Birmingham Clinical Trials Unit

Projects

Projects per year 2001 2011 2012 2014 2015 2016 2017 2018 2019 2021 2022 2030

• 1 Not started
• 62 Active
• 123 Finished

Projects per year

Search results

• Active

  Digital multi-component intervention to IMPROVE the care of older people living with Diabetes and chronic Kidney Disease: a type 2 hybrid effectiveness-implementation cluster randomised trial in primary care (Short title: IMPROVE DKD Trial)

  Jowett, S., Thomas, N., Mehta, S., Shukla, D., Crowe, F., Middleton, L., Nirantharakumar, K., Tearne, S. & Greaves, C.

  NIHR

  1/04/24 → 31/03/28

  Project: Other Government Departments

• COMbAT Fatigue: COproduction and evaluation of a self-MAnagemenT intervention for post-stroke Fatigue

  Jowett, S., Blackburn, S., Greaves, C., Tearne, S., Turner, G., Handley, K. & Greenfield, S.

  NIHR

  1/04/24 → 31/03/29

  Project: Other Government Departments

• Feasibility and acceptability of a supervised and self-directed technology-based Dual Task training programme for older adults at risk of falling

  Chiou, C., Kinghorn, P., Goodyear, V., Chechlacz, M., Rowland, N., Wilson, D., Stathi, A. & Magill, L.

  NIHR

  1/01/24 → 31/12/25

  Project: Other Government Departments

• NIHR Birmingham Keele Warwick RSS

  Miller, R., Thomas, N., Rowland, N., Mathers, J., Williams, I., Middleton, L., Roberts, T., Deeks, J., Calvert, M., Al-Janabi, H., Riley, R., Morris, K., Nirantharakumar, K., Hemming, K., Moore, D., Blackburn, S., Sitch, A. & Takwoingi, Y.

  NIHR

  1/10/23 → 30/09/28

  Project: Other Government Departments

• Mild Traumatic Brain Injury Biomarker Study, a prospective cohort biomarker study of military and civilian participants with mTBI: mTBI-Predict

  Jensen, O., Yiangou, A., Pringle, J., Fernandez-Espejo, D., Morris, K., Mullinger, K., Lucas, S., Bagshaw, A., Sitch, A., Deeks, J., Mazaheri, A., Dehghani, H., Ottridge, R., Ottridge, R., Rogers, J., Sinclair, A., Reynolds, R., Upthegrove, R., Terry, J., Park, H., Thaller, M., Hill, L. J., Jenkinson, N. & Smith, D.

  US ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY

  30/09/23 → 29/09/28

  Project: Research

• Optimising outcomes in pregnant women with epilepsy and their babies: Reducing maternal seizure risks and assessing long-term safety of antiepileptic drugs

  Hemming, K., Thangaratinam, S., Roberts, T., Morris, K., Allotey, J. & McNeill, R.

  NIHR

  1/06/23 → 31/05/28

  Project: Other Government Departments

• Golden hour for stroke [GHOST]

  Di Pietro, V., Belli, T., Bishop, J., Ahmed, Z., Hazeldine, J. & Nice, L.

  STROKE ASSOCIATION

  1/06/23 → 31/05/26

  Project: Research

• Semaglutide as an add-on treatment to optimise glycaemic control in children and young people with type 1 diabetes

  Calvert, M., Rowland, N., Barrett, T. & Narendran, P.

  JUVENILE DIABETES FOUNDATION INTERNATIONAL

  1/03/23 → 28/02/26

  Project: Research

• Efficacy and Mechanism Evaluation -Effectiveness of Electronic Cigarettes compared with varenicline for smoking cessation in patients with COPD and effect on the Lungs (EME-ECAL study)

  Scott, A., Sapey, E., Handley, K., Thickett, D., Parekh, D. & Farley, A.

  NIHR

  1/03/23 → 28/02/26

  Project: Other Government Departments

  • Neutrophils 100%
  • E-Cigarette Vapor 81%
  • Respiratory Burst 58%
  • vitamin D 50%
  • Vitamin D 39%

• Mild Traumatic Brain Injury - Predict (Baseline Variability Study) a prospective cohort biomarker study of military and civilian participants with mTBI (Linked to Project 1570897)

  Jenkinson, N., Dehghani, H., Upthegrove, R., Pringle, J., Jensen, O., Sinclair, A., Blanch, R., Reynolds, R., Hill, L. J., Sitch, A., Bagshaw, A., Lucas, S., Mazaheri, A., Rogers, J., Fernandez-Espejo, D., Mitchell, J., Deeks, J., Morris, K. & Mullinger, K.

