, In: Biochemical Journal. 443, p. 13-26 14 p.

Research output: Contribution to journal › Review article

Open Access

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86 Citations (Scopus)

1074 Downloads (Pure)

Targeted mutations in the ATR pathway define agent-specific requirements for cancer cell growth and survival

Wilsker, D., Chung, J. H., Pradilla, I., Petermann, E., Helleday, T. & Bunz, F., Jan 2012, In: Molecular Cancer Therapeutics. 11, 1, p. 98-107 10 p.

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

2010

Chk1 promotes replication fork progression by controlling replication initiation

Petermann, E., Woodcock, M. & Helleday, T., 14 Sept 2010, In: National Academy of Sciences. Proceedings. 107, 37, p. 16090-16095 6 p.

Research output: Contribution to journal › Article › peer-review

181 Citations (Scopus)

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

Petermann, E., Orta, M., Issaeva, N., Schultz, N. & Helleday, T., 1 Feb 2010, In: Molecular Cell. 37, 4, p. 492-502 11 p.

Research output: Contribution to journal › Article › peer-review

493 Citations (Scopus)

4 Downloads (Pure)

Methylated DNA Causes a Physical Block to Replication Forks Independently of Damage Signalling, O6-Methylguanine or DNA Single-Strand Breaks and Results in DNA Damage

Groth, P., Ausländer, S., Majumder, M., Schultz, N., Johansson, F., Petermann, E. & Helleday, T., 10 Sept 2010, In: Journal of Molecular Biology. 402, 1, p. 70-82 13 p.

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

251 Downloads (Pure)

Pathways of mammalian replication fork restart

Petermann, E. & Helleday, T., 15 Sept 2010, In: Nature Reviews. Molecular Cell Biology. 11, 10, p. 683-687 5 p.

Research output: Contribution to journal › Review article › peer-review

265 Citations (Scopus)

2009

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

Bryant, H., Petermann, E., Schultz, N., Jemth, A., Loseva, O., Issaeva, N., Johansson, F., Fernandez, S., McGlynn, P. & Helleday, T., 2 Sept 2009, In: The EMBO journal. 28, 17, p. 2601-2615 15 p.

Research output: Contribution to journal › Article › peer-review

392 Citations (Scopus)

8 Downloads (Pure)

2008

Claspin promotes normal replication fork rates in human cells

Petermann, E., Helleday, T. & Caldecott, K., 1 Jun 2008, In: Molecular Biology of the Cell. 19, 6, p. 2373-2378 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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82 Citations (Scopus)

402 Downloads (Pure)

DNA repair pathways as targets for cancer therapy

Helleday, T., Petermann, E., Lundin, C., Hodgson, B. & Sharma, R., 1 Mar 2008, In: Nature Reviews Cancer. 8, 3, p. 193-204 12 p.

Research output: Contribution to journal › Review article › peer-review

File

1083 Citations (Scopus)

4743 Downloads (Pure)

Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control

Wilsker, D., Petermann, E., Helleday, T. & Bunz, F., 30 Dec 2008, In: National Academy of Sciences. Proceedings. 105, 52, p. 20752-20757 6 p.

Research output: Contribution to journal › Article › peer-review

101 Citations (Scopus)

2007

Chk1 regulates the density of active replication origins during the vertebrate S phase

Maya-Mendoza, A., Petermann, E., Gillespie, D. A. F., Caldecott, K. W. & Jackson, D. A., 6 Jun 2007, In: The EMBO journal. 26, 11, p. 2719-2731 13 p.

Research output: Contribution to journal › Article › peer-review

182 Citations (Scopus)

34 Downloads (Pure)

DNA replication-associated lesions: importance in early tumorigenesis and cancer therapy

Petermann, E. & Helleday, T., 2007, In: Biochemical Society Transactions. 35, Pt 5, p. 1352-4 3 p.

Research output: Contribution to journal › Review article

4 Citations (Scopus)

2006

ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling

Stiff, T., Walker, S. A., Cerosaletti, K., Goodarzi, A. A., Petermann, E., Concannon, P., O'Driscoll, M. & Jeggo, P. A., 2006, In: The EMBO journal. 25, 24, p. 5775-82 8 p.

Research output: Contribution to journal › Article › peer-review

272 Citations (Scopus)

Chk1 requirement for high global rates of replication fork progression during normal vertebrate S phase

Petermann, E., Maya-Mendoza, A., Zachos, G., Gillespie, D. A. F., Jackson, D. A. & Caldecott, K. W., 2006, In: Molecular and Cellular Biology. 26, 8, p. 3319-26 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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144 Citations (Scopus)

218 Downloads (Pure)

Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase

Petermann, E. & Caldecott, K. W., 2006, In: Cell Cycle. 5, 19, p. 2203-9 7 p.

Research output: Contribution to journal › Review article

98 Citations (Scopus)

Measurement of chromosomal DNA single-strand breaks and replication fork progression rates

Breslin, C., Clements, P. M., El-Khamisy, S. F., Petermann, E., Iles, N. & Caldecott, K. W., 2006, In: Methods in Enzymology. 409, p. 410-25 16 p.

Research output: Contribution to journal › Review article

29 Citations (Scopus)

Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER

Petermann, E., Keil, C. & Oei, S. L., 2006, In: DNA Repair. 5, 5, p. 544-55 12 p.

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

2005

Importance of poly(ADP-ribose) polymerases in the regulation of DNA-dependent processes

Petermann, E., Keil, C. & Oei, S. L., 2005, In: Cellular and Molecular Life Sciences. 62, 7-8, p. 731-8 8 p.

Research output: Contribution to journal › Review article

46 Citations (Scopus)

Eva Petermann

Research output

Search results