Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Neratinib could be effective as monotherapy or in combination with trastuzumab in HER2-low breast cancer cells and organoid models
Arshad, M., Azad, A., Chan, P. Y. K., Vigneswara, V., Feldinger, K., Nafi, S. N. M., Laporte-Maguire, E., De Santo, C., Zuo, J., Shaaban, A. M. & Kong, A., 10 Apr 2024, (E-pub ahead of print) In: British Journal of Cancer.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Downloads (Pure) -
PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults
Fenwick, N., Weston, R., Wheatley, K., Hodgson, J., Marshall, L., Elliott, M., Makin, G., Ng, A., Brennan, B., Lowis, S., Adamski, J., Kilday, J. P., Cox, R., Gattens, M., Moore, A., Trahair, T., Ronghe, M., Campbell, M., Campbell, H. & Williams, M. W. & 10 others, , 31 Jan 2024, In: Frontiers in Oncology. 14, 9 p., 1296576.Research output: Contribution to journal › Article › peer-review
Open AccessFile97 Downloads (Pure) -
Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment
Panetti, S., McJannett, N. J., Fultang, L., Booth, S., Gneo, L., Scarpa, U., Smith, C., Vardon, A., Vettore, L., Whalley, C., Pan, Y., Varnai, C., Endou, H., Barlow, J., Tennant, D. A., Beggs, A. D., Mussai, F. J. & Santo, C. D., 9 May 2023, In: Blood Advances. 7, 9, p. 1754-1761 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile78 Downloads (Pure) -
A randomised evaluation of low-dose Ara-C plus pegylated recombinant arginase BCT-100 versus low dose Ara-C in older unfit patients with acute myeloid leukaemia: Results from the LI-1 trial
Mussai, F., De Santo, C., Cheng, P., Thomas, I. F., Ariti, C., Upton, L., Scarpa, U., Stavrou, V., Sydenham, M., Burnett, A. K., Knapper, S. K., Mehta, P., McMullin, M. F., Copland, M., Russell, N. H. & Dennis, M., 22 Nov 2022, (E-pub ahead of print) In: British Journal of Haematology. 2022, 00, p. 1-6 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile68 Downloads (Pure) -
G-CSF induces CD15+ CD14+ cells from granulocytes early in the physiological environment of pregnancy and the cancer immunosuppressive microenvironment
Maneta, E., Fultang, L., Taylor, J., Pugh, M., Jenkinson, W., Anderson, G., Coomarasamy, A., Kilby, M. D., Lissauer, D. M., Mussai, F. & De Santo, C., 17 May 2022, In: Clinical and Translational Immunology. 11, 5, 12 p., e1395.Research output: Contribution to journal › Article › peer-review
Open AccessFile172 Downloads (Pure)
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CAR BH3 DMG: Combining GD2 CAR T Cells With BH3 Mimetic In Diffuse Midline Glioma
Vardon, A. (Principal Investigator) & De Santo, C. (Co-Investigator)
THE ACADEMY OF MEDICAL SCIENCES
1/09/25 → 31/08/27
Project: Research
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Targeting Radiation-Induced Senescence in DMG: Identification of Novel Cell surface markers
Vardon, A. (Principal Investigator) & De Santo, C. (Co-Investigator)
1/09/25 → 31/08/27
Project: Research
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Phenotyping sarcoma Tumour Infiltrating Lymphocytes to improve sarcoma immunotherapy
De Santo, C. (Principal Investigator)
1/06/25 → 30/11/28
Project: Research
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reprogramming CAR-T immunotherapies for the paediatric metabolic microenvironment - Eveson 3 year project application 2023
De Santo, C. (Principal Investigator)
15/05/23 → 30/11/26
Project: Research
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A comprehensive immune landscaping of paediatric haematological, solid, and CNS tumours
De Santo, C. (Principal Investigator)
1/05/24 → 28/02/26
Project: Industry
Activities
- 1 Guest lecture or Invited talk
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Arginine metabolism - preclinical findings and therapeutic opportunities
Mussai, F. (Chair) & De Santo, C. (Chair)
7 Mar 2017Activity: Academic and Industrial events › Guest lecture or Invited talk