Research output per year
Research output per year
- 1 - 50 out of 60 results
Search results
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2021
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48
Clayton, S. A., Daley, K. K., Macdonald, L., Fernandez-vizarra, E., Bottegoni, G., O’Neil, J. D., Major, T., Griffin, D., Zhuang, Q., Adewoye, A. B., Woolcock, K., Jones, S. W., Goodyear, C., Elmesmari, A., Filer, A., Tennant, D. A., Alivernini, S., Buckley, C. D., Pitceathly, R. D. S., Kurowska-stolarska, M. & 1 others, , 8 Dec 2021, In: Science Advances. 7, 50, eabl5182.Research output: Contribution to journal › Article › peer-review
Open AccessFile15 Downloads (Pure) -
Spontaneously resolving joint inflammation is characterised by metabolic agility of fibroblast-like synoviocytes
Falconer, J., Pucino, V., Clayton, S., Marshall, J. L., Raizada, S., Adams, H., Philp, A., Clark, A. R., Filer, A., Raza, K., Young, S. & Buckley, C., 26 Aug 2021, In: Frontiers in immunology. 12, 13 p., 725641.Research output: Contribution to journal › Article › peer-review
Open AccessFile48 Downloads (Pure) -
2020
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis
Alivernini, S., MacDonald, L., Elmesmari, A., Finlay, S., Tolusso, B., Gigante, M. R., Petricca, L., Di Mario, C., Bui, L., Perniola, S., Attar, M., Gessi, M., Fedele, A. L., Chilaka, S., Somma, D., Sansom, S. N., Filer, A., McSharry, C., Millar, N. L., Kirschner, K. & 11 others, , Aug 2020, In: Nature Medicine. 26, 8, p. 1295-1306 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)647 Downloads (Pure) -
2019
Enhancing tristetraprolin activity reduces the severity of cigarette smoke-induced experimental chronic obstructive pulmonary disease.
Clark, A., 28 Oct 2019, In: Clinical and Translational Immunology.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration
Clark, A. R. & Ohlmeyer, M., 30 Sep 2019, In: Pharmacology & Therapeutics. 201, p. 181-201Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)205 Downloads (Pure) -
2017
Detection and characterisation of bone destruction in murine rheumatoid arthritis using statistical shape models
Brown, J. M., Ross, E., Desanti, G., Saghir, A., Clark, A., Buckley, C., Filer, A., Naylor, A. & Claridge, E., Aug 2017, In: Medical Image Analysis. 40, p. 30-43Research output: Contribution to journal › Article › peer-review
Open AccessFile8 Citations (Scopus)235 Downloads (Pure) -
Gain-of-function mutation of tristetraprolin impairs negative feedback control of macrophages in vitro, yet has overwhelmingly anti-inflammatory consequences in vivo.
O'Neil, J., Ross, E., Ridley, M., Rosner, D., Crowley, T., Smallie, T., Buckley, C. & Clark, A., Jun 2017, In: Molecular and Cellular Biology. 37, 11, e00536-16.Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Citations (Scopus)143 Downloads (Pure) -
Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin
Tang, T., Scambler, T. E., Smallie, T., Cunliffe, H. E., Ross, E. A., Rosner, D. R., O’neil, J. D. & Clark, A. R., 1 Dec 2017, In: Scientific Reports. 7, 1, 4350.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)132 Downloads (Pure) -
Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts
Crowley, T., O’neil, J. D., Adams, H., Thomas, A. M., Filer, A., Buckley, C. D. & Clark, A., 10 Feb 2017, In: Arthritis Research & Therapy. 19, 35.Research output: Contribution to journal › Article › peer-review
Open AccessFile30 Citations (Scopus)136 Downloads (Pure) -
Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression
Ross, E., Naylor, A., O'Neil, J., Crowley, T., Ridley, M., Crowe, J., Smallie, T., Tang, J. T., Turner, J., Norling, L. V., Dominguez, S., Perlman, H., Verrills, N. M., Kollias, G., Vitek, M. P., Filer, A., Buckley, C., Dean, J. L. & Clark, A., Mar 2017, In: Annals of the Rheumatic Diseases. 76, 3, p. 612-619Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Citations (Scopus)127 Downloads (Pure) -
Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment
Bulbrook, D., Brazier, H., Mahajan, P., Kliszczak, M., Fedorov, O., Marchese, F. P., Aubareda, A., Chalk, R., Picaud, S., Strain-Damerell, C., Filippakopoulos, P., Gileadi, O., Clark, A. R., Yue, W. W., Burgess-Brown, N. A. & Dean, J. L. E., 29 Dec 2017, (E-pub ahead of print) In: Journal of Molecular Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)213 Downloads (Pure) -
