Institute of Translational Medicine

Research output

Research output per year 2014 2020 2021 2022 2023 2024

• 35 Article
• 2 Review article
• 2 Preprint
• 1 Abstract

Research output per year

Research output per year

Search results

• 2024

  Academic drug discovery: Challenges and opportunities

  Murray, A. J., Cox, L. R., Adcock, H. V. & Roberts, R. A., Apr 2024, In: Drug Discovery Today. 29, 4, 6 p., 103918.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Drug Discovery 100%
  • Drug 51%
  • Pharmaceutical Preparations 13%
  • Amount 10%
  • Molecule 8%
  17 Downloads (Pure)
• 2023

  Hybrid use of Raman spectroscopy and artificial neural networks to discriminate Mycobacterium bovis BCG and other Mycobacteriales

  Macgregor-Fairlie, M., De Gomes, P., Weston, D., Rickard, J. J. S. & Goldberg Oppenheimer, P., 11 Dec 2023, In: PLoS ONE. 18, 12, e0293093.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Raman Spectrum Analysis 100%
  • Raman spectroscopy 94%
  • neural networks 82%
  • tuberculosis 57%
  • Raman Spectroscopy 57%
  13 Downloads (Pure)

• Link prediction in complex network using information flow

  Aziz, F., Slater, L. T., Bravo-Merodio, L., Acharjee, A. & Gkoutos, G. V., 5 Sept 2023, In: Scientific Reports. 13, 1, 16 p., 14660.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Information Services 100%
  • Forests 98%
  • Biological Transport 71%
  • Biological Science Disciplines 51%
  • Social Sciences 50%

• Magnetic Ion Channel Activation (MICA)-Enabled Screening Assay: A Dynamic Platform for Remote Activation of Mechanosensitive Ion Channels

  Unnithan, A. R., Rotherham, M., Markides, H. & El haj, A. J., 8 Feb 2023, In: International Journal of Molecular Sciences. 24, 4, 9 p., 3364.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Assays 100%
  • Ion Channels 84%
  • Screening 79%
  • Ions 78%
  • Chemical activation 76%
  30 Downloads (Pure)

• NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

  Sun, C., Seranova, E., Cohen, M. A., Chipara, M., Roberts, J., Astuti, D., Palhegyi, A. M., Acharjee, A., Sedlackova, L., Kataura, T., Otten, E. G., Panda, P. K., Lara-Reyna, S., Korsgen, M. E., Kauffman, K. J., Huerta-Uribe, A., Zatyka, M., Silva, L. F. S. E., Torresi, J., Zhang, S., & 20 othersHughes, G. W., Ward, C., Kuechler, E. R., Cartwright, D., Trushin, S., Trushina, E., Sahay, G., Buganim, Y., Lavery, G. G., Gsponer, J., Anderson, D. G., Frickel, E. M., Rosenstock, T. R., Barrett, T., Maddocks, O. D. K., Tennant, D. A., Wang, H., Jaenisch, R., Korolchuk, V. I. & Sarkar, S., 30 May 2023, In: Cell Reports. 42, 5, 26 p., 112372.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Nicotinamide 100%
  • Dinucleotide 99%
  • NAD 95%
  • Autophagy 88%
  • Adenine 85%
  1 Citation (Scopus)

  29 Downloads (Pure)

• Prognostic models for surgical-site infection in gastrointestinal surgery: systematic review

  NIHR Global Health Research Unit on Global Surgery, McLean, K. A., Goel, T., Lawday, S., Riad, A., Simoes, J., Knight, S. R., Ghosh, D., Glasbey, J. C., Bhangu, A. & Harrison, E. M., Nov 2023, In: British Journal of Surgery. 110, 11, p. 1441-1450 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Surgical Wound Infection 100%
  • Systematic Reviews 65%
  • ROC Curve 30%
  • Calibration 18%
  • Global Health 17%

• Tafamidis treatment in patients with transthyretin amyloid cardiomyopathy: a systematic review and meta-analysis

  Wang, J., Chen, H., Tang, Z., Zhang, J., Xu, Y., Wan, K., Hussain, K., Gkoutos, G. V., Han, Y. & Chen, Y., Sept 2023, In: EClinicalMedicine. 63, 12 p., 102172.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • tafamidis 100%
  • Prealbumin 66%
  • Cardiomyopathies 52%
  • Amyloid 51%
  • Meta-Analysis 40%
  66 Downloads (Pure)

