Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
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Lipopolysaccharide induces HIF-1α accumulation via MAPK p38–mediated mRNA stabilization and dexamethasone-sensitive protein stabilization
Lockwood, C., Daley, K. K., O'Neil, J. D., Heighes, K. J., Clayton, S. A. & Clark, A. R., Feb 2026, In: Journal of Biological Chemistry. 302, 2, 14 p., 111094.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection
Perez-Toledo, M., Beristain-Covarrubias, N., Pillaye, J., Persaud, R., Marcial Juarez, E., Jossi, S., Hitchcock, J., Alshayea, A., Channell, W., Wiersma, N., Lamerton, R., Kavanagh, D., Carestia, A., Horsnell, W., Henderson, I. R., Mackman, N., Clark, A. R., Jenne, C. N., Rayes, J. & Watson, S. & 1 others, , 10 Mar 2025, In: Nature Communications. 16, 16 p., 2356.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Downloads (Pure) -
Inflammation Dynamically Regulates Steroid Hormone Metabolism and Action within Macrophages in Rheumatoid Arthritis
Martin, C. S., Crastin, A., Sagmeister, M. S., Kalirai, M. S., Turner, J. D., MacDonald, L., Kurowska-Stolarska, M., Scheel-Toellner, D., Taylor, A. E., Gilligan, L. C., Storbeck, K., Price, M., Gorvin, C. M., Filer, A., Mahida, R., Clark, A. R., Jones, S. W., Raza, K., Hewison, M. & Hardy, R. S., Jul 2024, In: Journal of Autoimmunity. 147, 13 p., 103263.Research output: Contribution to journal › Article › peer-review
Open AccessFile93 Downloads (Pure) -
Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β
O’Neil, J. D., Bolimowska, O. O., Clayton, S. A., Tang, T., Daley, K. K., Lara-Reyna, S., Warner, J., Martin, C. S., Mahida, R. Y., Hardy, R. S., Arthur, J. S. C. & Clark, A. R., 24 Oct 2023, In: Frontiers in immunology. 14, 17 p., 1190261.Research output: Contribution to journal › Article › peer-review
Open AccessFile100 Downloads (Pure) -
Differential effect of lactate on synovial fibroblast and macrophage effector functions
Pucino, V., Nefla, M., Gauthier, V., Alsaleh, G., Clayton, S. A., Marshall, J., Filer, A., Clark, A. R., Raza, K. & Buckley, C. D., 22 May 2023, In: Frontiers in immunology. 14, 1183825.Research output: Contribution to journal › Article › peer-review
Open AccessFile93 Downloads (Pure)
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Phenotyping the novel AA467197-KO mouse
Clayton, S. (Principal Investigator) & Clark, A. (Co-Investigator)
1/10/23 → 30/09/26
Project: Research Councils
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Interrogating metabolic control of macrophage immune function by TNF-alpha [Sub-award of 1001749]
Dimeloe, S. (Principal Investigator), Drummond, R. (Co-Investigator), Clark, A. (Co-Investigator) & O'Shea, M. (Co-Investigator)
Kennedy Trust For Rheumatology Research
11/06/22 → 10/06/26
Project: Research
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AIM-for-RA
Raza, K. (Co-Investigator), Scheel-Toellner, D. (Co-Investigator), McGettrick, H. (Co-Investigator), Clark, A. (Co-Investigator) & Filer, A. (Principal Investigator)
NATIONAL INSTITUTE OF HEALTH, USA
22/03/22 → 31/12/26
Project: Research
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GSK student placement - Reversing the macrophage-driven inflammation in RA through exploiting glucocorticoid-mediated nodes of inflammation resolution via immunometabolism and HIF-related signalling, with consequences for fibroblast-like sy
Clark, A. (Principal Investigator)
3/07/23 → 3/10/23
Project: Industry
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Parsing the anti-inflammatory and immuno-suppressive effects of glucocorticoids [Sub-award of 1001749]
Sapey, E. (Co-Investigator), Clark, A. (Principal Investigator), Hardy, R. (Co-Investigator) & Parekh, D. (Co-Investigator)
Kennedy Trust For Rheumatology Research
1/08/21 → 31/07/24
Project: Research