2016
Activating protein phosphatase 2A (PP2A) enhances tristetraprolin (TTP) anti-inflammatory function in A549 lung epithelial cells
Rahman, M. M., Rumzhum, N. N., Hansbro, P. M., Morris, J. C., Clark, A., Verrills, N. M. & Ammit, A. J., 26 Jan 2016, (E-pub ahead of print) In: Cellular Signalling.Research output: Contribution to journal › Article › peer-review
Open AccessFile28 Citations (Scopus)132 Downloads (Pure) -
The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases
Clark, A. & Dean, J. L. E., 19 Oct 2016, In: Biochemical Society Transactions. 44, 5, p. 1321-1337Research output: Contribution to journal › Article › peer-review
Open AccessFile45 Citations (Scopus)121 Downloads (Pure) -
2015
Basal protein phosphatase 2A activity restrains cytokine expression: role for MAPKs and tristetraprolin
Rahman, M. M., Rumzhum, N. N., Morris, J. C., Clark, A. R., Verrills, N. M. & Ammit, A. J., 18 May 2015, In: Scientific Reports. 5, 16 p., 10063.Research output: Contribution to journal › Article › peer-review
Open AccessFile24 Citations (Scopus)19 Downloads (Pure) -
Dominant suppression of inflammation via targeted mutation of the mRNA destabilizing protein tristetraprolin
Ross, E. A., Smallie, T., Ding, Q., O'neil, J. D., Cunliffe, H. E., Tang, T., Rosner, D. R., Klevernic, I., Morrice, N. A., Monaco, C., Cunningham, A. F., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 265-276Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Citations (Scopus)141 Downloads (Pure) -
Dual-specificity phosphatase 1 and tristetraprolin cooperate to regulate macrophage responses to lipopolysaccharide
Smallie, T., Ross, E. A., Ammit, A. J., Cunliffe, H. E., Tang, T., Rosner, D. R., Ridley, M. L., Buckley, C. D., Saklatvala, J., Dean, J. L. & Clark, A. R., 1 Jul 2015, In: Journal of Immunology. 195, 1, p. 277-288Research output: Contribution to journal › Article › peer-review
Open AccessFile47 Citations (Scopus)160 Downloads (Pure) -
Temporal regulation of cytokine mRNA expression by tristetraprolin: dynamic control by p38 MAPK and MKP-1
Prabhala, P., Bunge, K., Rahman, M. M., Ge, Q., Clark, A. R. & Ammit, A. J., 1 May 2015, In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 308, 9, p. L973-L980 8 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
2014
Nonclassical Ly6C(-) Monocytes Drive the Development of Inflammatory Arthritis in Mice
Misharin, A. V., Cuda, C. M., Saber, R., Turner, J. D., Gierut, A. K., Haines, G. K., Berdnikovs, S., Filer, A., Clark, A. R., Buckley, C. D., Mutlu, G. M., Budinger, G. R. S. & Perlman, H., 23 Oct 2014, In: Cell Reports. 9, 2, p. 591-604 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile146 Citations (Scopus)225 Downloads (Pure) -
PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression
Bilal Iqbal, M., Johns, M., Cao, J., Liu, Y., Yu, S. C., Hyde, G. D., Laffan, M. A., Marchese, F. P., Cho, S. H., Clark, A. R., Gavins, F. N., Woollard, K. J., Blackshear, P. J., Mackman, N., Dean, J. L., Boothby, M. & Haskard, D. O., 4 Dec 2014, In: Blood. 124, 24, p. 3646-3655 10 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury
Pinart, M., Hussain, F., Shirali, S., Li, F., Zhu, J., Clark, A. R., Ammit, A. J. & Chung, K. F., 12 Oct 2014, In: European Journal of Pharmacology. 744, p. 108-114 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)34 Downloads (Pure) -
2012
Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1
Joanny, E., Ding, Q., Gong, L., Kong, P., Saklatvala, J. & Clark, A., 2012, In: British Journal of Pharmacology. 165, 4b, p. 1124-36 13 p.Research output: Contribution to journal › Article › peer-review
35 Citations (Scopus) -
Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis
Vattakuzhi, Y., Abraham, S. M., Freidin, A., Clark, A. & Horwood, N. J., 2012, In: Arthritis & Rheumatism. 64, 7, p. 2201-10 10 p.Research output: Contribution to journal › Article › peer-review
24 Citations (Scopus) -
2011
Dual specificity phosphatase 1 regulates human inducible nitric oxide synthase expression by p38 MAP kinase
Korhonen, R., Turpeinen, T., Nieminen, R., Taimi, V., Heittola, T., Sareila, O., Clark, A. R. & Moilanen, E., 22 Jun 2011, In: Mediators of Inflammation. 2011, 127587.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids
