Alex Sinclair

Projects

Projects per year 2007 2016 2018 2029

• 1 Not started
• 16 Active
• 26 Finished

Projects per year

Search results

• Active

  Military Traumatic Brain Injury Biomarker Study, a prospective cohort biomarker study of military and civilian participants with mTBI

  Lucas, S., Karavitaki, N., Bagshaw, A., Sinclair, A., Morris, K., Deeks, J., Blanch, R., Fernandez-Espejo, D., Upthegrove, R., Terry, J., Jensen, O., Belli, T., Sitch, A., Jenkinson, N., Mullinger, K., Dehghani, H., Smith, D., Mazaheri, A., Berhane, S. & Ottridge, R.

  MINISTRY OF DEFENCE

  1/12/21 → 30/11/29

  Project: Other Government Departments

• Intervention to Preserve Vision in Idiopathic Intracranial Hypertension: Evaluation of Clinical Effectiveness and Cost Effectiveness

  Sinclair, A., Frew, E., Watts, C., Bach, S. & Brock, K.

  NIHR

  1/09/21 → 28/02/27

  Project: Other Government Departments

• Mechanisms and therapeutics for headache in Idiopathic Intracranial Hypertension

  Yiangou, A. & Sinclair, A.

  Association of British Neurologists

  4/08/21 → 3/08/24

  Project: Research

• Sinclair SJT 2019 Defining new treatment and headache mechanisms in raised intracranial ressure

  Brock, K., Sinclair, A. & Barton, D.

  SIR JULES THORN CHARITABLE TRUST

  1/12/20 → 30/06/26

  Project: Research

• Exploring physiological responses to cortical spreading depression in an acute brain slice model

  Fulton, D., Sinclair, A. & Lavery, G.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/08/20 → 31/07/22

  Project: Research

• Identifying biomarkers through MicroRNA profiling.

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/20 → 1/07/23

  Project: Research

• Exploratory study of candidate molecular biomarkers in IIH patients

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/20 → 1/07/23

  Project: Research

• The molecular pathways underlying pathological brain water regulation

  Sinclair, A.

  Lundbeckfonden

  1/01/20 → 31/12/22

  Project: Research

• Defining mechanisms and new treatments for headache in raised intracranial Pressure

  Sinclair, A.

  Brain Research Trust

  1/08/19 → 31/03/23

  Project: Research

• Researching Exenatide in-vitro and in human in-vivo studies

  Sinclair, A.

  Invex Therapeutics Ltd

  1/08/19 → 31/12/22

  Project: Industry

• WT ISSF - IIH Pressure: Head - Human headache models in Idiopathic intracranial hypertension (IIH)

  Sinclair, A.

  THE WELLCOME TRUST

  1/05/19 → 31/08/22

  Project: Research

• Evaluating the relationship between obstructive sleep apnoea and androgen dysregulation in IIH

  Sinclair, A. & Tahrani, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 18/01/23

  Project: Research

• Defining the metabolite profile in IIH

  Sinclair, A. & Ludwig, C.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 30/06/22

  Project: Research

• Dissecting adipose and systemic androgen generation in women with idiopathic intracranial hypertension

  O'Reilly, M. & Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 30/06/22

  Project: Research

• Determining the effects of bariatric surgery on GLP-1 and ICP in IIH patients

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 18/01/23

  Project: Research

• UK Idiopathic Intracranial Hypertension Database

  Sinclair, A.

  HEALTHCARE QUALITY IMPROVEMENT PARTNERSHIP, IDIOPATHIC INTERCRANIAL HYPERTENSION UK

  1/01/13 → 31/12/22

  Project: Research

• Not started

  EPSRC Network+: Neurotechnology for enabling community-based diagnosis and care

  Sinclair, A. & Terry, J.

  ENGINEERING & PHYSICAL SCIENCE RESEARCH COUNCIL

  1/09/22 → 31/08/25

  Project: Research Councils

• Finished

  Utilising a glucagon-like peptide 1 receptor agonist to treat Space flight-Associated Neuro-ocular Syndrome

  Sinclair, A., Gates, S., Barton, D. & Terry, J.

  UK SPACE AGENCY

  1/10/21 → 31/03/22

  Project: Other Government Departments

• IIH Pressure Head

  Sinclair, A.

  IDIOPATHIC INTERCRANIAL HYPERTENSION UK

  1/07/18 → 30/06/19

  Project: Research

• Optogenetic generation of cortical spreading depression in mouse models of raised intracranial pressure

  Lavery, G. & Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 18/03/22

  Project: Research

• Idiopathic Intracranial Hypertension (IIH)

  Sinclair, A.

