Cancer and Genomic Sciences

Projects

Projects per year 1992 2004 2005 2006 2007 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2033

• 3 Not started
• 253 Active
• 1795 Finished

Projects per year

Search results

• Active

  Understanding the mechanisms of chemoresistance governed by PRMT5 and splicing in breast cancer stem cells

  Arnold, R. & Davies, C.

  BREAST CANCER NOW

  1/04/24 → 31/03/27

  Project: Research

• Mainstreaming Familial Cancer Testing in Bowel Cancer

  Lal, N. & Beggs, A.

  BOWEL CANCER UK

  1/04/24 → 30/09/25

  Project: Research

• The role of tetraspanin 6 in directing communication between B and T cells in breast cancer

  Berditchevski, F. & Long, H.

  BREAST CANCER NOW

  1/04/24 → 30/09/26

  Project: Research

• Senior Research Nurse

  Kearns, P.

  Cancer Research Uk

  1/04/24 → 31/03/29

  Project: Research

• MRC IAA: Realizing the potential of combinatorial proton beam therapy for the effective treatment of head and neck tumours

  Mehanna, H., Beggs, A., Parsons, J. & Kokalova Wheldon, T.

  Medical Research Council

  1/04/24 → 26/04/25

  Project: Research Councils

• MRC IAA: Evaluating the effects of the brain penetrant ATM inhibitor, AZD1390, on neurological recovery after traumatic brain injury

  Tuxworth, R., Ahmed, Z. & Di Pietro, V.

  Medical Research Council

  1/04/24 → 31/03/25

  Project: Research Councils

• Cryo-EM studies of a metazoan replisome captured ex vivo during elongation and termination

  Passaretti, P. & Gambus, A.

  Biotechnology & Biological Sciences Research Council

  1/03/24 → 28/02/27

  Project: Research Councils

• Understanding oncogenic human papillomavirus episome persistence and immune modulation in tonsil epithelia

  Parish, J. & Ferguson, J.

  Medical Research Council

  1/02/24 → 30/11/26

  Project: Research Councils

• HEM-iSMART: ITCC-104 - International proof of concept therapeutic Stratification trial of Molecular Anomalies in Relapsed or Refractory HEMatological malignancies in children

  Kearns, P.

  Cancer Research Uk

  1/02/24 → 31/01/31

  Project: Research

• The role of DONSON in DNA replication initiation

  Gambus, A. & Saponaro, M.

  Biotechnology & Biological Sciences Research Council

  15/01/24 → 14/01/27

  Project: Research Councils

• PINK - Provision of Integrated Computational Approaches for Addressing New Markets Goals for the Introduction of Safe-and-Sustainable-by-Design Chemicals and Materials

  Lynch, I., Gkoutos, G., Slater, K. & Karwath, A.

  UKRI Horizon Europe Underwriting – Innovate UK

  1/01/24 → 31/12/27

  Project: Research

• Investigating Novel High Risk Phenotypes in Mucinous Ovarian Cancer (MUCOVA)

  Beggs, A. & Sundar, S.

  BIRMINGHAM WOMEN'S CHARITABLE FUNDS

  1/01/24 → 31/12/26

  Project: Research

• eRaDicate - Innovative ligands for nuclear receptors to eradicate cancer relapse

  Hoogenkamp, M., Brown, G. & Stanulovic, V.

  UKRI Horizon Europe Underwriting – EPSRC

  1/01/24 → 31/12/27

  Project: Research

• MRC IAA: Targeting translational termination to treat nonsense mutation driven disease

  Beggs, A. & Coleman, M.

  Medical Research Council

  1/12/23 → 30/11/24

  Project: Research

• Interrogating the relationship between cancer field development in vulval squamous cell cancers and local cancer recurrence: A prospective study.

  Croft, W., Yap, J. & Pounds, R.

  BIRMINGHAM WOMEN'S CHARITABLE FUNDS

  1/11/23 → 1/07/27

  Project: Research

• Exploring new therapeutic opportunities based on replication stress and hydroxylase biology in next-generation chondrosarcoma models

  Beggs, A., Fletcher, S. & Coleman, M.

  The Royal Orthopaedic Charity

  1/11/23 → 31/08/24

  Project: Research

• BHP Starter Fellowship: Dr Charlotte Sherlaw-Sturrock

  Stewart, G.

  METCHLEY PARK MEDICAL SOCIETY

  2/10/23 → 10/12/24

  Project: Research

• Sample Size guidance for developing and validating reliable and fair AI PREDICTion models in healthcare (SS-PREDICT)

  Cazier, J., Riley, R., Snell, K., Archer, L., Nirantharakumar, K., Cazier, J., Ensor, J. & Denniston, A.