Li, F., Zhang, M., Hussain, F., Triantaphyllopoulos, K., Clark, A. R., Bhavsar, P. K., Zhou, X. & Chung, K. F., 1 Apr 2011, In: European Respiratory Journal. 37, 4, p. 933-942 10 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Citations (Scopus) -
2010
Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3, and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation: MAPK phosphatase 1 as a novel target for antirheumatic drugs
Nieminen, R., Korhonen, R., Moilanen, T., Clark, A. R. & Moilanen, E., 1 Jun 2010, In: Arthritis and Rheumatism. 62, 6, p. 1650-1659 10 p.Research output: Contribution to journal › Article › peer-review
46 Citations (Scopus) -
C-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis
Chaudhury, H., Zakkar, M., Boyle, J., Cuhlmann, S., Van Der Heiden, K., Luong, L. A., Davis, J., Platt, A., Mason, J. C., Krams, R., Haskard, D. O., Clark, A. R. & Evans, P. C., Mar 2010, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 3, p. 546-553 8 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Citations (Scopus) -
Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence
Tchen, C. R., Martins, J. R. S., Paktiawal, N., Perelli, R., Saklatvala, J. & Clark, A., 2010, In: Journal of Biological Chemistry. 285, 4, p. 2642-52 11 p.Research output: Contribution to journal › Article › peer-review
57 Citations (Scopus) -
Identification of NURR1 as a mediator of MIF signaling during chronic arthritis: Effects on glucocorticoid-induced MKP1
Ralph, J. A., Ahmed, A. U., Santos, L. L., Clark, A. R., McMorrow, J., Murphy, E. P. & Morand, E. F., Nov 2010, In: American Journal of Pathology. 177, 5, p. 2366-2378 13 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages
Smallie, T., Ricchetti, G., Horwood, N. J., Feldmann, M., Clark, A. & Williams, L. M., 2010, In: The Journal of Experimental Medicine. 207, 10, p. 2081-8 8 p.Research output: Contribution to journal › Article › peer-review
75 Citations (Scopus) -
MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment
Marchese, F. P., Aubareda, A., Tudor, C., Saklatvala, J., Clark, A. R. & Dean, J. L. E., 3 Sep 2010, In: Journal of Biological Chemistry. 285, 36, p. 27590-27600 11 p.Research output: Contribution to journal › Article › peer-review
Open Access110 Citations (Scopus) -
Mkp1 is a c-Jun target gene that antagonizes JNK-dependent apoptosis in sympathetic neurons
Kristiansen, M., Hughes, R., Patel, P., Jacques, T. S., Clark, A. R. & Ham, J., 11 Aug 2010, In: Journal of Neuroscience. 30, 32, p. 10820-10832 13 p.Research output: Contribution to journal › Article › peer-review
Open Access53 Citations (Scopus) -
2009
Post-transcriptional gene regulation by MAP kinases via AU-rich elements
Clark, A., Dean, J., Tudor, C. & Saklatvala, J., 1 Jan 2009, In: Frontiers in Bioscience. 14, 3, p. 847-871 25 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages
Tudor, C., Marchese, F. P., Hitti, E., Aubareda, A., Rawlinson, L., Gaestel, M., Blackshear, P. J., Clark, A. R., Saklatvala, J. & Dean, J. L. E., 18 Jun 2009, In: FEBS Letters. 583, 12, p. 1933-1938 6 p.Research output: Contribution to journal › Article › peer-review
76 Citations (Scopus) -
2008
Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
Zakkar, M., Chaudhury, H., Sandvik, G., Enesa, K., Luong, L. A., Cuhlmann, S., Mason, J. C., Krams, R., Clark, A. R., Haskard, D. O. & Evans, P. C., 26 Sep 2008, In: Circulation Research. 103, 7, p. 726-732 7 p.Research output: Contribution to journal › Article › peer-review
Open Access79 Citations (Scopus) -
2007
Anti-inflammatory functions of glucocorticoid-induced genes
Clark, A. R., 15 Sep 2007, In: Molecular and Cellular Endocrinology. 275, 1-2, p. 79-97 19 p.Research output: Contribution to journal › Article › peer-review
191 Citations (Scopus) -
2006
Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1
Abraham, S. M., Lawrence, T., Kleiman, A., Warden, P., Medghalchi, M., Tuckermann, J., Saklatvala, J. & Clark, A. R., 7 Aug 2006, In: Journal of Experimental Medicine. 203, 8, p. 1883-1889 7 p.Research output: Contribution to journal › Article › peer-review
Open Access320 Citations (Scopus) -
Dual-specificity phosphatase 1: A critical regulator of innate immune responses
