Angelo Agathanggelou

Research output

Research output per year 1994 2001 2002 2003 2004 2005 2013 2014 2015 2017 2018 2020 2021 2021

• 34 Article
• 4 Conference contribution
• 1 Abstract
• 1 Other contribution
• 1 More
  • 1 Preprint

Research output per year

Research output per year

Search results

• 2021

  Targeting the p53 Pathway in CLL: state of the art and future perspectives

  Kwok, M., Agathanggelou, A., Davies, N. & Stankovic, T., 18 Sept 2021, In: Cancers. 13, 18, 4681.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Synthetic Lethal Mutations 23%
  • Maintenance 22%
  • Clonal Evolution 21%
  • Genome 21%
  95 Downloads (Pure)

• TLR9 expression in chronic lymphocytic leukemia identifies a promigratory subpopulation and novel therapeutic target

  Kennedy, E., Coulter, E., Halliwell, E., Profitos-Peleja, N., Walsby, E., Clark, B., Phillips, E. H., Burley, T. A., Mitchell, S., Devereux, S., Fegan, C. D., Jones, C. I., Johnston, R., Chevassut, T., Schulz, R., Seiffert, M., Agathanggelou, A., Oldreive, C., Davies, N., Stankovic, T., & 3 othersLiloglou, T., Pepper, C. & Pepper, A. G. S., 3 Jun 2021, In: Blood. 137, 22, p. 3064-3078 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Toll-Like Receptor 9 100%
  • B-Cell Chronic Lymphocytic Leukemia 75%
  • Plasma 43%
  • Tyrosine 43%
  • RNA Sequencing 39%
  8 Citations (Scopus)

  83 Downloads (Pure)
• 2020

  Aniline-containing derivatives of parthenolide: Synthesis and anti-chronic lymphocytic leukaemia activity

  Quy, A., Li, X., Male, L., Stankovic, T., Agathanggelou, A. & Fossey, J., 27 Nov 2020, In: Tetrahedron. 76, 48, 131631.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Parthenolide 100%
  • parthenolide 94%
  • aniline 85%
  • B-Cell Chronic Lymphocytic Leukemia 62%
  • Leukemia 24%
  254 Downloads (Pure)

• Integrative analysis of spontaneous CLL regression highlights genetic and microenvironmental interdependency in CLL: natural history and mechanism of spontaneous CLL regression

  Kwok, M. C. K., Oldreive, C., Rawstron, A. C., Goel, A., Papatzikas, G., Jones, R., Drennan, S., Agathanggelou, A., Sharma-Oates, A., Evans, P., Smith, E., Dalal, S., Mao, J., Hollows, R., Gordon, N., Hamada, M., Davies, N., Parry, H., Beggs, A., Munir, T., & 10 othersMoreton, P., Paneesha, S., Pratt, G., Taylor, M., Forconi, F., Baird, D., Cazier, J-B., Moss, P., Hillmen, P. & Stankovic, T., 6 Feb 2020, In: Blood. 135, 6, p. 411-428 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proliferative 100%
  • Cell Death 79%
  • B-Cell Chronic Lymphocytic Leukemia 79%
  • Natural History 75%
  • Mutation 63%
  3 Citations (Scopus)

  148 Downloads (Pure)
• 2019

  Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia

  Li, X., Payne, D. T., Ampolu, B., Bland, N., Brown, J. T., Dutton, M. J., Fitton, C. A., Gulliver, A., Hale, L., Hamza, D., Jones, G., Lane, R., Leach, A. G., Male, L., Merisor, E. G., Morton, M. J., Quy, A., Roberts, R., Scarll, R., Schulz-utermoehl, T., & 4 othersStankovic, T., Stevenson, B., Fossey, J. S. & Agathanggelou, A., 1 Aug 2019, In: Medchemcomm. 10, 8, p. 1379-1390 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Parthenolide 100%
  • parthenolide 94%
  • B-Cell Chronic Lymphocytic Leukemia 62%
  • Bioavailability 38%
  • Biological Availability 35%
  5 Citations (Scopus)

  303 Downloads (Pure)
• 2018

  CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

  Zimmermann, M., Murina, O., Reijns, M. A. M., Agathanggelou, A., Challis, R., Tarnauskaitė, Ž., Muir, M., Fluteau, A., Aregger, M., McEwan, A., Yuan, W., Clarke, M., Lambros, M. B., Paneesha, S., Moss, P., Chandrashekhar, M., Angers, S., Moffat, J., Brunton, V. G., Hart, T., & 4 othersde Bono, J., Stankovic, T., Jackson, A. P. & Durocher, D., 12 Jul 2018, In: Nature. 559, 7713, p. 285-289 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ribonucleotides 100%
  • Poly(ADP-ribose) Polymerases 82%
  • Poly(ADP-ribose) Polymerase Inhibitors 61%
  • Ribonucleases 25%
  • Genes 18%
  110 Citations (Scopus)

