Alan Jones

Accepting PhD Students

PhD projects

The Jones research group has been funded by BISCA, the Wellcome Trust (UK), CRISM Therapeutics/Imphatec Ltd (Industry UK/Ireland), Medical Research Council (UK), the Royal Society of Chemistry (UK), CAPES (Brazil), Bolashak Foundation (Kazakhstan), LPDP (Indonesia), EJSP (Saudi Arabia), UNESP (Brazil), Erasmus+ mobility programme (EU), British Council (UK Govt), Science without Borders (Brazil), the Government of Botswana (Botswana), the Royal Society (London), King Khalid University (Saudi Arabia), and University of Birmingham amongst others. He was awarded alongside his collaborators (Wilkinson and Alexander) the Healthcare Science Excellence Prize in 2016. During his career he has published over 75+ research papers, 3 patents, and 2 book chapters.

The main theme of the multi-disciplinary research in the group is the development of underpinning science that pushes the boundaries of the chemical sciences within drug discovery. Prominent topics of research include:
1) electrosynthesis of drug metabolites including the late-stage modification of small molecules and peptides;
2) novel synthetic routes to sulfated bioactive molecules and peptides;
3) drug discovery projects including the small molecule allosteric inhibition of EAAT1 for T-ALL, design of novel EGFR/HER2 inhibitors for oncology, AI in drug development, and a glycomimetic platform for HGF-cMET modulation for cardiovascular indications; and 4) polypharmacology as a determinant of adverse drug reactions and drug toxicity in real-world settings.

PhD student enquires are welcome:

[1] Polypharmacology and Side Effects of Drugs, see: https://www.findaphd.com/phds/project/pharmacovigilance-and-polypharmacology-identification-of-differential-side-effects-within-drug-classes-and-links-to-their-unique-modes-of-action/?p171337

[2] Electrochemical synthesis of Drug Metabolites, see: https://www.findaphd.com/phds/project/drug-metabolism-prediction-detection-and-isolation/?p171338

[3] Targeting amino-acid transporters for treatment of cancer and neurological disorders (co-I with Dr Felix Chan), see: https://www.findaphd.com/phds/project/targeting-amino-acid-transporters-for-treatment-of-cancer-and-neurological-disorders/?p181764

Research activity per year

1 - 50 out of 111 results

2025

The Prevalence of Metabolic and Endocrine Adverse Drug Reactions (ADRs) Associated with Atypical Antipsychotics in Children and Adolescents with Autism Spectrum Disorder (ASD) in Saudi Arabia: Systematic Review.
Aljead, M., Jones, A. M. & Jalal, Z., 2025, PROSPERO.
Research output: Other contribution

Open Access
2024
A general method to access underexplored ylideneamino sulfates as interrupted Beckmann-type rearrangement intermediates
Zhou, Y. & Jones, A. M., 8 Apr 2024, In: Molecules. 29, 7, 14 p., 1667.
Research output: Contribution to journal › Article › peer-review

Open Access
File
80 Downloads (Pure)
A modified all-in-one DMSO-activating and base releasing reagent for the Parikh-Doering-type benzylic oxidation reaction
Xie, J., Male, L. & Jones, A. M., 3 Apr 2024, ChemRxiv, 10 p.
Research output: Working paper/Preprint › Preprint

File
174 Downloads (Pure)
A modified all-in-one DMSO-activating and base releasing reagent for the Parikh-Doering-type benzylic oxidation reaction
Xie, J., Male, L. & Jones, A. M., 10 Jul 2024, (E-pub ahead of print) In: Results in Chemistry. 101650.
Research output: Contribution to journal › Article › peer-review

