Research output per year
Research output per year
Organisation profile
Organisation profile
The Institute of Metabolism and Systems Research (IMSR) offers a highly multi-disciplinary, collaborative and nurturing environment that combines leading excellence in metabolic, endocrine and reproductive research with world class expertise in mass spectrometry, confocal imaging and computational systems science approaches.
IMSR provides strategic leadership for the University of Birmingham Metabolomics Core, which offers highly innovative approaches delivered by the Phenome Centre Birmingham, the Steroid Metabolomics Analysis Core (SMAC), the Metabolic Tracer Analysis Core (MTAC), and the Henry Wellcome Biomolecular NMR Facility.
IMSR researchers explore mechanisms of metabolic, endocrine and reproductive diseases and novel approaches to prognosis, diagnosis and treatment in four major areas:
- Metabolism and metabolic disease (cell metabolism, steroid metabolism, energy metabolism, exercise, nutrition, obesity and diabetes and their systemic consequences)
- Hormones and Reproduction (fertility, the developing fetus, early miscarriage and other complications of pregnancy, maternal health, newborn health)
- Hormones, Immunity and Inflammation (steroid hormone metabolism and action in antibacterial response, immunomodulation, and inflammatory diseases)
- Hormones, Metabolism and Cancer (hormonal regulation of tumorigenesis, cancer metabolism, hormone-producing and hormone-dependent cancers)
Our principal investigators employ all elements of the translational cascade, with a combination of in vitro and in vivo models, human in vivo physiology, innovative metabolome and in vivo imaging approaches, experimental medicine studies and clinical trials. IMSR investigators drive core components of the Centre of Membrane Proteins and Receptors (COMPARE).
UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Our work contributes towards the following SDG(s):
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SDG 1 No Poverty -
SDG 2 Zero Hunger -
SDG 3 Good Health and Well-being -
SDG 4 Quality Education -
SDG 5 Gender Equality -
SDG 8 Decent Work and Economic Growth -
SDG 9 Industry, Innovation, and Infrastructure -
SDG 10 Reduced Inequalities -
SDG 11 Sustainable Cities and Communities -
SDG 12 Responsible Consumption and Production -
SDG 13 Climate Action -
SDG 14 Life Below Water -
SDG 16 Peace, Justice and Strong Institutions
Fingerprint
Dive into the research topics where Metabolism and Systems Science is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
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A call to develop rigorous standards for excellence in idiopathic intracranial hypertension: RISE-IIH
MacKeith, D., Ellis, B., Katanga, J., Nitkunan, A., Sejourne, A., MacDiarmid, S., Budd, A., Voas-Clarke, C., Berman, G., Mollan, S. P. & Adeoye, J., Jun 2026, In: Eye. 40, 8, p. 1103-1105 3 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
Achondroplasia management in the era of targeted therapies: a meta-analysis of C-type natriuretic peptide analogs
Kamrul-Hasan, A. B. M., Uday, S., Nagendra, L., Dutta, D., Bhattacharya, S., Pappachan, J. M. & Ashraf, A. P., Jul 2026, In: Journal of the Endocrine Society. 10, 7, 21 p., bvag121.Research output: Contribution to journal › Review article › peer-review
Open AccessFile33 Downloads (Pure) -
Adolescent health across Asia Pacific, 2000–23: a systematic analysis for the Global Burden of Disease Study 2023
GBD 2023 Asia Pacific Adolescent Health Collaborators, Oct 2026, In: The Lancet Child and Adolescent Health. 10, 10, p. 731-754 24 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile23 Downloads (Pure)
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Low risk thyroid cancer: Intervention or ObservatioN trial (LION trial)
Nieto, H. (Co-Investigator), Boelaert, K. (Co-Investigator) & Soden, M. (Principal Investigator)
1/10/26 → 31/03/36
Project: Other Government Departments
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Methoxyflurane agaInst Standard Treatment for pain control in outpatient hysteroscopy [MIST]
De Silva, P. (Co-Investigator), Jackson, L. (Co-Investigator), Morris, K. (Principal Investigator) & Middleton, L. (Co-Investigator)
1/09/26 → 30/04/30
Project: Other Government Departments
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Characterisation of Ryanodine receptor (RyR)-mediated calcium dysregulation as a novel driver of steroidogenesis and adrenal tumorigenesis
Jamaluddin, A. (Principal Investigator)
1/08/26 → 31/07/27
Project: Research
Activities
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SOCIETY FOR ENDOCRINOLOGY (External organisation)
Read, M. (Member)
16 Sept 2026 → 16 Sept 2029Activity: Membership › Membership of working group or committee
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Cancer Cell International (Journal)
Read, M. (Editor)
Jun 2026Activity: Publication peer-review and editorial work › Editorial board of a journal
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AI-driven drug repurposing for rational design of new combinatorial therapies in RAI-refractory thyroid cancer
Read, M. (Speaker)
15 May 2026Activity: Academic and Industrial events › Conference, workshop or symposium
Datasets
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Research data supporting "Intracrine FFA4 Signaling Controls Lipolysis at Lipid Droplets"
O'Brien, S. (Creator) & Calebiro, D. (Supervisor), University of Birmingham, 23 Jul 2025
DOI: 10.25500/edata.bham.00001316
Dataset
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The art of coarse Stokes: Code for manuscript - Gallagher and Smith 2021, Roy. Soc. Open. Sci.
Gallagher, M. (Creator) & Smith, D. (Creator), The Royal Society, 26 May 2021
Dataset
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Coarse-graining the fluid flow around a human sperm
Smith, D. (Creator), Kirkman-Brown, J. (Creator), Ishimoto, K. (Creator), Gadelha, H. (Creator) & Gaffney, E. (Creator), University of Birmingham, 19 Feb 2017
Dataset
Prizes
Press/Media
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QEHB Consultant elected president of European Network for the Study of Adrenal Tumours
11/10/24
1 item of Media coverage
Press/Media: Press / Media
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Doing more with less: the flagellar end piece enhances the propulsive effectiveness of spermatozoa
Gallagher, M., Neal, C., Kirkman-Brown, J., Smith, D. & Hall-McNair, A.
9/07/20 → 13/07/20
3 items of Media coverage, 1 Media contribution
Press/Media: Press / Media
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An adjustable split ventilator for emergency use in COVID-19 patients
Shahzad, A., Wijns, W. & Laffey, J. G.
10/04/20 → 23/06/20
2 items of Media coverage, 1 Media contribution
Press/Media: Press / Media