  604 Downloads (Pure)

• Degradation of a novel DNA damage response protein, tankyrase 1 binding protein 1, following adenovirus infection

  Chalabi Hagkarim, N., Ryan, E., Byrd, P., Hollingworth, R., Shimwell, N., Agathanggelou, A., Vavasseur, M., Kolbe, V., Speisder, T., Dobner, T., Stewart, G. & Grand, R., 28 Mar 2018, (E-pub ahead of print) In: Journal of virology. 24 p., JVI.02034-17.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tankyrases 100%
  • Adenoviridae infections 94%
  • Adenoviridae Infections 80%
  • Adenoviridae 67%
  • DNA damage 57%
  7 Citations (Scopus)

  198 Downloads (Pure)
• 2017

  Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts

  Davies, N., Kwok, M., Gould, C., Oldreive, C., Mao, J., Parry, H., Smith, E., Agathanggelou, A., Pratt, G., Taylor, M., Moss, P., Griffiths, M. & Stankovic, T., 26 Apr 2017, In: OncoTarget. 8, 27, p. 44749-44760

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Cytogenetics 92%
  • Heterografts 84%
  • Chromosome Aberrations 68%
  • Karyotype 23%
  7 Citations (Scopus)

  172 Downloads (Pure)

• USP7 inhibition alters homologous recombination repair and targets CLL cells independent of ATM/p53 functional status

  Agathanggelou, A., Smith, E., Davies, N., Kwok, M., Zlatanou, A., Oldreive, C., Mao, J., Da Costa, D., Yadollahi, S., Perry, T., Kearns, P., Skowronska, A., Yates, E., Parry, H., Hillmen, P., Reverdy, C., Delansorne, R., Paneesha, S., Pratt, G., Moss, P., & 3 othersTaylor, M., Stewart, G. & Stankovic, T., 13 Jul 2017, In: Blood. 130, 2, p. 156–166

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ubiquitin-Specific Proteases 100%
  • Haematological 95%
  • Recombinational DNA Repair 86%
  • Ataxia Telangiectasia 84%
  • Genotoxic 79%
  35 Citations (Scopus)

  222 Downloads (Pure)
• 2016

  ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53 or ATM defective chronic lymphocytic leukemia cells

  Kwok, M., Davies, N., Agathanggelou, A., Smith, E., Oldreive, C., Petermann, E., Stewart, G., Brown, J., Lau, A., Pratt, G., Parry, H., Taylor, M., Moss, P., Hillmen, P. & Stankovic, T., 4 Feb 2016, In: Blood. 127, 5, p. 582-595

  Research output: Contribution to journal › Article › peer-review

  • Ibrutinib 100%
  • Synthetic Lethal Mutations 82%
  • Ataxia Telangiectasia 71%
  • Phosphotransferase Inhibitor 70%
  • Lethal 66%
  116 Citations (Scopus)

  32 Downloads (Pure)
• 2015

  Targeting the ataxia telangiectasia mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

  Agathanggelou, A., Weston, V. J., Perry, T., Davies, N. J., Skowronska, A., Payne, D. T., Fossey, J. S., Oldreive, C. E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, S. J., Hole, P. S., Darley, R. L., McMahon, M., Hayes, J. D., Moss, P., Stewart, G. S., Taylor, A. M. R., & 1 othersStankovic, T., 31 Aug 2015, In: Haematologica. 100, 8, p. 1076-1085 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Ataxia Telangiectasia 100%
  • B-Cell Chronic Lymphocytic Leukemia 83%
  • Reactive Oxygen Species 63%
  • Phenotype 47%
  • Oxidation-Reduction 16%
  9 Citations (Scopus)

  153 Downloads (Pure)

• T-cell number and subtype influence the disease course of primary chronic lymphocytic leukaemia xenografts in alymphoid mice

  Oldreive, C., Skowronska, A., Davies, N., Parry, H., Agathanggelou, A., Krysov, S., Packham, G., Rudzki, Z., Cronin, L., Vrzalikova, K., Murray, P., Odintsova, E., Pratt, G., Taylor, M., Moss, P. & Stankovic, T., 28 Oct 2015, In: Disease Models and Mechanisms. 8, p. 1401-1412 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • B-Cell Chronic Lymphocytic Leukemia 100%
  • Heterografts 84%
  • Cell Count 70%
  • T-Lymphocytes 58%
  • Drug 49%
  4 Citations (Scopus)