  UK Research and Innovation

  2/10/23 → 1/04/25

  Project: Research Councils

  • Validation Studies 100%
  • Sample Size 80%
  • Datasets 41%
  • fairness 21%
  • performance 20%

• Impact of Oral Disulfiram on Aldehyde Dehydrogenase (ALDH) Mediated Ocular Fibrosis in Mucous Membrane Pemphigoid [OcMMP]

  Barton, D., Fletcher, P., Rauz, S., Low, L., Romero, J., Barnes, N. & Wallace, G.

  Medical Research Council

  1/10/23 → 30/09/25

  Project: Research Councils

  • Bullous Pemphigoid 100%
  • Mucous Membrane 61%
  • Eye 47%
  • Genes 17%
  • Inflammation 15%

• Prognostic models in rare diseases: methodology development with application to Ewing sarcoma

  Kirton, L.

  NIHR

  1/10/23 → 30/09/28

  Project: Other Government Departments

• CRUK CRCTU Core Funding

  Fisher, B., Billingham, L., Bach, S., Kearns, P., Pratt, G., Bowden, S., Rea, D., Middleton, G. & Gates, S.

  Cancer Research Uk

  1/10/23 → 30/09/28

  Project: Research

• Towards the trialling of geroprotective agents to improve dynamic resilience in clinical populations: Closing fundamental knowledge gaps

  Duggal, N., Romero, J., Wilson, D., Jackson, T., Acharjee, A., Lourenco Rocha De Magalhaes, J. P., Mazaheri, A., Pinkney, T., Jones, S., McGettrick, H. & Lord, J.

  Wellcome Leap Inc.

  7/09/23 → 6/09/26

  Project: Research

  • Cetuximab 100%
  • Colorectal Neoplasms 63%
  • Transcription Factors 59%
  • Mutagenesis 58%
  • neoplasm-associated factor 33%

• Genetic determinants of Oxaliplatin induced-peripheral neuropathy.

  Ahmed, Z., Palles, C. & Tuxworth, R.

  Cancer Research Uk

  4/09/23 → 3/09/26

  Project: Research

• Remission induction of arthritis caused by cancer immunotherapy [REACT]: a randomised multicentre trial to guide initial therapy for checkpoint inhibitor [CPI] induced arthritis

  Rowe, A., Filer, A., Homer, V. & Fisher, B.

  NIHR

  1/09/23 → 31/08/28

  Project: Other Government Departments

• MonoGerm: A phase II trial of carboplatin or vinblastine monotherapy induction prior to radiotherapy for intracranial germinoma

  Billingham, L., Lawson, A., Kirton, L., Apps, J. & Arvanitis, T.

  Little Princess Trust

  1/08/23 → 31/07/33

  Project: Research

• Changing clinical practice in rare diseases through innovative trial designs: the CAPTIVATE node

  Barrett, T., Homer, V., Gates, S., Kearns, P. & Billingham, L.

  Medical Research Council

  3/07/23 → 2/07/28

  Project: Research Councils

• The mRNA cap epitranscriptome: Understanding an essential novel layer of gene expression in neuronal differentiation and function

  Arnold, R., Soller, M. & Tucker, J.

  Biotechnology & Biological Sciences Research Council

  1/07/23 → 30/06/26

  Project: Research

• Biomede 2.0: Full: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication

  Kearns, P.

  Cancer Research Uk

  1/07/23 → 30/06/33

  Project: Research

• BEACON2 - A multi-arm multi-stage platform trial for relapsed and refractory neuroblastoma

  Gates, S., Kearns, P., Firth, C. & Laidler, J.

  EUROPEAN SCIENCE FOUNDATION

  1/07/23 → 30/06/26

  Project: Research

• Glo-BNHL: Regeneron Collaboration - A Global Study Of Novel Agents In Relapsed And Refractory B-Non Hodgkin Lymphoma (B-NHL)

  Kearns, P., Billingham, L., Maycock, S., Holt, G. & Siddique, S.

  Regeneron Pharmaceuticals

  1/07/23 → 30/06/28

  Project: Industry

• Glo-BNHL: ADCT Collaboration: A Global Study of Novel Agents in Relapsed and Refractory B-Non Hodgkin Lymphoma

  Bishop, R., Maycock, S., Kearns, P. & Billingham, L.

  ADC Therapeutics

  1/07/23 → 30/06/27

  Project: Industry

• MRC IAA: Validation of new synthetic lethal gene targets of BRCA1 deficiency

  Gendoo, D. & Morris, J.

  Biotechnology & Biological Sciences Research Council, Medical Research Council

  1/06/23 → 31/03/25

  Project: Research Councils

• Using superselective glycan-binding nanoparticles to create a clinical assay for early ovarian cancer detection

  Sundar, S., Takwoingi, Y. & Mendes, P.

  Cancer Research Uk

  1/06/23 → 31/05/24

  Project: Research

• Understanding the developmental origins of a childhood brain cancer

  Badenhorst, P., Apps, J. & Halsall, J.

