Cancer and Genomic Sciences

Projects

Projects per year 1992 2004 2005 2006 2007 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2033

• 3 Not started
• 253 Active
• 1795 Finished

Projects per year

Search results

• Finished

  Leveraging a new class of cancer target for the benefit of mesothelioma diagnosis and treatment

  Coleman, M.

  Mesothelioma UK

  1/06/23 → 29/02/24

  Project: Research

• Leveraging a new class of drug target to develop novel combination therapies for Chondrosarcoma

  Coleman, M. & Fletcher, S.

  BONE CANCER RESEARCH TRUST

  17/04/23 → 16/08/23

  Project: Research

• Wellcome TDF: Chemical Targeting of Cells with Poor Replication Fork Protection

  Morris, J.

  THE WELLCOME TRUST

  1/04/23 → 13/10/23

  Project: Research

• Wellcome TDF: Development of a novel, potent, allosteric EAAT1 inhibitor derived from an in-house hit compound for the treatment of T-cell Acute Lymphoblastic Leukaemia

  Jones, A., Hoogenkamp, M. & Stanulovic, V.

  THE WELLCOME TRUST

  1/04/23 → 13/04/24

  Project: Research

• Wellcome TDF: Incorporation of urine DNA methylation into bladder cancer diagnosis

  Bryan, R., Ward, D. & Arnold, R.

  THE WELLCOME TRUST

  1/04/23 → 13/04/24

  Project: Research

• In-silico comparison of RNA based targeted assays for RET fusion testing

  Cazier, J.

  Eli Lilly & Company

  16/01/23 → 30/11/23

  Project: Industry

• Improving patient flows through acute medical departments through better patient selection for same day emergency care

  Parekh, D., Sapey, E. & Gkoutos, G.

  HEALTH DATA RESEARCH UK

  5/01/23 → 31/03/23

  Project: Research

• A systems biology approach for identification of host and microbial mechanisms and druggable targets for the treatment of PSC-IBD

  Beggs, A., Trivedi, P. & Iqbal, T.

  European Chrons And Choliris Organisation

  1/12/22 → 29/02/24

  Project: Research

• Understanding the rewiring of growth signalling in FLT3-ITD and RAS mutant leukaemias after treatment with FLT3 and RAS inhibitors

  Coleman, D.

  The Royal Society

  1/12/22 → 29/02/24

  Project: Research Councils

• ITTC fellowship - Shivani Bailey

  Gatz, S. & Evans, H.

  INNOVATIVE THERAPIES FOR CHILDREN WITH CANCER (ITCC)

  1/10/22 → 30/09/23

  Project: Research

• MSIPlus Assay

  Beggs, A.

  NHS Improvement

  1/10/22 → 31/03/24

  Project: Research

• MRC CiC: Establishment of Assays for the Assessment of Functional Activity and Selectivity of Novel EAAT1 Inhibitors

  Hoogenkamp, M. & Stanulovic, V.

  Medical Research Council

  1/09/22 → 31/03/23

  Project: Research Councils

• Interactions of TRAIP with transcription and replication processes

  Gambus, A. & Knowles, T.

  Biotechnology & Biological Sciences Research Council

  1/09/22 → 16/12/22

  Project: Research Councils

• Impact of the overexpression of RNA Pol II subunits on transcription and genome instability

  Saponaro, M.

  The Royal Society

  12/08/22 → 11/11/22

  Project: Research Councils

• Enhancing multi-omic single cell sequencing to resolve fundamental biological mechanisms in humans and non-human organisms

  Müller, F., Colbourne, J., Bonifer, C. & Beggs, A.

  Biotechnology & Biological Sciences Research Council

  1/08/22 → 31/07/23

  Project: Research Councils

• HALT (Halo-liganded transposase tagging): a novel technique for high-resolution whole-genome profiling of dynamic epigenetic regulators

  Badenhorst, P.

  Cancer Research Uk

  1/03/22 → 31/03/23

  Project: Research

• A screen to uncover resistance mechanisms against novel breast cancer therapies

  Morris, J. & Ronson, G.

  Cancer Research Uk

  1/03/22 → 31/03/23

  Project: Research

• Transcription initiation selection underlying radiosensitivity of colorectal cancer organoids

  Beggs, A., Wragg, J. & Müller, F.

