Apoorva Bhatt

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Apoorva Bhatt’s research interests include studying pathogenic mycobacteria and how they cause disease, with a particular focus on Mycobacterium tuberculosis, the causative agent of tuberculosis (TB). This includes using a genetic approach to identify pathways involved in the biosynthesis of virulence-related metabolites.

Complex lipids play an important role in the biology of the bacterium as a large proportion of the genome contains genes proposed to be involved in lipid biosynthesis. The pathways involved in lipid biosynthesis thus merit a detailed study. A broad aim of Dr Bhatt’s research is to understand how mycobacterial lipids are made, and the impact they have on virulence. His lab uses a genetic approach to address these questions by generating mutant strains that are defective in these pathways.

Research activity per year

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

SDG 3 Good Health and Well-being

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Dive into the research topics where Apoorva Bhatt is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

1 Similar Profiles

Relating corynebacterial cell envelope layers to its biochemical and physical properties
Modak, M., Waturuocha, U. W., Saini, D. K., Bhatt, A. & Besra, G. S., Dec 2025, In: The Cell Surface. 14, 9 p., 100162.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Downloads (Pure)
The deacetylase NagA mediates the remodelling and recycling of peptidoglycan derived amino sugars in mycobacteria
Guy, C. S., Cooper, C., Karlikowska, M., Harrison, J., Singh, A., Servín-González, L. S., Evans, C. A., Bakker, S. E., Bottrill, A., Bhatt, A., Mesnage, S., Besra, G. S. & Fullam, E., 14 Aug 2025, (E-pub ahead of print) In: The Journal of biological chemistry. 110597.
Research output: Contribution to journal › Article › peer-review

Open Access
Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly
Cui, Y., Lanne, A., Peng, X., Browne, E., Bhatt, A., Coltman, N. J., Craven, P., Cox, L. R., Cundy, N. J., Dale, K., Feula, A., Frampton, J., Fung, M., Morton, M., Goff, A., Salih, M., Lang, X., Li, X., Moon, C. & Pascoe, J. & 15 others, Portman, V., Press, C., Schulz-Utermoehl, T., Lee, S., Tortorella, M. D., Tu, Z., Underwood, Z. E., Wang, C., Yoshizawa, A., Zhang, T., Waddell, S. J., Bacon, J., Alderwick, L., Fossey, J. S. & Neagoie, C., 22 Feb 2024, In: Journal of Medicinal Chemistry. 67, 4, p. 2529-2548 20 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
147 Downloads (Pure)
Functional analysis of the Mycobacterium bovis AF2122/97 PhoPR system
Urtasun-Elizari, J. M., Ma, R., Pickford, H., Farrell, D., Gonzalez, G., Perets, V., Nakajima, C., Suzuki, Y., MacHugh, D. E., Bhatt, A. & Gordon, S. V., Sept 2024, In: Tuberculosis. 148, 8 p., 102544.
Research output: Contribution to journal › Article › peer-review

Open Access
File
55 Downloads (Pure)
Screening of Hydrophilic Polymers Reveals Broad Activity in Protecting Phages during Cryopreservation
Marton, H. L., Bhatt, A., Sagona, A. P., Kilbride, P. & Gibson, M. I., 8 Jan 2024, In: Biomacromolecules. 25, 1, p. 413-424 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
42 Downloads (Pure)

2 Active
18 Finished

Understanding complement-antibody responses against Mycobacterium abscessus biofilms; insights for immune-therapies
Bhatt, A. (Principal Investigator)
UK Health Security Agency (UKHSA)
5/01/26 → 4/01/30
Project: Research
Mechanisms of mycolic acid generation in mycobacteria
Besra, D. (Co-Investigator), Futterer, K. (Co-Investigator) & Bhatt, A. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/06/24 → 31/05/27
Project: Research Councils
The role of the anaplerotic node in redox homeostasis and pathogenesis of Mycobacterium tuberculosis and its exploitation
Bhatt, A. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
1/10/20 → 30/06/25
Project: Research Councils
A new mass spectrometer for structural proteomics and protein imaging
Thomas, C. (Co-Investigator), Grant, M. (Co-Investigator), Lovering, A. (Co-Investigator), Alderwick, L. (Co-Investigator), Tomlinson, M. (Co-Investigator), Winn, P. (Co-Investigator), Knowles, T. (Co-Investigator), Cooper, H. (Principal Investigator), Styles, I. (Co-Investigator), Gibbs, D. (Co-Investigator), Huber, D. (Co-Investigator), Bhatt, A. (Co-Investigator) & Leney, A. (Co-Investigator)
Biotechnology & Biological Sciences Research Council
1/07/19 → 30/06/20
Project: Research
Exploiting the microbial diversity of the Sundarbans mangrove delta to tackle infectious disease
May, R. (Co-Investigator) & Bhatt, A. (Principal Investigator)
Biotechnology & Biological Sciences Research Council
20/05/19 → 31/12/22
Project: Research Councils

Frontiers in Bacteriology (Journal)
Bhatt, A. (Editorial board member)
2020 → 2030
Activity: Publication peer-review and editorial work › Publication peer-review
Tuberculosis (Journal)
Bhatt, A. (Chair)
1 May 2018
Activity: Publication peer-review and editorial work › Publication peer-review
Tuberculosis (Journal)
Bhatt, A. (Chair)
1 May 2018
Activity: Publication peer-review and editorial work › Editorial board of a journal

Apoorva Bhatt

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Dive into details

Relating corynebacterial cell envelope layers to its biochemical and physical properties

The deacetylase NagA mediates the remodelling and recycling of peptidoglycan derived amino sugars in mycobacteria

Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly

Functional analysis of the Mycobacterium bovis AF2122/97 PhoPR system

Screening of Hydrophilic Polymers Reveals Broad Activity in Protecting Phages during Cryopreservation

Understanding complement-antibody responses against Mycobacterium abscessus biofilms; insights for immune-therapies

Mechanisms of mycolic acid generation in mycobacteria

The role of the anaplerotic node in redox homeostasis and pathogenesis of Mycobacterium tuberculosis and its exploitation

A new mass spectrometer for structural proteomics and protein imaging

Exploiting the microbial diversity of the Sundarbans mangrove delta to tackle infectious disease

Frontiers in Bacteriology (Journal)

Tuberculosis (Journal)

Tuberculosis (Journal)

Apoorva Bhatt

Personal profile

Expertise related to UN Sustainable Development Goals

Fingerprint

Collaborations and top research areas from the last five years

Research output

Projects

Activities