Research output per year
Research output per year
Personal profile
Biography
After completing her undergraduate degree in Pharmacy, Ayesha studied for a Masters in Applied Biomolecular Technology at the University of Nottingham. Ayesha’s research career commenced with doctoral studies at the University of Birmingham (UoB), where she read to elucidate the biosynthetic pathway of the antibiotic, mupirocin, in Pseudomonas fluorescens NCIMB 10586. After completing her doctoral thesis, she worked at UoB as a post-doctoral research fellow on a BBSRC-funded project investigating the molecular pathways and mechanism of acid resistance in E.coli K12 and E.coli O157:H7 (Sakai) using transcriptomics (microarrays) and metabolomics. This was followed by an exciting opportunity at Aston University where she was tasked with setting up and applying genomic evaluation technologies to projects at the interface between drug delivery and genomics.
Ayesha began her academic career as a Senior Lecturer in Pharmaceutical Microbiology at the University of Wolverhampton's School of Pharmacy. Subsequently, she moved to the University of Leicester as an Associate Professor in Pharmaceutical Science, where she co-led the design and establishment of the new MPharm program. In 2024, she joined the University of Birmingham to develop oral biofilm research and lead on the infection theme.
Research interests
Ayesha Rahman is an Associate Professor in Microbiology based in Dentistry at the School of Health Sciences. Her research aims to take an interdisciplinary approach to study the mechanisms of antimicrobial resistance (AMR) and to develop appropriate drug delivery strategies, particularly against biofilms. Additionally, she is interested in evaluating the clinical effectiveness of antibiotics, used both therapeutically and prophylactically, by conducting systematic reviews and meta-analyses of existing clinical evidence. Ayesha has received BBSRC case awards to support her research.
Current projects:
- MIBTP-Case award: Mechanistic Evaluation of the effect of dry coated antibiotic amino-acid complexes in Pseudomonas aeruginosa
- Preparation of Micro/Nanoparticles for the delivery of high-dose antimicrobial agents to the respiratory system in cystic fibrosis patients
- Investigation of the effect of amino acids on P. aeruginosa biofilms and pigment formation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Science, Acyl carrier proteins in the biosynthesis of mupirocin by Pseudomonas fluorescens NCIMB 10586, The University of Birmingham
2 Oct 2001 → 30 Aug 2005
Award Date: 30 Aug 2005
Master in Science, University of Nottingham
2 Oct 2000 → 30 Jun 2001
Award Date: 30 Jun 2001
Bachelor of Pharmacy, Bachelor of Pharmacy,
1 Jun 1995 → 30 Jun 1999
Award Date: 30 Jun 1999
Keywords
- RS Pharmacy and materia medica
- Pharmaceutical Microbiology
- RK Dentistry
- Oral Biofilms
- RM Therapeutics. Pharmacology
- drug discovery
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Collaborations and top research areas from the last five years
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Evaluating the role of amino acids and isothermal dry particle coating in modulating buccal permeation of large molecule drug vancomycin
Rajabi, A., Idrees, M., Rahman, A., Iyire, A., Wyatt, D., Koner, J. & Mohammed, A. R., 24 Aug 2024, In: Scientific Reports. 14, 1, 16 p., 19678.Research output: Contribution to journal › Article › peer-review
Open AccessFile59 Downloads (Pure) -
Evaluation of the Effect of Leaf Development in Plectranthus amboinicus L. on Antimicrobial Activity and Virulence Factors of Pseudomonas aeruginosa PAO1 and Staphylococcus aureus NCTC8325
Sawant, S., Baldwin, T. C., Khan, H. & Rahman, A., Jan 2023, In: Current Microbiology. 80, 1, 16 p., 24.Research output: Contribution to journal › Article › peer-review
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Evaluation of the Effect of Plectranthus amboinicus L. Leaf Extracts on the Bacterial Antioxidant System and Cell Membrane Integrity of Pseudomonas aeruginosa PA01 and Staphylococcus aureus NCTC8325
Sawant, S., Baldwin, T. C., Metryka, O. & Rahman, A., 20 Jun 2023, In: Pathogens. 12, 6, 17 p., 853.Research output: Contribution to journal › Article › peer-review
Open AccessFile21 Downloads (Pure) -
Acidic amino acids as counterions of ciprofloxacin: Effect on growth and pigment production in Staphylococcus aureus NCTC 8325 and Pseudomonas aeruginosa PAO1
Warraich, A. A., Mohammed, A. U. R., Gibson, H., Hussain, M. & Rahman, A. S., 29 Apr 2021, In: PLOS One. 16, 4, 25 p., e0250705.Research output: Contribution to journal › Article › peer-review
Open AccessFile46 Downloads (Pure) -
Profiling gene expression dynamics underpinning conventional testing approaches to better inform pre-clinical evaluation of an age appropriate spironolactone formulation
Russell, C., Hussain, M., Huen, D., Rahman, A. S. & Mohammed, A. R., 2 Jan 2021, In: Pharmaceutical Development and Technology. 26, 1, p. 101-109 9 p.Research output: Contribution to journal › Article › peer-review