  MINISTRY OF DEFENCE

  1/12/22 → 31/12/24

  Project: Other Government Departments

  • Traumatic Brain Injury 100%
  • Tomography 76%
  • Systematic Review 74%
  • Brain Concussion 68%
  • Optical Coherence Tomography 54%

• Placebo controlled, blinded, RCT investigating BCG vaccine use in reducing respiratory exacerbations

  Bishop, J., Turner, A., O'Shea, M., Gale, N., Cunningham, A. & Jarrett, H.

  NIHR

  1/09/22 → 30/11/26

  Project: Other Government Departments

• C-Safe: Improving maternal and perinatal outcomes through safe and appropriate caesarean sections in low- and middle-income countries

  Jones, L., Lilford, R., Hemming, K., Coomarasamy, A., Thangaratinam, S., Zamora, J., Sobhy, S., Gillett, C. & Wilson, A.

  Medical Research Council

  1/09/22 → 31/08/27

  Project: Research Councils

• Cefalexin for UTIs - Right treatment Length in Young children: the CURLY trial

  Oppong, R., McNally, A., Ottridge, R., Morris, K., Marriott, J., Middleton, L. & Woolley, R.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/09/22 → 28/02/25

  Project: Other Government Departments

• PeRcutaneous Thermal ABLation Of Benign Intrathyroidal Tumours (1766096)

  Boelaert, K., Sharma, N., Patel, S., Kigozi, J. & Rowland, N.

  NIHR

  1/09/22 → 31/12/27

  Project: Other Government Departments

• Effectiveness of Electronic Cigarettes compared with varenicline for smoking cessation in patients with chronic obstructive pulmonary disease and effect on Lung health (ECAL study)

  Scott, A., Handley, K., Sapey, E., Adab, P., Jowett, S., Farley, A., Jordan, R., Parekh, D. & Thickett, D.

  NIHR

  1/09/22 → 30/09/25

  Project: Other Government Departments

  • Neutrophils 100%
  • E-Cigarette Vapor 81%
  • Respiratory Burst 58%
  • vitamin D 50%
  • Vitamin D 39%

• Amiodarone vs Betablockade for new onset atrial fibRillation in icU - a Pragmatic sTudy

  Slinn, G., Parekh, D., Mehta, S., Veenith, T., Gao Smith, F. & Jowett, S.

  NIHR

  1/09/22 → 30/11/26

  Project: Other Government Departments

• Novel Diagnostics Of Early Stage Ovarian Cancer - Collaboration With AOA Diagnostics (ROCkeTS)

  Ottridge, R., Takwoingi, Y., Ottridge, R. & Sundar, S.

  Aoa Diagnostics UK Ltd

  1/08/22 → 31/12/24

  Project: Research

• A pilot study to assess the safety, effectiveness and practical utility of remote patient monitoring to guide the timing of valve intervention in patients with asymptomatic severe aortic stenosis (APRAISE-AS)

  Stubbs, C., Brocklehurst, P., Mehta, S., Fabritz, L., Kyte, D. & Magill, L.

  NIHR

  18/07/22 → 16/09/24

  Project: Other Government Departments

  • Smartphone 100%
  • Cardiac Arrhythmias 69%
  • Communications Media 26%
  • Photoplethysmography 24%
  • Computer Security 22%

• Parasternal nerve block trial

  Mehta, R., Slinn, G., Gao Smith, F. & Morgese, C.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/05/22 → 30/04/24

  Project: Other Government Departments

• Fit4Surgery 2: A randomised controlled trial to investigate App-based comprehensive prehabilitation programme versus usual care to enhance recovery of physical function and reduce complications after lung cancer surgery

  Pinkney, T., Fenton, S., Oppong, R., Duda, J., Mehta, R., Gao Smith, F. & Naidu, B.

  NIHR

  1/05/22 → 31/10/25

  Project: Other Government Departments

• OCEaN: Optimisation before Crohn’s surgery using Exclusive enteral Nutrition

  Mathers, J., Rowland, N., Oppong, R., Pinkney, T., Kaur, M. & Magill, L.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/05/22 → 31/10/26

  Project: Other Government Departments

• Military Traumatic Brain Injury Biomarker Study, a prospective cohort biomarker study of military and civilian participants with mTBI

  Lucas, S., Karavitaki, N., Bagshaw, A., Sinclair, A., Morris, K., Deeks, J., Blanch, R., Fernandez-Espejo, D., Upthegrove, R., Terry, J., Jensen, O., Belli, T., Sitch, A., Jenkinson, N., Mullinger, K., Dehghani, H., Smith, D., Mazaheri, A., Berhane, S. & Ottridge, R.

  MINISTRY OF DEFENCE

  17/12/21 → 31/12/24

  Project: Other Government Departments

• Administration routes of steroids in the first-line treatment of idiopathic sudden sensorineural hearing loss (STARFISH)

  Roberts, T. & Mehta, S.