  Cancer Research Uk

  1/03/22 → 31/03/23

  Project: Research

• Real-time super-resolution imaging of DNA replication and repair

  Gambus, A. & Gilhooly, N.

  Cancer Research Uk

  1/03/22 → 31/03/23

  Project: Research

• Wellcome TDF: Developing and validating a hypoxia-immune treatment response classifier for oropharyngeal cancer

  Batis, N., Brooks, J. & Mehanna, H.

  THE WELLCOME TRUST

  7/02/22 → 6/08/22

  Project: Research

• Wellcome TDF: Development of Surface Plasmon Resonance (SPR) and Saturation Transfer Difference NMR spectroscopy (STD-NMR) to assess EAAT1 target engagement

  Hoogenkamp, M.

  THE WELLCOME TRUST

  1/02/22 → 31/08/22

  Project: Research

• Mainstreaming clinical molecular diagnostics using Nanopore sequencing

  Beggs, A.

  Oxford Nanopore Technologies ltd

  3/01/22 → 2/01/24

  Project: Research

• Generating small molecule inhibitors of the BPTF PHD-modified histone tail interaction

  Badenhorst, P.

  EVOTEC (UK) LIMITED, BRISTOL MYERS SQUIBB PHARMACEUTICALS

  1/01/22 → 31/12/22

  Project: Research

• Pharmaceutical targeting of RAS in Acute Myeloid Leukaemia with RAS mutations or FLT3-ITD

  Coleman, D.

  LEUKAEMIA UK

  1/01/22 → 29/02/24

  Project: Research

  • Acute Myeloid Leukemia 100%
  • stem cells 82%
  • Gene Regulatory Networks 81%
  • Regulon 78%
  • leukemias 64%

• Ongoing validation of AI digital reader for lateral flow devices for SARS-CoV-2

  Beggs, A.

  DEPARTMENT OF HEALTH & SOCIAL CARE

  15/12/21 → 31/03/23

  Project: Research

• Phase 1 COVID-19 Immunity - National Core Study (Phase 1 IMM-NCS) PHASE 1 - OCTAVE ADOLESCENT: linked to Project 1617675 and Original Award WT:1568864

  Kearns, P.

  Medical Research Council, NIHR

  15/12/21 → 31/03/23

  Project: Research Councils

• Functional characterisation of novel breast cancer-associated IDH3α mutations

  Bardella, C.

  The Royal Society

  15/11/21 → 14/11/22

  Project: Research Councils

• Unveiling the intermolecular interactions and conformational changes of the eukaryotic helicase during DNA replication termination using cross-linking mass spectrometry (XL-MS)

  Passaretti, P. & Gambus, A.

  The Royal Society

  1/11/21 → 31/10/23

  Project: Research Councils

• The genomic landscape of chemotherapy responses in upper tract urothelial carcinoma patients in the POUT trial: POUT-gen

  Ward, D., Bryan, R. & Arnold, R.

  Janssen-Cilag Limited

  1/11/21 → 28/02/23

  Project: Industry

• Exploring the acceptability and feasibility of early surveillance for autoimmune diabetes (ELSA)

  Barrett, T., Shukla, D., Narendran, P. & Greenfield, S.

  NIHR CENTRAL COMMISSIONING FACILITY

  1/11/21 → 30/11/23

  Project: Other Government Departments

  • Type 1 Diabetes Mellitus 100%
  • Pediatrics 72%
  • Diabetic Ketoacidosis 71%
  • Population 43%
  • Education 35%

• WT ISSF 2021 (R9): Joao Silva Pilot Data Award

  Silva, J.

  THE WELLCOME TRUST

  1/10/21 → 30/08/22

  Project: Research

• WT ISSF 2021 (R9): Daniel Coleman Pilot Data Award

  Coleman, D.

  THE WELLCOME TRUST

  1/10/21 → 30/09/22

  Project: Research

• WT ISSF 2021 (R9): Claire Palles Pilot Data Award - Preliminary data funding

  Palles, C. & Galavotti, S.

  THE WELLCOME TRUST

  1/10/21 → 30/04/22

  Project: Research

• WT ISSF 2021 (R9): Roland Arnold Pilot Data Award

  Arnold, R.

