Research output per year
Research output per year
- 31 results
Search results
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2023
A Fully Automated and Explainable Algorithm for the Prediction of Malignant Transformation in Oral Epithelial Dysplasia
Shephard, A. J., Bashir, R. M. S., Mahmood, H., Jahanifar, M., Minhas, F., Raza, S. E. A., McCombe, K. D., Craig, S. G., James, J., Brooks, J., Nankivell, P., Mehanna, H., Khurram, S. A. & Rajpoot, N. M., 6 Jul 2023.Research output: Working paper/Preprint › Preprint
File43 Downloads (Pure) -
CTCF regulates hepatitis B virus cccDNA chromatin topology
Dobrica, M. O., Varghese, C. S., Harris, J. M., Ferguson, J., Magri, A., Arnold, R., Várnai, C., Parish, J. L. & McKeating, J. A., 6 Sept 2023, bioRxiv.Research output: Working paper/Preprint › Preprint
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Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Koestler, S. A., Ball, M. L., Muresan, L., Dinakaran, V. & White, R., 3 Sept 2023, bioRxiv.Research output: Working paper/Preprint › Preprint
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2022
Assessment of 115 symptoms for Long COVID (post-COVID-19 condition) and their risk factors in non-hospitalised individuals: a retrospective matched cohort study in UK primary care
Subramanian, A., Nirantharakumar, K., Hughes, S., Myles, P., Williams, T., Gokhale, K., Taverner, T., Chandan, J., Brown, K., Simms-Williams, N., Shah, A., Singh, M., Kidy, F., Okoth, K., Hotham, R., Bashir, N., Cockburn, N., Lee, S., Turner, G., Gkoutos, G., & 16 others, 15 Feb 2022, Research Square.Research output: Working paper/Preprint › Preprint
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Forecasting waiting lists for elective procedures and surgery in England: a modelling study
Nepogodiev, D., Acharya, R., Chaudhry, D., Glasbey, J. C., Harris, B., Li, E., Jolly, K. & Bhangu, A., 23 Jun 2022, medRxiv.Research output: Working paper/Preprint › Preprint
Open Access -
Practical guidance for running late-phase platform protocols for clinical trials: lessons from experienced UK clinical trials units
Love, S. B., Cafferty, F., Snowdon, C., Carty, K., Savage, J., Pallmann, P., McParland, L., Brown, L. J., Masters, L., Schiavone, F., Hague, D., Townsend, S., Amos, C., South, A., Sturgeon, K., Langley, R. E., Maughan, T. S., James, N., Hall, E., Kernaghan, S., & 16 others, 9 Mar 2022, Research Square.Research output: Working paper/Preprint › Preprint
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Protocol for the Tessa Jowell BRAIN MATRIX Platform Study
Watts, C., Savage, J., Patel, A., Mant, R., Wykes, V., Pohl, U., Bulbeck, H., Apps, J., Sharpe, R., Thompson, G., Waldman, A., Ansorge, O., Billingham, L. & Watts, C., 31 Jul 2022, medRxiv.Research output: Working paper/Preprint › Preprint
File36 Downloads (Pure) -
Subgroup analyses in randomised controlled trials frequently categorise continuous subgroup information
Williamson, S. F., Grayling, M. J., Mander, A. P., Noor, N., Savage, J., Yap, C. & Wason, J. M. S., 7 Apr 2022, SSRN, (SSRN Electronic Journal).Research output: Working paper/Preprint › Preprint
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2021
A digital score of tumour-associated stroma infiltrating lymphocytes predicts survival in head and neck squamous cell carcinoma
Shaban, M., Raza, S. E. A., Hassan, M., Jamshed, A., Mushtaq, S., Loya, A., Batis, N., Brooks, J., Nankivell, P., Sharma, N., Robinson, M., Mehanna, H., Khurram, S. A. & Rajpoot, N., 16 Apr 2021, arXiv.Research output: Working paper/Preprint › Preprint
File188 Downloads (Pure) -
Boronic ester derivative-dependent activity of parthenolide analogues
Li, X., Williams, G., Quy, A., Zhao, Y., Male, L., Anslyn, E., Stankovic, T., Leach, A., Agathanggelou, A. & Fossey, J., 28 Oct 2021, ChemRxiv.Research output: Working paper/Preprint › Preprint
