Research output per year
Research output per year
- 1 - 50 out of 52 results
Search results
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2024
H-NS is a bacterial transposon capture protein
Cooper, C., Legood, S., Wheat, R. L., Forrest, D., Sharma, P., Haycocks, J. R. J. & Grainger, D. C., 20 Aug 2024, In: Nature Communications. 15, 7137.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
2023
An unexpected abundance of bidirectional promoters within Salmonella Typhimurium plasmids
Middlemiss, A. D., Warman, E. A., Forrest, D., Haycocks, J. R. J. & Grainger, D. C., 19 May 2023, In: Microbiology. 169, 5, 001339.Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Downloads (Pure) -
A simple mechanism for integration of quorum sensing and cAMP signalling in V. cholerae
Walker, L., Haycocks, J., van Kessel, J. C., Dalia, T. N., Dalia, A. B. & Grainger, D., 5 Apr 2023, (Submitted) In: eLife.Research output: Contribution to journal › Article › peer-review
File25 Downloads (Pure) -
A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae
Walker, L. M., Haycocks, J. RJ., Van Kessel, J. C., Dalia, T. N., Dalia, A. B. & Grainger, D. C., 6 Jul 2023, In: eLife. 12, 22 p., RP86699.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
Mapping direct and indirect MarA/SoxS/Rob/RamA regulons in Salmonella Typhimurium reveals repression of csgD and biofilm formation
Middlemiss, A. D., Haycocks, J. R. J., Stringer, A. M., Piddock, L. J. V., Wade, J. T. & Grainger, D. C., 19 May 2023, In: Microbiology. 169, 5, 001330.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Downloads (Pure) -
The environmentally-regulated interplay between local three-dimensional chromatin organisation and transcription of proVWX in E. coli
Rashid, F-Z. M., Crémazy, F. G. E., Hofmann, A., Forrest, D., Grainger, D. C., Heermann, D. W. & Dame, R. T., 17 Nov 2023, In: Nature Communications. 14, 1, 25 p., 7478.Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Downloads (Pure) -
2022
Genome-wide mapping of Vibrio cholerae VpsT binding identifies a mechanism for c-di-GMP homeostasis
Guest, T., Haycocks, J. R. J., Warren, G. Z. L. & Grainger, D. C., 11 Jan 2022, In: Nucleic Acids Research. 50, 1, p. 149-159 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile86 Downloads (Pure) -
Xenogeneic silencing strategies in bacteria are dictated by RNA polymerase promiscuity
Forrest, D., Warman, E. A., Erkelens, A. M., Dame, R. T. & Grainger, D. C., 3 Mar 2022, In: Nature Communications. 13, 1, 1149.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Downloads (Pure) -
2021
Widespread divergent transcription from bacterial and archaeal promoters is a consequence of DNA sequence symmetry
Warman, E., Forrest, D., Guest, T., Haycocks, J., Wade, J. T. & Grainger, D., 6 May 2021, (E-pub ahead of print) In: Nature Microbiology. 6, 6, p. 746-756Research output: Contribution to journal › Article › peer-review
Open AccessFile246 Downloads (Pure) -
2020
A non-canonical promoter element drives spurious transcription of horizontally acquired bacterial genes
Warman, E. A., Singh, S. S., Gubieda, A. G. & Grainger, D. C., 21 May 2020, In: Nucleic Acids Research. 48, 9, p. 4891-4901 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Citations (Scopus)160 Downloads (Pure) -
2019
The Escherichia coli MarA protein regulates the ycgZ-ymgABC operon to inhibit biofilm formation
Kettles, R. A., Tschowri, N., Lyons, K. J., Sharma, P., Hengge, R., Webber, M. A. & Grainger, D. C., Nov 2019, In: Molecular Microbiology. 112, 5, p. 1609-1625 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Citations (Scopus)229 Downloads (Pure) -
The quorum sensing transcription factor AphA directly regulates natural competence in Vibrio cholerae
Haycocks, J. R. J., Warren, G. Z. L., Walker, L. M., Chlebek, J. L., Dalia, T. N., Dalia, A. B. & Grainger, D. C., 28 Oct 2019, In: PLoS Genetics. 15, 10, e1008362.Research output: Contribution to journal › Article › peer-review
Open AccessFile7 Citations (Scopus)194 Downloads (Pure) -
