Research output per year
Research output per year
- 1 - 50 out of 68 results
Search results
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2023
Organometallic Pillarplexes That Bind DNA 4-Way Holliday Junctions and Forks
Craig, J. S., Melidis, L., Williams, H. D., Dettmer, S. J., Heidecker, A. A., Altmann, P. J., Guan, S., Campbell, C., Browning, D. F., Sigel, R. K. O., Johannsen, S., Egan, R. T., Aikman, B., Casini, A., Pöthig, A. & Hannon, M. J., 15 Jun 2023, (E-pub ahead of print) In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Downloads (Pure) -
2022
Inexpensive protein overexpression driven by the NarL transcription activator protein
Hothersall, J., Lai, S., Zhang, N., Godfrey, R., Ruanto, P., Bischoff, S., Robinson, C., Overton, T., Busby, S. & Browning, D., 13 May 2022, In: Biotechnology and Bioengineering. 119, 6, p. 1614-1623 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile116 Downloads (Pure) -
New vectors for urea-inducible recombinant protein production
Hothersall, J., Osgerby, A., Godfrey, R., Overton, T., Busby, S. & Browning, D., 25 Dec 2022, In: New Biotechnology. 72, p. 89-96 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Downloads (Pure) -
Novel organisation and regulation of the pic promoter from enteroaggregative and uropathogenic Escherichia coli
Alhammadi, M. M., Godfrey, R. E., Ingram, J. O., Singh, G., Bathurst, C. L., Busby, S. J. W. & Browning, D. F., Dec 2022, In: Virulence. 13, 1, p. 1393-1406 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile69 Downloads (Pure) -
2021
Antimicrobial Resistance and Comparative Genome Analysis of Klebsiella pneumoniae Strains Isolated in Egypt
Abdelwahab, R., Alhammadi, M. M., Hassan, E. A., Ahmed, E. H., Abu-faddan, N. H., Daef, E. A., Busby, S. J. W. & Browning, D. F., 5 Sept 2021, In: Microorganisms. 9, 9, 15 p., 1880.Research output: Contribution to journal › Article › peer-review
Open AccessFile108 Downloads (Pure) -
BamA and BamD are essential for the secretion of trimeric autotransporter adhesins
Rooke, J. L., Icke, C., Wells, T. J., Rossiter, A. E., Browning, D. F., Morris, F. C., Leo, J. C., Schütz, M. S., Autenrieth, I. B., Cunningham, A. F., Linke, D. & Henderson, I. R., 23 Feb 2021, In: Frontiers in Microbiology. 12, 628879.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)195 Downloads (Pure) -
The PAR promoter expression system: modified lac promoters for controlled recombinant protein production in Escherichia coli
Hothersall, J., Godfrey, R., Fanitsios, C., Overton, T., Busby, S. & Browning, D., 25 Sept 2021, In: New Biotechnology. 64, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile667 Downloads (Pure) -
2020
Activation by NarL at the Escherichia coli ogt promoter
Ruanto, P., Chismon, D. J., Hothersall, J., Godfrey, R. E., Lee, D. J., Busby, S. J. W. & Browning, D. F., 14 Aug 2020, In: The Biochemical journal. 477, 15, p. 2807-2820 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile216 Downloads (Pure) -
An ideal spacing is required for the control of Class II CRP-dependent promoters by the status of CRP K100
Écija-Conesa, A., Gallego-Jara, J., Lozano Terol, G., Browning, D. F., Busby, S. J. W., Wolfe, A. J., Cánovas Díaz, M. & de Diego Puente, T., 11 Nov 2020, In: FEMS Microbiology Letters. 367, 20Research output: Contribution to journal › Article › peer-review
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Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: similarities and differences
Abdelwahab, R., Yasir, M., Godfrey, R. E., Christie, G. S., Element, S. J., Saville, F., Hassan, E. A., Ahmed, E. H., Abu-Faddan, N. H., Daef, E. A., Busby, S. J. W. & Browning, D. F., 29 Dec 2020, (E-pub ahead of print) In: Virulence. 12, 1, p. 57-74 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)252 Downloads (Pure) -