  NIHR

  1/12/21 → 30/04/25

  Project: Other Government Departments

• Randomised controlled trial of EArly transjugular intrahepatiC porTosystemic stent-shunt in Acute Variceal Bleeding (REACT-AVB)

  Moakes, C., Brocklehurst, P., Slinn, G. & Jowett, S.

  NIHR

  1/12/21 → 30/11/27

  Project: Other Government Departments

  • Randomized Controlled Trials 100%
  • Hemorrhage 95%
  • Fibrosis 36%
  • Cost-Benefit Analysis 28%
  • Publications 27%

• Improving outcomes for children and young people with diabetes from socio-economically deprived and/or ethnic minority groups

  Brocklehurst, P., Greenfield, S., Rowland, N., Narendran, P. & Barrett, T.

  NIHR CENTRAL COMMISSIONING FACILITY

  1/10/21 → 31/12/26

  Project: Other Government Departments

  • Self-Management 100%
  • Vulnerable Populations 64%
  • chronic illness 45%
  • Caregivers 42%
  • Child 40%

• NIHR Global Health Research Unit on Global Surgery: Establishing a Sustainable Network of Surgical Research

  Brocklehurst, P., Magill, L., Chakrabortee, S., Roberts, T., Lilford, R., Dufty, T., Pinkney, T., Morton, D., Bhangu, A., Davies, J., Hardy, P. & Oppong, R.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/10/21 → 30/06/26

  Project: Other Government Departments

  • transport system 100%
  • income 81%
  • modeling 38%
  • effect 21%
  • services 19%

• MovIng to Support Sustained Improvement of Outcomes iN Rheumatoid Arthritis - MISSION-RA

  Fenton, S. & Ottridge, R.

  NIHR TRAINEES COORDINATING CENTRE

  1/10/21 → 30/09/26

  Project: Research

• Bp response Assessment BY Pregnancy AntihyperteNsive Drug treAtment (BABY PANDA) study

  Stubbs, C. & Moakes, C.

  NIHR

  1/10/21 → 30/09/25

  Project: Other Government Departments

• Multimorbidity in Pregnancy: Determinant, Consequences, Clusters and Trajectories

  Brocklehurst, P., Nirantharakumar, K., Thangaratinam, S. & Taylor, B.

  Medical Research Council

  1/09/21 → 31/08/25

  Project: Research Councils

  • Pregnancy 100%
  • Pregnant Women 77%
  • Multimorbidity 76%
  • Polypharmacy 60%
  • Pregnancy Complications 49%

• Del Nido versus St. Thomas’ blood cardioplegia: a multi-centre randomised controlled trial in children undergoing cardiac surgery

  Scholefield, B., Handley, K., Jarrett, H., Brocklehurst, P. & Drury, N.

  British Heart Foundation

  26/07/21 → 25/07/24

  Project: Research

• Home-based EXercise and motivAtional program before and after Liver Transplantation: ExaLT Trial

  Slinn, G., Brocklehurst, P., Duda, J., Fenton, S. & Mehta, S.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/06/21 → 30/06/26

  Project: Other Government Departments

• ROTATE Rotation of the fetal head at full cervical dilatation

  Hardy, P., Jones, L. & Brocklehurst, P.

  NIHR

  1/05/21 → 30/04/28

  Project: Other Government Departments

• OpticAl Coherence TomograpHy Angiography for the dEtection of Neovascular Age-related Macular Degeneration: a Comprehensive Diagnostic Accuracy Study -the ATHENA study

  Takwoingi, Y., Brocklehurst, P., McKinnon, W. & Deeks, J.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/05/21 → 30/04/24

  Project: Other Government Departments

• A person-centred Needs Informed model of Care for people with HIV (NICHE), to improve wellbeing, mental health and reduce socio-economic disadvantages and stigma

  Woolley, R., Brocklehurst, P. & Rowland, N.

  NIHR

  1/05/21 → 30/04/26

  Project: Other Government Departments

• The clinical and cost-effectiveness of Stimulant compared with Non-stimulant medication for adults with Attention-deficit / hyperactivity disorder and a history of Psychosis or biPolar disordER

  Broome, M., Ottridge, R., Hardy, P., Marwaha, S., Al-Janabi, H. & Woolley, R.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/01/21 → 31/10/25

  Project: Other Government Departments

• FOxTROT 2 and 3: personalising and refining neo-adjuvant chemotherapy in locally advanced but resectable colon cancer

  Magill, L., Beggs, A. & Morton, D.

  Yorkshire Cancer Research

  1/12/20 → 31/05/30

  Project: Research

• Ambulatory oxygen for pulmonary fibrosis (OxyPuF) - OPEN FOR DISSEMINATION ONLY

  Gale, N., Jowett, S., Mehta, R., Thickett, D. & Turner, A.