  186 Downloads (Pure)

• USP7 is essential for maintaining Rad18 stability and DNA damage tolerance

  Zlatanou, A., Stewart, G., Agathanggelou, A., Stankovic, T. & Miller, E., 2015, In: Oncogene.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage 100%
  • Genomic Instability 63%
  • Polyubiquitin 41%
  • Genome 38%
  • Recombinational DNA Repair 37%
  45 Citations (Scopus)

  701 Downloads (Pure)
• 2013

  BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia

  Da Costa, D., Agathanggelou, A., Perry, T., Weston, V., Petermann, E., Zlatanou, A., Oldreive, C., Wei, W., Stewart, G., Longman, J., Smith, E., Kearns, P., Knapp, S. & Stankovic, T., Jul 2013, In: Blood Cancer Journal. 3, 7, e126.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 100%
  • Pediatrics 65%
  • Dexamethasone 26%
  • Proto-Oncogene Proteins c-myc 20%
  • Down-Regulation 20%
  62 Citations (Scopus)

  233 Downloads (Pure)
• 2010

  Induction of a CD8(+) T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia

  Goodyear, O., Agathanggelou, A., Novitzky Basso, I., Siddique, S., McSkeane, T., Ryan, G., Vyas, P., Cavenagh, J., Stankovic, T., Moss, P. & Craddock, C., 1 Sept 2010, In: Blood. 116, 11, p. 1908-1918 11 p.

  Research output: Contribution to journal › Article

  • Sodium Valproate 100%
  • Azacitidine 77%
  • Valproate 76%
  • Testicular Neoplasms 66%
  • Valproic Acid 63%
  240 Citations (Scopus)
• 2009

  Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response.

  Marston, E., Weston, V., Jesson, J., Maina, E., McConville, C., Agathanggelou, A., Skowronska, A., Mapp, K., Sameith, K., Powell, J., Lawson, S., Kearns, P., Falciani, F., Taylor, A. & Stankovic, T., 1 Jan 2009, In: Blood. 113, 1, p. 117-26 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Ionizing Radiation 100%
  • Double-Stranded DNA Breaks 94%
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma 80%
  • Pediatrics 52%
  • Apoptosis 40%
  19 Citations (Scopus)
• 2007

  Depletion of the Ras association domain family 1, isoform A-associated novel mitochondrial associated protein, C19)RF5/MAP1S, causes mitotic abnormalities

  Dallol, A., Cooper, W., Al-Mulla, F., Agathanggelou, A., Maher, E. & Latif, F., 15 Jan 2007, In: Cancer Research. 67, 2, p. 492-500 9 p.

  Research output: Contribution to journal › Article

  • Mitochondrial Proteins 100%
  • Microtubules 85%
  • Microtubule-Organizing Center 78%
  • Protein Isoforms 70%
  • Centrosome 66%
  41 Citations (Scopus)
• 2005

  Involvement of the RASSF1A tumor suppressor gene in controlling cell migration

  Dallol, A., Agathanggelou, A., Tommasi, S., Pfeifer, GP., Maher, E. & Latif, F., 1 Jan 2005, In: Cancer Research. 65, 17, p. 7653-7659 7 p.

  Research output: Contribution to journal › Article

  • Tumor Suppressor Genes 100%
  • Cell Movement 82%
  • Microtubules 65%
  • HeLa Cells 50%
  • Fibroblasts 50%
  70 Citations (Scopus)

• Role of the RAS association domain family 1 (RASSF1) tumor suppresor gene in human cancers

  Agathanggelou, A., Cooper, W. & Latif, F., 1 May 2005, In: Cancer Research. 65, p. 3497-3508 12 p.

  Research output: Contribution to journal › Article

  • Protein Isoforms 100%
  • Methylation 89%
  • Genes 79%
  • Neoplasms 63%
  • Tumor Suppressor Genes 48%
  334 Citations (Scopus)

• Transcriptional regulation of Cyclin A2 by RASSF1A through the enhanced binding of p120E4F to the Cyclin A2 promotor

  Ahmed-Choudhury, J., Agathanggelou, A., Fenton, S., Ricketts, C., Clark, GJ., Maher, E. & Latif, F., 1 Apr 2005, In: Cancer Research. 65, p. 2690-2697 8 p.