2018
cAMP Receptor Protein Controls Vibrio cholerae Gene Expression in Response to Host Colonization
Manneh-Roussel, J., Haycocks, J. R. J., Magán, A., Perez-soto, N., Voelz, K., Camilli, A., Krachler, A. & Grainger, D. C., 10 Jul 2018, In: mBio. 9, 4, e00966-18.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Citations (Scopus)261 Downloads (Pure) -
Determination of the 3D genome organization of bacteria using Hi-C
Crémazy, F. G., Rashid, F. Z. M., Haycocks, J. R., Lamberte, L. E., Grainger, D. C. & Dame, R. T., 2018, Bacterial Chromatin: Methods and Protocols. Dame, R. T. (ed.). New York, NY: Humana Press, p. 3-18 16 p. (Methods in Molecular Biology; vol. 1837).Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Citations (Scopus) -
2017
CsrA maximizes expression of the AcrAB multidrug resistance transporter
Ricci, V., Attah, V., Overton, T., Grainger, D. C. & Piddock, L. J. V., 15 Dec 2017, In: Nucleic Acids Research. 45, 22, p. 12798–12807Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)191 Downloads (Pure) -
Horizontally acquired AT-rich genes in Escherichia coli cause toxicity by sequestering RNA polymerase
Lamberte, L. E., Baniulyte, G., Singh, S. S., Stringer, A. M., Bonocora, R. P., Stracy, M., Kapanidis, A. N., Wade, J. T. & Grainger, D. C., 9 Jan 2017, In: Nature Microbiology. 2, 16249.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)277 Downloads (Pure) -
Prognostic significance of high GFI1 expression in AML of normal karyotype and its association with a FLT3-ITD signature
Volpe, G., Walton, D., Grainger, D., Ward, C., Cauchy, P., Blakemore, D., Coleman, D., Cockerill, P., Garcia, P. & Frampton, J., 11 Sept 2017, In: Scientific Reports. 7, 11148.Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)206 Downloads (Pure) -
Spurious transcription and its impact on cell function
Wade, J. T. & Grainger, D. C., 5 Oct 2017, In: Transcription.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)178 Downloads (Pure) -
The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity
Sharma, P., Haycocks, J., Middlemiss, A., Kettles, R., Sellars, L., Ricci, V., Piddock, L. & Grainger, D., 13 Nov 2017, (E-pub ahead of print) In: Nature Communications. 8, 1, 1444 (2017).Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)249 Downloads (Pure) -
2016
Structure and function of bacterial H-NS protein
Grainger, D. C., 15 Dec 2016, In: Biochemical Society Transactions. 44, 6, p. 1561-1569 9 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
The unexpected complexity of bacterial genomes
Grainger, D. C., Jul 2016, In: Microbiology. 162, 7, p. 1167-1172 6 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Citations (Scopus) -
Unusually Situated Binding Sites for Bacterial Transcription Factors Can Have Hidden Functionality
Haycocks, J. R. J. & Grainger, D. C., 3 Jun 2016, In: PLoS ONE. 11, 6, e0157016.Research output: Contribution to journal › Article › peer-review
Open AccessFile13 Citations (Scopus)175 Downloads (Pure) -
2015
DNA recognition by Escherichia coli CbpA protein requires a conserved arginine-minor-groove interaction
Chintakayala, K., Sellars, L. E., Singh, S. S., Shahapure, R., Westerlaken, I., Meyer, A. S., Dame, R. T. & Grainger, D. C., 27 Feb 2015, In: Nucleic Acids Research. 43, 4, p. 2282-2292Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)217 Downloads (Pure) -
The molecular basis for control of ETEC enterotoxin expression in response to environment and host
Haycocks, J. R. J., Sharma, P., Stringer, A. M., Wade, J. T. & Grainger, D. C., 8 Jan 2015, In: PLoS pathogens. 11, 1, e1004605.Research output: Contribution to journal › Article › peer-review
Open AccessFile25 Citations (Scopus)220 Downloads (Pure) -
2014
Widespread suppression of intragenic transcription initiation by H-NS
Singh, S. S., Singh, N., Bonocora, R. P., Fitzgerald, D. M., Wade, J. T. & Grainger, D., 1 Feb 2014, In: Genes & Development. 28, 3, p. 214-219 6 p.Research output: Contribution to journal › Article › peer-review