Open Access
Approaches to the Sulfation of Small Molecules: Current Progress and Future Directions
Alshehri, J. & Jones, A., 8 Apr 2024, ChemRxiv.
Research output: Working paper/Preprint › Preprint
Associations between Suspected Adverse Drug Reactions of HMG-CoA Reductase Inhibitors and Polypharmacology Using a National Registry Approach
Yousaf, H. & Jones, A. M., 3 Jul 2024, In: Pharmacoepidemiology. 3, 3, p. 241-251 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
43 Downloads (Pure)
Chemical Approaches to the Sulfation of Small Molecules: Current Progress and Future Directions
Alshehri, J. & Jones, A. M., 3 Jul 2024, (E-pub ahead of print) In: Essays in Biochemistry. 18 p., EBC20240001.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
130 Downloads (Pure)
Cobdock: an accurate and practical machine learning-based consensus blind docking method
Ugurlu, S. Y., McDonald, D., Lei, H., Jones, A. M., Li, S., Tong, H. Y., Butler, M. S. & He, S., 11 Jan 2024, In: Journal of Cheminformatics. 16, 1, 19 p., 5.
Research output: Contribution to journal › Article › peer-review

Open Access
File
160 Downloads (Pure)
Computational Predictive and Electrochemical Detection of Metabolites (CP-EDM) of Piperine
Asra, R., Ribeiro Povinelli, A. P. R., Zazeri, G. & Jones, A. M., 20 May 2024, In: Molecules. 29, 10, 14 p., 2406.
Research output: Contribution to journal › Article › peer-review

Open Access
File
33 Downloads (Pure)
Computational Predictive and Electrochemical Detection of Metabolites (CP-EDM) of Piperine
Asra, R., Povinelli, A. P. R., Zazeri, G. & Jones, A. M., 29 Mar 2024, ChemRxiv.
Research output: Working paper/Preprint › Preprint

File
25 Downloads (Pure)
Conductive Polypropylene Additive Manufacturing Feedstock: Application to Aqueous Electroanalysis and Unlocking Nonaqueous Electrochemistry and Electrosynthesis
Ramos, D. L. O., Crapnell, R. D., Asra, R., Bernalte, E., Oliveira, A., Muñoz, R. A. A., Richter, E. M., Jones, A. M. & Banks, C. E., 2 Oct 2024, (E-pub ahead of print) In: ACS Applied Materials & Interfaces.
Research output: Contribution to journal › Article › peer-review

Open Access
File
147 Downloads (Pure)
Conductive polypropylene additive manufacturing feedstock: Application to aqueous electroanalysis and unlocking non-aqueous electrochemistry and electrosynthesis
Ramos, D., Crapnell, R., Asra, R., Bernalte, E., Oliveria, A., Munoz, R., Richter, E., Jones, A. M. & Banks, C. E., 24 Sept 2024, (Accepted/In press) In: ACS Applied Materials & Interfaces.
Research output: Contribution to journal › Article › peer-review
Corrigendum: A Sulfuryl Group Transfer Strategy to Selectively Prepare Sulfated Steroids and Isotopically Labelled Derivatives
Alshehri, J., Gill, D. & Jones, A. M., 19 Dec 2024, In: Frontiers in Molecular Biosciences. 11, 2 p., 1504226.
Research output: Contribution to journal › Comment/debate › peer-review

Open Access
Electrochemical Synthesis of Added Valuable Purine Alkaloid Metabolites from Caffeine Feedstock Employing a Structure Electro-Activity Relationship (SeAR) Approach
Asra, R. & Jones, A. M., 13 Jun 2024, ChemRxiv.
Research output: Working paper/Preprint › Working paper

File
4 Downloads (Pure)
Electrochemical Synthesis of Purine Alkaloid Metabolites from Caffeine
Asra, R. & Jones, A. M., 16 Dec 2024, In: ChemElectroChem. 11, 24, 4 p., e202400439.
Research output: Contribution to journal › Article › peer-review

Open Access
File
16 Downloads (Pure)
Electrochemical Synthesis of the in human S-oxide metabolites of phenothiazine containing Anti-Psychotic Medications
Asra, R., Malmakova, A. & Jones, A. M., 22 Apr 2024, ChemRxiv, p. 1-22, 22 p.
Research output: Working paper/Preprint › Preprint

Open Access
Electrochemical Synthesis of the In Human S-oxide Metabolites of Phenothiazine-Containing Antipsychotic Medications
Asra, R., Malmakova, A. E. & Jones, A. M., 26 Jun 2024, In: Molecules. 29, 13, 16 p., 3038.
Research output: Contribution to journal › Article › peer-review