  Research output: Contribution to journal › Article

  • Cyclin A2 100%
  • transcription factor p120(E4F) 97%
  • Cell Cycle 24%
  • HeLa Cells 20%
  • Small Interfering RNA 17%
  35 Citations (Scopus)
• 2004

  Frequent epigenetic inactivation of the RASSF1A tumor suppresor gene in Hodgkin's lymphoma

  Murray, P., Qiu, GH., Fu, L., Waites, ER., Srivastava, G., Heys, L., Agathanggelou, A., Latif, F., Grundy, R., Mann, J., Starczynski, J., Crocker, J., Parkes, SE., Ambinder, RF., Young, L. & Tao, Q., 1 Jan 2004, In: Oncogene. 23, 6, p. 1326-1331 6 p.

  Research output: Contribution to journal › Article

  • Hodgkin Disease 100%
  • Epigenomics 85%
  • Genes 39%
  • Reed-Sternberg Cells 34%
  • Methylation 33%
  56 Citations (Scopus)

• Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppresor gene

  Fenton, S., Dallol, A., Agathanggelou, A., Hesson, L., Ahmed-Choudhury, J., Baksh, S., Sardet, C., Dammann, R., Minna, JD., Downward, J., Maher, E. & Latif, F., 1 Jan 2004, In: Cancer Research. 64, 1, p. 102-107 6 p.

  Research output: Contribution to journal › Article

  • transcription factor p120(E4F) 100%
  • Genes 16%
  • Tumor Suppressor Genes 16%
  • Neoplasms 13%
  • Tumor Suppressor Protein p14ARF 12%
  64 Citations (Scopus)

• RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics

  Dallol, A., Agathanggelou, A., Fenton, S., Ahmed-Choudhury, J., Hesson, L., Vos, MD., Clark, GJ., Downward, J., Maher, E. & Latif, F., 1 Jan 2004, In: Cancer Research. 64, 12, p. 4112-4116 5 p.

  Research output: Contribution to journal › Article

  • Microtubule-Associated Proteins 100%
  • Microtubules 81%
  • microtubule-associated protein 1B 44%
  • Neoplasms 22%
  • Nocodazole 19%
  120 Citations (Scopus)
• 2003

  Detection of RASSF1A aberrant promoter hypermethylation in sputum from chronic smokers and ductal carcinoma in situ from breast cancer patients

  Honorio, S., Agathanggelou, A., Schuermann, M., Pankow, W., Viacava, P., Maher, E. & Latif, F., 9 Jan 2003, In: Oncogene. 22, 1, p. 147-150 4 p.

  Research output: Contribution to journal › Article

  • Carcinoma, Intraductal, Noninfiltrating 100%
  • Sputum 83%
  • Smokers 71%
  • Methylation 61%
  • Breast Neoplasms 53%
  110 Citations (Scopus)

• Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers

  Agathanggelou, A., Dallol, A., Zochbauer-Muller, S., Morrissey, C., Honorio, S., Hesson, L., Martinsson, T., Kuo, M., Yuen, PW., Maher, E., Minna, JD. & Latif, F., 13 Mar 2003, In: Oncogene. 22, 10, p. 1580-1588 9 p.

  Research output: Contribution to journal › Article

  • Suppressor Genes 100%
  • Methylation 64%
  • Epigenomics 62%
  • Neuroblastoma 47%
  • Tumor Cell Line 40%
  87 Citations (Scopus)

• Identification of Novel Gene Expression Targets for the Ras Association Domain Family 1 (RASSF1A) Tumor Suppressor Gene in Non-Small Cell Lung Cancer and Neuroblastoma

  Agathanggelou, A., Bihche, I., Ahmed-Choudhury, J., Nicke, B., Dammann, R., Baksh, S., Gao, B., Minna, JD., Downward, J., Maher, E. & Latif, F., 1 Jan 2003, In: Cancer Research. 63, p. 5344-5351 8 p.

  Research output: Contribution to journal › Article

  • Neuroblastoma 100%
  • Tumor Suppressor Genes 98%
  • Non-Small Cell Lung Carcinoma 89%
  • Gene Expression 60%
  • Genes 40%
  78 Citations (Scopus)
• 2002

  CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis and cytokine secretion

  Gallagher, N., Eliopoulos, A., Agathanggelou, A., Oates, J., Crocker, J. & Young, L., 1 Apr 2002, In: Molecular Pathology. 55, 2, p. 110-120 11 p.