Rotaxanating metallo-supramolecular nano-cylinder helicates to switch DNA junction binding
Hooper, C. A. J., Cardo, L., Craig, J. S., Melidis, L., Garai, A., Egan, R. T., Sadovnikova, V., Burkert, F., Male, L., Hodges, N. J., Browning, D. F., Rosas, R., Liu, F., Rocha, F. V., Lima, M. A., Liu, S., Bardelang, D. & Hannon, M. J., 9 Dec 2020, In: Journal of the American Chemical Society. 142, 49, p. 20651-20660 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1 Citation (Scopus)435 Downloads (Pure) -
Structure of dual-BON domain protein DolP identifies phospholipid binding as a new mechanism for protein localization
Bryant, J. A., Morris, F. C., Knowles, T. J., Maderbocus, R., Heinz, E., Boelter, G., Alodaini, D., Colyer, A., Wotherspoon, P. J., Staunton, K. A., Jeeves, M., Browning, D. F., Sevastsyanovich, Y. R., Wells, T. J., Rossiter, A. E., Bavro, V. N., Sridhar, P., Ward, D. G., Chong, Z.-S. & Goodall, E. C. A. & 9 others, , Dec 2020, In: eLife. 9Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2019
Bacterial transcription factors: regulation by pick 'n' mix
Browning, D. F., Butala, M. & Busby, S. J. W., 20 Sept 2019, In: Journal of Molecular Biology. 431, 20, p. 4067-4077 11 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile15 Citations (Scopus)621 Downloads (Pure) -
Distinct intraspecies virulence mechanisms regulated by a conserved transcription factor
Connolly, J. P. R., O'Boyle, N., Turner, N. C. A., Browning, D. F. & Roe, A. J., 24 Sept 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 39, p. 19695-19704 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)190 Downloads (Pure) -
Escherichia coli "TatExpress" strains export several g/L human growth hormone to the periplasm by the Tat pathway
Guerrero Montero, I., Richards, K. L., Jawara, C., Browning, D. F., Peswani, A. R., Labrit, M., Allen, M., Aubry, C., Davé, E., Humphreys, D. P., Busby, S. J. W. & Robinson, C., Dec 2019, In: Biotechnology and Bioengineering. 116, 12, p. 3282-3291 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)222 Downloads (Pure) -
Exploitation of the Escherichia coli lac operon promoter for controlled recombinant protein production
Browning, D. F., Godfrey, R. E., Richards, K. L., Robinson, C. & Busby, S. J. W., 30 Apr 2019, In: Biochemical Society Transactions. 47, 2, p. 755-763 9 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile9 Citations (Scopus)921 Downloads (Pure) -
Organization and architecture of AggR-dependent promoters from enteroaggregative Escherichia coli
Yasir, M., Icke, C., Abdelwahab, R., Haycocks, J. R., Godfrey, R. E., Sazinas, P., Pallen, M. J., Henderson, I. R., Busby, S. J. W. & Browning, D. F., 1 Feb 2019, In: Molecular Microbiology. 111, 2, p. 534-551 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)345 Downloads (Pure) -
Oxygen and contact with human intestinal epithelium independently stimulate virulence gene expression in enteroaggregative Escherichia coli
Ellis, S. J., Yasir, M., Browning, D. F., Busby, S. J. W. & Schüller, S., Jun 2019, In: Cellular Microbiology. 21, 6, 12 p., e13012.Research output: Contribution to journal › Article › peer-review
Open AccessFile2 Citations (Scopus)347 Downloads (Pure) -
Position effects on promoter activity in Escherichia coli and their consequences for antibiotic-resistance determinants
Cooke, K., Browning, D. F., Lee, D. J., Blair, J. M. A., McNeill, H. E., Huber, D., Busby, S. J. W. & Bryant, J. A., 28 Jun 2019, In: Biochemical Society Transactions. 47, 3, p. 839-845 7 p.Research output: Contribution to journal › Review article › peer-review