• Tissue-resident, extravascular Ly6c- monocytes are critical for inflammation in the synovium

  Montgomery, A. B., Chen, S. Y., Wang, Y., Gadhvi, G., Mayr, M. G., Cuda, C. M., Dominguez, S., Moradeke Makinde, H-K., Gurra, M. G., Misharin, A. V., Mandelin, A. M., Ruderman, E. M., Thakrar, A., Brar, S., Carns, M., Aren, K., Akbarpour, M., Filer, A., Nayar, S., Teososio, A., & 5 othersMajor, T., Bharat, A., Budinger, G. R. S., Winter, D. R. & Perlman, H., 30 May 2023, In: Cell Reports. 42, 5, 25 p., 112513.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Synovial Membrane 100%
  • Marker 74%
  • Monocytes 70%
  • Inflammation 50%
  • Rheumatoid Arthritis 35%
• 2022

  A call for patient-centred textbook outcomes for emergency surgery and trauma

  Naumann, D. N., Bhangu, A., Brooks, A., Martin, M., Cotton, B. A., Khan, M., Midwinter, M. J., Pearce, L., Bowley, D. M., Holcomb, J. B. & Griffiths, E. A., 18 Aug 2022, (E-pub ahead of print) In: British Journal of Surgery. znac271.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  33 Downloads (Pure)

• A qualitative exploration of nutrition screening, assessment and oral support used in patients undergoing cancer surgery in low-and middle-income countries

  Sowerbutts, A. M., Knight, S. R., Lapitan, M. C. M., Qureshi, A. U., Maimbo, M., Yenli, E. M. T. A., Tabiri, S., Ghosh, D., Kingsley, P. A., Sundar, S., Shaw, C. A., Valparaiso, A., Alviz, C. A., Bhangu, A., Theodoratou, E., Weiser, T. G., Harrison, E. M. & Burden, S. T., 18 Feb 2022, In: Nutrients. 14, 4, 863.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • nutrition assessment 100%
  • Nutrition Assessment 90%
  • malnutrition 83%
  • surgery 76%
  • Malnutrition 71%
  22 Downloads (Pure)

• Associating transcriptomics data with inflammatory markers to understand tumour microenvironment in hepatocellular carcinoma

  Bahcivanci, B., Shafiha, R., Gkoutos, G. V. & Acharjee, A., 18 Jun 2022, (E-pub ahead of print) In: Cancer Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tumor Microenvironment 100%
  • Hepatocellular Carcinoma 77%
  • Macrophages 67%
  • Datasets 43%
  • Regulatory T-Lymphocytes 40%
  68 Downloads (Pure)

• Eligibility for early rhythm control in patients with atrial fibrillation in the UK Biobank

  Kany, S., Cardoso, V. R., Bravo, L., Williams, J. A., Schnabel, R., Fabritz, L., Gkoutos, G. V. & Kirchhof, P., 14 Jul 2022, (E-pub ahead of print) In: Heart.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Atrial Fibrillation 100%
  • Primary Health Care 19%
  • Population 14%
  • Safety 14%
  • Anti-Arrhythmia Agents 14%
  34 Downloads (Pure)

• Evaluating semantic similarity methods for comparison of text-derived phenotype profiles

  Slater, L. T., Russell, S., Makepeace, S., Carberry, A., Karwath, A., Williams, J. A., Fanning, H., Ball, S., Hoehndorf, R. & Gkoutos, G. V., 5 Feb 2022, In: BMC Medical Informatics and Decision Making. 22, 1, 12 p., 33.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Semantics 100%
  • semantics 76%
  • Phenotype 58%
  • Differential Diagnosis 37%
  • information content 30%
  85 Downloads (Pure)

• Evaluating the detection ability of a range of epistasis detection methods on simulated data for pure and impure epistatic models

  Russ, D., Williams, J. A., Cardoso, V. R., Bravo-Merodio, L., Pendleton, S. C., Aziz, F., Acharjee, A. & Gkoutos, G. V., 18 Feb 2022, In: PLoS ONE. 17, 2, 19 p., e0263390.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • epistasis 100%
  • Datasets 65%
  • Aptitude 56%
  • atrial fibrillation 54%
  • loci 50%
  74 Downloads (Pure)

• Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction

  Nayar, S., Pontarini, E., Campos, J., Berardicurti, O., Smith, C. G., Asam, S., Gardner, D. H., Colafrancesco, S., Lucchesi, D., Coleby, R., Chung, M-M., Iannizzotto, V., Hunter, K., Bowman, S. J., Carlesso, G., Herbst, R., McGettrick, H. M., Browning, J., Buckley, C. D., Fisher, B. A., & 2 othersBombardieri, M. & Barone, F., 4 May 2022, In: Communications Biology. 5, 1, 413.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tertiary Lymphoid Structures 100%
  • Inducible T-Cell Co-Stimulator Ligand 23%
  • Chemokines 22%
  • Inflammation 13%
  • Antigen-Presenting Cells 12%
  54 Downloads (Pure)

• Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study

  COV-AD consortium, 2 Jun 2022, In: Frontiers in immunology. 13, 912571.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • SARS Virus 100%
  • Seroepidemiologic Studies 75%
  • Antibody Formation 60%
  • Immunization 57%
  • Vaccines 50%
  57 Downloads (Pure)

• Integration of stool microbiota, proteome and amino acid profiles to discriminate patients with adenomas and colorectal cancer

  Bosch, S., Acharjee, A., Quraishi, M. N., Bijnsdorp, I. V., Rojas, P., Bakkali, A., Jansen, E. E., Stokkers, P., Kuijvenhoven, J., Pham, T. V., Beggs, A. D., Jimenez, C. R., Struys, E. A., Gkoutos, G. V., de Meij, T. G. & de Boer, N. K., 31 Dec 2022, In: Gut Microbes. 14, 1, 15 p., 2139979.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Proteome 100%
  • Microbiota 94%
  • Adenoma 89%
  • Colorectal Neoplasms 76%
  • Amino Acids 67%
  26 Downloads (Pure)

• Iron-mediated epigenetic activation of NRF2 targets

  Horniblow, R. D., Pathak, P., Balacco, D. L., Acharjee, A., Lles, E., Gkoutos, G., Beggs, A. D. & Tselepis, C., Mar 2022, In: Journal of Nutritional Biochemistry. 101, 108929.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glutathione 100%
  • NAD(P)H 97%
  • Epigenomics 97%
  • Iron 92%
  • Quinone 70%
  68 Downloads (Pure)

• SARS-CoV-2 Vaccine Responses in Individuals with Antibody Deficiency: Findings from the COV-AD Study

  COV-AD consortium, 14 Apr 2022, In: Journal of Clinical Immunology. 42, 5, p. 923-934 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  26 Downloads (Pure)

• The potential of fecal microbiota and amino acids to detect and monitor patients with adenoma

  Bosch, S., Acharjee, A., Quraishi, M. N., Rojas, P., Bakkali, A., Jansen, E. E., Brizzio Brentar, M., Kuijvenhoven, J., Stokkers, P., Struys, E., Beggs, A. D., Gkoutos, G. V., de Meij, T. G. & de Boer, N. K., 21 Feb 2022, In: Gut Microbes. 14, 1, 16 p., 2038863.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Microbiota 100%
  • Adenoma 94%
  • Amino Acids 70%
  • Endoscopy 24%
  • Colonoscopy 18%
  54 Downloads (Pure)
• 2021

  A fast, accurate, and generalisable heuristic-based negation detection algorithm for clinical text

  Slater, L. T., Bradlow, W., Motti, D. F., Hoehndorf, R., Ball, S. & Gkoutos, G. V., Mar 2021, In: Computers in Biology and Medicine. 130, 8 p., 104216.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Heuristics 100%
  • Datasets 41%
  • Data Mining 31%
  • Text mining 30%
  • Gold 28%
  1 Citation (Scopus)

  190 Downloads (Pure)

• Evaluation and improvement of the National Early Warning Score (NEWS2) for COVID-19: a multi-hospital study

  Carr, E., Bendayan, R., Bean, D., Stammers, M., Wang, W., Zhang, H., Searle, T., Kraljevic, Z., Shek, A., Phan, H. T. T., Muruet, W., Gupta, R. K., Shinton, A. J., Wyatt, M., Shi, T., Zhang, X., Pickles, A., Stahl, D., Zakeri, R., Noursadeghi, M., & 28 othersO'Gallagher, K., Rogers, M., Folarin, A., Karwath, A., Wickstrøm, K. E., Köhn-Luque, A., Slater, L., Cardoso, V. R., Bourdeaux, C., Holten, A. R., Ball, S., McWilliams, C., Roguski, L., Borca, F., Batchelor, J., Amundsen, E. K., Wu, X., Gkoutos, G. V., Sun, J., Pinto, A., Guthrie, B., Breen, C., Douiri, A., Wu, H., Curcin, V., Teo, J. T., Shah, A. M. & Dobson, R. J. B., Dec 2021, In: BMC medicine. 19, 1, 16 p., 23.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Early Warning Score 100%
  • National Health Programs 16%
  • University Hospitals 16%
  • Confidence Intervals 9%
  • Area Under Curve 8%
  5 Citations (Scopus)

