Alex Sinclair

Projects

Projects per year 2007 2016 2018 2028

• 12 Active
• 36 Finished

Projects per year

Search results

• Active

  The role of glucagon-like peptide 1 in migraine

  Hill, L. J. & Sinclair, A.

  Pain Relief Foundation

  1/09/24 → 31/08/25

  Project: Research

• Mild Traumatic Brain Injury Biomarker Study, a prospective cohort biomarker study of military and civilian participants with mTBI: mTBI-Predict

  Jensen, O., Yiangou, A., Pringle, J., Fernandez-Espejo, D., Morris, K., Mullinger, K., Lucas, S., Bagshaw, A., Sitch, A., Deeks, J., Mazaheri, A., Dehghani, H., Ottridge, R., Ottridge, R., Rogers, J., Sinclair, A., Reynolds, R., Upthegrove, R., Terry, J., Park, H., Thaller, M., Hill, L. J., Jenkinson, N. & Smith, D.

  US ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY

  30/09/23 → 29/09/28

  Project: Research

• Mild Traumatic Brain Injury - Predict (Baseline Variability Study) a prospective cohort biomarker study of military and civilian participants with mTBI (Linked to Project 1570897)

  Jenkinson, N., Dehghani, H., Upthegrove, R., Pringle, J., Jensen, O., Sinclair, A., Blanch, R., Reynolds, R., Hill, L. J., Sitch, A., Bagshaw, A., Lucas, S., Mazaheri, A., Rogers, J., Fernandez-Espejo, D., Mitchell, J., Deeks, J., Morris, K., Mullinger, K. & Wilson, M.

  MINISTRY OF DEFENCE

  1/12/22 → 31/12/24

  Project: Other Government Departments

  • Traumatic Brain Injury 100%
  • Tomography 76%
  • Systematic Review 74%
  • Brain Concussion 68%
  • Optical Coherence Tomography 54%

• NIHR BRC Theme - Sarcopenia

  Greig, C., Hardy, R., Mauro, C., Gkoutos, G., Romero, J., Fenton, S., Jackson, T., Nirantharakumar, K., Lai, Y., Duggal, N., Rowe, A., Sinclair, A., Jones, S., Breen, L. & Lord, J.

  NIHR

  1/12/22 → 30/11/27

  Project: Other Government Departments

• NIHR BRC Theme - Women's Metabolic Health

  Idkowiak, J., Thangaratinam, S., Smith, R., Prete, A., Da Silva Xavier, G., Zamora, J., Coomarasamy, A., Allotey, J., Rowe, A., Mauro, C., Sinclair, A., Devall, A. & Gillett, C.

  NIHR

  1/12/22 → 30/11/27

  Project: Other Government Departments

• EPSRC Network+: Neurotechnology for enabling community-based diagnosis and care

  Sinclair, A. & Terry, J.

  Engineering & Physical Science Research Council

  1/10/22 → 30/09/25

  Project: Research Councils

  • Epilepsy 100%
  • Seizures 71%
  • Therapeutics 19%
  • Computer Simulation 12%
  • Nervous System Diseases 12%

• Military Traumatic Brain Injury Biomarker Study, a prospective cohort biomarker study of military and civilian participants with mTBI

  Lucas, S., Karavitaki, N., Bagshaw, A., Sinclair, A., Morris, K., Deeks, J., Blanch, R., Fernandez-Espejo, D., Upthegrove, R., Terry, J., Jensen, O., Belli, T., Sitch, A., Jenkinson, N., Mullinger, K., Dehghani, H., Smith, D., Mazaheri, A., Berhane, S. & Ottridge, R.

  MINISTRY OF DEFENCE

  17/12/21 → 31/12/24

  Project: Other Government Departments

• Intervention to Preserve Vision in Idiopathic Intracranial Hypertension: Evaluation of Clinical Effectiveness and Cost Effectiveness

  Sinclair, A., Frew, E., Watts, C., Bach, S., Brock, K. & Hill, L. J.

  NIHR

  1/09/21 → 28/02/27

  Project: Other Government Departments

• Mechanisms and therapeutics for headache in Idiopathic Intracranial Hypertension

  Yiangou, A. & Sinclair, A.