  THE WELLCOME TRUST

  1/10/21 → 30/09/22

  Project: Research

• WT ISSF 2021 (R9) - Neville Gilhooly Pilot Data Award

  Gilhooly, N.

  THE WELLCOME TRUST

  1/10/21 → 31/03/22

  Project: Research

• Creating the Network for New York School Studies

  Gkoutos, G. & Cran, R.

  Arts and Humanities Research Council

  1/10/21 → 31/12/23

  Project: Research

• COVID19 - National COVID cancer antibody survey

  Lee, L.

  BLOODWISE

  30/09/21 → 30/04/23

  Project: Research

• OCTAVE DUO - Phase 2 funds: Linked to Phase 1 - Project 1722784

  Kearns, P., Rea, D., Richter, A. & Kirkham, A.

  Medical Research Council

  13/08/21 → 30/09/23

  Project: Research Councils

• Metchley Park Medical Society and University of Birmingham Starter Fellowship - Dr. Kelly Ward

  Bryan, R.

  METCHLEY PARK MEDICAL SOCIETY

  4/08/21 → 3/08/22

  Project: Research

  • Urinary Bladder Neoplasms 100%
  • Mitomycin 49%
  • Bacillus 29%
  • Pharmaceutical Preparations 18%
  • Therapeutics 17%

• Phase 1 COVID-19 Immunity – National Core Study (Phase 1 IMM-NCS) PHASE 1 - OCTAVE DUO

  Rea, D., Kirkham, A., Richter, A. & Kearns, P.

  BLOODWISE, Medical Research Council

  1/08/21 → 31/03/23

  Project: Research Councils

• Cogstack Natural Language Processing (NLP) AI based clinical coding and data processing for transformation and improvement of research, planning and care

  Sapey, E. & Gkoutos, G.

  NIHR

  1/08/21 → 31/07/23

  Project: Other Government Departments

• Lister Institute summer studentship

  Gambus, A.

  LISTER INSTITUTE OF PREVENTATIVE MEDICINE

  5/07/21 → 10/09/21

  Project: Research

• Understanding Mechanisms of Thrombosis and Thrombocytopenia in COVID-19 and with SARS-CoV-2 Vaccines

  Nicolson, P. & Watson, S.

  NIHR

  1/07/21 → 28/02/23

  Project: Other Government Departments

  • Idiopathic Thrombocytopenic Purpura 100%
  • Vaccines 63%
  • Biomarkers 54%
  • Extracellular Traps 33%
  • Histones 33%

• EPSRC IAA (2021 R7) Paula Mendes FOF - A pilot clinical study on a glycan serum test for the early detection of ovarian cancer recurrence

  Yap, J. & Mendes, P.

  Engineering & Physical Science Research Council

  1/06/21 → 30/06/22

  Project: Research Councils

• MHC Class II expression in MSS (non-MHC Class II inducible) colorectal cancer

  Middleton, G. & Beggs, A.

  CANCER RESEARCH TECHNOLOGY LTD

  1/05/21 → 9/09/22

  Project: Industry

• Biliary microRNAs: Novel biomarkers to improve the challenging diagnosis of cholangiocarcinoma

  Beggs, A.

  ROYAL COLLEGE OF SURGEONS

  29/04/21 → 28/04/23

  Project: Research

• The impact of the NIHR Associate PI scheme on trial delivery

  Pinkney, T., Magill, L., Jones, L. & Wilkin, R.

  CRN: WEST MIDLANDS

  6/04/21 → 5/10/22

  Project: Research

• Integrating Biomedical Networks and Semantic Information for Neural network Analysis of Quantitative Information

  Gkoutos, G.

  KING ABDULLAH UNIVERSITY OF SCIENCE & TECHNOLOGY

  1/04/21 → 30/09/23

  Project: Research

• MW-ATTC - Runway

  Calvert, M., Newsome, P., Craddock, C., Sharpe, R., Filer, A. & Curbishley, S.

  TECHNOLOGY STRATEGY BOARD

  1/04/21 → 31/03/22

  Project: Other Government Departments

• OCTAVE: Observational Patient Cohorts-T-cells Antibodies And Vaccine Efficacy In SARS-CoV-2 (Part 2): linked to original award WT:1568864

  Kirkham, A., Richter, A., Kearns, P. & Rea, D.

  Medical Research Council

  1/04/21 → 31/03/23

  Project: Research Councils