Open Access79 Citations (Scopus) -
2013
E. coli Fis protein insulates the cbpA gene from uncontrolled transcription
Chintakayala, K., Singh, S. S., Rossiter, A. E., Shahapure, R., Dame, R. T. & Grainger, D. C., 17 Jan 2013, In: PLoS Genetics. 9, 1, e1003152.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Citations (Scopus)298 Downloads (Pure) -
H-NS can facilitate specific DNA-binding by RNA polymerase in AT-rich gene regulatory regions
Singh, S. & Grainger, D., 20 Jun 2013, In: PLoS Genetics. 9, 6, e1003589.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Citations (Scopus)207 Downloads (Pure) -
2011
A Conserved Acidic Amino Acid Mediates the Interaction between Modulators and Co-Chaperones in Enterobacteria
Chintakayala, K. & Grainger, D., 1 Aug 2011, In: Journal of Molecular Biology. 411, 2, p. 313-320 8 p.Research output: Contribution to journal › Article
5 Citations (Scopus) -
Chromosomal Macrodomains and Associated Proteins: Implications for DNA Organization and Replication in Gram Negative Bacteria
Dame, RT., Kalmykowa, OJ. & Grainger, D., 16 Jun 2011, In: PLoS Genetics. 7, 6, p. e1002123-Research output: Contribution to journal › Article
Open Access74 Citations (Scopus) -
Escherichia Coli σ70 Senses Sequence and Conformation of the Promoter Spacer Region
Singh, S., Typas, A., Hengge, R. & Grainger, D., 1 Jul 2011, In: Nucleic Acids Research. 39, 12, p. 5109-5118 10 p.Research output: Contribution to journal › Article
Open Access43 Citations (Scopus) -
The Escherichia coli K-12 MntR Miniregulon Includes dps, Which Encodes the Major Stationary-Phase DNA-Binding Protein
Yamamoto, K., Ishihama, A., Busby, S. & Grainger, D., 1 Mar 2011, In: Journal of Bacteriology. 193, 6, p. 1477-1480 4 p.Research output: Contribution to journal › Article
26 Citations (Scopus) -
2010
Dimerization and DNA-dependent aggregation of the Escherichia coli nucleoid protein and chaperone CbpA
Cosgriff, S., Chintakayala, K., Chim, YTA., Chen, X., Allen, S., Lovering, A. & Grainger, D., 1 Sept 2010, In: Molecular Microbiology. 77, 5, p. 1289-1300 12 p.Research output: Contribution to journal › Article
29 Citations (Scopus) -
Dynamic Distribution of SeqA Protein across the Chromosome of Escherichia coli K-12
Sanchez-Romero, MA., Busby, S., Dyer, NP., Ott, S., Millard, AD. & Grainger, D., 18 May 2010, In: mBio. 1, 1, p. e00012-10-e00012-10Research output: Contribution to journal › Article
Open Access40 Citations (Scopus) -
Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression.
Browning, D., Grainger, D. & Busby, S., 13 Oct 2010, In: Current Opinion in Microbiology.Research output: Contribution to journal › Article
201 Citations (Scopus) -
Transcriptional Regulation by Nucleoid-Associated Proteins at Complex Promoters in Escherichia coli
Browning, D., Grainger, D., Xu, M., Busby, S., Dame, RT. & Dorman, CJ., 1 Jan 2010, Bacterial Chromatin.Research output: Chapter in Book/Report/Conference proceeding › Chapter
2 Citations (Scopus) -
2008
Autoregulation of the Escherichia coli melR promoter: repression involves four molecules of MelR.
Samarasinghe, S., El-Robh, MS., Grainger, D., Zhang, W., Soultanas, P. & Busby, S., 1 May 2008, In: Nucleic Acids Research. 36, 8, p. 2667-76 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)123 Downloads (Pure) -
Genome-wide identification of binding sites for the nitric oxide-sensitive transcriptional regulator NsrR
Efromovich, S., Grainger, D., Bodenmiller, D. & Spiro, S., 1 Jan 2008, In: Methods in Enzymology. 437, p. 211-233 23 p.Research output: Contribution to journal › Review article
23 Citations (Scopus) -
Global regulators of transcription in Escherichia coli: mechanisms of action and methods for study
Grainger, D., Busby, S., Laskin, AI., Gadd, GM. & Sariaslani, S., 1 Jan 2008, Advances in Applied Microbiology. Vol. 65.Research output: Chapter in Book/Report/Conference proceeding › Chapter
24 Citations (Scopus) -
Methods for studying global patterns of DNA binding by bacterial transcription factors and RNA polymerase.