  NIHR

  1/11/20 → 31/10/25

  Project: Other Government Departments

• Calcium Supplementation for Prevention of Pre-eclampsia in High Risk Women: CaPE Trial

  Middleton, L., Ewer, A., Brocklehurst, P. & Jackson, L.

  NIHR

  1/11/20 → 30/04/25

  Project: Other Government Departments

• Reinforcement of Closure of Stoma Site- 5 to 8 year extended follow-up - Open for Dissemination only

  Roberts, T., Monahan, M., Wilkin, R., Mehta, S., Magill, L., Bhangu, A., Morton, D., Handley, K. & Benson, R.

  NIHR

  1/11/20 → 30/04/24

  Project: Other Government Departments

• The effectiveness and cost-effectiveness of Assets-based feeding help Before and After birth (ABA) for improving breastfeeding initiation and continuation

  Sitch, A., Hardy, P., Jolly, K., MacArthur, C., Roberts, T. & Tearne, S.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/10/20 → 31/03/25

  Project: Other Government Departments

  • Breast Feeding 100%
  • Cost-Benefit Analysis 86%
  • Parturition 69%
  • Randomized Controlled Trials 67%
  • Mothers 47%

• Laparoscopic versus abdominal hysterectomy trial (LAVA)

  McKinnon, W., Middleton, L., Roberts, T., Brocklehurst, P., Jones, L. & Woolley, R.

  NIHR

  1/07/20 → 30/06/27

  Project: Other Government Departments

• Discontinuation of growth hormone treatment in pubertal children: The growth hormone deficiency (GHD)reversal study

  Cummins, C., Oppong, R., Woolley, R., Mathers, J. & Rowland, N.

  NIHR

  1/06/20 → 30/11/27

  Project: Other Government Departments

• Pregnancy AntihyperteNsive Drugs: which Agent is best?

  Hardy, P. & Brocklehurst, P.

  NIHR

  1/04/20 → 30/09/25

  Project: Other Government Departments

• Stopping anticoagulation for isolated or incidental sub-segmental pulmonary embolism (STOPAPE) - OPEN FOR DISSEMINATION ONLY

  Turner, A., Greenfield, S., Newnham, M., Jowett, S., Lasserson, D., Cummins, C. & Jarrett, H.

  NIHR

  1/12/19 → 31/12/24

  Project: Other Government Departments

• Antidepressant for the prevention of DEPression following first episode Psychosis trial (ADEPP)

  Barnes, N., Upthegrove, R., Ottridge, R., Patel, S. & Al-Janabi, H.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/11/19 → 30/06/26

  Project: Other Government Departments

  • Psychotic Disorders 100%
  • Immunotherapy 47%
  • Psychology Recognition 47%
  • Depression 35%
  • Affective Symptoms 32%

• Early detection and treatment of post-partum hemorrhage using the MOTIVE bundle : a World Health Organization cluster randomized trial with health economic analysis (the E-MOTIVE study)

  Devall, A., Hemming, K., Roberts, T., Middleton, L., Brocklehurst, P., Coomarasamy, A., Martin, J., Gallos, I., Morris, K. & Price, M.

  The Bill & Melinda Gates Foundation

  1/11/19 → 30/06/25

  Project: Research

• The VITDALIZE UK Sudy: Effect of high-dose vitamin D3 on 28-day-mortality in adult critically ill patients with severe vitamin D deficiency

  Thickett, D., Jackson, L., Parekh, D., Soden, M. & Slinn, G.

  NIHR EVALUATION, TRIALS AND STUDIES COORDINATING CENTRE

  1/10/19 → 31/01/26

  Project: Other Government Departments

• STAR-TREC Phase 3: Saving the rectum by watchful waiting or TransAnal surgery following (chemo)Radiotherapy versus Total mesorectal excision for early Rectal Cancer

  Gates, S., Beggs, A., Kaur, M., Kaur, M., Tomlinson, I., Bowden, S., Bach, S. & Brock, K.

  Cancer Research Uk

  1/08/19 → 31/07/27

  Project: Research

• 'Snacktivity' to promote physical activity and reduce future risk of disease in the population

  Tearne, S., Greenfield, S., Rowland, N., Jolly, K., Greaves, C. & Frew, E.

  NIHR

  1/07/19 → 30/06/24

  Project: Other Government Departments

• A Personalised Early Warning Decision Support System with novel Saliva Bio-Profiling to Predict and Prevent Acute Exacerbations of Chronic Obstructive Pulmonary Disease - Predict&Prevent AECOPD - OPEN FOR DISSEMINATION ONLY

  Jarrett, H., Jowett, S., Mehta, R., Turner, A. & Gale, N.

  NIHR

  1/06/19 → 31/05/24

  Project: Other Government Departments