Open Access
File
33 Downloads (Pure)
Electrochemical Synthesis of the In Human S-oxide Metabolites of Phenothiazine-Containing Antipsychotic Medications
Asra, R., Malmakova, A. E. & Jones, A. M., 26 Jun 2024, In: Molecules. 29, 13, 16 p., 3038.
Research output: Contribution to journal › Article › peer-review

Open Access
File
31 Downloads (Pure)
Multiaction Pt(IV) Complexes: Cytotoxicity in Ovarian Cancer Cell Lines and Mechanistic Studies
Tabrizi, L., Jones, A. M., Romero-Canelon, I. & Erxleben, A., 12 Aug 2024, In: Inorganic Chemistry. 63, 32, p. 14958-14968 11 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
87 Downloads (Pure)
Novel Glycomimetics Protect Against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro by Attenuation of the RAGE/ERK/CREB Pathway
Sidgwick, G. P., Weston, R., Mahmoud, A. M., Serracino-inglott, F., Mahesh Tandel, S., Skeoch, S., Bruce, I. N., Jones, A. M., Alexander, M. Y. & Wilkinson, F. L., 8 Feb 2024, In: Cells. 13, 4, 312.
Research output: Contribution to journal › Article › peer-review

Open Access
File
30 Downloads (Pure)
Rearrangement of Arylsulfamates and Sulfates To Para-Sulfonyl Anilines and Phenols
Zhou, Y. & Jones, A. M., 23 Mar 2024, In: Molecules. 29, 7, 1445.
Research output: Contribution to journal › Article › peer-review

Open Access
File
49 Downloads (Pure)
Suspected Adverse Drug Reactions Associated With Leukotriene Receptor Antagonists Versus First Line Asthma Medications: A National Registry-Pharmacology Approach
Khan, M., Hirsch, C. & Jones, A. M., Jun 2024, (Accepted/In press) medRxiv.
Research output: Working paper/Preprint › Preprint
The Interplay Between Molecular Architecture, Pharmacology, and Suspected Adverse Drug Reactions Associated with Non-Steroidal Androgen Antagonists in The United Kingdom
Dhillon, S., Antolin, A. & Jones, A. M., Jul 2024, medRxiv.
Research output: Working paper/Preprint › Preprint
The Relationship Between Suspected Adverse Drug Reactions Of HMG-Coa Reductase Inhibitors And Polypharmacology Using A National Registry Approach
Yousaf, H. & Jones, A. M., 3 Apr 2024, medRxiv, 13 p.
Research output: Working paper/Preprint › Preprint

File
6 Downloads (Pure)
The Role of Polarity Medium in the Efficiency of Albumin Binding with Hydrophobic Ligands: Experimental Studies and Molecular Dynamics Investigation
Zazeri, G., Povinelli, A. P. R., de Carvalho Bertozo, L., Jones, A. M. & Ximenes, V. F., 25 Nov 2024, In: International Journal of Molecular Sciences. 25, 23, 17 p., 12664.
Research output: Contribution to journal › Article › peer-review

Open Access
File
10 Downloads (Pure)
United Kingdom National Register Study of Anti-Epileptic Medications: Suspected Foetal Congenital And Pregnancy-Associated Side Effects
Phillips, B., Evans, I., Skerrett, V. & Jones, A. M., 27 Mar 2024, medRxiv.
Research output: Working paper/Preprint › Preprint
2023
Birmingham Environment for Academic Research: Case studies volume 3
Ghumra, A. (Editor), Acil, N., Barker, J., Baziotis, C., Beltran Hernandez, A., Dai, D., Deakin, J., Dettmer, S., Fentham, D., Fontrodona-Bach, A., Hart-Villamil, R., Jenkins, B., Jia, X., Jones, A. M., Morris, A., Murakami, A., Seymour, R., Da Silva Xavier, G., Smith, C. & Tashev, S. & 4 others, Turner, J., Uche, E. O., Xia, X. & Zhong, J., Dec 2023, 30 p. University of Birmingham.
Research output: Other contribution

Open Access
Green electrosynthesis of drug metabolites
Asra, R. & Jones, A. M., 7 Mar 2023, (E-pub ahead of print) In: Toxicology Research. p. 1-28 28 p., tfad009.
Research output: Contribution to journal › Article › peer-review