  EXELOGEN INC

  31/05/18 → 30/05/21

  Project: Research

• The role of androgens in regulating ICP

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 31/12/21

  Project: Research

• The role of adipose tissue in IIH

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 31/12/21

  Project: Research

• The role of glucogen-like peptide 1 in neuroprotection

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 31/12/21

  Project: Research

• Using solid state telemetry to assess the intracranial pressure lowering effects of exendin-4 in an experimental model of traumatic hydrocephalus

  Sinclair, A.

  The Ramc Charity (Royal Army Medical Corps)

  1/01/18 → 31/12/21

  Project: Research

• Use of Exendin-4 in IIH, Hydrocephalus and Trauma

  Sinclair, A. & Botfield, H.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/16 → 30/11/18

  Project: Research

• Charaterising the transcriptome of adipose tissue in idiopathic intracranial hypertension patients to futher the understanding of idiopathic intracranial hypertenision pathogenesis.

  Sinclair, A. & Botfield, H.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/16 → 30/11/18

  Project: Research

• The role of GLP-1 agonists in CSF pressure and neuroprotection following Traumatic Brain Injury

  Belli, T. & Sinclair, A.

  Royal Centre For Defence Medicine

  1/08/16 → 31/07/19

  Project: Other Government Departments

• Industry Collaborative Research Grant to fund headache nurse.

  Sinclair, A.

  ELECTROCORE LLC

  15/02/16 → 14/02/18

  Project: Research

• Evaluating the efficacy of candidate drugs in inhibiting CSF secretion

  Sinclair, A. & Botfield, H.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/02/16 → 31/01/18

  Project: Research

• Characterising the Androgen Metabolic Signature in IIH

  Sinclair, A., Arlt, W. & O'Reilly, M.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/16 → 31/12/17

  Project: Research

• Equipment funding for IIH weight trials

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/15 → 30/09/19

  Project: Research

• MRC CiC 2015/16 - Repurposing glucagon-like peptide-1 therapies to treat idiopathic intracranial hypertension

  Sinclair, A.

  Medical Research Council

  1/08/15 → 30/09/17

  Project: Research Councils

• Modulation of cerebrospinal fluid secretion by glucagon-like peptide-1

  Sinclair, A. & Gonzalez, A.

  THE WELLCOME TRUST

  22/06/15 → 21/08/15

  Project: Research

• The role of glucagon-like peptide 1 in cerebral spinal fluid secretion

  Sinclair, A. & Gonzalez, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/04/15 → 31/03/17

  Project: Research

• Safety and efficacy of an IIß-HSD1 inhibitor in Idiopathic Intracranial Hypertension

  Sinclair, A.

  ASTRA ZENECA UK LIMITED

  1/03/15 → 29/02/20

  Project: Industry

• Evaluating an IIß-HSD1 inhibitor and adipose in Idiopathic Intracranial Hypertension

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/14 → 1/08/18

  Project: Research

• Establishing in vitro choroid plexus and arachnoid granulation cell functional model systems of CSF secretion and drainage to further understanding into the pathogenesis¿s of Idiopathic intracranial hypertension

  Sinclair, A. & Gonzalez, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  17/01/14 → 15/07/15

  Project: Research

• Assessing the Therapeutic Efficacy of an 11Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in Idiopathic Intracranial Hypertension (IIH)

  Sinclair, A., Tomlinson, J. & Stewart, P.

  Medical Research Council

  12/08/13 → 11/08/17

  Project: Research Councils

  • Pseudotumor Cerebri 100%
  • 11-beta-Hydroxysteroid Dehydrogenases 27%
  • Intracranial Pressure 26%
  • Headache 21%
  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 21%

• Sustained treatment of Idiopathic Intracranial Hypertension (IIH) through weight loss induced by bariatric surgery

  Sinclair, A.

  NIHR TRAINEES COORDINATING CENTRE

  1/06/13 → 31/10/18

  Project: Research

  • Pseudotumor Cerebri 100%
  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 51%
  • 11-beta-Hydroxysteroid Dehydrogenases 27%
  • Intracranial Pressure 25%
  • Bariatric Surgery 24%

• Analysis of Pathogenic and Regulatory T Cells in Relapsing-Remitting Multiple Sclerosis

  Curnow, J., Douglas, M., Sinclair, A. & Mazibrada, G.

  THE MULTIPLE SCLEROSIS SOCIETY

  1/10/10 → 15/11/11

  Project: Research

• Corticosteroids, Intracranial Pressure and the Pathogenesis of Idiopathic Intracranial Hypertension

  Rauz, S., Walker, E., Sinclair, A. & Stewart, P.

  Medical Research Council

  1/07/07 → 30/06/10

  Project: Research Councils

  • Pseudotumor Cerebri 100%
  • Headache 62%
  • Quality of Life 47%
  • Papilledema 15%
  • Weight Loss 15%

• Corticosteroids, Intercranial Pressure and the Pathogenesis of Idiopathic Intercranial Hypertension

  Rauz, S., Walker, E., Sinclair, A. & Stewart, P.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/07 → 30/06/12

  Project: Research