  Association of British Neurologists

  4/08/21 → 3/08/25

  Project: Research

• Sinclair SJT 2019 Defining new treatment and headache mechanisms in raised intracranial pressure

  Brock, K., Sinclair, A., Barton, D. & Hill, L. J.

  Invex Therapeutics Ltd, SIR JULES THORN CHARITABLE TRUST

  1/12/20 → 31/12/27

  Project: Research

• Defining mechanisms and new treatments for headache in raised intracranial Pressure

  Sinclair, A.

  Brain Research Trust

  1/08/19 → 31/10/24

  Project: Research

• UK Idiopathic Intracranial Hypertension Database

  Sinclair, A.

  HEALTHCARE QUALITY IMPROVEMENT PARTNERSHIP, IDIOPATHIC INTERCRANIAL HYPERTENSION UK

  1/01/13 → 31/12/25

  Project: Research

• Finished

  Utilising a glucagon-like peptide 1 receptor agonist to treat Space flight-Associated Neuro-ocular Syndrome

  Sinclair, A., Gates, S., Barton, D. & Terry, J.

  UK SPACE AGENCY

  1/10/21 → 31/03/22

  Project: Other Government Departments

• Exploring physiological responses to cortical spreading depression in an acute brain slice model

  Fulton, D., Sinclair, A. & Lavery, G.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/08/20 → 31/07/22

  Project: Research

• Identifying biomarkers through MicroRNA profiling.

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/20 → 1/07/23

  Project: Research

• Exploratory study of candidate molecular biomarkers in IIH patients

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/20 → 1/07/23

  Project: Research

• The molecular pathways underlying pathological brain water regulation

  Sinclair, A.

  Lundbeckfonden

  1/01/20 → 31/12/22

  Project: Research

• Researching Exenatide in-vitro and in human in-vivo studies

  Sinclair, A.

  Invex Therapeutics Ltd

  1/08/19 → 1/07/24

  Project: Industry

• WT ISSF - IIH Pressure: Head - Human headache models in Idiopathic intracranial hypertension (IIH)

  Sinclair, A.

  THE WELLCOME TRUST

  1/05/19 → 31/08/22

  Project: Research

• IIH Pressure Head

  Sinclair, A.

  IDIOPATHIC INTERCRANIAL HYPERTENSION UK

  1/07/18 → 30/06/19

  Project: Research

• Evaluating the relationship between obstructive sleep apnoea and androgen dysregulation in IIH

  Sinclair, A. & Tahrani, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 18/01/23

  Project: Research

• Dissecting adipose and systemic androgen generation in women with idiopathic intracranial hypertension

  O'Reilly, M. & Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 30/06/22

  Project: Research

• Defining the metabolite profile in IIH

  Sinclair, A. & Ludwig, C.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 30/06/22

  Project: Research

• Optogenetic generation of cortical spreading depression in mouse models of raised intracranial pressure

  Lavery, G. & Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/18 → 18/03/22

  Project: Research

• Idiopathic Intracranial Hypertension (IIH)

  Sinclair, A.

  EXELOGEN INC

  31/05/18 → 30/05/21

  Project: Research

• Determining the effects of bariatric surgery on GLP-1 and ICP in IIH patients

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 18/01/23

  Project: Research

• The role of androgens in regulating ICP

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 31/12/21

  Project: Research

• The role of adipose tissue in IIH

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 31/12/21

  Project: Research

• Using solid state telemetry to assess the intracranial pressure lowering effects of exendin-4 in an experimental model of traumatic hydrocephalus

  Sinclair, A.

  The Ramc Charity (Royal Army Medical Corps)

  1/01/18 → 31/03/24

  Project: Research

• The role of glucogen-like peptide 1 in neuroprotection

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/18 → 31/12/21

  Project: Research

• Charaterising the transcriptome of adipose tissue in idiopathic intracranial hypertension patients to futher the understanding of idiopathic intracranial hypertenision pathogenesis.

  Sinclair, A. & Botfield, H.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/16 → 30/11/18

  Project: Research

• Use of Exendin-4 in IIH, Hydrocephalus and Trauma

  Sinclair, A. & Botfield, H.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/16 → 30/11/18

  Project: Research

• The role of GLP-1 agonists in CSF pressure and neuroprotection following Traumatic Brain Injury

  Belli, T. & Sinclair, A.

