Personal profile
Research interests
Biography
After qualifying as a pharmacist, I studied for a PhD in Immunology and Pharmaceutical Biology with Professor Johannes Gerdes at the University of Kiel (awarded summa cum laude). I then joined the Department of Rheumatology at the University of Birmingham as a Research Fellow.
In 2004 I was awarded a 5 year Career Development Fellowship, followed by a Career Progression Fellowship by Arthritis Research UK leading to a tenured post as a Senior Research Fellow. In 2015 I was promoted to Reader.
Qualifications
Registered Pharmacist, University of Kiel, Germany
Dr rer. nat. (PhD in Immunology and Pharmaceutical Biology)
Member of the Higher Education Academy
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Granzyme K activates the entire complement cascade
Donada, C. A., Theisen, E., Zhang, F., Nathan, A., Fairfield, M. L., Rupani, K. V., Jones, D., Johannes, K. P., Accelerating Medicines Partnership RA/SLE Network, Raychaudhuri, S., Dwyer, D. F., Jonsson, A. H. & Brenner, M. B., 1 May 2025, In: Nature. 641, p. 211–221 11 p.Research output: Contribution to journal › Article › peer-review
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Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
Accelerating Medicines Partnership RA/SLE Network, Faust, H. J., Cheng, T. Y., Korsunsky, I., Watts, G. F. M., Gal-Oz, S. T., Trim, W. V., Kongthong, S., Jonsson, A. H., Simmons, D. P., Zhang, F., Padera, R., Chubinskaya, S., Wei, K., Raychaudhuri, S., Lynch, L., Moody, D. B. & Brenner, M. B., Dec 2024, In: Nature Communications. 15, 1, 20 p., 9859.Research output: Contribution to journal › Article › peer-review
Open AccessFile93 Downloads (Pure) -
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue
Bell, R. D., Brendel, M., Konnaris, M. A., Xiang, J., Otero, M., Fontana, M. A., Bai, Z., Krenitsky, D. M., Meednu, N., Rangel-Moreno, J., Scheel-Toellner, D., Carr, H., Nayar, S., McMurray, J., DiCarlo, E., Anolik, J. H., Donlin, L. T., Orange, D. E., Kenney, H. M. & Schwarz, E. M. & 3 others, , 29 Aug 2024, In: Nature Communications. 15, 7503.Research output: Contribution to journal › Article › peer-review
Open AccessFile58 Downloads (Pure) -
Inflammation Dynamically Regulates Steroid Hormone Metabolism and Action within Macrophages in Rheumatoid Arthritis
Martin, C. S., Crastin, A., Sagmeister, M. S., Kalirai, M. S., Turner, J. D., MacDonald, L., Kurowska-Stolarska, M., Scheel-Toellner, D., Taylor, A. E., Gilligan, L. C., Storbeck, K., Price, M., Gorvin, C. M., Filer, A., Mahida, R., Clark, A. R., Jones, S. W., Raza, K., Hewison, M. & Hardy, R. S., Jul 2024, In: Journal of Autoimmunity. 147, 13 p., 103263.Research output: Contribution to journal › Article › peer-review
Open AccessFile116 Downloads (Pure) -
Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus
Law, C., Wacleche, V. S., Cao, Y., Pillai, A., Sowerby, J., Sowerby, B., Horisberger, A., Bracero, S., Skidanova, V., Li, Z. J., Adejoorin, I., Dillon, E., Benque, I. J., Pena Nunez, D., Simmons, D. P., Keegan, J., Chen, L., Baker, T., Brohawn, P. Z. & Al-Mossawi, H. & 16 others, , 25 Jul 2024, In: Nature. 631, p. 857-866 33 p.Research output: Contribution to journal › Article › peer-review
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AIM-for-RA
Raza, K. (Co-Investigator), Scheel-Toellner, D. (Co-Investigator), McGettrick, H. (Co-Investigator), Clark, A. (Co-Investigator) & Filer, A. (Principal Investigator)
NATIONAL INSTITUTE OF HEALTH, USA
22/03/22 → 31/12/26
Project: Research
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Increasing confidence in RANKL as a therapeutic target in Sjogren's Syndrome
Scheel-Toellner, D. (Co-Investigator), Fisher, B. (Principal Investigator), Nayar, S. (Co-Investigator) & Filer, A. (Co-Investigator)
British Sjögren’s Syndrome Association
1/10/24 → 30/09/25
Project: Research
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Synovial lymphocyte diversity and origin in childhood onset arthritis
Croft, A. (Principal Investigator) & Scheel-Toellner, D. (Co-Investigator)
DAPHNE JACKSON MEMORIAL FELLOWSHIP TRUST
15/05/23 → 14/05/26
Project: Research
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The ability of small molecular inhibitors of CXCR1/2 to influence the onset, persistence and resolution of inflammation arthritis
McGettrick, H. (Principal Investigator) & Scheel-Toellner, D. (Co-Investigator)
5/04/21 → 30/06/22
Project: Research
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BREATHE – B cell Receptor Evaluation for Antibodies to protect Human Exposure to SARS-CoV-2
Scheel-Toellner, D. (Principal Investigator) & Richter, A. (Co-Investigator)
1/07/20 → 30/06/21
Project: Research