Abraham, S. M. & Clark, A. R., 1 Dec 2006, In: Biochemical Society Transactions. 34, 6, p. 1018-1023 6 p.Research output: Contribution to journal › Article › peer-review
111 Citations (Scopus) -
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element
Hitti, E., Iakovleva, T., Brook, M., Deppenmeier, S., Gruber, A. D., Radzioch, D., Blackshear, P. J., Kotlyarov, A., Gaestel, M. & Clark, A., 2006, In: Molecular and Cellular Biology.Research output: Contribution to journal › Article › peer-review
318 Citations (Scopus) -
Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways
Brook, M., Tchen, C. R., Santalucia, T., McIlrath, J., Arthur, J. S. C., Saklatvala, J. & Clark, A. R., 1 Mar 2006, In: Molecular and Cellular Biology. 26, 6, p. 2408-2418 11 p.Research output: Contribution to journal › Article › peer-review
Open Access212 Citations (Scopus) -
The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression
Bell, S. E., Sanchez, M. J., Spasic-Boskovic, O., Santalucia, T., Gambardella, L., Burton, G. J., Murphy, J. J., Norton, J. D., Clark, A. R. & Turner, M., 1 Nov 2006, In: Developmental Dynamics. 235, 11, p. 3144-3155 12 p.Research output: Contribution to journal › Article › peer-review
66 Citations (Scopus) -
2005
Stabilization of IFN-γ mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells
Mavropoulos, A., Sully, G., Cope, A. P. & Clark, A. R., 1 Jan 2005, In: Blood. 105, 1, p. 282-288 7 p.Research output: Contribution to journal › Article › peer-review
87 Citations (Scopus) -
2004
Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: Evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1)
Sully, G., Dean, J. L. E., Wait, R., Rawlinson, L., Santalucia, T., Saklatvala, J. & Clark, A. R., 1 Feb 2004, In: Biochemical Journal. 377, 3, p. 629-639 11 p.Research output: Contribution to journal › Article › peer-review
72 Citations (Scopus) -
The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself
Tchen, C. R., Brook, M., Saklatvala, J. & Clark, A. R., 30 Jul 2004, In: Journal of Biological Chemistry. 279, 31, p. 32393-32400 8 p.Research output: Contribution to journal › Article › peer-review
Open Access123 Citations (Scopus) -
2003
Control of the expression of inflammatory response genes
Saklatvala, J., Dean, J. & Clark, A., 1 Jan 2003, In: Biochemical Society Symposium. 70, p. 95-106 12 p.Research output: Contribution to journal › Article › peer-review
105 Citations (Scopus) -
2002
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38
Lasa, M., Abraham, S. M., Boucheron, C., Saklatvala, J. & Clark, A. R., 1 Nov 2002, In: Molecular and Cellular Biology. 22, 22, p. 7802-7811 10 p.Research output: Contribution to journal › Article › peer-review
Open Access310 Citations (Scopus) -
Identification of a novel AU-rich-element-binding protein which is related to AUF1
Dean, J. L. E., Sully, G., Wait, R., Rawlinson, L., Clark, A. R. & Saklatvala, J., 15 Sep 2002, In: Biochemical Journal. 366, 3, p. 709-719 11 p.Research output: Contribution to journal › Article › peer-review
52 Citations (Scopus) -
2001
Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38
Lasa, M., Brook, M., Saklatvala, J. & Clark, A. R., 8 Feb 2001, In: Molecular and Cellular Biology. 21, 3, p. 771-780 10 p.Research output: Contribution to journal › Article › peer-review
Open Access212 Citations (Scopus) -
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
Mahtani, K. R., Brook, M., Dean, J. L. E., Sully, G., Saklatvala, J. & Clark, A. R., 16 Oct 2001, In: Molecular and Cellular Biology. 21, 19, p. 6461-6469 9 p.Research output: Contribution to journal › Article › peer-review
Open Access381 Citations (Scopus) -
The 3′ Untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR
Dean, J. L. E., Wait, R., Mahtani, K. R., Sully, G., Clark, A. R. & Saklatvala, J., 1 Jan 2001, In: Molecular and Cellular Biology. 21, 3, p. 721-730 10 p.Research output: Contribution to journal › Article › peer-review
Open Access236 Citations (Scopus) -
2000
Regulation of cyclooxygenase 2 mRNA stability by the mitogen- activated protein kinase p38 signaling cascade
Lasa, M., Mahtani, K. R., Finch, A., Brewer, G., Saklatvala, J. & Clark, A. R., 1 Jun 2000, In: Molecular and Cellular Biology. 20, 12, p. 4265-4274 10 p.Research output: Contribution to journal › Article › peer-review
Open Access360 Citations (Scopus)