Open Access
File
89 Downloads (Pure)
Solvent-induced Lag-phase on the Formation of Lysozyme Amyloid Fibrils Triggered by SDS: Biophysical Experimental and in Silico Study of Solvent Effects
Zazeri, G., Ribeiro Povinelli, A., Pavan, N. M., Ximenes, V. F. & Jones, A. M., 30 Sept 2023, In: Molecules. 28, 19, 14 p., 6891.
Research output: Contribution to journal › Article › peer-review

Open Access
File
61 Downloads (Pure)
2022
A computational–experimental investigation of the molecular mechanism of interleukin-6-piperine interaction
Povinelli, A. P. R., Zazeri, G., Jones, A. M. & Cornélio, M. L., 20 Jul 2022, In: International Journal of Molecular Sciences. 23, 14, 14 p., 7994.
Research output: Contribution to journal › Article › peer-review

Open Access
File
81 Downloads (Pure)
Angiotensin II receptor blockers (ARBs) and manufacturing contamination: a retrospective national register study into suspected associated adverse drug reactions
Salim, H. & Jones, A. M., 8 Jun 2022, In: British Journal of Clinical Pharmacology. 2022, 11, p. 1-16 16 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
292 Downloads (Pure)
A Sulfonative rearrangement of N-aryl sulfamates to para-sulfonyl anilines
Zhou, Y. & Jones, A. M., 30 Jun 2022, ChemRxiv.
Research output: Working paper/Preprint › Preprint
Discovery and characterization of a cryptic secondary binding site in the molecular chaperone HSP70
O’Connor, S., Le Bihan, Y.-V., Westwood, I. M., Liu, M., Mak, O. W., Zazeri, G., Povinelli, A. P. R., Jones, A. M., van Montfort, R., Reynisson, J. & Collins, I., 26 Jan 2022, In: Molecules. 27, 3, 22 p., 817.
Research output: Contribution to journal › Article › peer-review

Open Access
File
105 Downloads (Pure)
Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale
Sandhu, D., Antolin, A., Cox, A. & Jones, A. M., Feb 2022, In: British Journal of Clinical Pharmacology. 88, 2, p. 742-752
Research output: Contribution to journal › Article › peer-review

Open Access
File
212 Downloads (Pure)
Suspected adverse drug reactions of the type 2 antidiabetic drug class dipeptidyl-peptidase IV inhibitors (DPP4i): can polypharmacology help explain?
Jones, L. & Jones, A. M., 30 Jun 2022, medRxiv.
Research output: Working paper/Preprint › Preprint
Suspected adverse drug reactions of the type 2 antidiabetic drug class dipeptidyl-peptidase IV inhibitors (DPP4i): can polypharmacology help explain?
Jones, L. & Jones, A. M., 5 Dec 2022, In: Pharmacology research & perspectives. 10, 6, 10 p., e01029.
Research output: Contribution to journal › Article › peer-review

Open Access
File
171 Downloads (Pure)
2021
A sulfuryl group transfer strategy to selectively prepare sulfated steroids and isotopically labelled derivatives
Alshehri, J., Gill, D. & Jones, A. M., 24 Dec 2021, In: Frontiers in Molecular Bioscience. 8, 776900.
Research output: Contribution to journal › Article › peer-review

Open Access
File
102 Downloads (Pure)
Dialling-in new reactivity into the Shono-type anodic oxidation reaction
Jones, A. M., Sept 2021, In: The Chemical Record. 21, 9, p. 2120-2129
Research output: Contribution to journal › Article › peer-review
Organoruthenium complexes with benzo-fused pyrithiones overcome platinum resistance in ovarian cancer cells
Kladnik, J., Coverdale, J. P. C., Kljun, J., Burmeister, H., Lippman, P., Ellis, F. G., Jones, A. M., Ott, I., Romero-Canelón, I. & Turel, I., 20 May 2021, In: Cancers. 13, 10, 21 p., 2493.
Research output: Contribution to journal › Article › peer-review

Open Access
File
1 Citation (Scopus)