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CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults
Veenith, T., Fisher, B. A., Slade, D., Rowe, A., Sharpe, R., Thickett, D. R., Whitehouse, T., Rowland, M., Scriven, J., Parekh, D., Bowden, S. J., Savage, J. S., Richards, D., Bion, J., Kearns, P. & Gates, S., 12 Feb 2021, medRxiv, p. 1-15, 15 p.Research output: Working paper/Preprint › Preprint
Open Access -
Children develop strong and sustained cross-reactive immune responses against Spike protein following SARS-CoV-2 infection, with enhanced recognition of variants of concern
Dowell, A., Butler, M. S., Jinks, E., Tut, G., Lancaster, T., Sylla, P., Begum, J., Bruton, R., Pearce, H., Verma, K., Logan, N., Tyson, G., Spalkova, E., Margielewska-Davies, S., Taylor, G., Syrimi, E., Baawuah, F., Beckmann, J., Okike, I., Ahmad, S., & 25 others, 28 Sept 2021, medRxiv.Research output: Working paper/Preprint › Preprint
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Clinical characteristics with inflammation profiling of Long-COVID and association with one-year recovery following hospitalisation in the UK: a prospective observational study
PHOSP-COVID Collaborative Group, 20 Dec 2021, medRxiv.Research output: Working paper/Preprint › Preprint
Open Access -
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
Vilaplana-Lopera, N., Almaghrabi, R., Papatzikas, G., González, E., Cunningham, A., Erdem, A., Schnuetgen, F., Raghavan, M., Potluri, S., Cazier, J., Schuringa, JJ., Reed, MAC., Günther, UL. & Garcia, P., 21 Jan 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
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CTCF association with episomal HPV16 genomes regulates viral oncogene transcription and splicing
Groves, I. J., Tang, G., Pentland, I., Parish, J. L. & Coleman, N., 18 Feb 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
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Evaluating semantic similarity methods for comparison of text-derived phenotype profiles
Slater, L. T., Russell, S., Makepeace, S., Carberry, A., Karwath, A., Williams, J. A., Fanning, H., Ball, S., Hoehndorf, R. & Gkoutos, G. V., 9 Aug 2021, medRxiv, 12 p.Research output: Working paper/Preprint › Preprint
Open Access -
Gata2a maintains cebpa and npm1a in haematopoietic stem cells to sustain lineage differentiation and genome stability
Mahony, C. B., Noyvert, B., Vrljicak, P., Ott, S., Higgs, M. & Monteiro, R., 19 Jul 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
Open Access -
Imaging nanoscale nuclear structures with expansion microscopy
Faulkner, E. L., Pike, J. A., Densham, R. M., Garlick, E., Thomas, S. G., Neely, R. K. & Morris, J. R., 4 May 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
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Impaired Neutralisation of SARS-CoV-2 Delta Variant in Vaccinated Patients With B Cell Chronic Lymphocytic Leukaemia
Parry, H. M., Mcilroy, G., Bruton, R., Damery, S., Tyson, G., Logan, N., Davis, C., Willett, B., Zuo, J., Ali, M., Kaur, M., Stephens, C., Brant, D., Otter, A., Mcskeane, T., Rolfe, H., Faustini, S., Richter, A. G., Lee, S., Wandroo, F., & 4 others, 12 Oct 2021, Elsevier, (SSRN Electronic Journal).Research output: Working paper/Preprint › Preprint
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Namilumab or infliximab compared to standard of care in hospitalised patients with COVID-19 (CATALYST): a phase 2 randomised adaptive trial
Fisher, B. A., Veenith, T., Slade, D., Gaskell, C., Rowland, M., Whitehouse, T., Scriven, J., Parekh, D., Balasubramaniam, M. S., Cooke, G., Morley, N., Gabriel, Z., Wise, M. P., Porter, J., McShane, H., Ho, L-P., Newsome, P. N., Rowe, A., Sharpe, R., Thickett, D. R., & 4 others, 9 Jun 2021, medRxiv, p. 1-26, 26 p.Research output: Working paper/Preprint › Preprint