  Research output: Contribution to journal › Article

  • Ovarian Epithelial Carcinoma 100%
  • Cytokines 53%
  • I-kappa B Proteins 53%
  • Apoptosis 52%
  • NF-kappa B 51%
  54 Citations (Scopus)

• Frequent 3p allele loss and epigenetic inactivation of RASSF1A tumour suppressor gene from region 3p21.3 in head and neck squamous cell carcinoma

  Hogg, R., Honorio, S., Martinez, A., Agathanggelou, A., Dallol, A., Fullwood, P., Weichselbaum, R., Kuo, M., Maher, E. & Latif, F., 1 Aug 2002, In: European Journal of Cancer. 38, 12, p. 1585-1592 8 p.

  Research output: Contribution to journal › Article

  • Squamous Cell Carcinoma of Head and Neck 100%
  • Tumor Suppressor Genes 88%
  • Epigenomics 78%
  • Alleles 65%
  • Methylation 47%
  83 Citations (Scopus)
• 2001

  Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma.

  Morrissey, C., Martinez, A., Zatyka, M., Agathanggelou, A., Honorio, S., Astuti, D., Morgan, N., Moch, H., Richards, F., Kishida, T., Yao, M., Schraml, P., Latif, F. & Maher, E., 1 Oct 2001, In: Cancer Research. 61, 19, p. 7277-81 5 p.

  Research output: Contribution to journal › Article

  • Tumor Suppressor Genes 100%
  • Renal Cell Carcinoma 97%
  • Epigenomics 88%
  • Methylation 51%
  • Alleles 32%
  200 Citations (Scopus)

• Identification of a single nucleotide polymorphism in the human Alpha 2 Delta 2 calcium channel subunit gene

  Honorio, S., Gordon, K., MaCartney, D., Agathanggelou, A. & Latif, F., 1 Dec 2001, In: Molecular and Cellular Probes. 15, 6, p. 391-393 3 p.

  Research output: Contribution to journal › Article
  2 Citations (Scopus)

• Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours

  Agathanggelou, A., Honorio, S., MaCartney, D., Martinez, A., Dallol, A., Rader, E., Fullwood, P., Chauhan, A., Walker, R., Shaw, JA., Hosoe, S., Lerman, MI., Minna, JD., Maher, E. & Latif, F., 22 Mar 2001, In: Oncogene. 20, 12, p. 1509-1518 10 p.

  Research output: Contribution to journal › Article

  • Methylation 100%
  • Breast Neoplasms 70%
  • Lung 59%
  • Neoplasms 35%
  • Mutation 23%
  358 Citations (Scopus)

• RASSF1A promoter region CpG island hypermethylation in phaeochromocytomas and neuroblastomas

  Astuti, D., Agathanggelou, A., Honorio, S., Dallol, A., Martinsson, T., Kogner, P., Cummins, C., Neumann, HPH., Voutilainen, R., Dahlia, P., Eng, C., Latif, F. & Maher, E., 8 Nov 2001, In: Oncogene. 20, 51, p. 7573-7577 5 p.

  Research output: Contribution to journal › Article

  • CpG Islands 100%
  • Pheochromocytoma 92%
  • Neuroblastoma 82%
  • Genetic Promoter Regions 79%
  • Methylation 66%
  118 Citations (Scopus)
• 1995

  Non-Hodgkin's lymphoma, coeliac disease, and Epstein-Barr virus: a study of 13 cases of enteropathy-associated T- and B-cell lymphoma

  Ilyas, M., Niedobitek, G., Agathanggelou, A., Barry, R. E., Read, A. E., Tierney, R., Young, L. S. & Rooney, N., Oct 1995, In: Journal of Pathology. 177, 2, p. 115-22 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Enteropathy-Associated T-Cell Lymphoma 100%
  • Celiac Disease 65%
  • B-Cell Lymphoma 61%
  • Human Herpesvirus 4 58%
  • Non-Hodgkin's Lymphoma 55%
  37 Citations (Scopus)
• 1994

  Latent Epstein-Barr virus infection in cottontop tamarins. A possible model for Epstein-Barr virus infection in humans

  Niedobitek, G., Agathanggelou, A., Finerty, S., Tierney, R., Watkins, P., Jones, E. L., Morgan, A., Young, L. S. & Rooney, N., Oct 1994, In: The American Journal of Pathology. 145, 4, p. 969-78 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Epstein-Barr Virus Infections 100%
  • Human Herpesvirus 4 82%
  • Lymphoma 51%
  • Animals 25%
  • Viruses 20%
  34 Citations (Scopus)