  Royal Centre For Defence Medicine

  1/08/16 → 31/07/19

  Project: Other Government Departments

• Industry Collaborative Research Grant to fund headache nurse.

  Sinclair, A.

  ELECTROCORE LLC

  15/02/16 → 14/02/18

  Project: Research

• Evaluating the efficacy of candidate drugs in inhibiting CSF secretion

  Sinclair, A. & Botfield, H.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/02/16 → 31/01/18

  Project: Research

• Characterising the Androgen Metabolic Signature in IIH

  Sinclair, A., Arlt, W. & O'Reilly, M.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/01/16 → 31/12/17

  Project: Research

• Equipment funding for IIH weight trials

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/15 → 30/09/19

  Project: Research

• MRC CiC 2015/16 - Repurposing glucagon-like peptide-1 therapies to treat idiopathic intracranial hypertension

  Sinclair, A.

  Medical Research Council

  1/08/15 → 30/09/17

  Project: Research Councils

• Modulation of cerebrospinal fluid secretion by glucagon-like peptide-1

  Sinclair, A. & Gonzalez, A.

  THE WELLCOME TRUST

  22/06/15 → 21/08/15

  Project: Research

• The role of glucagon-like peptide 1 in cerebral spinal fluid secretion

  Sinclair, A. & Gonzalez, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/04/15 → 31/03/17

  Project: Research

• Safety and efficacy of an IIß-HSD1 inhibitor in Idiopathic Intracranial Hypertension

  Sinclair, A.

  ASTRA ZENECA UK LIMITED

  1/03/15 → 29/02/20

  Project: Industry

• Evaluating an IIß-HSD1 inhibitor and adipose in Idiopathic Intracranial Hypertension

  Sinclair, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/12/14 → 1/08/18

  Project: Research

• Establishing in vitro choroid plexus and arachnoid granulation cell functional model systems of CSF secretion and drainage to further understanding into the pathogenesis¿s of Idiopathic intracranial hypertension

  Sinclair, A. & Gonzalez, A.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  17/01/14 → 15/07/15

  Project: Research

• Assessing the Therapeutic Efficacy of an 11Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in Idiopathic Intracranial Hypertension (IIH)

  Sinclair, A., Tomlinson, J. & Stewart, P.

  Medical Research Council

  12/08/13 → 11/08/17

  Project: Research Councils

  • Pseudotumor Cerebri 100%
  • Intracranial Pressure 30%
  • Headache 20%
  • 11-beta-Hydroxysteroid Dehydrogenases 19%
  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 14%

• Sustained treatment of Idiopathic Intracranial Hypertension (IIH) through weight loss induced by bariatric surgery

  Sinclair, A.

  NIHR TRAINEES COORDINATING CENTRE

  1/06/13 → 31/10/18

  Project: Research

  • Pseudotumor Cerebri 100%
  • Intracranial Pressure 32%
  • Headache 20%
  • 2-(1-(5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl)-3-piperidyl)acetic acid 16%
  • Bariatric Surgery 14%

• Analysis of Pathogenic and Regulatory T Cells in Relapsing-Remitting Multiple Sclerosis

  Curnow, J., Douglas, M., Sinclair, A. & Mazibrada, G.

  THE MULTIPLE SCLEROSIS SOCIETY

  1/10/10 → 15/11/11

  Project: Research

• Corticosteroids, Intracranial Pressure and the Pathogenesis of Idiopathic Intracranial Hypertension

  Rauz, S., Walker, E., Sinclair, A. & Stewart, P.

  Medical Research Council

  1/07/07 → 30/06/10

  Project: Research Councils

  • Pseudotumor Cerebri 100%
  • Headache 62%
  • Quality of Life 47%
  • Papilledema 15%
  • Weight Loss 15%

• Corticosteroids, Intercranial Pressure and the Pathogenesis of Idiopathic Intercranial Hypertension

  Rauz, S., Walker, E., Sinclair, A. & Stewart, P.

  MIDLAND NEUROSCIENCE TEACHING & RESEARCH FUND

  1/07/07 → 30/06/12

  Project: Research