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RPRD proteins control transcription in human cells
Winczura, K., Ceylan, H., Sledziowska, M., Jones, M., Fagarasan, H., Wang, J., Saponaro, M., Arnold, R., Hebenstreit, D. & Grzechnik, P., 20 Jun 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
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Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial
Menne, T., Slade, D., Savage, J., Johnson, S., Irving, J. A. E., Kearns, P. R., Plummer, R., Shenton, G., Veal, G. J., Vormoor, B., Vormoor, J. & Billingham, L., 25 Oct 2021, medRxiv.Research output: Working paper/Preprint › Preprint
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The chromatin insulator CTCF regulates HPV18 transcript splicing and differentiation-dependent late gene expression
Ferguson, J., Leon, K. C., Pentland, I., Stockton, J., Günther, T., Beggs, A., Roberts, S., Noyvert, B. & Parish, J. L., 1 May 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
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The molecular landscape of well differentiated retroperitoneal liposarcoma
Tyler, R., Dilworth, M., James, J., Blakeway, D., Stockton, J., Morton, D., Taniere, P., Gourevitch, D., Desai, A. & Beggs, A. D., 4 Jan 2021, MDPI, 34 p.Research output: Working paper/Preprint › Preprint
Open AccessFile197 Downloads (Pure) -
Towards similarity-based differential diagnostics for common diseases
Slater, L. T., Karwath, A., Williams, J. A., Russell, S., Makepeace, S., Carberry, A., Hoehndorf, R. & Gkoutos, G. V., 27 Jan 2021, bioRxiv.Research output: Working paper/Preprint › Preprint
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2020
COVIDTrach; a prospective cohort study of mechanically ventilated COVID-19 patients undergoing tracheostomy in the UK
COVIDTrach collaborative, 30 Nov 2020, medRxiv.Research output: Working paper/Preprint › Preprint
Open Access -
Response to neoadjuvant chemoradiotherapy in rectal cancer is associated with RAS/AKT pathway dysregulation and high tumour mutational burden
Stockton, J. D., Tee, L., Whalley, C., James, J., Dilworth, M., Wheat, R., Nieto, T., Geh, I. & Beggs, A. D., 4 Feb 2020, medRxiv.Research output: Working paper/Preprint › Preprint
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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score
Knight, S. R., Ho, A., Pius, R., Buchan, I., Carson, G., Drake, T. M., Dunning, J., Fairfield, C. J., Gamble, C., Green, C. A., Gupta, R. K., Halpin, S., Hardwick, H., Holden, K., Horby, P. W., Jackson, C., McLean, K. A., Merson, L., Nguyen-Van-Tam, J. S., Norman, L., & 15 others, 2 Aug 2020, medRxiv.Research output: Working paper/Preprint › Preprint
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The transition from primary colorectal cancer to isolated peritoneal malignancy is associated with a hypermutant, hypermethylated state
Hallam, S., Stockton, J., Bryer, C., Whalley, C., Pestinger, V., Youssef, H. & Beggs, A. D., 25 Feb 2020, medRxiv.Research output: Working paper/Preprint › Preprint
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Use of an integrated pan-cancer oncology enrichment NGS assay to measure tumour mutational burden and detect clinically actionable variants
Pestinger, V., Smith, M., Sillo, T., Findlay, J. M., Laes, J-F., Martin, G., Middleton, G., Taniere, P. & Beggs, A. D., 4 Feb 2020, medRxiv.Research output: Working paper/Preprint › Preprint
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2019
Pharmacologically targeting a novel pathway of sodium iodide symporter trafficking to enhance radioiodine uptake
Fletcher, A., Read, M., Thornton, C., Larner, D., Poole, V., Brookes, K., Nieto, H., Alshahrani, M., Thompson, R., Lavery, G., Campbell, M., Boelaert, K., Turnell, A., Smith, V. & McCabe, C., 7 May 2019, bioRxiv, 37 p.Research output: Working paper/Preprint › Preprint