  256 Downloads (Pure)

• Infrastructure and operating processes of PIONEER, the HDR-UK Data Hub in Acute Care and the workings of the Data Trust Committee: a protocol paper

  Gallier, S., Price, G., Pandya, H., McCarmack, G., James, C., Ruane, B., Forty, L., Crosby, B. L., Atkin, C., Evans, R., Dunn, K. W., Marston, E., Crawford, C., Levermore, M., Modhwadia, S., Attwood, J., Perks, S., Doal, R., Gkoutos, G., Dormer, R., & 3 othersRosser, A., Fanning, H. & Sapey, E., 13 Apr 2021, In: BMJ health & care informatics. 28, 1, 9 p., e100294.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Health 100%
  • Education 34%
  • Community Health Services 34%
  • Confidentiality 33%
  • Ambulances 32%
  153 Downloads (Pure)

• Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study

  Harper, L., Hewitt, C., Litchfield, I., Morgan, M., Chanouzas, D., Caulfield, H., Coughlan, L., Dean, C., Fletcher, K., Cramp, F., Greenfield, S., Rowland, N., Jowett, S., Kodabuckus, S., Tearne, S., Sehmi, S., Edwardson, C., Dawkins, N. P. & Daley, A., 22 Jan 2021, (E-pub ahead of print) In: Rheumatology. 60, 9, p. 4130-4140

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Feasibility Studies 100%
  • Vasculitis 98%
  • Fatigue 80%
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 79%
  • Exercise 62%
  99 Downloads (Pure)

• NFnetFu: A novel workflow for microbiome data fusion

  Bisht, V., Acharjee, A. & Gkoutos, G. V., Aug 2021, In: Computers in Biology and Medicine. 135, 104556.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Workflow 100%
  • Microbiota 89%
  • Data Analysis 67%
  141 Downloads (Pure)

• Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis

  Garcia, A. M., Bishop, E., Li, D., Jeffery, L., Garten, A., Thakker, A., Certo, M., Mauro, C., Tennant, D. A., Dimeloe, S., Evelo, C. T., Coort, S. L. & Hewison, M., Jul 2021, In: The Journal of Steroid Biochemistry and Molecular Biology. 211, 10 p., 105891.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • 1,25-dihydroxyvitamin D 100%
  • Dendritic Cells 67%
  • Fatty Acids 63%
  • Metabolic 60%
  • Fatty Acid 60%
  168 Downloads (Pure)
• 2020

  Development of the FAST-M maternal sepsis bundle for use in low-resource settings: a modified Delphi process

  Lissauer, D., Cheshire, J., Dunlop, C., Taki, F., Wilson, A., Smith, J. M., Daniels, R., Kissoon, N., Malata, A., Chirwa, T., Lwesha, V. M., Mhango, C., Mhango, E., Makwenda, C., Banda, L., Munthali, L., Nambiar, B., Hussein, J., Williams, H. M., Devall, A. J., & 5 othersGallos, I., Merriel, A., Bonet, M., Souza, J. P. & Coomarasamy, A., 1 Feb 2020, In: BJOG: An International Journal of Obstetrics and Gynaecology. 127, 3, p. 416-423 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Infectious Pregnancy Complications 100%
  • Consensus 54%
  • Delivery of Health Care 21%
  • Sepsis 18%
  • Patient Care Bundles 18%
  6 Citations (Scopus)

• Ensemble learning for poor prognosis predictions: a case study on SARS-CoV2

  Wu, H., Zhang, H., Karwath, A., Ibrahim, Z., Shi, T., Zhang, X., Wang, K., Sun, J., Dhaliwal, K., Bean, D., Cardoso, V. R., Li, K., Teo, J. T., Banerjee, A., Gao-Smith, F., Whitehouse, T., Veenith, T., Gkoutos, G. V., Wu, X., Dobson, R., & 1 othersGuthrie, B., 13 Nov 2020, (E-pub ahead of print) In: Journal of the American Medical Informatics Association.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Calibration 100%
  • China 78%
  • Learning 70%
  • Pandemics 51%
  • Clinical Decision-Making 50%
  85 Downloads (Pure)