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2018
Lytic gene expression in the temperate bacteriophage GIL01 is activated by a phage-encoded LexA homologue
Fornelos, N., Browning, D. F., Pavlin, A., Podlesek, Z., Hodnik, V., Salas, M. & Butala, M., 12 Oct 2018, In: Nucleic Acids Research. 46, 18, p. 9432–9443Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)168 Downloads (Pure) -
2017
Antigen localization influences the magnitude and kinetics of the endogenous adaptive immune response to recombinant Salmonella vaccines
Sevastsyanovich, Y. R., Withers, D. R., Marriott, C. L., Morris, F. C., Wells, T. J., Browning, D. F., Beriotto, I., Ross, E., Ali, H. O., Wardius, C. A., Cunningham, A. F., Henderson, I. R. & Rossiter, A. E., 17 Nov 2017, In: Infection and Immunity. 85, 12 p., e00593-17.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)109 Downloads (Pure) -
Escherichia coli "TatExpress" strains super-secrete human growth hormone into the bacterial periplasm by the Tat pathway
Browning, D. F., Richards, K. L., Peswani, A. R., Roobol, J., Busby, S. J. W. & Robinson, C., 26 Aug 2017, In: Biotechnology and Bioengineering.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Citations (Scopus)220 Downloads (Pure) -
Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells
O'Donoghue, E., Sirisaengtaksin, N., Browning, D., Bielska, E., Hadis, M., Fernandez-Trillo, F., Alderwick, L., Jabbari, S. & Krachler, A. M., 29 Nov 2017, In: PLoS pathogens. 13, 11, p. e1006760Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Citations (Scopus)364 Downloads (Pure) -
Regulation of nrf operon expression in pathogenic enteric bacteria: sequence divergence reveals new regulatory complexity
Godfrey, R. E., Lee, D. J., Busby, S. J. W. & Browning, D. F., 11 May 2017, In: Molecular Microbiology. 104, 4, p. 580–594Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)182 Downloads (Pure) -
2016
Local and global regulation of transcription initiation in bacteria
Browning, D. F. & Busby, S. J. W., 8 Aug 2016, In: Nature Reviews Microbiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile180 Citations (Scopus)1492 Downloads (Pure) -
Regulation, sensory domains and roles of two Desulfovibrio desulfuricans ATCC27774 Crp family transcription factors, HcpR1 and HcpR2, in response to nitrosative stress
Cadby, I. T., Ibrahim, S. A., Faulkner, M., Lee, D. J., Browning, D., Busby, S. J., Lovering, A. L., Stapleton, M. R., Green, J. & Cole, J. A., 16 Dec 2016, In: Molecular Microbiology. 102, 6, p. 1120-1137 18 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus) -
The Use and Abuse of LexA by Mobile Genetic Elements
Fornelos, N., Browning, D. F. & Butala, M., 9 May 2016, In: Trends in Microbiology. 24, 5, p. 391-401 11 p.Research output: Contribution to journal › Review article › peer-review
30 Citations (Scopus) -
2015
Cross-species chimeras reveal BamA POTRA and β-barrel domains must be fine-tuned for efficient OMP insertion
Browning, D. F., Bavro, V. N., Mason, J. L., Sevastsyanovich, Y. R., Rossiter, A. E., Jeeves, M., Wells, T. J., Knowles, T. J., Cunningham, A. F., Donald, J. W., Palmer, T., Overduin, M. & Henderson, I. R., 12 Aug 2015, In: Molecular Microbiology. 97, 4, p. 646–659Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)523 Downloads (Pure) -
Expression of different bacterial cytotoxins is controlled by two global transcription factors, CRP and Fis, that cooperate in a shared-recruitment mechanism