193 Downloads (Pure)
Polypharmacology of clinical sodium glucose co-transport protein 2 inhibitors and relationship to suspected adverse drug reactions
Matharu, K., Chana, K., Ferro, C. & Jones, A. M., Oct 2021, In: Pharmacology Research and Perspectives. 9, 5, 11 p., e00867.
Research output: Contribution to journal › Article › peer-review

Open Access
File
237 Downloads (Pure)
The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: Absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies
Gill, D., Ribeiro Povinelli, A., Zazeri, G., Shamir, S. A., Mahmoud, A. M., Wilkinson, F. L., Alexander, M. Y., Cornelio, M. L. & Jones, A. M., 1 May 2021, In: RSC Medicinal Chemistry. 12, 5, p. 779-790 12 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
173 Downloads (Pure)
Tributylsulfoammonium betaine
Jones, A. M., 30 Apr 2021, e-EROS: Encyclopedia of Reagents for Organic Synthesis. Charette, A., Bode, J., Rovis, T. & Shenvi, R. (eds.). Wiley, (Electronic Encyclopedia of Reagents for Organic Synthesis).
Research output: Chapter in Book/Report/Conference proceeding › Entry for encyclopedia/dictionary
Unravelling the interaction of piperlongumine with the nucleotide-binding domain of HSP70: a spectroscopic and in silico study
Ribeiro Povinelli, A., Zazeri, G., Jones, A. M. & Cornelio, M. L., 13 Dec 2021, In: Pharmaceuticals (Basel, Switzerland). 14, 12, 1298.
Research output: Contribution to journal › Article › peer-review

Open Access
File
99 Downloads (Pure)
2020
Aminothiazolones as potent, selective and cell active inhibitors of the PIM kinase family
Quevedo, C. E., J. R. Bataille, C., Byrne, S., Durbin, M., Elkins, J., Guillermo, A., Jones, A. M., Knapp, S., Nadali, A., Walker, R. G., Wilkinson, I., Wynne, G. M., Davies, S. G. & Russell, A. J., 15 Nov 2020, In: Bioorganic & Medicinal Chemistry. 28, 22, 115724.
Research output: Contribution to journal › Article › peer-review
A novel exchange method to access sulfated molecules
Alshehri, J. A., Benedetti, A. M. & Jones, A. M., 6 Oct 2020, In: Scientific Reports. 10, 1, 16559.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

217 Downloads (Pure)
A systematic review of the effectiveness of Coenzyme Q10 in reducing mortality in patients with heart failure
Zahid, M., Jones, A. M. & Jalal, Z., Apr 2020, In: International Journal of Pharmacy Practice. 28, S1, p. 76-77 2 p.
Research output: Contribution to journal › Abstract › peer-review
Chemical methods for N- and O-sulfation of small molecules, amino acids and peptides
Benedetti, A. M., Gill, D., Tsang, C. & Jones, A. M., 1 Apr 2020, In: ChemBioChem. 21, 7, p. 938-942 5 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

352 Downloads (Pure)
Clinical potential of targeting fibroblast growth factor‐23 and αKlotho in the treatment of uremic cardiomyopathy
Law, J. P., Price, A. M., Pickup, L., Radhakrishnan, A., Weston, C., Jones, A. M., McGettrick, H. M., Chua, W., Steeds, R. P., Fabritz, L., Kirchhof, P., Pavlovic, D., Townend, J. N. & Ferro, C. J., 9 Apr 2020, In: Journal of the American Heart Association. 9, 7, 15 p., e016041.
Research output: Contribution to journal › Article › peer-review

Open Access
File
3 Citations (Scopus)

272 Downloads (Pure)
Electrically Driven N(_sp ²)- C(_sp ^2/3) Bond Cleavage of Sulfonamides
Wetzel, A. & Jones, A. M., 2 Mar 2020, In: ACS Sustainable Chemistry & Engineering. 8, 8, p. 3487-3493 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
5 Citations (Scopus)

350 Downloads (Pure)
Lysyl oxidase like-2 (LOXL2): an emerging oncology target
Chopra, V., Sangarappillai, R., Romero-Canelón, I. & Jones, A. M., Feb 2020, In: Advanced Therapeutics. 3, 2, 23 p., 1900119.
Research output: Contribution to journal › Review article › peer-review

Open Access
File
506 Downloads (Pure)

Alan Jones

Research output

Search results