  Brain Research Trust

  1/06/23 → 31/05/26

  Project: Research

• KETO-LUNG

  Billingham, L., Tennant, D., Savage, J., Middleton, G. & Fletcher, P.

  Cancer Research Uk

  1/06/23 → 31/05/26

  Project: Research

• COMBined Blood And Tissue prediction for immunotherapy response in recurrent/metastatic head and neck squamous cell carcinoma (COMBAT HNSCC)

  Payne, K. & Gendoo, D.

  THE ACADEMY OF MEDICAL SCIENCES

  1/05/23 → 30/04/25

  Project: Research

• The role of epigenetic regulation of haemato-endothelial cell differentiation by class IIa histone deacetylases

  Monteiro, R.

  British Heart Foundation

  1/05/23 → 30/04/26

  Project: Research

  • Zebrafish 100%
  • Bone Marrow 72%
  • Kidney 52%
  • Cell Separation 28%
  • Hematopoiesis 26%

• Understanding the mechanisms of treatment resistance in colorectal cancer using organoid models

  Beggs, A.

  Medical Research Council

  1/05/23 → 30/04/28

  Project: Research Councils

  • Exocrine Pancreatic Insufficiency 100%
  • Gastrointestinal Microbiome 72%
  • Pancreatic Neoplasms 69%
  • Routine Diagnostic Tests 69%
  • Enzyme Replacement Therapy 64%

• New Insights into the cellular response to complex DNA damage induced by proton beam therapy

  Parsons, J.

  Medical Research Council

  1/04/23 → 30/04/25

  Project: Research Councils

  • Linear Energy Transfer 100%
  • DNA Damage 68%
  • Ionizing Radiation 63%
  • poly ADP-ribose glycohydrolase 45%
  • DNA Repair 40%

• the establishment/continuation of an NIHR Patient Safety Research Collaboration (“NIHR PSRC”)

  Mannion, R., Lilford, R., Gkoutos, G., Turner, A., Zamora, J., Nirantharakumar, K., Gillett, C., Sartori, J., Rockey, J., Bion, J., Thangaratinam, S., Allotey, J., Waring, J., Watson, S., Skrybant, M., Sapey, E., Harper, L. & Takwoingi, Y.

  NIHR

  1/04/23 → 31/03/28

  Project: Other Government Departments

• Characterisation of the steroid metabolome in mucinous ovarian cancer

  Sundar, S. & Foster, P.

  BIRMINGHAM WOMEN'S CHARITABLE FUNDS, The Eve Appeal

  1/04/23 → 31/03/26

  Project: Research

• YCMB-LR: Prospective international SIOPE/CONNECT phase-III trial to improve neurocognitive outcomes in young children with low-risk medulloblastoma

  Kearns, P.

  Cancer Research Uk

  1/04/23 → 31/03/33

  Project: Research

• Analysing the radiobiology of uveal melanoma in response to photons and protons: Optimising radiosensitivity through targeting the cellular DNA damage response

  Parsons, J.

  FIGHT FOR SIGHT

  6/03/23 → 5/03/26

  Project: Research

• Semaglutide as an add-on treatment to optimise glycaemic control in children and young people with type 1 diabetes

  Calvert, M., Rowland, N., Barrett, T. & Narendran, P.

  JUVENILE DIABETES FOUNDATION INTERNATIONAL

  1/03/23 → 28/02/26

  Project: Research

• CONCEPT Study: Prospective pilot Cohort study for secondary cytoreductive surgery in patients with PARP-i maintenance

  Sundar, S. & Magill, L.

  BIRMINGHAM WOMEN'S CHARITABLE FUNDS

  1/03/23 → 28/02/26

  Project: Research

• Epithelial barrier model: in silico modelling and high throughput assessment

  Poologasundarampillai, G., Gendoo, D. & Wiench, M.

  NATIONAL CENTRE FOR THE REPLACEMENT, REFINEMENT & REDUCTION OF ANIMALS IN RESEARCH

  15/02/23 → 14/02/25

  Project: Research

• Using a Novel Biomarker Approach to Transform Ovarian Cancer Diagnostic Pathways

  Takwoingi, Y., Roberts, T. & Sundar, S.

  NHS Improvement

  10/02/23 → 9/08/24

  Project: Research

• Targeting the ATM-CHK2 pathway as a therapeutic avenue for rare neurodegenerative diseases

  Beggs, A., Tuxworth, R., Bardella, C. & Ahmed, Z.

  LifeArc

  1/02/23 → 31/07/24

  Project: Research

• Exploring the tissue-specific disease mechanisms underlying tRNA- synthetase-associated peripheral neuropathies

  Cazier, J.

  The Research Foundation - Flanders (FWO)

  1/02/23 → 31/12/25

  Project: Research

• LifeArc Pathfinder

  Sarkar, S.

  LifeArc

  1/02/23 → 31/07/24

  Project: Research