Rossiter, A. E., Godfrey, R. E., Connolly, J. A., Busby, S. J. W., Henderson, I. R. & Browning, D. F., 1 Mar 2015, In: Biochem J. 466 , 2 pp323-335Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Silencing of DNase colicin E8 gene expression by a complex nucleoprotein assembly ensures timely colicin induction
Kamenšek, S., Browning, D. F., Podlesek, Z., Busby, S. J. W., Žgur-bertok, D. & Butala, M., 26 Jun 2015, In: PLoS Genetics. 11, 6, e1005354.Research output: Contribution to journal › Article › peer-review
Open AccessFile12 Citations (Scopus)200 Downloads (Pure) -
2014
Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing
Wells, T. J., Whitters, D., Sevastsyanovich, Y. R., Heath, J. N., Pravin, J., Goodall, M., Browning, D. F., O'Shea, M. K., Cranston, A., De Soyza, A., Cunningham, A. F., MacLennan, C. A., Henderson, I. R. & Stockley, R. A., 25 Aug 2014, In: The Journal of Experimental Medicine. 211, 9, p. 1893-1904 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Citations (Scopus)194 Downloads (Pure) -
2013
Genotypic and phenotypic characterisation of enteroaggregative Escherichia coli from children in Rio de Janeiro, Brazil
França, F. L. S., Wells, T. J., Browning, D. F., Nogueira, R. T., Sarges, F. S., Pereira, A. C., Cunningham, A. F., Lucheze, K., Rosa, A. C. P., Henderson, I. R., De Luna, M. D. G. & Cascales, E. (Editor), 30 Jul 2013, In: PLoS ONE. 8, 7, e69971.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)262 Downloads (Pure) -
Laboratory adapted Escherichia coli K-12 becomes a pathogen of Caenorhabditis elegans upon restoration of O antigen biosynthesis
Browning, D. F., Wells, T. J., França, F. L. S., Morris, F. C., Sevastsyanovich, Y. R., Bryant, J. A., Johnson, M. D., Lund, P. A., Cunningham, A. F., Hobman, J. L., May, R. C., Webber, M. A. & Henderson, I. R., Mar 2013, In: Molecular Microbiology. 87, 5, p. 939-50 12 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Mutational and topological analysis of the Escherichia coli BamA protein
Browning, D. F., Matthews, S. A., Rossiter, A. E., Sevastsyanovich, Y. R., Jeeves, M., Mason, J. L., Wells, T. J., Wardius, C. A., Knowles, T. J., Cunningham, A. F., Bavro, V. N., Overduin, M. & Henderson, I. R., 23 Dec 2013, In: PLoS ONE. 8, 12, e84512.Research output: Contribution to journal › Article › peer-review
Open AccessFile20 Citations (Scopus)327 Downloads (Pure) -
2012
Double locking of an Escherichia coli promoter by two repressors prevents premature colicin expression and cell lysis
Butala, M., Sonjak, S., Kamenšek, S., Hodošček, M., Browning, D. F., Žgur-Bertok, D. & Busby, S. J. W., 2012, In: Molecular Microbiology. 86, 1, p. 129-39 11 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
2011
Complete Genome Sequence of the Crohn's Disease-Associated Adherent-Invasive Escherichia coli Strain HM605
Clarke, D. J., Chaudhuri, R. R., Martin, H. M., Campbell, B. J., Rhodes, J. M., Constantinidou, C., Pallen, M. J., Loman, N. J., Cunningham, A. F., Browning, D. F. & Henderson, I. R., Sept 2011, In: Journal of Bacteriology. 193, 17, p. 4540-4540 1 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Citations (Scopus) -
SadA, a Trimeric Autotransporter from Salmonella enterica Serovar Typhimurium, Can Promote Biofilm Formation and Provides Limited Protection against Infection.
Raghunathan, D., Wells, T., Morris, F., Shaw, R., Bobat, S., Peters, S., Paterson, G., Jensen, K., Leyton, D., Blair, J., Browning, D., Pravin, J., Flores-Langarica, A., Hitchcock, J., Moraes, C., Piazza, R., Maskell, D., Webber, M., May, R. & MacLennan, C. & 3 others, , 1 Nov 2011, In: Infection and Immunity. 79, 11, p. 4342-52 11 p.Research output: Contribution to journal › Article
57 Citations (Scopus) -
Size and conformation limits to secretion of disulfide-bonded loops in autotransporter proteins.