• The effect of Ramadan fasting on cardiovascular events and risk factors in patients with type 2 diabetes: A systematic review

  Almulhem, M., Susarla, R., Alabdulaali, L., Khunti, K., Karamat, M. A., Rasiah, T., Tahrani, A. A., Hanif, W. & Nirantharakumar, K., Jan 2020, In: Diabetes Research and Clinical Practice. 159, p. 107918

  Research output: Contribution to journal › Article › peer-review

  • Islam 100%
  • Fasting 75%
  • Type 2 Diabetes Mellitus 71%
  • Systematic Reviews 69%
  • Libraries 16%

• Towards semantic interoperability: finding and repairing hidden contradictions in biomedical ontologies

  Slater, L. T., Gkoutos, G. V. & Hoehndorf, R., 15 Dec 2020, In: BMC Medical Informatics and Decision Making. 20, Suppl 10, p. 311 311.

  Research output: Contribution to journal › Article › peer-review

  • Biological Ontologies 100%
  • Semantics 60%
  • ontology 55%
  • semantics 46%
  • iron and steel industry 9%
  3 Citations (Scopus)

• Tuberculosis diagnostics: overcoming ancient challenges with modern solutions

  MacGregor-Fairlie, M., Wilkinson, S., Besra, G. S. & Goldberg Oppenheimer, P., 1 Dec 2020, In: Emerging topics in life sciences. 4, 4, p. 423-436 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Tuberculosis 100%
  • Molecular Biology 49%
  • Disease Eradication 42%
  • Weapons 38%
  • Modern 1601-history 37%
  139 Downloads (Pure)
• 2019

  A randomised controlled trial of extended anticoagulation treatment versus standard treatment for the prevention of recurrent venous thromboembolism (VTE) and post-thrombotic syndrome in patients being treated for a first episode of unprovoked VTE (the ExACT study)

  Bradbury, C., Fletcher, K., Sun, Y., Heneghan, C. J., Gardiner, C., Roalfe, A., Hardy, P., McCahon, D., Heritage, G., Shackleford, H., Hobbs, R. & Fitzmaurice, D., 12 Nov 2019, (E-pub ahead of print) In: British Journal of Haematology. 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Venous Thromboembolism 100%
  • Randomized Controlled Trials 62%
  • fibrin fragment D 54%
  • Quality of Life 39%
  • Hemorrhage 29%
  2 Citations (Scopus)

  375 Downloads (Pure)

• Ex vivo culture of keratinocytes on papillary and reticular dermal layers remodels skin explants differently: towards improved wound care

  Bage, T., Edymann, T., Metcalfe, A. D., Dheansa, B. & Mbundi, L., Oct 2019, In: Archives of Dermatological Research. 311, 8, p. 647-652 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Keratinocytes 100%
  • Extracellular Matrix 65%
  • Skin 56%
  • Dermis 53%
  • Wounds and Injuries 50%
  2 Citations (Scopus)

• Non-identifiability of parameters for a class of shear-thinning rheological models, with implications for haematological fluid dynamics

  Gallagher, M. T., Wain, R., Dari, S., Whitty, J. & Smith, D., 6 Mar 2019, In: Journal of Biomechanics. 85, p. 230-238 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Shear thinning 100%
  • Hydrodynamics 88%
  • Fluid dynamics 80%
  • Datasets 60%
  • Rheology 47%
  4 Citations (Scopus)

  243 Downloads (Pure)
• 2018

  Treatment of fatigue with physical activity and behavioural change support in Vasculitis – study protocol for an open-label randomised controlled feasibility study

  Harper, L., Morgan, M., Chanouzas, D., Caulfield, H., Coughlan, L., Dean, C., Fletcher, K., Cramp, F., Greenfield, S., Hewitt, C., Ives, N., Jowett, S. & Daley, A., Dec 2018, In: BMJ open. 8, 10, e023769.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Feasibility Studies 100%
  • Vasculitis 98%
  • Fatigue 80%
  • Exercise 62%
  • Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 55%
  6 Citations (Scopus)

  155 Downloads (Pure)