Grainger, D. & Busby, S., 1 Aug 2008, In: Biochemical Society Transactions. 36, Pt 4, p. 754-7 4 p.Research output: Contribution to journal › Article
14 Citations (Scopus) -
Selective repression by Fis and H-NS at the Escherichia coli dps promoter.
Grainger, D., Goldberg, M., Lee, D. & Busby, S., 1 Jun 2008, In: Molecular Microbiology. 68, 6, p. 1366-77 12 p.Research output: Contribution to journal › Article
95 Citations (Scopus) -
The Escherichia coli RutR transcription factor binds at targets within genes as well as intergenic regions
Shimada, T., Ishihama, A., Busby, S. & Grainger, D., 1 Jan 2008, In: Nucleic Acids Research. 36, 12, p. 3950-3955 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile104 Citations (Scopus)216 Downloads (Pure) -
2007
Genomic analysis of protein?DNA interactions in bacteria: insights into transcription and chromosome organization
Wade, JT., Struhl, K., Busby, S. & Grainger, D., 1 Jul 2007, In: Molecular Microbiology. 65, 1, p. 21-26 6 p.Research output: Contribution to journal › Review article
82 Citations (Scopus) -
Transcription factor distribution in Escherichia coli: studies with FNR protein
Grainger, D., Aiba, H., Hurd, D., Browning, D. & Busby, S., 1 Jan 2007, In: Nucleic Acids Research. 35, 1, p. 269-278 10 p.Research output: Contribution to journal › Article
Open Access101 Citations (Scopus) -
2006
Association of nucleoid proteins with coding and non-coding segments of the Escherichia coli genome
Grainger, D., Hurd, D., Goldberg, M. & Busby, S., 26 Aug 2006, In: Nucleic Acids Research. 34, 16, p. 4642-4652 11 p.Research output: Contribution to journal › Article
Open Access215 Citations (Scopus) -
Extensive functional overlap between sigma factors in Escherichia coli
Wade, JT., Roa, DC., Grainger, D., Hurd, D., Busby, S., Struhl, K. & Nudler, E., 6 Aug 2006, In: Nature Structural and Molecular Biology. 13, 9, p. 806-814 9 p.Research output: Contribution to journal › Article
127 Citations (Scopus) -
2005
How do bacteria turn their genes on and off?
Grainger, D., Busby, S., Hurd, D., Holdstock, J. & Harrison, M., 1 Jan 2005, In: Genetic Engineering News. 25, 17, p. 46-47 2 p.Research output: Contribution to journal › Article
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Integration of three signals at the Escherichia coli nrf promoter: a role for Fis protein in catabolite repression
Browning, D., Grainger, D., Beatty, CM., Wolfe, AJ., Cole, J. & Busby, S., 1 Jul 2005, In: Molecular Microbiology. 57, 2, p. 496-510 15 p.Research output: Contribution to journal › Article
38 Citations (Scopus) -
Studies of the distribution of Escherichia coli cAMP receptor protein and RNA polymerase along with E coli chromosome
Grainger, D., Hurd, D., Harrison, M., Holdstock, J. & Busby, S., 28 Nov 2005, In: National Academy of Sciences. Proceedings. 102, 49, p. 17693-17698 6 p.Research output: Contribution to journal › Article
218 Citations (Scopus) -
2004
Genomic studies with Escheria coli MelR protein: applications of chromatin immunoprecipitation and microarrays
Grainger, D., Overton, T., Wade, JT., Tamai, E., Hobman, J., Constantinidou, C. & Busby, S., 1 Jan 2004, In: Journal of Bacteriology. 186, p. 6938-6943 6 p.Research output: Contribution to journal › Article
83 Citations (Scopus) -
Transcription activation at the Escherichia coli melAB promoter: interactions of MelR with its DNA target site and with domain 4 of the RNA polymerase sigma subunit
Grainger, D. C., Webster, C. L., Belyaeva, T. A., Hyde, E. I. & Busby, S. J. W., Mar 2004, In: Molecular Microbiology. 51, 5, p. 1297-1309 13 p.Research output: Contribution to journal › Article › peer-review
25 Citations (Scopus)