Caroline’s research group investigates how impairments in the trafficking and signalling of membrane proteins contribute to endocrine disorders.

The Gorvin group currently has active research programmes investigating:

1) How metabolic GPCRs cross-talk and interact with accessory proteins to regulate appetite (funded by a Wellcome Trust & Royal Society Sir Henry Dale Fellowship),

2) The interaction between GPCRs in bone metabolism and obesity (funded by Novo Nordisk),

3) How genetic alterations in the calcium-sensing receptor, and components of its signalling pathway, contribute to human disorders of calcium homeostasis.

This research combines microscopy techniques (including single molecule imaging) with signalling assays (e.g. BRET, HTRF, TR-FRET, AlphaScreen and reporter assays) in primary and immortalised cell-lines. Caroline collaborates with both basic science researchers and clinicians to advance understanding of GPCR signalling in endocrine and metabolic disease. 

Current group members:

Aqfan Jamaluddin (Post-doc)

Rachael Wyatt (Research Technician)

Holly Brittain (MRC DTP, PhD Metabolism and Systems Research)

Caroline obtained her BSc (Hons) in Biomedical Science with Industrial Experience in 2008 from the University of Manchester. She spent her year in industry in 2007 at AstraZeneca plc in the in vitro electrophysiology team. Caroline then moved to the University of Oxford for her PhD studies, where her research focussed on the cellular mechanisms by which mutations in a chloride-proton antiporter cause the renal disorder Dent’s disease. She also spent time on secondment at UMC St Radboud, Nijmegen, The Netherlands, during this period. Caroline continued in Oxford undertaking postdoctoral research investigating the signalling and trafficking of the GPCR, calcium-sensing receptor, and its role in calcium homeostasis. 

She moved to the MSS in January 2018 to establish her research group. Caroline’s research group has active research programmes investigating:

1) How metabolic GPCRs cross-talk and interact with accessory proteins to regulate appetite (funded by a Wellcome Trust & Royal Society Sir Henry Dale Fellowship),

2) The interaction between GPCRs in bone metabolism and obesity (funded by Novo Nordisk),

3) How genetic alterations in the calcium-sensing receptor, and components of its signalling pathway, contribute to human disorders of calcium homeostasis.

She has recently completed a research secondment at Weill Cornell Medicine and Queen Mary University of London.

DPhil in Clinical Medicine, University of Oxford, 2012.

BSc (Hons) in Biomedical Science with Industrial Experience, University of Manchester, 2008.