Leyton, D., Sevastsyanovich, Y., Browning, D., Rossiter, A., Wells, T., Fitzpatrick, R., Overduin, M., Cunningham, A. & Henderson, I., 17 Oct 2011, In: Journal of Biological Chemistry. 286, 49, p. 42283-42291 9 p.Research output: Contribution to journal › Article
59 Citations (Scopus) -
Structure and function of BamE within the outer membrane and the beta-barrel assembly machine
Knowles, T., Browning, D., Jeeves, M., Maderbocus, R., Rajesh, S., Sridhar, P., Manoli, E., Emery, D., Sommer, U., Spencer, A., Leyton, D., Squire, D., Chaudhuri, R., Viant, M., Cunningham, A., Henderson, I. & Overduin, M., 1 Feb 2011, In: EMBO Reports. 12, 2, p. 123-128 6 p.Research output: Contribution to journal › Article
71 Citations (Scopus) -
The Essential beta-Barrel Assembly Machinery Complex Components BamD and BamA Are Required for Autotransporter Biogenesis
Rossiter, A., Leyton, D., Tveen-Jensen, K., Browning, D., Sevastsyanovich, Y., Knowles, T., Nichols, K., Cunningham, A., Overduin, M., Schembri, M. & Henderson, I., 1 Aug 2011, In: Journal of Bacteriology. 193, 16, p. 4250-4253 4 p.Research output: Contribution to journal › Article
54 Citations (Scopus) -
Transcription of the plasmid-encoded toxin gene from Enteroaggregative Escherichia coli is regulated by a novel co-activation mechanism involving CRP and Fis.
Rossiter, A., Browning, D., Leyton, D., Johnson, M., Godfrey, R., Wardius, C., Desvaux, M., Cunningham, A., Ruiz-Perez, F., Nataro, J., Busby, S. & Henderson, I., 4 May 2011, In: Molecular Microbiology. 81, 1, p. 179-191 13 p.Research output: Contribution to journal › Article
25 Citations (Scopus) -
2010
Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide sensing transcription repressor to an upstream site.
Browning, D., Lee, D., Spiro, S. & Busby, S., 14 May 2010, In: Journal of Bacteriology.Research output: Contribution to journal › Article
15 Citations (Scopus) -
Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression.
Browning, D., Grainger, D. & Busby, S., 13 Oct 2010, In: Current Opinion in Microbiology.Research output: Contribution to journal › Article
201 Citations (Scopus) -
Modulation of Shigella virulence in response to available oxygen in vivo
Marteyn, B., West, N., Browning, D., Cole, J., Shaw, J., Palm, F., Mounier, J., Prevost, M., Sansonetti, P. & Tang, C., 1 May 2010, In: Nature. 465, 7296, p. 355-U113Research output: Contribution to journal › Article
217 Citations (Scopus) -
The unusual extended signal peptide region is not required for secretion and function of an Escherichia coli autotransporter.
Leyton, D., de Luna, M., Sevastsyanovich, Y., Tveen Jensen, K., Browning, D., Scott-Tucker, A. & Henderson, I., 1 Oct 2010, In: FEMS Microbiology Letters. 311, 2, p. 133-9 7 p.Research output: Contribution to journal › Article
14 Citations (Scopus) -
Transcriptional Regulation by Nucleoid-Associated Proteins at Complex Promoters in Escherichia coli
Browning, D., Grainger, D., Xu, M., Busby, S., Dame, R. & Dorman, C., 1 Jan 2010, Bacterial Chromatin.Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Citations (Scopus) -
Unusual organization, complexity and redundancy at the Escherichia coil hcp-hcr operon promoter
Chismon, D., Browning, D., Farrant, G. & Busby, S., 1 Aug 2010, In: Biochemical Journal. 430, p. 61-68 8 p.Research output: Contribution to journal › Article
13 Citations (Scopus) -
2009
Activation and repression at the Escherichia coli ynfEFGHI operon promoter.
Xu, M., Busby, S. & Browning, D., 27 Feb 2009, In: Journal of Bacteriology.Research output: Contribution to journal › Article
8 Citations (Scopus) -
Assays for transcription factor activity
Browning, D., Savery, N., Kolb, A. & Busby, S., 1 Jan 2009, Methods in Molecular Biology: DNA - Protein interactions. LeBlanc, B. & Moss, T. (eds.). 3rd ed. Humana Press, p. 368-87 19 p. (Methods in Molecular Biology™, Methods and Protocols; vol. 543).Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Competition between NarL-dependent activation and Fis-dependent repression controls expression from the Escherichia coli yeaR and ogt promoters
Squire, D., Xu, M., Cole, J., Busby, S. & Browning, D., 26 Feb 2009, In: Biochemical Journal. 420, p. 249-257 9 p.Research output: Contribution to journal › Article
23 Citations (Scopus)